RTECS:XO8576500 The Registry of Toxic Effects of Chemical Substances | CDC/NIOSH

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Threitol, 1,4 - dithio - , DL -

RTECS #: XO8576500

CAS #: 27565-41-9

UPDATE: August 2006 MW: 154.26 MF: C₄H₁₀O₂S₂

NOTE:

TOXICITY DATA HAVE NOT BEEN EVALUATED. OMISSION OF A SUBSTANCE OR NOTATION DOES NOT IMPLY ANY RELIEF FROM REGULATORY RESPONSIBILITY.

TABLE OF CONTENTS:

SYNONYMS:

MUTATION DATA:

ACUTE TOXICITY DATA:

NIOSH DOCUMENTATION AND SURVEILLANCE:

REFERENCES:

SYNONYMS:

(R,R) - (+ - ) - 1,4 - Dimercapto - 2,3 - butanediol

2,3 - Butanediol, 1,4 - dimercapto - , DL - threo -

2,3 - Butanediol, 1,4 - dimercapto - , (R,R) - (+ - ) - (9CI)

Cleland's reagent

DL - 1,4 - Dithiothreitol

DL - Dithiothreitol

DL - threo - 1,4 - Dimercapto - 2,3 - butanediol

Dithiothreitol

rac - Dithiothreitol

SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

MUTATION DATA AND REFERENCES:
SYSTEM TEST ROUTE/
ORGANISM/
TISSUE DOSE REFERENCE
DNA damage other microorganisms 1 mmol/L BBRCA9 77,1150,1977
DNA inhibition rat liver 1 mmol/L ABBIA4 166,400,1975
mutation in microorganisms Escherichia coli 100 痢/plate (-enzymatic activation step) MUREAV 467,41,2000
mutation in microorganisms Salmonella typhimurium 100 痢/plate (+/-enzymatic activation step) ABCHA6 45,327,1981
micronucleus test non-mammalian species embryo 2 mmol/L JCLBA3 60,497,1974

REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

TUMORIGENIC DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
intraperitoneal
mouse lethal dose (50 percent kill): 169 mg/kg N/R JMCMAR 15,600,1972
intraperitoneal
mouse lowest published toxic dose: 50 mg/kg Behavioral: Altered sleep time (including change in righting reflex) PSCHDL 174,283,2004
intraperitoneal
rat lowest published toxic dose: 25 mg/kg Behavioral: Altered sleep time (including change in righting reflex) PSCHDL 174,283,2004
intraperitoneal
rat lowest published toxic dose: 25 mg/kg Behavioral: Change in psychophysiological tests PSCHDL 174,283,2004
intraperitoneal
rat lowest published toxic dose: 25 mg/kg Behavioral: Alteration of operant conditioning

Behavioral: Change in psychophysiological tests PSCHDL 174,283,2004
intravenous
mouse lethal dose (50 percent kill): 94 mg/kg N/R ARZNAD 22,1434,1972
subcutaneous
mouse lethal dose (50 percent kill): 333 mg/kg N/R ARZNAD 22,1434,1972

OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

REVIEWS:
ORGANIZATION STANDARD
REFERENCE

N/R N/R N/R

STANDARDS AND REGULATIONS:
ORGANIZATION STANDARD
REFERENCE

N/R N/R N/R

NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X2950;
Number of Industries 1;
Total Number of Facilities 35;
Number of Occupations 3;
Total Number of Employees Exposed 627;
Total Number of Female Employees Exposed 436

STATUS IN FEDERAL AGENCIES:
ORGANIZATION
REFERENCE

N/R

REFERENCES:
CODEN
REFERENCE

ABBIA4 Archives of Biochemistry and Biophysics. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.31- 1951-
ABCHA6 Agricultural and Biological Chemistry. (Maruzen Co. Ltd., POB 5050, Tokyo International, Tokyo 100-31, Japan) V.25- 1961-
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
BBRCA9 Biochemical and Biophysical Research Communications. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
JCLBA3 Journal of Cell Biology. (Rockefeller Univ. Press, 1230 York Ave., New York, NY 10003) V.12- 1962-
JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
PSCHDL Psychopharmacology (Berlin). (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.47- 1976-

Used in clinical chemistry

RTECS Compound Description:
Mutagen

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