RTECS:XH9800000 The Registry of Toxic Effects of Chemical Substances

4 - Thia - 1 - azabicyclo (3.2.0) heptane - 2 - carboxylic acid, 3,3 - dimethyl - 7 - oxo - 6 - (2 - phenylacetamido) - , monosodium salt

RTECS #: XH9800000

CAS #: 69-57-8

UPDATE: May 2009 MW: 356.40 MF: C₁₆H₁₇N₂O₄S•Na

NOTE:

TOXICITY DATA HAVE NOT BEEN EVALUATED. OMISSION OF A SUBSTANCE OR NOTATION DOES NOT IMPLY ANY RELIEF FROM REGULATORY RESPONSIBILITY.

TABLE OF CONTENTS:

SYNONYMS:

REPRODUCTIVE EFFECTS DATA:

TUMORIGENIC DATA:

ACUTE TOXICITY DATA:

REVIEWS:

NIOSH DOCUMENTATION AND SURVEILLANCE:

STATUS IN FEDERAL AGENCIES:

REFERENCES:

SYNONYMS:

American penicillin

Benzylpenicillinic acid sodium salt

Benzylpenicillin sodium

Benzylpenicillin sodium salt

Crystapen

Mycofarm

Novocillin

Pen - A - Brasive

Penicillin - G, monosodium salt

Penicillin G, sodium

Penilaryn

Sodium benzylpenicillin

Sodium benzylpenicillin G

Sodium benzylpenicillinate

Sodium penicillin G

Sodium penicillin II

Veticillin

SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

MUTATION DATA AND REFERENCES:
SYSTEM TEST ROUTE/
ORGANISM/
TISSUE DOSE REFERENCE
N/R N/R N/R N/R

REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
oral
rat lowest published toxic dose: 1,500 mg/kg (6-11 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) ANTBAL 18,815,1973
subcutaneous
mouse lowest published toxic dose: 30 mg/kg (14 day pregnant) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) CRSBAW 158,528,1964
subcutaneous
rat lowest published toxic dose: 1,500 mg/kg (1-5 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) ANTBAL 18,815,1973

TUMORIGENIC DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
subcutaneous
rat lowest published toxic dose: 1,840 mg/kg/46 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Blood: Lymphoma including Hodgkin's disease

Tumorigenic: Tumors at site of application BJCAAI 15,85,1961

ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
intracerebral
mouse lethal dose (50 percent kill): 3,800 µg/kg Behavioral: Convulsions or effect on seizure threshold NYKZAU 55,23,1959
intramuscular
cat lowest published toxic dose: 400,000 units/kg Behavioral: Convulsions or effect on seizure threshold FATOAO 49,22,1986
intramuscular
cat lowest published toxic dose: 500,000 units/kg Brain and Coverings: Changes in surface EEG

Behavioral: Convulsions or effect on seizure threshold FATOAO 50,33,1987
intramuscular
guinea pig lowest published lethal dose: 60 mg/kg N/R LBASAE 30,524,1980
intramuscular
mouse lethal dose (50 percent kill): 2,800 mg/kg N/R ARZNAD 9,31,1959
intraperitoneal
mouse lethal dose (50 percent kill): 3,314 mg/kg N/R ABANAE 3,540,1955/1956
intravenous
guinea pig lowest published lethal dose: 150 mg/kg Gastrointestinal: Other changes

Nutritional and Gross Metabolic: Other changes ARZNAD 9,31,1959
intravenous
mouse lethal dose (50 percent kill): 1,500 mg/kg Behavioral: Convulsions or effect on seizure threshold

Behavioral: Change in motor activity (specific assay)

Lung, Thorax, or Respiration: Other changes ARZNAD 9,31,1959
intravenous
mouse lethal dose (50 percent kill): 3,090 mg/kg N/R VCVPS* -,373,1998
intravenous
rat lethal dose (50 percent kill): 3,020 mg/kg Cardiac: Other changes

Lung, Thorax, or Respiration: Respiratory depression ARZNAD 9,31,1959
oral
guinea pig lowest published lethal dose: 30 mg/kg Behavioral: Food intake (animal)

Gastrointestinal: Hypermotility, diarrhea VCVPS* -,373,1998
oral
mouse lethal dose (50 percent kill): >4 gm/kg N/R ABANAE 3,540,1955/1956
oral
rat lethal dose (50 percent kill): 6,916 mg/kg Behavioral: Tremor

Behavioral: Convulsions or effect on seizure threshold

Gastrointestinal: Other changes AMPMAR 39,259,1978
parenteral
rat lethal dose (50 percent kill): 2,900 µg/kg N/R AACHAX -,863,1965
subcutaneous
mouse lethal dose (50 percent kill): 4,750 mg/kg N/R NYKZAU 55,23,1959

OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

REVIEWS:
ORGANIZATION STANDARD
REFERENCE

TOXICOLOGY REVIEW
HUTOX* -,429,1996

STANDARDS AND REGULATIONS:
ORGANIZATION STANDARD
REFERENCE

N/R N/R N/R

NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X4380;
Number of Industries 1;
Total Number of Facilities 137;
Number of Occupations 5;
Total Number of Employees Exposed 7,315;
Total Number of Female Employees Exposed 5,985

STATUS IN FEDERAL AGENCIES:
ORGANIZATION
REFERENCE

EPA GENETOX PROGRAM 1988, Inconclusive: D melanogaster Sex-linked lethal

REFERENCES:
CODEN
REFERENCE

AACHAX Antimicrobial Agents and Chemotherapy (1961-70). (Ann Arbor, MI) 1961-70. For publisher information, see AMACCQ.
ABANAE Antibiotics Annual. (New York, NY) 1953-60. For publisher information, see AMACCQ.
AMPMAR Archives des Maladies Professionnelles de Medecine du Travail et de Securite Sociale. (SPPIF, B.P.22, F-41353 Vineuil, France) V.7- 1946-
ANTBAL Antibiotiki. (Moscow, USSR) V.1-29, 1956-84. For publisher information, see AMBIEH.
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
BJCAAI British Journal of Cancer. (Macmillan Press Ltd., Houndmills, Basingstoke, Hants. RG21 2XS, UK) V.1- 1947-
CRSBAW Comptes Rendus des Seances de la Societe de Biologie et de Ses Filiales. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1849-
FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939-
HUTOX*

LBASAE Laboratory Animal Science. (American Assoc. for Laboratory Animal Science, 210 N. Hammes Ave., Suite 205, Joliet, IL 60435) V.21- 1971-
NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944-
VCVPS* "Vrednie chemichescie veshestva. Prirodnie organicheskie soedinenia" (Hazardous substances. Nature products.) Volkova N.V. et al., Sankt-Peterburg, 1998.

Used as an antibiotic

NIOSH PROFILE (GRAIN HANDLERS), SRI, 2/77

FDA-proprietary drug

RTECS Compound Description:
   Tumorigen
   Drug
   Mutagen
   Reproductive Effector
   Natural Product

ALT CAS #: 1406-09-3
Click Here for Additional Information about RTECS

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SYNONYMS:
American penicillin Benzylpenicillinic acid sodium salt Benzylpenicillin sodium Benzylpenicillin sodium salt Crystapen Mycofarm Novocillin Pen - A - Brasive Penicillin - G, monosodium salt	Penicillin G, sodium Penilaryn Sodium benzylpenicillin Sodium benzylpenicillin G Sodium benzylpenicillinate Sodium penicillin G Sodium penicillin II Veticillin

SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
N/R	N/R	N/R	N/R

MUTATION DATA AND REFERENCES:
SYSTEM TEST	ROUTE/ ORGANISM/ TISSUE	DOSE	REFERENCE
N/R	N/R	N/R	N/R

REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
oral rat	lowest published toxic dose: 1,500 mg/kg (6-11 day pregnant)	Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)	ANTBAL 18,815,1973
subcutaneous mouse	lowest published toxic dose: 30 mg/kg (14 day pregnant)	Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)	CRSBAW 158,528,1964
subcutaneous rat	lowest published toxic dose: 1,500 mg/kg (1-5 day pregnant)	Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)	ANTBAL 18,815,1973

TUMORIGENIC DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
subcutaneous rat	lowest published toxic dose: 1,840 mg/kg/46 week- intermittent	Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Blood: Lymphoma including Hodgkin's disease Tumorigenic: Tumors at site of application	BJCAAI 15,85,1961

ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
intracerebral mouse	lethal dose (50 percent kill): 3,800 µg/kg	Behavioral: Convulsions or effect on seizure threshold	NYKZAU 55,23,1959
intramuscular cat	lowest published toxic dose: 400,000 units/kg	Behavioral: Convulsions or effect on seizure threshold	FATOAO 49,22,1986
intramuscular cat	lowest published toxic dose: 500,000 units/kg	Brain and Coverings: Changes in surface EEG Behavioral: Convulsions or effect on seizure threshold	FATOAO 50,33,1987
intramuscular guinea pig	lowest published lethal dose: 60 mg/kg	N/R	LBASAE 30,524,1980
intramuscular mouse	lethal dose (50 percent kill): 2,800 mg/kg	N/R	ARZNAD 9,31,1959
intraperitoneal mouse	lethal dose (50 percent kill): 3,314 mg/kg	N/R	ABANAE 3,540,1955/1956
intravenous guinea pig	lowest published lethal dose: 150 mg/kg	Gastrointestinal: Other changes Nutritional and Gross Metabolic: Other changes	ARZNAD 9,31,1959
intravenous mouse	lethal dose (50 percent kill): 1,500 mg/kg	Behavioral: Convulsions or effect on seizure threshold Behavioral: Change in motor activity (specific assay) Lung, Thorax, or Respiration: Other changes	ARZNAD 9,31,1959
intravenous mouse	lethal dose (50 percent kill): 3,090 mg/kg	N/R	VCVPS* -,373,1998
intravenous rat	lethal dose (50 percent kill): 3,020 mg/kg	Cardiac: Other changes Lung, Thorax, or Respiration: Respiratory depression	ARZNAD 9,31,1959
oral guinea pig	lowest published lethal dose: 30 mg/kg	Behavioral: Food intake (animal) Gastrointestinal: Hypermotility, diarrhea	VCVPS* -,373,1998
oral mouse	lethal dose (50 percent kill): >4 gm/kg	N/R	ABANAE 3,540,1955/1956
oral rat	lethal dose (50 percent kill): 6,916 mg/kg	Behavioral: Tremor Behavioral: Convulsions or effect on seizure threshold Gastrointestinal: Other changes	AMPMAR 39,259,1978
parenteral rat	lethal dose (50 percent kill): 2,900 µg/kg	N/R	AACHAX -,863,1965
subcutaneous mouse	lethal dose (50 percent kill): 4,750 mg/kg	N/R	NYKZAU 55,23,1959

OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
N/R	N/R	N/R	N/R

REVIEWS:
ORGANIZATION	STANDARD	REFERENCE
TOXICOLOGY REVIEW		HUTOX* -,429,1996

STANDARDS AND REGULATIONS:
ORGANIZATION	STANDARD	REFERENCE
N/R	N/R	N/R

NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION	STANDARD or SURVEY	REFERENCE
National Occupational Exposure Survey 1983	National Occupational Exposure Survey 1983: Hazard Code: X4380; Number of Industries 1; Total Number of Facilities 137; Number of Occupations 5; Total Number of Employees Exposed 7,315; Total Number of Female Employees Exposed 5,985

STATUS IN FEDERAL AGENCIES:
ORGANIZATION	REFERENCE
EPA GENETOX PROGRAM 1988, Inconclusive: D melanogaster Sex-linked lethal

REFERENCES:
CODEN	REFERENCE
AACHAX	Antimicrobial Agents and Chemotherapy (1961-70). (Ann Arbor, MI) 1961-70. For publisher information, see AMACCQ.
ABANAE	Antibiotics Annual. (New York, NY) 1953-60. For publisher information, see AMACCQ.
AMPMAR	Archives des Maladies Professionnelles de Medecine du Travail et de Securite Sociale. (SPPIF, B.P.22, F-41353 Vineuil, France) V.7- 1946-
ANTBAL	Antibiotiki. (Moscow, USSR) V.1-29, 1956-84. For publisher information, see AMBIEH.
ARZNAD	Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
BJCAAI	British Journal of Cancer. (Macmillan Press Ltd., Houndmills, Basingstoke, Hants. RG21 2XS, UK) V.1- 1947-
CRSBAW	Comptes Rendus des Seances de la Societe de Biologie et de Ses Filiales. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1849-
FATOAO	Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939-
HUTOX*
LBASAE	Laboratory Animal Science. (American Assoc. for Laboratory Animal Science, 210 N. Hammes Ave., Suite 205, Joliet, IL 60435) V.21- 1971-
NYKZAU	Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944-
VCVPS*	"Vrednie chemichescie veshestva. Prirodnie organicheskie soedinenia" (Hazardous substances. Nature products.) Volkova N.V. et al., Sankt-Peterburg, 1998.