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o - Toluidine, 4 - chloro -

RTECS #: XU5000000

CAS #: 95-69-2

UPDATE: February 2008 MW: 141.61 MF: C7H8ClN


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. TUMORIGENIC DATA:
  4. ACUTE TOXICITY DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. 2 - Amino - 5 - chlorotoluene
  2. 2 - Methyl - 4 - chloroaniline
  3. 3 - Chloro - 6 - aminotoluene
  4. 4 - Chloro - 2 - methylaniline
  5. 4 - Chloro - 2 - methylbenzeneamine
  6. 4 - Chloro - 2 - toluidine
  7. 4 - Chloro - 6 - methylaniline
  8. 4 - Chloro - o - toluidine
  9. 4 - Chloro - ortho - toluidine
  10. 5 - Chloro - 2 - aminotoluene
  11. Benzenamine, 4 - chloro - 2 - methyl - (9CI)
  12. Brentamine Fast Red TR Base
  13. Daito Red Base TR
  1. Diazo Fast Red TRA
  2. Fast Red 5CT Base
  3. Fast Red Base TR
  4. Fast Red TR
  5. Fast Red TRO Base
  6. Kako Red TR Base
  7. Kambamine Red TR
  8. Mitsui Red TR Base
  9. Red Base NTR
  10. Red TR Base
  11. Sanyo Fast Red TR Base
  12. Tulabase Fast Red TR
  13. p - Chloro - o - toluidine


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
DNA damage oral
mouse 		600 mg/kg MUREAV 440,1,1999
DNA inhibition oral
mouse 		200 mg/kg MUREAV 46,305,1977
DNA repair Escherichia coli 2 gm/disc JPFCD2 19,95,1984
DNA repair Salmonella typhimurium 250 mg/disc JPFCD2 19,95,1984
unscheduled DNA synthesis rat liver 100 µmol/L MUREAV 221,263,1989
mutation in microorganisms Salmonella typhimurium 400 µg/plate (+enzymatic activation step) JPFCD2 19,95,1984
mutation in microorganisms Salmonella typhimurium 200 nmol/plate (-enzymatic activation step) JAFCAU 34,157,1986
other mutation test systems human HeLa cell 1 mmol/L BECTA6 11,184,1974


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lowest published toxic dose: 6,720 mg/kg/80 week- continuous Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Musculoskeletal: Tumors 		NTIS** OTS0543864


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
wild bird 		lethal dose (50 percent kill): 75 mg/kg N/R AECTCV 12,355,1983
oral
rat 		lethal dose (50 percent kill): 1,058 mg/kg N/R NNGADV 1,301,1976
subcutaneous
cat 		lowest published lethal dose: 310 mg/kg Behavioral: Ataxia

Gastrointestinal: Nausea or vomiting

Blood: Methemoglobinemia- Carboxhemoglobinemia 		AHBAAM 110,12,1933


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
International Agency for Research on Cancer (IARC) Cancer Review Animal Sufficient Evidence IMEMDT 77,564,2000
International Agency for Research on Cancer (IARC) Cancer Review Human Limited Evidence IMEMDT 77,564,2000
International Agency for Research on Cancer (IARC) Cancer Review Group 2A IMEMDT 77,564,2000
TOXICOLOGY REVIEW
FCTOD7 44,1699,2006
TOXICOLOGY REVIEW
BCLPT* 96,131,2005


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Exposure Limit - FINLAND Carcinogen, JAN1999
Occupational Exposure Limit - SWITZERLAND MAK- week 2 ppm (12 mg/m3), Skin, Carcinogen, DEC2006


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: T0066;
Number of Industries 2;
Total Number of Facilities 77;
Number of Occupations 3;
Total Number of Employees Exposed 1,397
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: T0066;
Number of Industries 1;
Total Number of Facilities 16;
Number of Occupations 1;
Total Number of Employees Exposed 250;
Total Number of Female Employees Exposed 250


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Positive: Carcinogenicity-mouse/rat
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used in the production of azo dyes, and an intermediate for the production of pigments
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-8896
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NTP 11th Report on Carcinogens,2004:Reasonably anticipated to be a human carcinogen


REFERENCES:

CODEN
REFERENCE
AECTCV Archives of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 070944) V.1- 1973-
AHBAAM Archiv fuer Hygiene und Bakteriologie. (Munich, Fed. Rep. Ger.) V.101-154, 1929-71. For publisher information, see ZHPMAT.
BCLPT* Basic & clinical pharmacology & toxicology (Copenhagen, Denmark : Nordic Pharmacological Society Oxford, UK : Distributed by Blackwell Munksgaard) V.94- 2004-
BECTA6 Bulletin of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1966-
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982-
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
JAFCAU Journal of Agricultural and Food Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) V.1- 1953-
JPFCD2 Journal of Environmental Science and Health, Part B: Pesticides, Food Contaminants, and Agricultural Wastes. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.B11- 1976-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NNGADV Nippon Noyaku Gakkaishi. Journal of the Pesticide Science Society of Japan. (Nippon Noyaku Gakkai, 1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan) V.1- 1976-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.

Used in the production of azo dyes, and an intermediate for the production of pigments

RTECS Compound Description:
   Tumorigen
   Mutagen
   Human Data

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