RTECS:XH9100000 The Registry of Toxic Effects of Chemical Substances

4 - Thia - 1 - azabicyclo (3.2.0) heptane - 2 - carboxylic acid, 3,3 - dimethyl - 6 - (5 - methyl - 3 - phenyl - 4 - isoxazolecarboxamido) - 7 - oxo - , monosodium salt

RTECS #: XH9100000

CAS #: 1173-88-2

UPDATE: February 2003 MW: 423.45 MF: C₁₉H₁₈N₃O₅S翝a

NOTE:

TOXICITY DATA HAVE NOT BEEN EVALUATED. OMISSION OF A SUBSTANCE OR NOTATION DOES NOT IMPLY ANY RELIEF FROM REGULATORY RESPONSIBILITY.

TABLE OF CONTENTS:

SYNONYMS:

ACUTE TOXICITY DATA:

OTHER MULTIPLE DOSE DATA:

NIOSH DOCUMENTATION AND SURVEILLANCE:

REFERENCES:

SYNONYMS:

5 - Methyl - 3 - phenyl - 4 - isoxazolyl penicillin, sodium

BRL 1400

Bactocill

Bristopen

Cryptocillin

Micropenin

Monosodium oxacillin

Oxabel

Oxacillin sodium

Oxacillin sodium salt

P 12

Penicillin P - 12

Prostaphlin

SQ 16423

Sodium oxacillin

Stapenor

Staphcillin V

SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

MUTATION DATA AND REFERENCES:
SYSTEM TEST ROUTE/
ORGANISM/
TISSUE DOSE REFERENCE
N/R N/R N/R N/R

REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

TUMORIGENIC DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
intraperitoneal
rat lethal dose (50 percent kill): 1,500 mg/kg N/R ARZNAD 15,322,1965
intravenous
human lowest published toxic dose: 1,200 mg/kg/7 day Liver: Liver function tests impaired AIMDAP 138,915,1978
intravenous
mouse lethal dose (50 percent kill): 1,399 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Ataxia

Lung, Thorax, or Respiration: Dyspnea FATOAO 31,232,1968
intravenous
mouse lethal dose (50 percent kill): 1.5 gm/kg N/R VCVPS* -,379,1998
intravenous
rat lethal dose (50 percent kill): 2,150 痢/kg N/R NIIRDN 6,147,1982
oral
cat lowest published lethal dose: >750 mg/kg N/R ARZNAD 15,322,1965
oral
mouse lethal dose (50 percent kill): >10 gm/kg N/R NIIRDN 6,147,1982
oral
rat lethal dose (50 percent kill): 10 gm/kg N/R VCVPS* -,379,1998
oral
woman lowest published toxic dose: 4,560 mg/kg/11 week- intermittent Liver: Other changes

Musculoskeletal: Other changes RMMJAK 62,34,1965
subcutaneous
mouse lethal dose (50 percent kill): 2,600 痢/kg N/R NIIRDN 6,147,1982
subcutaneous
rat lethal dose (50 percent kill): 3,900 痢/kg N/R NIIRDN 6,147,1982

OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
unreported route
human lowest published toxic dose: 0.28 gm/kg/7 day- intermittent Skin: After systemic exposure: Dermatitis, allergic

Blood: Luekopenia

Nutritional and Gross Metabolic: Body temperature increase VCVPS* -,379,1998

REVIEWS:
ORGANIZATION STANDARD
REFERENCE

N/R N/R N/R

STANDARDS AND REGULATIONS:
ORGANIZATION STANDARD
REFERENCE

N/R N/R N/R

NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X4485;
Number of Industries 1;
Total Number of Facilities 151;
Number of Occupations 6;
Total Number of Employees Exposed 3,615;
Total Number of Female Employees Exposed 2,410

STATUS IN FEDERAL AGENCIES:
ORGANIZATION
REFERENCE

N/R

REFERENCES:
CODEN
REFERENCE

AIMDAP Archives of Internal Medicine. (AMA, 535 N. Dearborn St., Chicago, IL 60610) V.1- 1908-
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939-
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan)
RMMJAK Rocky Mountain Medical Journal. (Denver, Co) V.35-76, 1938-79.
VCVPS* "Vrednie chemichescie veshestva. Prirodnie organicheskie soedinenia" (Hazardous substances. Nature products.) Volkova N.V. et al., Sankt-Peterburg, 1998.

RTECS Compound Description:
Drug
Human Data

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SYNONYMS:
5 - Methyl - 3 - phenyl - 4 - isoxazolyl penicillin, sodium BRL 1400 Bactocill Bristopen Cryptocillin Micropenin Monosodium oxacillin Oxabel Oxacillin sodium	Oxacillin sodium salt P 12 Penicillin P - 12 Prostaphlin SQ 16423 Sodium oxacillin Stapenor Staphcillin V

SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
N/R	N/R	N/R	N/R

MUTATION DATA AND REFERENCES:
SYSTEM TEST	ROUTE/ ORGANISM/ TISSUE	DOSE	REFERENCE
N/R	N/R	N/R	N/R

REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
N/R	N/R	N/R	N/R

TUMORIGENIC DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
N/R	N/R	N/R	N/R

ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
intraperitoneal rat	lethal dose (50 percent kill): 1,500 mg/kg	N/R	ARZNAD 15,322,1965
intravenous human	lowest published toxic dose: 1,200 mg/kg/7 day	Liver: Liver function tests impaired	AIMDAP 138,915,1978
intravenous mouse	lethal dose (50 percent kill): 1,399 mg/kg	Behavioral: Somnolence (general depressed activity) Behavioral: Ataxia Lung, Thorax, or Respiration: Dyspnea	FATOAO 31,232,1968
intravenous mouse	lethal dose (50 percent kill): 1.5 gm/kg	N/R	VCVPS* -,379,1998
intravenous rat	lethal dose (50 percent kill): 2,150 痢/kg	N/R	NIIRDN 6,147,1982
oral cat	lowest published lethal dose: >750 mg/kg	N/R	ARZNAD 15,322,1965
oral mouse	lethal dose (50 percent kill): >10 gm/kg	N/R	NIIRDN 6,147,1982
oral rat	lethal dose (50 percent kill): 10 gm/kg	N/R	VCVPS* -,379,1998
oral woman	lowest published toxic dose: 4,560 mg/kg/11 week- intermittent	Liver: Other changes Musculoskeletal: Other changes	RMMJAK 62,34,1965
subcutaneous mouse	lethal dose (50 percent kill): 2,600 痢/kg	N/R	NIIRDN 6,147,1982
subcutaneous rat	lethal dose (50 percent kill): 3,900 痢/kg	N/R	NIIRDN 6,147,1982

OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
unreported route human	lowest published toxic dose: 0.28 gm/kg/7 day- intermittent	Skin: After systemic exposure: Dermatitis, allergic Blood: Luekopenia Nutritional and Gross Metabolic: Body temperature increase	VCVPS* -,379,1998

STANDARDS AND REGULATIONS:
ORGANIZATION	STANDARD	REFERENCE
N/R	N/R	N/R

NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION	STANDARD or SURVEY	REFERENCE
National Occupational Exposure Survey 1983	National Occupational Exposure Survey 1983: Hazard Code: X4485; Number of Industries 1; Total Number of Facilities 151; Number of Occupations 6; Total Number of Employees Exposed 3,615; Total Number of Female Employees Exposed 2,410

REFERENCES:
CODEN	REFERENCE
AIMDAP	Archives of Internal Medicine. (AMA, 535 N. Dearborn St., Chicago, IL 60610) V.1- 1908-
ARZNAD	Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
FATOAO	Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939-
NIIRDN	Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan)
RMMJAK	Rocky Mountain Medical Journal. (Denver, Co) V.35-76, 1938-79.
VCVPS*	"Vrednie chemichescie veshestva. Prirodnie organicheskie soedinenia" (Hazardous substances. Nature products.) Volkova N.V. et al., Sankt-Peterburg, 1998.