RTECS:XI0388300 The Registry of Toxic Effects of Chemical Substances

5 - Thia - 1 - azabicyclo (4.2.0) oct - 2 - ene - 2 - carboxylic acid, 3 - (hydroxymethyl) - 8 - oxo - 7 - (2 - (2 - thienyl) acetamido) - , acetate, monosodium salt

RTECS #: XI0388300

CAS #: 58-71-9

UPDATE: February 2003 MW: 418.44 MF: C₁₆H₁₅N₂O₆S₂•Na

NOTE:

TOXICITY DATA HAVE NOT BEEN EVALUATED. OMISSION OF A SUBSTANCE OR NOTATION DOES NOT IMPLY ANY RELIEF FROM REGULATORY RESPONSIBILITY.

TABLE OF CONTENTS:

SYNONYMS:

REPRODUCTIVE EFFECTS DATA:

ACUTE TOXICITY DATA:

OTHER MULTIPLE DOSE DATA:

NIOSH DOCUMENTATION AND SURVEILLANCE:

STATUS IN FEDERAL AGENCIES:

REFERENCES:

SYNONYMS:

7 - (Thiophene - 2 - acetamido) cephalosporanic acid sodium salt

Averon - 1

Cefalothine sodium

Cefalothin sodium

Cefalotina sodica (Spanish)

Cephalothin sodium

Ceporacin

Cepovenin

Chephalotin

Coaxin

Keflin

Lilly 38253

Lospoven

Microtin

Sodium cephalothin

Synclotin

Toricelocin

SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

MUTATION DATA AND REFERENCES:
SYSTEM TEST ROUTE/
ORGANISM/
TISSUE DOSE REFERENCE
N/R N/R N/R N/R

REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
subcutaneous
mouse lowest published toxic dose: 1,000 mg/kg (9 day pregnant) Reproductive: Effects on embryo or fetus: Fetal death

Reproductive: Other developmental abnormalities VCVPS* -,392,1998
subcutaneous
mouse lowest published toxic dose: 1,000 mg/kg (10 day pregnant) Reproductive: Effects on embryo or fetus: Fetal death

Reproductive: Other developmental abnormalities VCVPS* -,392,1998
subcutaneous
mouse lowest published toxic dose: 1,000 mg/kg (18 day pregnant) Reproductive: Effects on embryo or fetus: Fetal death

Reproductive: Other developmental abnormalities VCVPS* -,392,1998

TUMORIGENIC DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
intramuscular
child lowest published toxic dose: 89 mg/kg/19 day- intermittent Blood: Angranulocytosis AACHAX -,272,1963
intramuscular
man lowest published toxic dose: 955 mg/kg/22 day- intermittent Blood: Angranulocytosis AACHAX -,272,1963
intramuscular
mouse lethal dose (50 percent kill): >4 gm/kg N/R AMACCQ 1,67,1972
intraperitoneal
mouse lethal dose (50 percent kill): 5,670 mg/kg Eye: Other eye effects

Behavioral: Convulsions or effect on seizure threshold

Skin and Appendages: Other: Hair JJANAX 27,746,1974
intraperitoneal
rat lethal dose (50 percent kill): 6,250 mg/kg N/R TXAPA9 18,185,1971
intravenous
cat lethal dose : >1 gm/kg N/R JIDIAQ 137,S51,1978
intravenous
dog lowest published lethal dose: 6 gm/kg Eye: Lacrimation

Behavioral: Convulsions or effect on seizure threshold

Gastrointestinal: Nausea or vomiting JJANAX 28,205,1975
intravenous
guinea pig lethal dose (50 percent kill): 150 mg/kg Behavioral: Convulsions or effect on seizure threshold CLMEA3 70,1123,1963
intravenous
mouse lethal dose (50 percent kill): 4,800 mg/kg Eye: Other eye effects

Behavioral: Convulsions or effect on seizure threshold

Skin and Appendages: Other: Hair JJANAX 27,746,1974
intravenous
mouse lethal dose (50 percent kill): 5,000 mg/kg N/R VCVPS* -,392,1998
intravenous
rat lethal dose (50 percent kill): 5,600 mg/kg Eye: Lacrimation

Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Dyspnea JJANAX 28,231,1975
intravenous
rabbit lethal dose : >2 gm/kg N/R JIDIAQ 137,S51,1978
intravenous
woman lowest published toxic dose: 20 mg/kg Blood: Thrombocytopenia AIMEAS 77,401,1972
oral
mouse lethal dose : >20 gm/kg N/R JJANAX 28,81,1975
oral
rat lethal dose (50 percent kill): >10 gm/kg N/R JJANAX 27,746,1974
subcutaneous
guinea pig lethal dose (50 percent kill): 110 mg/kg Behavioral: Convulsions or effect on seizure threshold CLMEA3 70,1123,1963
subcutaneous
mouse lethal dose (50 percent kill): 7,500 mg/kg N/R JACHDX 6(Suppl A),79,1980
subcutaneous
rat lethal dose (50 percent kill): 7,500 mg/kg Lung, Thorax, or Respiration: Acute pulmonary edema CLMEA3 70,1123,1963

OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
intramuscular
rat lowest published toxic dose: 48 gm/kg/30 day- intermittent Endocrine: Changes in thyroid weight

Blood: Changes in erythrocyte (RBC) count

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases JJANAX 27,746,1974
intraperitoneal
rat lowest published toxic dose: 96 gm/kg/30 day- intermittent Liver: Changes in liver weight

Endocrine: Changes in adrenal weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases JJANAX 27,746,1974
intraperitoneal
rat lowest published toxic dose: 78 gm/kg/26 week- intermittent Blood: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field JJANAX 28,195,1975
intravenous
dog lowest published toxic dose: 52 gm/kg/30 day- intermittent Gastrointestinal: Nausea or vomiting

Liver: Other changes

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) JJANAX 28,205,1975
intravenous
dog lowest published toxic dose: 15 gm/kg/10 day- intermittent Eye: Lacrimation

Gastrointestinal: Changes in structure or function of salivary glands

Gastrointestinal: Nausea or vomiting JJANAX 28,205,1975
intravenous
rat lowest published toxic dose: 63 gm/kg/21 day- intermittent Lung, Thorax, or Respiration: Respiratory stimulation

Kidney, Ureter, and Bladder: Changes in bladder weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain NKRZAZ 26(Suppl 1),185,1978
intravenous
rat lowest published toxic dose: 72,900 mg/kg/31 day- intermittent Gastrointestinal: Other changes

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases JJANAX 28,231,1975

REVIEWS:
ORGANIZATION STANDARD
REFERENCE

N/R N/R N/R

STANDARDS AND REGULATIONS:
ORGANIZATION STANDARD
REFERENCE

N/R N/R N/R

NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 83944;
Number of Industries 1;
Total Number of Facilities 33;
Number of Occupations 1;
Total Number of Employees Exposed 1,650
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 83944;
Number of Industries 1;
Total Number of Facilities 620;
Number of Occupations 11;
Total Number of Employees Exposed 22,644;
Total Number of Female Employees Exposed 18,457

STATUS IN FEDERAL AGENCIES:
ORGANIZATION
REFERENCE

EPA GENETOX PROGRAM 1988, Negative: E coli polA without S9

REFERENCES:
CODEN
REFERENCE

AACHAX Antimicrobial Agents and Chemotherapy (1961-70). (Ann Arbor, MI) 1961-70. For publisher information, see AMACCQ.
AIMEAS Annals of Internal Medicine. (American College of Physicians, 4200 Pine St., Philadelphia, PA 19104) V.1- 1927-
AMACCQ Antimicrobial Agents and Chemotherapy. (American Soc. for Microbiology, 1913 I St., NW, Washington, DC 20006) V.1- 1972-
CLMEA3 Clinical Medicine. (Northfield, IL) V.31-33, 1924-26; V.47-85, 1940-78.
JACHDX Journal of Antimicrobial Chemotherapy. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1975-
JIDIAQ Journal of Infectious Diseases. (Univ. of Chicago Press, Journals Div., POB 37005, Chicago, IL 60637) V.1- 1904-
JJANAX Japanese Journal of Antibiotics. (Japan Antibiotics Research Assoc., 2-20-8 Kamiosaki, Shinagawa-ku, Tokyo 141, Japan) V.21- 1968-
NKRZAZ Chemotherapy (Tokyo). (Nippon Kagaku Ryoho Gakkai, 2-20-8 Kamiosaki, Shinagawa-Ku, Tokyo 141, Japan) V.1- 1953-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
VCVPS* "Vrednie chemichescie veshestva. Prirodnie organicheskie soedinenia" (Hazardous substances. Nature products.) Volkova N.V. et al., Sankt-Peterburg, 1998.

Used as an antibacterial agent

FDA-proprietary drug

RTECS Compound Description:
   Drug
   Mutagen
   Reproductive Effector
   Human Data

Click Here for Additional Information about RTECS

NIOSH Home | NIOSH Search | Site Index | Topic List | RTECS List | Contact Us

SYNONYMS:
7 - (Thiophene - 2 - acetamido) cephalosporanic acid sodium salt Averon - 1 Cefalothine sodium Cefalothin sodium Cefalotina sodica (Spanish) Cephalothin sodium Ceporacin Cepovenin Chephalotin	Coaxin Keflin Lilly 38253 Lospoven Microtin Sodium cephalothin Synclotin Toricelocin

SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
N/R	N/R	N/R	N/R

MUTATION DATA AND REFERENCES:
SYSTEM TEST	ROUTE/ ORGANISM/ TISSUE	DOSE	REFERENCE
N/R	N/R	N/R	N/R

REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
subcutaneous mouse	lowest published toxic dose: 1,000 mg/kg (9 day pregnant)	Reproductive: Effects on embryo or fetus: Fetal death Reproductive: Other developmental abnormalities	VCVPS* -,392,1998
subcutaneous mouse	lowest published toxic dose: 1,000 mg/kg (10 day pregnant)	Reproductive: Effects on embryo or fetus: Fetal death Reproductive: Other developmental abnormalities	VCVPS* -,392,1998
subcutaneous mouse	lowest published toxic dose: 1,000 mg/kg (18 day pregnant)	Reproductive: Effects on embryo or fetus: Fetal death Reproductive: Other developmental abnormalities	VCVPS* -,392,1998

TUMORIGENIC DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
N/R	N/R	N/R	N/R

ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
intramuscular child	lowest published toxic dose: 89 mg/kg/19 day- intermittent	Blood: Angranulocytosis	AACHAX -,272,1963
intramuscular man	lowest published toxic dose: 955 mg/kg/22 day- intermittent	Blood: Angranulocytosis	AACHAX -,272,1963
intramuscular mouse	lethal dose (50 percent kill): >4 gm/kg	N/R	AMACCQ 1,67,1972
intraperitoneal mouse	lethal dose (50 percent kill): 5,670 mg/kg	Eye: Other eye effects Behavioral: Convulsions or effect on seizure threshold Skin and Appendages: Other: Hair	JJANAX 27,746,1974
intraperitoneal rat	lethal dose (50 percent kill): 6,250 mg/kg	N/R	TXAPA9 18,185,1971
intravenous cat	lethal dose : >1 gm/kg	N/R	JIDIAQ 137,S51,1978
intravenous dog	lowest published lethal dose: 6 gm/kg	Eye: Lacrimation Behavioral: Convulsions or effect on seizure threshold Gastrointestinal: Nausea or vomiting	JJANAX 28,205,1975
intravenous guinea pig	lethal dose (50 percent kill): 150 mg/kg	Behavioral: Convulsions or effect on seizure threshold	CLMEA3 70,1123,1963
intravenous mouse	lethal dose (50 percent kill): 4,800 mg/kg	Eye: Other eye effects Behavioral: Convulsions or effect on seizure threshold Skin and Appendages: Other: Hair	JJANAX 27,746,1974
intravenous mouse	lethal dose (50 percent kill): 5,000 mg/kg	N/R	VCVPS* -,392,1998
intravenous rat	lethal dose (50 percent kill): 5,600 mg/kg	Eye: Lacrimation Behavioral: Convulsions or effect on seizure threshold Lung, Thorax, or Respiration: Dyspnea	JJANAX 28,231,1975
intravenous rabbit	lethal dose : >2 gm/kg	N/R	JIDIAQ 137,S51,1978
intravenous woman	lowest published toxic dose: 20 mg/kg	Blood: Thrombocytopenia	AIMEAS 77,401,1972
oral mouse	lethal dose : >20 gm/kg	N/R	JJANAX 28,81,1975
oral rat	lethal dose (50 percent kill): >10 gm/kg	N/R	JJANAX 27,746,1974
subcutaneous guinea pig	lethal dose (50 percent kill): 110 mg/kg	Behavioral: Convulsions or effect on seizure threshold	CLMEA3 70,1123,1963
subcutaneous mouse	lethal dose (50 percent kill): 7,500 mg/kg	N/R	JACHDX 6(Suppl A),79,1980
subcutaneous rat	lethal dose (50 percent kill): 7,500 mg/kg	Lung, Thorax, or Respiration: Acute pulmonary edema	CLMEA3 70,1123,1963

OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
intramuscular rat	lowest published toxic dose: 48 gm/kg/30 day- intermittent	Endocrine: Changes in thyroid weight Blood: Changes in erythrocyte (RBC) count Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases	JJANAX 27,746,1974
intraperitoneal rat	lowest published toxic dose: 96 gm/kg/30 day- intermittent	Liver: Changes in liver weight Endocrine: Changes in adrenal weight Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases	JJANAX 27,746,1974
intraperitoneal rat	lowest published toxic dose: 78 gm/kg/26 week- intermittent	Blood: Other changes Nutritional and Gross Metabolic: Weight loss or decreased weight gain Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	JJANAX 28,195,1975
intravenous dog	lowest published toxic dose: 52 gm/kg/30 day- intermittent	Gastrointestinal: Nausea or vomiting Liver: Other changes Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)	JJANAX 28,205,1975
intravenous dog	lowest published toxic dose: 15 gm/kg/10 day- intermittent	Eye: Lacrimation Gastrointestinal: Changes in structure or function of salivary glands Gastrointestinal: Nausea or vomiting	JJANAX 28,205,1975
intravenous rat	lowest published toxic dose: 63 gm/kg/21 day- intermittent	Lung, Thorax, or Respiration: Respiratory stimulation Kidney, Ureter, and Bladder: Changes in bladder weight Nutritional and Gross Metabolic: Weight loss or decreased weight gain	NKRZAZ 26(Suppl 1),185,1978
intravenous rat	lowest published toxic dose: 72,900 mg/kg/31 day- intermittent	Gastrointestinal: Other changes Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases	JJANAX 28,231,1975

STANDARDS AND REGULATIONS:
ORGANIZATION	STANDARD	REFERENCE
N/R	N/R	N/R

NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION	STANDARD or SURVEY	REFERENCE
National Occupational Hazard Survey 1974	National Occupational Hazard Survey 1974: Hazard Code: 83944; Number of Industries 1; Total Number of Facilities 33; Number of Occupations 1; Total Number of Employees Exposed 1,650
National Occupational Exposure Survey 1983	National Occupational Exposure Survey 1983: Hazard Code: 83944; Number of Industries 1; Total Number of Facilities 620; Number of Occupations 11; Total Number of Employees Exposed 22,644; Total Number of Female Employees Exposed 18,457

STATUS IN FEDERAL AGENCIES:
ORGANIZATION	REFERENCE
EPA GENETOX PROGRAM 1988, Negative: E coli polA without S9

REFERENCES:
CODEN	REFERENCE
AACHAX	Antimicrobial Agents and Chemotherapy (1961-70). (Ann Arbor, MI) 1961-70. For publisher information, see AMACCQ.
AIMEAS	Annals of Internal Medicine. (American College of Physicians, 4200 Pine St., Philadelphia, PA 19104) V.1- 1927-
AMACCQ	Antimicrobial Agents and Chemotherapy. (American Soc. for Microbiology, 1913 I St., NW, Washington, DC 20006) V.1- 1972-
CLMEA3	Clinical Medicine. (Northfield, IL) V.31-33, 1924-26; V.47-85, 1940-78.
JACHDX	Journal of Antimicrobial Chemotherapy. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1975-
JIDIAQ	Journal of Infectious Diseases. (Univ. of Chicago Press, Journals Div., POB 37005, Chicago, IL 60637) V.1- 1904-
JJANAX	Japanese Journal of Antibiotics. (Japan Antibiotics Research Assoc., 2-20-8 Kamiosaki, Shinagawa-ku, Tokyo 141, Japan) V.21- 1968-
NKRZAZ	Chemotherapy (Tokyo). (Nippon Kagaku Ryoho Gakkai, 2-20-8 Kamiosaki, Shinagawa-Ku, Tokyo 141, Japan) V.1- 1953-
TXAPA9	Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
VCVPS*	"Vrednie chemichescie veshestva. Prirodnie organicheskie soedinenia" (Hazardous substances. Nature products.) Volkova N.V. et al., Sankt-Peterburg, 1998.