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5 - Thia - 1 - azabicyclo (4,2,0) oct - 2 - ene - 2 - carboxylic acid, 3 - ( (acetyloxy) methyl) - 7 - ( ( (2 - amino - 4 - thiazolyl) (methoxyimino) acetyl) amino) - 8 - oxo - , (6R - (6 - alpha,7 - beta (Z) ) ) , sodium salt

RTECS #: XI0250000

CAS #: 64485-93-4

UPDATE: November 2007 MW: 477.48 MF: C16H16N5O7S2•Na


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. NIOSH DOCUMENTATION AND SURVEILLANCE:
  7. REFERENCES:

SYNONYMS:

  1. CTX
  2. Cefotaxime sodium
  3. Claforan
  1. HR 756
  2. RU 24756
  3. Sodium 7 - (2 - (2 - amino - 4 - thiazolyl) - 2 - methoxyiminoacetamido) cephalosporanate


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
mutation in microorganisms Saccharomyes cerevisiae 238 mg/L/16 hour MUTAEX 20,105,2004


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intravenous
rabbit 		lowest published toxic dose: 325 mg/kg (6-18 day pregnant) Reproductive: Effects on embryo or fetus: Fetal death OYYAA2 21,375,1981


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intramuscular
dog 		lethal dose (50 percent kill): >716 mg/kg N/R IYKEDH 13,349,1982
intramuscular
rat 		lethal dose (50 percent kill): >2,000 mg/kg N/R IJTOFN 23,41,2004
intraperitoneal
mouse 		lethal dose (50 percent kill): 10 gm/kg N/R NIIRDN 6,APP-8,1982
intraperitoneal
rat 		lethal dose (50 percent kill): 10 gm/kg Behavioral: Food intake (animal)

Behavioral: Ataxia

Lung, Thorax, or Respiration: Other changes 		NKRZAZ 28(Suppl 1),98,1980
intravenous
child 		lowest published toxic dose: 1,800 mg/kg/18 day- intermittent Blood: Angranulocytosis DICPBB 17,739,1983
intravenous
dog 		lethal dose (50 percent kill): >1,500 mg/kg N/R JACHDX 6(Suppl A),79,1980
intravenous
mouse 		lethal dose (50 percent kill): 6,845 mg/kg N/R ANKHEW 35(5),25,1990
intravenous
rat 		lethal dose (50 percent kill): 7 gm/kg N/R NIIRDN 6,APP-8,1982
intravenous
rabbit 		lethal dose (50 percent kill): 1,880 mg/kg Behavioral: Food intake (animal)

Behavioral: Ataxia

Lung, Thorax, or Respiration: Other changes 		NKRZAZ 28(Suppl 1),98,1980
oral
mouse 		lethal dose (50 percent kill): >20 gm/kg Behavioral: Food intake (animal)

Behavioral: Ataxia

Lung, Thorax, or Respiration: Other changes 		NKRZAZ 28(Suppl 1),98,1980
oral
rat 		lethal dose (50 percent kill): >20 gm/kg Behavioral: Food intake (animal)

Behavioral: Ataxia

Lung, Thorax, or Respiration: Other changes 		NKRZAZ 28(Suppl 1),98,1980
subcutaneous
mouse 		lethal dose (50 percent kill): 12,950 mg/kg N/R NIIRDN 6,APP-8,1982
subcutaneous
rat 		lethal dose (50 percent kill): 18,400 mg/kg Behavioral: Food intake (animal)

Behavioral: Ataxia

Lung, Thorax, or Respiration: Other changes 		NKRZAZ 28(Suppl 1),98,1980


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intramuscular
rat 		lowest published toxic dose: 10,080 mg/kg/4 week- intermittent Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases 		ANKHEW 35(5),25,1990
intravenous
rat 		lowest published toxic dose: 30 gm/kg/30 day- intermittent Skin: After systemic exposure: Dermatitis, other NKRZAZ 28(Suppl 1),98,1980
intravenous
rat 		lowest published toxic dose: 7,560 mg/kg/2 week- intermittent Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases 		ANKHEW 35(5),25,1990


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X5623;
Number of Industries 1;
Total Number of Facilities 44;
Number of Occupations 3;
Total Number of Employees Exposed 8,498;
Total Number of Female Employees Exposed 7,477


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
N/R


REFERENCES:

CODEN
REFERENCE
ANKHEW Antibiotiki i Khimioterapiya. Antibiotics and Chemotherapy. (V/O Me zhdunarodnaya Kniga, 113095 Moskow, USSR) V.33- 1988-
DICPBB Drug Intelligence and Clinical Pharmacy. (POB 42435, Cincinnati, OH 45242) V.3- 1969-
IJTOFN International Journal of Toxicology. (Taylor & Francis, 47 Runway Rd., Suite g, Levittown, PA 19057) V.16- 1997-
IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970-
JACHDX Journal of Antimicrobial Chemotherapy. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1975-
MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1986-
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan)
NKRZAZ Chemotherapy (Tokyo). (Nippon Kagaku Ryoho Gakkai, 2-20-8 Kamiosaki, Shinagawa-Ku, Tokyo 141, Japan) V.1- 1953-
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967-

FDA-proprietary drug

RTECS Compound Description:
   Drug
   Mutagen
   Reproductive Effector
   Human Data

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