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Thiophene, tetrahydro - , 1,1 - dioxide

RTECS #: XN0700000

CAS #: 126-33-0

UPDATE: February 2006 MW: 120.18 MF: C4H8O2S


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. STANDARDS AND REGULATIONS:
  6. NIOSH DOCUMENTATION AND SURVEILLANCE:
  7. STATUS IN FEDERAL AGENCIES:
  8. REFERENCES:

SYNONYMS:

  1. 1,1 - Dioxidetetrahydrothiofuran
  2. 1,1 - Dioxidetetrahydrothiophene
  3. 1,1 - Dioxothiolan
  4. 2,3,4,5 - Tetrahydrothiophene - 1,1 - dioxide
  5. Bondelane A
  6. Bondolane A
  7. Cyclic tetramethylene sulfone
  8. Cyclotetramethylene sulfone
  9. Dihydrobutadiene sulphone
  10. Dioxothiolan
  11. Sulfalone
  12. Sulfolan
  1. Sulfolane
  2. Sulpholane
  3. Sulphoxaline
  4. Tetrahydrothiofen - 1,1 - dioxid (Czech)
  5. Tetrahydrothiophene dioxide
  6. Tetrahydrothiophene 1,1 - dioxide
  7. Tetramethylene sulfone
  8. Thiacyclopentane dioxide
  9. Thiocyclopentane - 1,1 - dioxide
  10. Thiolane - 1,1 - dioxide
  11. Thiophane dioxide
  12. Thiophan sulfone


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		253 mg mild BJIMAG 23,302,1966


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lethal concentration : >250 mg/m3/8 hour N/R NTIS** OTS0535072
intraperitoneal
mouse 		lethal dose (50 percent kill): 1,250 mg/kg Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation RPTOAN 42,97,1979
intraperitoneal
rat 		lethal dose (50 percent kill): 1,600 mg/kg N/R TOXID9 4,22,1984
intravenous
mouse 		lethal dose (50 percent kill): 1,080 mg/kg Behavioral: Convulsions or effect on seizure threshold

Behavioral: Excitement 		AIPTAK 119,423,1959
oral
mouse 		lethal dose (50 percent kill): 1,900 mg/kg N/R 34ZIAG -,560,1969
oral
rat 		lethal dose (50 percent kill): 1,540 µL/kg N/R AIHAAP 30,470,1969
subcutaneous
rat 		lethal dose (50 percent kill): 1,620 µL/kg N/R NTIS** OTS0535072
skin
rat 		lethal dose (50 percent kill): >3,800 mg/kg N/R BJIMAG 23,302,1966
skin
rabbit 		lethal dose (50 percent kill): 3,180 µL/kg Liver: Other changes

Kidney, Ureter, and Bladder: Other changes

Skin: After systemic exposure: Dermatitis, other 		NTIS** OTS0535072


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
guinea pig 		lowest published toxic concentration: 200 mg/m3/23 hour/90 day- continuous Blood: Changes in leukocyte (WBC) count TXAPA9 40,463,1977
inhalation
monkey 		lowest published toxic concentration: 495 mg/m3/8 hour/27 day- intermittent Lung, Thorax, or Respiration: Other changes

Liver: Fatty liver degeneration

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		TXAPA9 40,463,1977
oral
dog 		lowest published toxic dose: 6,350 mg/kg/23 week- intermittent Vascular: Pulse pressure increase NTIS** OTS0533719
oral
rat 		lowest published toxic dose: 6,750 mg/kg/2 week- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		NTIS** OTS0533719


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Exposure Limit - RUSSIA short term exposure limit 40 mg/m3, JUN2003


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 80612;
Number of Industries 2;
Total Number of Facilities 27;
Number of Occupations 3;
Total Number of Employees Exposed 143
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 80612;
Number of Industries 5;
Total Number of Facilities 386;
Number of Occupations 10;
Total Number of Employees Exposed 6,635;
Total Number of Female Employees Exposed 322


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as a selective solvent for liquid-vapor extractions
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
34ZIAG "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958-
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898-
BJIMAG British Journal of Industrial Medicine. (British Medical Journal, Box 560B, Kennebunkport, ME 04046) V.1- 1944-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
RPTOAN Russian Pharmacology and Toxicology (English Translation). Translation of FATOAO. (Euromed Pub., 33, Woodlands Rd., Surbiton, Surrey, UK) V.30- 1967-
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-

Used as a selective solvent for liquid-vapor extractions

RTECS Compound Description:
   Drug
   Primary Irritant

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