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Thyroxine, monosodium salt, D -

RTECS #: XP3582990

CAS #: 137-53-1

UPDATE: September 1997 MW: 798.85 MF: C15H10I4NO4•Na


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. REPRODUCTIVE EFFECTS DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. NIOSH DOCUMENTATION AND SURVEILLANCE:
  6. REFERENCES:

SYNONYMS:

  1. 3:5:3':5' - Tetraiodo - D - thyronine sodium
  2. Biotirmone
  3. Choloxin
  4. D - T4 sodium
  5. D - Thyroxine sodium salt
  6. D - Tyrosine, O - (4 - hydroxy - 3,5 - diiodophenyl) - 3,5 - diiodo - , monosodium salt (9CI)
  7. Debetrol
  8. Dethyrona
  9. Detyroxin
  10. Dextroid
  1. Dextrothyroxine sodium
  2. Dextroxin
  3. Dynothel
  4. Lisolipin
  5. Nadrothyron D
  6. Sodium dextrothyroxine
  7. Sodium D - T4
  8. Sodium D - thyroxine
  9. Travenon


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rabbit 		lowest published toxic dose: 29 mg/kg (1-29 day pregnant) Reproductive: Effects on embryo or fetus: Fetal death DABBBA 32,1182,1971
oral
rabbit 		lowest published toxic dose: 15 mg/kg (15-29 day pregnant) Reproductive: Effects on newborn: Physical DABBBA 32,1182,1971
oral
rabbit 		lowest published toxic dose: 16 mg/kg (16-31 day pregnant) Reproductive: Specific developmental abnormalities: Cardiovascular (circulatory) system SDMEAL 21,33,1968


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
woman 		lowest published toxic dose: 12 µg/kg/12 day- intermittent Liver: Hepatitis (hepatocellular necrosis), diffuse

Liver: Liver function tests impaired

Nutritional and Gross Metabolic: Body temperature increase 		JJMDAT 23,282,1984


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 1,500 mg/kg/30 day- continuous Vascular: BP elevation not characterized in autonomic section

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		TAKHAA 29,207,1970
oral
rat 		lowest published toxic dose: 222 mg/kg/24 week- continuous Vascular: BP elevation not characterized in autonomic section

Kidney, Ureter, and Bladder: Changes in bladder weight

Endocrine: Evidence of thyroid hyperfunction 		TAKHAA 29,565,1970


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X5407;
Number of Industries 1;
Total Number of Facilities 9;
Number of Occupations 1;
Total Number of Employees Exposed 63;
Total Number of Female Employees Exposed 9


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
N/R


REFERENCES:

CODEN
REFERENCE
DABBBA Dissertation Abstracts International, B: The Sciences and Engineering. (University Microfilms International, 300 N. Zeeb Rd., Ann Arbor, MI 48106) V.30- 1969-
JJMDAT Japanese Journal of Medicine. (Nankodo Co., Ltd., POB 5272, Tokyo International 100-31, Japan) V.1-30, 1962-1991. For publisher information, see IEDIEP.
SDMEAL South Dakota Journal of Medicine. (South Dakota Medical Assoc., 608 West Ave. N, Sioux Falls, SD 57104) V.18- 1965-
TAKHAA Takeda Kenkyusho Ho. Journal of the Takeda Research Laboratories. (Takeda Yakuhin Kogyo K.K., 2-17-85 Jusohon-machi, Yodogawa-ku, Osaka 532, Japan) V.29- 1970-

RTECS Compound Description:
   Reproductive Effector
   Human Data
   Hormone

Click Here for Additional Information about RTECS

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