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Thymol

RTECS #: XP2275000

CAS #: 89-83-8

UPDATE: November 2008 MW: 150.24 MF: C10H14O


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. ACUTE TOXICITY DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. 1 - Methyl - 3 - hydroxy - 4 - isopropylbenzene
  2. 2 - Isopropyl - 5 - methylphenol
  3. 3 - Hydroxy - p - cymene
  4. 3 - Hydroxy - 1 - methyl - 4 - isopropylbenzene
  5. 3 - Methyl - 6 - isopropylphenol
  6. 3 - p - Cymenol
  7. 5 - Methyl - 2 - isopropyl - 1 - phenol
  8. 5 - Methyl - 2 - (1 - methylethyl) phenol
  9. Isopropyl cresol
  1. Phenol, 5 - methyl - 2 - (1 - methylethyl) - (9CI)
  2. Phenol, 2 - isopropyl - 5 - methyl -
  3. Thyme camphor
  4. Thymic acid
  5. m - Cresol, 6 - isopropyl -
  6. m - Thymol
  7. p - Cymene, 3 - hydroxy -
  8. p - Cymen - 3 - ol


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis hamster lung 10 mmol/L/6 hour (+enzymatic activation step) MUREAV 517,187,2002
cytogenetic analysis human other cell types 100 µmol/L/30 hour MUREAV 650,39,2008
DNA damage human lymphocyte 100 µmol/L/30 minute TXAPA9 197,258,2004
unscheduled DNA synthesis hamster embryo 1 mg/L SHIGAZ 74,1365,1987
morphological transform hamster embryo 3 mg/L SHIGAZ 74,1365,1987
sister chromatid exchange hamster embryo 300 µg/L SHIGAZ 74,1365,1987


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
subcutaneous
rat 		lowest published toxic dose: 20 mg/kg (4 day prior to copulation) Reproductive: Maternal effects: Uterus, cervix, vagina JSICAZ 19,264,1960


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
guinea pig 		lowest published lethal dose: 300 mg/kg N/R HBTXAC 5,172,1959
intraperitoneal
mouse 		lethal dose (50 percent kill): 110 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Ataxia 		QJDRAZ 19,1,1981
intravenous
dog 		lowest published lethal dose: 150 mg/kg Lung, Thorax, or Respiration: Dyspnea THERAP 3,109,1948
intravenous
mouse 		lethal dose (50 percent kill): 100 mg/kg Behavioral: Sleep JMCMAR 23,1350,1980
intravenous
rabbit 		lowest published lethal dose: 60 mg/kg N/R HBTXAC 5,172,1959
oral
cat 		lowest published lethal dose: 250 mg/kg N/R HBTXAC 5,172,1959
oral
guinea pig 		lethal dose (50 percent kill): 880 mg/kg Behavioral: Tremor

Behavioral: Coma

Gastrointestinal: Gastritis 		FCTXAV 2,327,1964
oral
guinea pig 		lethal dose (50 percent kill): 880 mg/kg Reproductive: Paternal effects: Testes, epididymis, sperm duct FEREAC 70,21773,2005
oral
guinea pig 		lethal dose (50 percent kill): 880 mg/kg N/R FEREAC 71,2889,2006
oral
human 		lethal dose (50 percent kill): 2,000 mg/kg N/R FEREAC 68,33876,2003
oral
human 		lethal dose (50 percent kill): 2 gm/kg Reproductive: Paternal effects: Testes, epididymis, sperm duct

Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands

Endocrine: Androgenic 		FEREAC 70,21773,2005
oral
mammal (species unspecified) 		lethal dose (50 percent kill): >2 gm/kg Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands FEREAC 70,21773,2005
oral
mouse 		lethal dose (50 percent kill): 640 mg/kg Peripheral Nerve and Sensation: Spastic paralysis with/without sensory change

Lung, Thorax, or Respiration: Respiratory stimulation 		OSDIAF 5,111,1956
oral
mouse 		lethal dose (50 percent kill): 640 mg/kg Behavioral: Change in motor activity (specific assay)

Behavioral: Ataxia 		FEREAC 70,21773,2005
oral
mouse 		lethal dose (50 percent kill): 640 mg/kg N/R FEREAC 71,2889,2006
oral
rat 		lethal dose (50 percent kill): 980 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Ataxia

Behavioral: Coma 		FCTXAV 2,327,1964
oral
rat 		lethal dose (50 percent kill): 980 mg/kg Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct

Related to Chronic Data: Changes in testicular weight 		FEREAC 70,21773,2005
oral
rat 		lethal dose (50 percent kill): 980 mg/kg N/R FEREAC 71,2889,2006
oral
rabbit 		lowest published lethal dose: 750 mg/kg N/R JPETAB 17,261,1921
subcutaneous
frog 		lowest published lethal dose: 150 mg/kg N/R HBTXAC 5,172,1959
subcutaneous
guinea pig 		lowest published lethal dose: 1,100 mg/kg N/R HBTXAC 5,172,1959
subcutaneous
mouse 		lethal dose (50 percent kill): 243 mg/kg Behavioral: Somnolence (general depressed activity)

Skin and Appendages: Other: Hair 		OSDIAF 5,111,1956
subcutaneous
rat 		lowest published lethal dose: 1,600 mg/kg N/R HBTXAC 5,172,1959


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
TOXICOLOGY REVIEW
JRPMAP 12,27,1974
TOXICOLOGY REVIEW
FEREAC 71,2889,2006


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: RED Completed RBREV* -,282,1998


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 73040;
Number of Industries 9;
Total Number of Facilities 617;
Number of Occupations 15;
Total Number of Employees Exposed 13,138
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 73040;
Number of Industries 16;
Total Number of Facilities 1,050;
Number of Occupations 23;
Total Number of Employees Exposed 21,355;
Total Number of Female Employees Exposed 14,083


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Inconclusive: D melanogaster Sex-linked lethal
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as an antibacterial and antifungal agent
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7.
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
HBTXAC "Handbook of Toxicology," 4 vols., Philadelphia, W.B. Saunders Co., 1956-59
JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963-
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
JRPMAP Journal of Reproductive Medicine. (2 Jacklynn Ct., St. Louis, MO 63132) V.3- 1969-
JSICAZ Journal of Scientific and Industrial Research, Section C: Biological Sciences. (New Delhi, India) V.14-21, 1955-62. For publisher information, see IJEBA6.
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
OSDIAF Osaka Shiritsu Daigaku Igaku Zasshi. Journal of the Osaka City Medical Center. (Osaka, Japan) V.4-23, 1955-74. For publisher information, see OIGZDE.
QJDRAZ Quarterly Journal of Crude Drug Research. (Lisse, Netherlands) V.1-19, 1961-81. For publisher information, see IJCREE.
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
SHIGAZ Shigaku. Ondotology. (Nippon Shika Daigaku Shigakkai, 1-9-20 Fujimi, Chiyodaku, Tokyo 102, Japan) V.38- 1949-
THERAP Therapie. (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris, France) V.1- 1946-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-

Used as an antibacterial and antifungal agent

FDA-over the counter drug

RTECS Compound Description:
   Agricultural Chemical
   Drug
   Mutagen
   Reproductive Effector
   Human Data

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