RTECS:XI0368400 The Registry of Toxic Effects of Chemical Substances

5 - Thia - 1 - azabicyclo (4.2.0) oct - 2 - ene - 2 - carboxylic acid, 7 - ( ( (2 - amino - 4 - thiazolyl) (methoxyimino) acetyl) amino) - 8 - oxo - 3 - ( ( (1,2,5,6 - tetrahydro - 2 - methyl - 5,6 - dioxo - 1,2,4 - triazin - 3 - yl) thio) methyl) - , (6R - (6alpha,7beta (Z) ) ) -

RTECS #: XI0368400

CAS #: 73384-59-5

UPDATE: August 2007 MW: 554.62 MF: C₁₈H₁₈N₈O₇S₃

NOTE:

TOXICITY DATA HAVE NOT BEEN EVALUATED. OMISSION OF A SUBSTANCE OR NOTATION DOES NOT IMPLY ANY RELIEF FROM REGULATORY RESPONSIBILITY.

TABLE OF CONTENTS:

SYNONYMS:

ACUTE TOXICITY DATA:

OTHER MULTIPLE DOSE DATA:

REVIEWS:

REFERENCES:

SYNONYMS:

Biotrakson

Ceftriaxone

SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

MUTATION DATA AND REFERENCES:
SYSTEM TEST ROUTE/
ORGANISM/
TISSUE DOSE REFERENCE
N/R N/R N/R N/R

REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

TUMORIGENIC DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
intramuscular
man lowest published toxic dose: 14,286 痢/kg Behavioral: Hallucinations, distorted perceptions

Cardiac: Arrythmias (indlucing changes in conduction)

Lung, Thorax, or Respiration: Dyspnea LLRGDY 55,415,2000
intravenous
human lowest published toxic dose: 28 mg/kg Gastrointestinal: Hypermotility, diarrhea VCVPS* -,399,1998
intravenous
mouse lethal dose (50 percent kill): 2.8 gm/kg N/R VCVPS* -,399,1998
intravenous
rat lethal dose (50 percent kill): 2 gm/kg N/R VCVPS* -,399,1998
intravenous
rabbit lethal dose (50 percent kill): 240 mg/kg N/R VCVPS* -,399,1998

OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
intramuscular
human lowest published toxic dose: 98 mg/kg/7 day- intermittent Blood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases VCVPS* -,400,1998
intramuscular
human lowest published toxic dose: 140 mg/kg/10 day- intermittent Gastrointestinal: Hypermotility, diarrhea

Gastrointestinal: Nausea or vomiting

Skin: After systemic exposure: Dermatitis, allergic VCVPS* -,400,1998
intravenous
monkey lowest published toxic dose: 840 mg/kg/2 week- intermittent Gastrointestinal: Hypermotility, diarrhea VCVPS* -,399,1998
intravenous
monkey lowest published toxic dose: 72.8 gm/kg/26 week- intermittent Kidney, Ureter, and Bladder: Renal function tests depressed VCVPS* -,399,1998
intravenous
rat lowest published toxic dose: 111.5 gm/kg/13 week- intermittent Vascular: Acute arterial occulsion VCVPS* -,399,1998

REVIEWS:
ORGANIZATION STANDARD
REFERENCE

TOXICOLOGY REVIEW
MUREAV 488,151,2001
TOXICOLOGY REVIEW
PHMREP 51,211,2005
TOXICOLOGY REVIEW
EMMUEG 43,143,2004
TOXICOLOGY REVIEW
CLTHE* 28,1857,2006

STANDARDS AND REGULATIONS:
ORGANIZATION STANDARD
REFERENCE

N/R N/R N/R

NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION STANDARD or SURVEY
REFERENCE

N/R N/R N/R

STATUS IN FEDERAL AGENCIES:
ORGANIZATION
REFERENCE

N/R

REFERENCES:
CODEN
REFERENCE

CLTHE* Clinical Therapeutics : The International Peer-Reviewed Journal of Drug Therapy (Elsevier, USA) V.17- 1995-
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
LLRGDY Allergy. (Munksgaard International Publishers Ltd., POB 2148, 35 Norre Sogade, DK-1016 Copenhagen K, Denmark) V.33- 1978-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
PHMREP Pharmacological Research. (Academic Press, 24-28 Oval Rd. London NW1 7DX, UK) V.21- 1989-
VCVPS* "Vrednie chemichescie veshestva. Prirodnie organicheskie soedinenia" (Hazardous substances. Nature products.) Volkova N.V. et al., Sankt-Peterburg, 1998.

Used as an antibacterial agent

RTECS Compound Description:
Drug
Human Data

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SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
N/R	N/R	N/R	N/R

MUTATION DATA AND REFERENCES:
SYSTEM TEST	ROUTE/ ORGANISM/ TISSUE	DOSE	REFERENCE
N/R	N/R	N/R	N/R

REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
N/R	N/R	N/R	N/R

TUMORIGENIC DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
N/R	N/R	N/R	N/R

ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
intramuscular man	lowest published toxic dose: 14,286 痢/kg	Behavioral: Hallucinations, distorted perceptions Cardiac: Arrythmias (indlucing changes in conduction) Lung, Thorax, or Respiration: Dyspnea	LLRGDY 55,415,2000
intravenous human	lowest published toxic dose: 28 mg/kg	Gastrointestinal: Hypermotility, diarrhea	VCVPS* -,399,1998
intravenous mouse	lethal dose (50 percent kill): 2.8 gm/kg	N/R	VCVPS* -,399,1998
intravenous rat	lethal dose (50 percent kill): 2 gm/kg	N/R	VCVPS* -,399,1998
intravenous rabbit	lethal dose (50 percent kill): 240 mg/kg	N/R	VCVPS* -,399,1998

OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
intramuscular human	lowest published toxic dose: 98 mg/kg/7 day- intermittent	Blood: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases	VCVPS* -,400,1998
intramuscular human	lowest published toxic dose: 140 mg/kg/10 day- intermittent	Gastrointestinal: Hypermotility, diarrhea Gastrointestinal: Nausea or vomiting Skin: After systemic exposure: Dermatitis, allergic	VCVPS* -,400,1998
intravenous monkey	lowest published toxic dose: 840 mg/kg/2 week- intermittent	Gastrointestinal: Hypermotility, diarrhea	VCVPS* -,399,1998
intravenous monkey	lowest published toxic dose: 72.8 gm/kg/26 week- intermittent	Kidney, Ureter, and Bladder: Renal function tests depressed	VCVPS* -,399,1998
intravenous rat	lowest published toxic dose: 111.5 gm/kg/13 week- intermittent	Vascular: Acute arterial occulsion	VCVPS* -,399,1998

REVIEWS:
ORGANIZATION	STANDARD	REFERENCE
TOXICOLOGY REVIEW		MUREAV 488,151,2001
TOXICOLOGY REVIEW		PHMREP 51,211,2005
TOXICOLOGY REVIEW		EMMUEG 43,143,2004
TOXICOLOGY REVIEW		CLTHE* 28,1857,2006

STANDARDS AND REGULATIONS:
ORGANIZATION	STANDARD	REFERENCE
N/R	N/R	N/R

NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION	STANDARD or SURVEY	REFERENCE
N/R	N/R	N/R

REFERENCES:
CODEN	REFERENCE
CLTHE*	Clinical Therapeutics : The International Peer-Reviewed Journal of Drug Therapy (Elsevier, USA) V.17- 1995-
EMMUEG	Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
LLRGDY	Allergy. (Munksgaard International Publishers Ltd., POB 2148, 35 Norre Sogade, DK-1016 Copenhagen K, Denmark) V.33- 1978-
MUREAV	Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
PHMREP	Pharmacological Research. (Academic Press, 24-28 Oval Rd. London NW1 7DX, UK) V.21- 1989-
VCVPS*	"Vrednie chemichescie veshestva. Prirodnie organicheskie soedinenia" (Hazardous substances. Nature products.) Volkova N.V. et al., Sankt-Peterburg, 1998.