RTECS:XP2071000 The Registry of Toxic Effects of Chemical Substances

Thymidine

RTECS #: XP2071000

CAS #: 50-89-5

UPDATE: October 1997 MW: 242.26 MF: C₁₀H₁₄N₂O₅

NOTE:

TOXICITY DATA HAVE NOT BEEN EVALUATED. OMISSION OF A SUBSTANCE OR NOTATION DOES NOT IMPLY ANY RELIEF FROM REGULATORY RESPONSIBILITY.

TABLE OF CONTENTS:

SYNONYMS:

MUTATION DATA:

REPRODUCTIVE EFFECTS DATA:

ACUTE TOXICITY DATA:

NIOSH DOCUMENTATION AND SURVEILLANCE:

STATUS IN FEDERAL AGENCIES:

REFERENCES:

SYNONYMS:

2' - Deoxythymidine

5 - Methyldeoxyurindine

DThyd

Deoxythymidine

Thymidin

Thyminedeoxyriboside

Thymine - 2 - deoxyriboside

dT

SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

MUTATION DATA AND REFERENCES:
SYSTEM TEST ROUTE/
ORGANISM/
TISSUE DOSE REFERENCE
cytogenetic analysis hamster fibroblast 500 ľmol/L CYTOAN 49,667,1984
cytogenetic analysis intraperitoneal
mouse 800 mg/kg NULSAK 20,252,1977
DNA damage mammal (species unspecified) lymphocyte 150 mmol/L PNASA6 48,686,1962
DNA inhibition human other cell types 1 mmol/L CNREA8 35,2872,1975
DNA inhibition human HeLa cell 250 mg/L JCLLAX 69,331,1967
DNA inhibition oral
mouse 1 gm/kg MUREAV 46,305,1977
DNA inhibition mouse other cell types 2 mmol/L BIJOAK 123,385,1971
unscheduled DNA synthesis intraperitoneal
mouse 100 ľg/kg AHISA9 46,181,1973
unscheduled DNA synthesis mouse fibroblast 1 ľmol/L JMCMAR 29,797,1986
micronucleus test intraperitoneal
mouse 740 mg/kg MUREAV 301,45,1993
mutation in mammalian somatic cells hamster lung 200 ľmol/L BICMBE 64,809,1982
other mutation test systems human HeLa cell 250 mg/L JCLLAX 69,331,1967
other mutation test systems human HeLa cell 2 mmol/L JCLLAX 73,109,1969
phage inhibition capacity Escherichia coli 1 gm/L ZAPOAK 12,583,1972
sister chromatid exchange hamster fibroblast 500 ľmol/L CYTOAN 49,667,1984
sister chromatid exchange hamster lung 3 mmol/L CHROAU 90,46,1984
sperm morphology intraperitoneal
mouse 4 gm/kg MUREAV 200,249,1988

REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
intraperitoneal
mouse lowest published toxic dose: 20 gm/kg (5 day male) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) MUREAV 200,249,1988
oral
mouse lowest published toxic dose: 400 mg/kg (11 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system TJADAB 32,32A,1985
parenteral
mouse lowest published toxic dose: 800 mg/kg (8 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) TJADAB 32,229,1985

TUMORIGENIC DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
intraperitoneal
mouse lethal dose (50 percent kill): 2,512 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Change in motor activity (specific assay) JPETAB 207,504,1978

OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

REVIEWS:
ORGANIZATION STANDARD
REFERENCE

N/R N/R N/R

STANDARDS AND REGULATIONS:
ORGANIZATION STANDARD
REFERENCE

N/R N/R N/R

NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X7245;
Number of Industries 2;
Total Number of Facilities 213;
Number of Occupations 3;
Total Number of Employees Exposed 578;
Total Number of Female Employees Exposed 141

STATUS IN FEDERAL AGENCIES:
ORGANIZATION
REFERENCE

EPA GENETOX PROGRAM 1988, Positive: V79 cell culture-gene mutation
EPA GENETOX PROGRAM 1988, Negative: Cell transform.-C3H/10T1/2
EPA GENETOX PROGRAM 1988, Inconclusive: Carcinogenicity-mouse/rat
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used in molecular biology and genetic engineering
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001

REFERENCES:
CODEN
REFERENCE

AHISA9 Acta Histochemica. Zeitschrift fuer Histologische Topochemie. (VEB Gustav Fischer Verlag, Postfach 176, Jena DDR-6900, Ger. Dem. Rep.) V.1- 1954-
BICMBE Biochimie. (SPPIF, B.P.22, F-41353 Vineuil, France) V.53- 1971-
BIJOAK Biochemical Journal. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1906-
CHROAU Chromosoma. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1939-
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941-
CYTOAN Cytologia. (Japan Pub. Trading Co. (USA), 1255 Howard St., San Francisco, CA 94103) V.1- 1929-
JCLLAX Journal of Cellular Physiology. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.67- 1966-
JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963-
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NULSAK Nucleus (Calcutta). (Dr. A.K. Sharma, Centre of Advanced Studies in Cell and Chromosome Research, Calcutta, 35 Baliygunge Circular Rd., Calcutta 700 019, India) V.1- 1958-
PNASA6 Proceedings of the National Academy of Sciences of the United States of America. (National Academy of Sciences, Printing & Pub. Office, 2101 Constitution Ave., Washington, DC 20418) V.1- 1915-
TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968-
ZAPOAK Zeitschrift fuer Allgemeine Mikrobiologie. (Akademie-Verlag GmbH, Postfach 1233, Berlin DDR-1086 Ger. Dem. Rep.) V.1- 1960-

Used in molecular biology and genetic engineering

RTECS Compound Description:
   Mutagen
   Reproductive Effector
   Human Data

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SYNONYMS:
2' - Deoxythymidine 5 - Methyldeoxyurindine DThyd Deoxythymidine	Thymidin Thyminedeoxyriboside Thymine - 2 - deoxyriboside dT

SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
N/R	N/R	N/R	N/R

MUTATION DATA AND REFERENCES:
SYSTEM TEST	ROUTE/ ORGANISM/ TISSUE	DOSE	REFERENCE
cytogenetic analysis	hamster fibroblast	500 ľmol/L	CYTOAN 49,667,1984
cytogenetic analysis	intraperitoneal mouse	800 mg/kg	NULSAK 20,252,1977
DNA damage	mammal (species unspecified) lymphocyte	150 mmol/L	PNASA6 48,686,1962
DNA inhibition	human other cell types	1 mmol/L	CNREA8 35,2872,1975
DNA inhibition	human HeLa cell	250 mg/L	JCLLAX 69,331,1967
DNA inhibition	oral mouse	1 gm/kg	MUREAV 46,305,1977
DNA inhibition	mouse other cell types	2 mmol/L	BIJOAK 123,385,1971
unscheduled DNA synthesis	intraperitoneal mouse	100 ľg/kg	AHISA9 46,181,1973
unscheduled DNA synthesis	mouse fibroblast	1 ľmol/L	JMCMAR 29,797,1986
micronucleus test	intraperitoneal mouse	740 mg/kg	MUREAV 301,45,1993
mutation in mammalian somatic cells	hamster lung	200 ľmol/L	BICMBE 64,809,1982
other mutation test systems	human HeLa cell	250 mg/L	JCLLAX 69,331,1967
other mutation test systems	human HeLa cell	2 mmol/L	JCLLAX 73,109,1969
phage inhibition capacity	Escherichia coli	1 gm/L	ZAPOAK 12,583,1972
sister chromatid exchange	hamster fibroblast	500 ľmol/L	CYTOAN 49,667,1984
sister chromatid exchange	hamster lung	3 mmol/L	CHROAU 90,46,1984
sperm morphology	intraperitoneal mouse	4 gm/kg	MUREAV 200,249,1988

REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
intraperitoneal mouse	lowest published toxic dose: 20 gm/kg (5 day male)	Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)	MUREAV 200,249,1988
oral mouse	lowest published toxic dose: 400 mg/kg (11 day pregnant)	Reproductive: Specific developmental abnormalities: Musculoskeletal system	TJADAB 32,32A,1985
parenteral mouse	lowest published toxic dose: 800 mg/kg (8 day pregnant)	Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)	TJADAB 32,229,1985

TUMORIGENIC DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
N/R	N/R	N/R	N/R

ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
intraperitoneal mouse	lethal dose (50 percent kill): 2,512 mg/kg	Behavioral: Somnolence (general depressed activity) Behavioral: Change in motor activity (specific assay)	JPETAB 207,504,1978

OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
N/R	N/R	N/R	N/R

STANDARDS AND REGULATIONS:
ORGANIZATION	STANDARD	REFERENCE
N/R	N/R	N/R

NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION	STANDARD or SURVEY	REFERENCE
National Occupational Exposure Survey 1983	National Occupational Exposure Survey 1983: Hazard Code: X7245; Number of Industries 2; Total Number of Facilities 213; Number of Occupations 3; Total Number of Employees Exposed 578; Total Number of Female Employees Exposed 141

STATUS IN FEDERAL AGENCIES:
ORGANIZATION	REFERENCE
EPA GENETOX PROGRAM 1988, Positive: V79 cell culture-gene mutation
EPA GENETOX PROGRAM 1988, Negative: Cell transform.-C3H/10T1/2
EPA GENETOX PROGRAM 1988, Inconclusive: Carcinogenicity-mouse/rat
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used in molecular biology and genetic engineering
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001

REFERENCES:
CODEN	REFERENCE
AHISA9	Acta Histochemica. Zeitschrift fuer Histologische Topochemie. (VEB Gustav Fischer Verlag, Postfach 176, Jena DDR-6900, Ger. Dem. Rep.) V.1- 1954-
BICMBE	Biochimie. (SPPIF, B.P.22, F-41353 Vineuil, France) V.53- 1971-
BIJOAK	Biochemical Journal. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1906-
CHROAU	Chromosoma. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1939-
CNREA8	Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941-
CYTOAN	Cytologia. (Japan Pub. Trading Co. (USA), 1255 Howard St., San Francisco, CA 94103) V.1- 1929-
JCLLAX	Journal of Cellular Physiology. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.67- 1966-
JMCMAR	Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963-
JPETAB	Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
MUREAV	Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NULSAK	Nucleus (Calcutta). (Dr. A.K. Sharma, Centre of Advanced Studies in Cell and Chromosome Research, Calcutta, 35 Baliygunge Circular Rd., Calcutta 700 019, India) V.1- 1958-
PNASA6	Proceedings of the National Academy of Sciences of the United States of America. (National Academy of Sciences, Printing & Pub. Office, 2101 Constitution Ave., Washington, DC 20418) V.1- 1915-
TJADAB	Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968-
ZAPOAK	Zeitschrift fuer Allgemeine Mikrobiologie. (Akademie-Verlag GmbH, Postfach 1233, Berlin DDR-1086 Ger. Dem. Rep.) V.1- 1960-