RTECS:XI0387000 The Registry of Toxic Effects of Chemical Substances

5 - Thia - 1 - azabicyclo (4.2.0) oct - 2 - ene - 2 - carboxylic acid, 3 - (hydroxymethyl) - 8 - oxo - 7 - (2 - (4 - pyridylthio) acetamido) - , acetate (ester)

RTECS #: XI0387000

CAS #: 21593-23-7

UPDATE: September 1998 MW: 423.49 MF: C₁₇H₁₇N₃O₆S₂

NOTE:

TOXICITY DATA HAVE NOT BEEN EVALUATED. OMISSION OF A SUBSTANCE OR NOTATION DOES NOT IMPLY ANY RELIEF FROM REGULATORY RESPONSIBILITY.

TABLE OF CONTENTS:

SYNONYMS:

ACUTE TOXICITY DATA:

OTHER MULTIPLE DOSE DATA:

NIOSH DOCUMENTATION AND SURVEILLANCE:

REFERENCES:

SYNONYMS:

Cefapirin

Cefaprin

Cephapirin

Cephapirine

SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

MUTATION DATA AND REFERENCES:
SYSTEM TEST ROUTE/
ORGANISM/
TISSUE DOSE REFERENCE
N/R N/R N/R N/R

REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

TUMORIGENIC DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
intraperitoneal
mouse lethal dose (50 percent kill): 8,899 mg/kg Behavioral: Altered sleep time (including change in righting reflex)

Cardiac: Arrythmias (indlucing changes in conduction)

Lung, Thorax, or Respiration: Dyspnea TOIZAG 21,279,1974
intraperitoneal
rat lethal dose (50 percent kill): 7,850 mg/kg Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Dyspnea

Gastrointestinal: Hypermotility, diarrhea TOIZAG 21,279,1974
intravenous
man lowest published toxic dose: 514 痢/kg/9 day- intermittent Liver: Jaundice, other or unclassified DICPBB 19,553,1985
intravenous
mouse lethal dose (50 percent kill): >7,602 mg/kg Behavioral: Altered sleep time (including change in righting reflex)

Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Dyspnea TOIZAG 21,279,1974
intravenous
rat lethal dose (50 percent kill): 6,048 mg/kg Eye: Retinal changes pigmentary deposition, retinitis, other)

Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Other changes TOIZAG 21,279,1974
oral
mouse lethal dose (50 percent kill): 26,088 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Ataxia

Behavioral: Irritability TOIZAG 21,279,1974
oral
rat lethal dose (50 percent kill): 16,356 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Ataxia

Behavioral: Irritability TOIZAG 21,279,1974
subcutaneous
mouse lethal dose (50 percent kill): 13,556 mg/kg Behavioral: Altered sleep time (including change in righting reflex)

Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Dyspnea TOIZAG 21,279,1974
subcutaneous
rat lethal dose (50 percent kill): >14,400 mg/kg Behavioral: Antipsychotic TOIZAG 21,279,1974

OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
intraperitoneal
rat lowest published toxic dose: 327,600 mg/kg/13 week- intermittent Liver: Other changes

Kidney, Ureter, and Bladder: Changes in bladder weight

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field TOIZAG 21,211,1974
intraperitoneal
rat lowest published toxic dose: 163,800 mg/kg/26 week- intermittent Gastrointestinal: Other changes

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) TOIZAG 21,211,1974
subcutaneous
rat lowest published toxic dose: 195 gm/kg/13 week- intermittent Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain TOIZAG 21,211,1974

REVIEWS:
ORGANIZATION STANDARD
REFERENCE

N/R N/R N/R

STANDARDS AND REGULATIONS:
ORGANIZATION STANDARD
REFERENCE

N/R N/R N/R

NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X8348;
Number of Industries 1;
Total Number of Facilities 56;
Number of Occupations 1;
Total Number of Employees Exposed 112;
Total Number of Female Employees Exposed 56

STATUS IN FEDERAL AGENCIES:
ORGANIZATION
REFERENCE

N/R

REFERENCES:
CODEN
REFERENCE

DICPBB Drug Intelligence and Clinical Pharmacy. (POB 42435, Cincinnati, OH 45242) V.3- 1969-
TOIZAG Toho Igakkai Zasshi. Journal of Medical Society of Toho University. (Toho Daigaku Igakkai, 21-16, Omori-nishi, 5-chome, Ota-ku, Tokyo 143, Japan) V.1- 1954-

Used as an antibiotic

RTECS Compound Description:
Drug
Human Data

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SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
N/R	N/R	N/R	N/R

MUTATION DATA AND REFERENCES:
SYSTEM TEST	ROUTE/ ORGANISM/ TISSUE	DOSE	REFERENCE
N/R	N/R	N/R	N/R

REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
N/R	N/R	N/R	N/R

TUMORIGENIC DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
N/R	N/R	N/R	N/R

ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
intraperitoneal mouse	lethal dose (50 percent kill): 8,899 mg/kg	Behavioral: Altered sleep time (including change in righting reflex) Cardiac: Arrythmias (indlucing changes in conduction) Lung, Thorax, or Respiration: Dyspnea	TOIZAG 21,279,1974
intraperitoneal rat	lethal dose (50 percent kill): 7,850 mg/kg	Behavioral: Convulsions or effect on seizure threshold Lung, Thorax, or Respiration: Dyspnea Gastrointestinal: Hypermotility, diarrhea	TOIZAG 21,279,1974
intravenous man	lowest published toxic dose: 514 痢/kg/9 day- intermittent	Liver: Jaundice, other or unclassified	DICPBB 19,553,1985
intravenous mouse	lethal dose (50 percent kill): >7,602 mg/kg	Behavioral: Altered sleep time (including change in righting reflex) Behavioral: Convulsions or effect on seizure threshold Lung, Thorax, or Respiration: Dyspnea	TOIZAG 21,279,1974
intravenous rat	lethal dose (50 percent kill): 6,048 mg/kg	Eye: Retinal changes pigmentary deposition, retinitis, other) Behavioral: Convulsions or effect on seizure threshold Lung, Thorax, or Respiration: Other changes	TOIZAG 21,279,1974
oral mouse	lethal dose (50 percent kill): 26,088 mg/kg	Behavioral: Somnolence (general depressed activity) Behavioral: Ataxia Behavioral: Irritability	TOIZAG 21,279,1974
oral rat	lethal dose (50 percent kill): 16,356 mg/kg	Behavioral: Somnolence (general depressed activity) Behavioral: Ataxia Behavioral: Irritability	TOIZAG 21,279,1974
subcutaneous mouse	lethal dose (50 percent kill): 13,556 mg/kg	Behavioral: Altered sleep time (including change in righting reflex) Behavioral: Somnolence (general depressed activity) Lung, Thorax, or Respiration: Dyspnea	TOIZAG 21,279,1974
subcutaneous rat	lethal dose (50 percent kill): >14,400 mg/kg	Behavioral: Antipsychotic	TOIZAG 21,279,1974

OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
intraperitoneal rat	lowest published toxic dose: 327,600 mg/kg/13 week- intermittent	Liver: Other changes Kidney, Ureter, and Bladder: Changes in bladder weight Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	TOIZAG 21,211,1974
intraperitoneal rat	lowest published toxic dose: 163,800 mg/kg/26 week- intermittent	Gastrointestinal: Other changes Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)	TOIZAG 21,211,1974
subcutaneous rat	lowest published toxic dose: 195 gm/kg/13 week- intermittent	Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Nutritional and Gross Metabolic: Weight loss or decreased weight gain	TOIZAG 21,211,1974

STANDARDS AND REGULATIONS:
ORGANIZATION	STANDARD	REFERENCE
N/R	N/R	N/R

NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION	STANDARD or SURVEY	REFERENCE
National Occupational Exposure Survey 1983	National Occupational Exposure Survey 1983: Hazard Code: X8348; Number of Industries 1; Total Number of Facilities 56; Number of Occupations 1; Total Number of Employees Exposed 112; Total Number of Female Employees Exposed 56

REFERENCES:
CODEN	REFERENCE
DICPBB	Drug Intelligence and Clinical Pharmacy. (POB 42435, Cincinnati, OH 45242) V.3- 1969-
TOIZAG	Toho Igakkai Zasshi. Journal of Medical Society of Toho University. (Toho Daigaku Igakkai, 21-16, Omori-nishi, 5-chome, Ota-ku, Tokyo 143, Japan) V.1- 1954-