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4 - Thia - 1 - azabicyclo (3.2.0) heptane - 2 - carboxylic acid, 3,3 - dimethyl - 7 - oxo - 6 - (2 - phenoxy - acetamido) - , monopotassium salt

RTECS #: XH9275000

CAS #: 132-98-9

UPDATE: May 2008 MW: 388.51 MF: C16H17N2O5S•K


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. REVIEWS:
  6. NIOSH DOCUMENTATION AND SURVEILLANCE:
  7. STATUS IN FEDERAL AGENCIES:
  8. REFERENCES:

SYNONYMS:

  1. Apsin VK
  2. Beromycin
  3. Beromycin (penicillin)
  4. Betapen - VK
  5. Calciopen K
  6. Cliacil
  7. Compocillin - VK
  8. D - alpha - Phenoxymethylpenicillinate K salt
  9. Distakaps V - K
  10. Distaquaine V - K
  11. Dowpen V - K
  12. Fenoxypen
  13. Isocillin
  14. Megacillin oral
  15. Oracil - VK
  16. Orapen
  17. Ospeneff
  18. Pedipen
  19. Pen - V - K powder
  20. Pen - Vee - K
  21. Pen - Vee - K powder
  22. Penagen
  1. Pencompren
  2. Penicillin V potassium
  3. Penicillin V potassium salt
  4. Penicillin VK
  5. Penicillin potassium phenoxymethyl
  6. Penvikal
  7. Phenoxymethylpenicillin potassium
  8. Potassium penicillin V
  9. Potassium penicillin V salt
  10. Potassium phenoxymethylpenicillin
  11. Primcillin
  12. Qidpen VK
  13. Robicillin VK
  14. Rocillin - VK
  15. Roscopenin
  16. SK - Penicillin VK
  17. Stabillin VK syrup 125
  18. Stabillin VK syrup 62.5
  19. Sumapen VK
  20. V - Cillin K
  21. Veetids
  22. Vepen


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis hamster ovary 9 gm/L NTPTR* NTP-TR-336,1988
cytogenetic analysis human lymphocyte 3 gm/L MUTAEX 4,439,1989
mutation in microorganisms mouse lymphocyte 250 mg/L (+enzymatic activation step) EMMUEG 12(Suppl 13),103,1988
sister chromatid exchange hamster ovary 500 mg/L NTPTR* NTP-TR-336,1988


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intramuscular
rat 		lethal dose (50 percent kill): 1,124 mg/kg N/R PJPPAA 29,39,1977
intraperitoneal
mouse 		lethal dose (50 percent kill): 1,351 mg/kg N/R NIIRDN 6,661,1982
intraperitoneal
rat 		lethal dose (50 percent kill): 1,750 mg/kg N/R ARZNAD 12,751,1962
intravenous
mouse 		lethal dose (50 percent kill): 1 gm/kg N/R ARZNAD 12,751,1962
oral
mouse 		lethal dose (50 percent kill): >4 gm/kg N/R NIIRDN 6,661,1982
oral
rat 		lethal dose (50 percent kill): >1,040 mg/kg N/R TXAPA9 18,185,1971
subcutaneous
mouse 		lethal dose (50 percent kill): >4 gm/kg N/R NIIRDN 6,661,1982


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lowest published toxic dose: 16,250 mg/kg/13 week- intermittent Gastrointestinal: Other changes TXCYAC 56,123,1989
oral
rat 		lowest published toxic dose: 195 gm/kg/13 week- intermittent Gastrointestinal: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		TXCYAC 56,123,1989


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
TOXICOLOGY REVIEW
MUREAV 584,1,2005


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 82270;
Number of Industries 2;
Total Number of Facilities 1,844;
Number of Occupations 3;
Total Number of Employees Exposed 3,026
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 82270;
Number of Industries 2;
Total Number of Facilities 301;
Number of Occupations 11;
Total Number of Employees Exposed 6,483;
Total Number of Female Employees Exposed 3,052


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as a pharmaceutical and veterinary drug
NCI Carcinogenesis Studies (gavage);no evidence:mouse,rat


REFERENCES:

CODEN
REFERENCE
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1986-
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan)
NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206-
PJPPAA Polish Journal of Pharmacology and Pharmacy. (ARS Polona, POB 1001, 00-068 Warsaw 1, Poland) V.25-44, 1973-92. For publisher information, see PJPAE3
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973-

Used as a pharmaceutical and veterinary drug

FDA-proprietary drug

RTECS Compound Description:
   Tumorigen
   Drug
   Mutagen
   Human Data

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