RTECS:XI0388000 The Registry of Toxic Effects of Chemical Substances

5 - Thia - 1 - azabicyclo (4.2.0) oct - 2 - ene - 2 - carboxylic acid, 3 - (hydroxymethyl) - 8 - oxo - 7 - (2 - (2 - thienyl) acetamido) - , acetate (ester)

RTECS #: XI0388000

CAS #: 153-61-7

UPDATE: July 1997 MW: 396.46 MF: C₁₆H₁₆N₂O₆S₂

NOTE:

TOXICITY DATA HAVE NOT BEEN EVALUATED. OMISSION OF A SUBSTANCE OR NOTATION DOES NOT IMPLY ANY RELIEF FROM REGULATORY RESPONSIBILITY.

TABLE OF CONTENTS:

SYNONYMS:

MUTATION DATA:

REPRODUCTIVE EFFECTS DATA:

ACUTE TOXICITY DATA:

OTHER MULTIPLE DOSE DATA:

NIOSH DOCUMENTATION AND SURVEILLANCE:

REFERENCES:

SYNONYMS:

7 - (2 - Thienylacetamido) cephalosporanic acid

7 - (Thiophene - 2 - acetamido) cephalosporanic acid

Cefalotin

Cephalothin

Cephalotin

SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

MUTATION DATA AND REFERENCES:
SYSTEM TEST ROUTE/
ORGANISM/
TISSUE DOSE REFERENCE
phage inhibition capacity other microorganisms 25 痢/plate ZMMPAO 231,369,1975

REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
subcutaneous
mouse lowest published toxic dose: 18 gm/kg (9-11 day pregnant) Reproductive: Effects on embryo or fetus: Fetal death

Reproductive: Specific developmental abnormalities: Skin and skin appendages SEIJBO 16,250,1976
subcutaneous
rat lowest published toxic dose: 8,800 mg/kg (7-17 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system NKRZAZ 27(Suppl 6),245,1979
unreported route
mouse lowest published toxic dose: 9 gm/kg (9-11 day pregnant) Reproductive: Effects on embryo or fetus: Fetal death

Reproductive: Other developmental abnormalities TJADAB 14,250,1976

TUMORIGENIC DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
intracerebral
mouse lethal dose (50 percent kill): 81 mg/kg N/R AACHAX -,863,1965
intramuscular
mouse lethal dose (50 percent kill): 7 gm/kg Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) BYYADW 3,220,1978
intraperitoneal
rat lethal dose (50 percent kill): 4,296 mg/kg N/R ANTBAL 26,44,1981
intravenous
mouse lethal dose (50 percent kill): 4,990 mg/kg N/R NKRZAZ 26(Suppl 1),150,1978
intravenous
rat lethal dose (50 percent kill): >5 gm/kg Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Acute pulmonary edema

Kidney, Ureter, and Bladder: Other changes NKRZAZ 31(Suppl 3),817,1983
parenteral
rat lethal dose (50 percent kill): 23 mg/kg N/R AACHAX -,863,1965
subcutaneous
mouse lethal dose (50 percent kill): >4 gm/kg N/R AMACCQ 3,40,1973
subcutaneous
rat lethal dose (50 percent kill): 10 gm/kg Kidney, Ureter, and Bladder: Other changes NKRZAZ 27(Suppl 6),124,1979

OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
intramuscular
rat lowest published toxic dose: 31 gm/kg/31 day- intermittent Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) ANTBAL 26,44,1981
intravenous
rat lowest published toxic dose: 21 gm/kg/21 day- intermittent Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Kidney, Ureter, and Bladder: Other changes in urine composition

Nutritional and Gross Metabolic: Changes in: Na NKRZAZ 40(Suppl 4),162,1992
subcutaneous
rat lowest published toxic dose: 70 gm/kg/35 day- intermittent Blood: Normocytic anemia

Skin: After systemic exposure: Dermatitis, other

Nutritional and Gross Metabolic: Weight loss or decreased weight gain NKRZAZ 31(Suppl 3),817,1983

REVIEWS:
ORGANIZATION STANDARD
REFERENCE

N/R N/R N/R

STANDARDS AND REGULATIONS:
ORGANIZATION STANDARD
REFERENCE

N/R N/R N/R

NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 83991;
Number of Industries 1;
Total Number of Facilities 33;
Number of Occupations 3;
Total Number of Employees Exposed 1,452
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 83991;
Number of Industries 1;
Total Number of Facilities 290;
Number of Occupations 8;
Total Number of Employees Exposed 21,013;
Total Number of Female Employees Exposed 19,052

STATUS IN FEDERAL AGENCIES:
ORGANIZATION
REFERENCE

N/R

REFERENCES:
CODEN
REFERENCE

AACHAX Antimicrobial Agents and Chemotherapy (1961-70). (Ann Arbor, MI) 1961-70. For publisher information, see AMACCQ.
AMACCQ Antimicrobial Agents and Chemotherapy. (American Soc. for Microbiology, 1913 I St., NW, Washington, DC 20006) V.1- 1972-
ANTBAL Antibiotiki. (Moscow, USSR) V.1-29, 1956-84. For publisher information, see AMBIEH.
BYYADW Byoin Yakugaku. Hospital Pharmacology. (Yakuji Nippon Sha, 1-11 Izumi-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan) V.1- 1975-
NKRZAZ Chemotherapy (Tokyo). (Nippon Kagaku Ryoho Gakkai, 2-20-8 Kamiosaki, Shinagawa-Ku, Tokyo 141, Japan) V.1- 1953-
SEIJBO Senten Ijo. Congenital Anomalies. (Nippon Senten Ijo Gakkai, c/o Kinki Daigaku Igakubu Kaibagaku Kyoshitsu, 380 Nishiyama, Sayama-cho, Mirami-Kawachi-gun, Osaka-fu, Japan) V.1-26, 1960-86. For publisher information, see CGANE7.
TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968-
ZMMPAO Zentralblatt fuer Bakteriologie, Parasitenkunde, Infektionskrankheiten und Hygiene, Abteilung 1: Originale, Reihe A: Medizinische Mikrobiologie und Parasitologie. (Stuttgart, Fed. Rep. Ger.) V.217-245, 1971-79.

RTECS Compound Description:
   Drug
   Mutagen
   Reproductive Effector

Click Here for Additional Information about RTECS

NIOSH Home | NIOSH Search | Site Index | Topic List | Contact Us

SYNONYMS:
7 - (2 - Thienylacetamido) cephalosporanic acid 7 - (Thiophene - 2 - acetamido) cephalosporanic acid Cefalotin	Cephalothin Cephalotin

SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
N/R	N/R	N/R	N/R

MUTATION DATA AND REFERENCES:
SYSTEM TEST	ROUTE/ ORGANISM/ TISSUE	DOSE	REFERENCE
phage inhibition capacity	other microorganisms	25 痢/plate	ZMMPAO 231,369,1975

REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
subcutaneous mouse	lowest published toxic dose: 18 gm/kg (9-11 day pregnant)	Reproductive: Effects on embryo or fetus: Fetal death Reproductive: Specific developmental abnormalities: Skin and skin appendages	SEIJBO 16,250,1976
subcutaneous rat	lowest published toxic dose: 8,800 mg/kg (7-17 day pregnant)	Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) Reproductive: Specific developmental abnormalities: Musculoskeletal system	NKRZAZ 27(Suppl 6),245,1979
unreported route mouse	lowest published toxic dose: 9 gm/kg (9-11 day pregnant)	Reproductive: Effects on embryo or fetus: Fetal death Reproductive: Other developmental abnormalities	TJADAB 14,250,1976

TUMORIGENIC DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
N/R	N/R	N/R	N/R

ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
intracerebral mouse	lethal dose (50 percent kill): 81 mg/kg	N/R	AACHAX -,863,1965
intramuscular mouse	lethal dose (50 percent kill): 7 gm/kg	Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)	BYYADW 3,220,1978
intraperitoneal rat	lethal dose (50 percent kill): 4,296 mg/kg	N/R	ANTBAL 26,44,1981
intravenous mouse	lethal dose (50 percent kill): 4,990 mg/kg	N/R	NKRZAZ 26(Suppl 1),150,1978
intravenous rat	lethal dose (50 percent kill): >5 gm/kg	Behavioral: Convulsions or effect on seizure threshold Lung, Thorax, or Respiration: Acute pulmonary edema Kidney, Ureter, and Bladder: Other changes	NKRZAZ 31(Suppl 3),817,1983
parenteral rat	lethal dose (50 percent kill): 23 mg/kg	N/R	AACHAX -,863,1965
subcutaneous mouse	lethal dose (50 percent kill): >4 gm/kg	N/R	AMACCQ 3,40,1973
subcutaneous rat	lethal dose (50 percent kill): 10 gm/kg	Kidney, Ureter, and Bladder: Other changes	NKRZAZ 27(Suppl 6),124,1979

OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
intramuscular rat	lowest published toxic dose: 31 gm/kg/31 day- intermittent	Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)	ANTBAL 26,44,1981
intravenous rat	lowest published toxic dose: 21 gm/kg/21 day- intermittent	Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) Kidney, Ureter, and Bladder: Other changes in urine composition Nutritional and Gross Metabolic: Changes in: Na	NKRZAZ 40(Suppl 4),162,1992
subcutaneous rat	lowest published toxic dose: 70 gm/kg/35 day- intermittent	Blood: Normocytic anemia Skin: After systemic exposure: Dermatitis, other Nutritional and Gross Metabolic: Weight loss or decreased weight gain	NKRZAZ 31(Suppl 3),817,1983

STANDARDS AND REGULATIONS:
ORGANIZATION	STANDARD	REFERENCE
N/R	N/R	N/R

NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION	STANDARD or SURVEY	REFERENCE
National Occupational Hazard Survey 1974	National Occupational Hazard Survey 1974: Hazard Code: 83991; Number of Industries 1; Total Number of Facilities 33; Number of Occupations 3; Total Number of Employees Exposed 1,452
National Occupational Exposure Survey 1983	National Occupational Exposure Survey 1983: Hazard Code: 83991; Number of Industries 1; Total Number of Facilities 290; Number of Occupations 8; Total Number of Employees Exposed 21,013; Total Number of Female Employees Exposed 19,052

REFERENCES:
CODEN	REFERENCE
AACHAX	Antimicrobial Agents and Chemotherapy (1961-70). (Ann Arbor, MI) 1961-70. For publisher information, see AMACCQ.
AMACCQ	Antimicrobial Agents and Chemotherapy. (American Soc. for Microbiology, 1913 I St., NW, Washington, DC 20006) V.1- 1972-
ANTBAL	Antibiotiki. (Moscow, USSR) V.1-29, 1956-84. For publisher information, see AMBIEH.
BYYADW	Byoin Yakugaku. Hospital Pharmacology. (Yakuji Nippon Sha, 1-11 Izumi-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan) V.1- 1975-
NKRZAZ	Chemotherapy (Tokyo). (Nippon Kagaku Ryoho Gakkai, 2-20-8 Kamiosaki, Shinagawa-Ku, Tokyo 141, Japan) V.1- 1953-
SEIJBO	Senten Ijo. Congenital Anomalies. (Nippon Senten Ijo Gakkai, c/o Kinki Daigaku Igakubu Kaibagaku Kyoshitsu, 380 Nishiyama, Sayama-cho, Mirami-Kawachi-gun, Osaka-fu, Japan) V.1-26, 1960-86. For publisher information, see CGANE7.
TJADAB	Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968-
ZMMPAO	Zentralblatt fuer Bakteriologie, Parasitenkunde, Infektionskrankheiten und Hygiene, Abteilung 1: Originale, Reihe A: Medizinische Mikrobiologie und Parasitologie. (Stuttgart, Fed. Rep. Ger.) V.217-245, 1971-79.