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4 - Thia - 1 - azabicyclo (3.2.0) heptane - 2 - carboxylic acid, 6 - (2 - amino - 2 - phenylacetamido) - 3,3 - dimethyl - 7 - oxo - , sodium salt, D - ( - ) -

RTECS #: XH8400000

CAS #: 69-52-3

UPDATE: February 2008 MW: 371.42 MF: C16H18N3O4S•Na


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. ACUTE TOXICITY DATA:
  3. OTHER MULTIPLE DOSE DATA:
  4. REVIEWS:
  5. NIOSH DOCUMENTATION AND SURVEILLANCE:
  6. REFERENCES:

SYNONYMS:

  1. Alpen - N
  2. Amcill - S
  3. Ampicillin sodium
  4. Ampicillin sodium salt
  5. Binotal sodium
  6. Citteral
  7. D ( - ) - alpha - Aminobenzylpenicillin sodium salt
  8. Domicillin
  9. Omnipen - N
  1. PEN A/N
  2. Penbritin - S
  3. Penialmen
  4. Polycillin - N
  5. Principen/N
  6. Sodium D - ( - ) - alpha - aminobenzylpenicillin
  7. Sodium amipicillin
  8. Sodium binotal
  9. Sodium P - 50


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intramuscular
mouse 		lowest published toxic dose: 17.12 mg/kg Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) BPBLEO 29,1559,2006
intraperitoneal
mouse 		lethal dose (50 percent kill): 5,700 mg/kg N/R TXAPA9 18,185,1971
intraperitoneal
rat 		lethal dose (50 percent kill): 7,400 mg/kg N/R TXAPA9 18,185,1971
intravenous
mouse 		lowest published lethal dose: 2,657 mg/kg Behavioral: Tremor

Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Respiratory depression 		BJPCAL 18,356,1962
oral
mouse 		lethal dose (50 percent kill): >5,314 mg/kg N/R BJPCAL 18,356,1962
oral
rat 		lethal dose (50 percent kill): >5,314 mg/kg N/R BJPCAL 18,356,1962
oral
woman 		lowest published toxic dose: 100 mg/kg/5 day Gastrointestinal: Hypermotility, diarrhea

Gastrointestinal: Other changes 		LANCAO 2,707,1978
subcutaneous
mouse 		lethal dose (50 percent kill): >5,314 mg/kg N/R BJPCAL 18,356,1962
subcutaneous
rat 		lethal dose (50 percent kill): >5,314 mg/kg N/R BJPCAL 18,356,1962


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intramuscular
rat 		lowest published toxic dose: 210 mg/kg/7 day- intermittent Kidney, Ureter, and Bladder: Other changes in urine composition

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases 		INJPD2 18,110,1986


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
International Agency for Research on Cancer (IARC) Cancer Review Animal Limited Evidence IMEMDT 50,153,1990
International Agency for Research on Cancer (IARC) Cancer Review Human Inadequate Evidence IMEMDT 50,153,1990
International Agency for Research on Cancer (IARC) Cancer Review Group 3 IMEMDT 50,153,1990
TOXICOLOGY REVIEW
INTEAG 15,7,1974


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X3564;
Number of Industries 2;
Total Number of Facilities 549;
Number of Occupations 8;
Total Number of Employees Exposed 23,006;
Total Number of Female Employees Exposed 18,439


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
N/R


REFERENCES:

CODEN
REFERENCE
BJPCAL British Journal of Pharmacology and Chemotherapy. (London, UK) V.1-33, 1946-68. For publisher information, see BJPCBM.
BPBLEO Biological and Pharmaceutical Bulletin. (Pharmaceutical Society of Japan, 2-12-15-201 Shibuya Shibuya-ku, Tokyo 150, Japan) V.16- 1993-
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
INJPD2 Indian Journal of Pharmacology. (Dept. of Pharmacology, Baranas Hindu Univ., Varanasi 221 005, India) V.1- 1968(?)-
INTEAG Internist. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1960-
LANCAO Lancet. (7 Adam St., London WC2N 6AD, UK) V.1- 1823-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-

Used as an antibacterial agent

FDA-proprietary drug

RTECS Compound Description:
   Tumorigen
   Drug
   Human Data

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