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Testosterone, propionate

RTECS #: XA3115000

CAS #: 57-85-2

UPDATE: May 2009 MW: 344.54 MF: C22H32O3


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. TUMORIGENIC DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. REVIEWS:
  8. STANDARDS AND REGULATIONS:
  9. NIOSH DOCUMENTATION AND SURVEILLANCE:
  10. STATUS IN FEDERAL AGENCIES:
  11. REFERENCES:

SYNONYMS:

  1. Agovirin
  2. Androst - 4 - en - 3 - one, 17 - (1 - oxopropoxy) - (17 - beta) -
  3. Androtest P
  4. Androteston
  5. Andrusol - P
  6. Anertan
  7. Aquaviron
  8. Bio - testiculina
  9. Enarmon
  10. Homandren
  11. Hormoteston
  12. Masenate
  13. NSC 9166
  14. Nasdol
  15. Okasa - Mascul
  16. Orchiol
  17. Orchistin
  18. Oreton
  19. Oreton propionate
  20. Pantestin
  21. Propiokan
  22. Recthormone testosterone
  1. Sterandryl
  2. Synandrol
  3. Synerone
  4. TP
  5. Telipex
  6. Testaform
  7. Testex
  8. Testodet
  9. Testodrin
  10. Testogen
  11. Testonique
  12. Testormol
  13. Testosteron propionate
  14. Testosterone - 17 - beta - propionate
  15. Testoviron (ampule)
  16. Testoxyl
  17. Testrex
  18. Tostrin
  19. Uniteston
  20. Vulvan
  21. delta (sup 4) - Androstene - 17 - beta - propionate - 3 - one
  22. neo - Hombreol


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis unreported route
other fish 		500 µg BEXBBO 15,329,1980
DNA damage rat liver 300 µmol/L SinJF# 26OCT1982
morphological transform hamster embryo 1 mg/L CRNGDP 16,1329,1995
sperm morphology unreported route
other fish 		500 µg BEXBBO 15,329,1980
sperm morphology subcutaneous
rat 		10 mg/kg AMTUA3 8,68,1971


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intracerebral
mouse 		lowest published toxic dose: 2 mg/kg (1 day prior to copulation) Reproductive: Maternal effects: Ovaries, fallopian tubes TJADAB 25,351,1982
intracerebral
mouse 		lowest published toxic dose: 2 mg/kg (1 day male) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) TJADAB 25,351,1982
intracerebral
rat 		lowest published toxic dose: 10 µg/kg (77 day prior to copulation) Reproductive: Maternal effects: Ovaries, fallopian tubes

Reproductive: Maternal effects: Menstrual cycle changes or disorders

Reproductive: Other effects on female 		ENDOAO 79,1135,1966
implant
domestic animal 		lowest published toxic dose: 3,045 µg/kg (40-60 day pregnant) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)

Reproductive: Effects on newborn: Biochemical and metabolic

Reproductive: Effects on newborn: Physical 		JANSAG 65,1465,1987
implant
rat 		lowest published toxic dose: 10 µg/kg (77 day prior to copulation) Reproductive: Maternal effects: Ovaries, fallopian tubes

Reproductive: Maternal effects: Uterus, cervix, vagina

Reproductive: Maternal effects: Menstrual cycle changes or disorders 		ENDOAO 79,1135,1966
implant
rat 		lowest published toxic dose: 30 µg/kg (77 day prior to copulation) Reproductive: Other effects on female ENDOAO 79,1135,1966
intramuscular
dog 		lowest published toxic dose: 30 mg/kg (60 day male) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct 		JOETD7 27,327,1989
intramuscular
guinea pig 		lowest published toxic dose: 110 mg/kg (50 day prior to copulation) Reproductive: Other effects on female

Reproductive: Effects on fertility: Male fertility index (e.g., # males impregnating females per # males exposed to fertile nonpregnant females) 		ENDOAO 72,429,1963
intramuscular
man 		lowest published toxic dose: 10,714 µg/kg (30 day male) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) CCPTAY 5,295,1972
intramuscular
man 		lowest published toxic dose: 4,286 µg/kg (14 day male) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) ANYAA9 55,725,1952
intramuscular
mouse 		lowest published toxic dose: 15 mg/kg (7-12 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system

Reproductive: Specific developmental abnormalities: Urogenital system

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) 		OYYAA2 7,723,1973
intramuscular
mouse 		lowest published toxic dose: 15 mg/kg (7-12 day pregnant) Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) 		OYYAA2 7,723,1973
intramuscular
mouse 		lowest published toxic dose: 240 mg/kg (7-12 day pregnant) Reproductive: Specific developmental abnormalities: Eye, ear OYYAA2 7,723,1973
intramuscular
pig 		lowest published toxic dose: 142 mg/kg (40-77 day pregnant) Reproductive: Specific developmental abnormalities: Urogenital system

Reproductive: Effects on newborn: Delayed effects 		ENDKAC 63,161,1974
intramuscular
pig 		lowest published toxic dose: 140 mg/kg (29-35 day pregnant) Reproductive: Maternal effects: Menstrual cycle changes or disorders BIREBV 36,581,1987
intramuscular
pig 		lowest published toxic dose: 140 mg/kg (39-45 day pregnant) Reproductive: Maternal effects: Menstrual cycle changes or disorders BIREBV 36,581,1987
intramuscular
rat 		lowest published toxic dose: 6,250 µg/kg (1 day prior to copulation) Reproductive: Maternal effects: Ovaries, fallopian tubes JPHYA7 172,393,1964
intramuscular
rat 		lowest published toxic dose: 1,200 µg/kg (9-14 day pregnant) Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Specific developmental abnormalities: Musculoskeletal system

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) 		OYYAA2 7,723,1973
intramuscular
rat 		lowest published toxic dose: 3,600 µg/kg (9-14 day pregnant) Reproductive: Specific developmental abnormalities: Urogenital system

Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)

Reproductive: Effects on newborn: Weaning or lactation index (e.g., # alive at weaning per # alive at day 4) 		OYYAA2 7,723,1973
intramuscular
rat 		lowest published toxic dose: 3,600 µg/kg (9-14 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) OYYAA2 7,723,1973
intramuscular
rat 		lowest published toxic dose: 50 µg/kg (1 day prior to copulation) Reproductive: Effects on fertility: Female fertility index (e.g., # females pregnant per # sperm positive females; # females pregnant per # females mated) JPHYA7 172,393,1964
intramuscular
rabbit 		lowest published toxic dose: 15,750 µg/kg (21 day male) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) IJMRAQ 71,375,1980
intramuscular
woman 		lowest published toxic dose: 3 mg/kg (6 day prior to copulation) Reproductive: Maternal effects: Menstrual cycle changes or disorders PSEBAA 37,689,1938
intraperitoneal
rat 		lowest published toxic dose: 4,550 mg/kg (26 week male) Reproductive: Paternal effects: Testes, epididymis, sperm duct

Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands 		KSRNAM 7,2786,1973
intraperitoneal
rat 		lowest published toxic dose: 4,550 mg/kg (26 week prior to copulation) Reproductive: Maternal effects: Ovaries, fallopian tubes

Reproductive: Maternal effects: Uterus, cervix, vagina 		KSRNAM 7,2786,1973
multiple
rat 		lowest published toxic dose: 52,500 µg/kg (15 day prior to copulation) Reproductive: Other effects on female SCIEAS 181,770,1973
oral
rat 		lowest published toxic dose: 100 mg/kg (17-20 day pregnant) Reproductive: Specific developmental abnormalities: Urogenital system ECJPAE 24,77,1977
oral
rat 		lowest published toxic dose: 25 mg/kg (16-20 day pregnant) Reproductive: Specific developmental abnormalities: Urogenital system ARZNAD 36,1069,1986
oral
rabbit 		lowest published toxic dose: 24,500 µg/kg (49 day male) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Effects on fertility: Male fertility index (e.g., # males impregnating females per # males exposed to fertile nonpregnant females) 		EXCEDS 81,137,1983
parenteral
guinea pig 		lowest published toxic dose: 98 mg/kg (24-68 day pregnant) Reproductive: Specific developmental abnormalities: Urogenital system

Reproductive: Effects on newborn: Delayed effects 		ENDOAO 65,369,1959
parenteral
man 		lowest published toxic dose: 8,570 µg/kg (24 day male) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct 		JCENA4 10,816,1950
parenteral
rat 		lowest published toxic dose: 15 mg/kg (15-20 day pregnant) Reproductive: Effects on newborn: Behavioral JOENAK 25,549,1962
parenteral
rat 		lowest published toxic dose: 250 µg/kg (1 day prior to copulation) Reproductive: Maternal effects: Ovaries, fallopian tubes

Reproductive: Effects on fertility: Other measures of fertility 		ENDOAO 77,859,1965
parenteral
rat 		lowest published toxic dose: 500 µg/kg (1 day prior to copulation) Reproductive: Maternal effects: Uterus, cervix, vagina ENDOAO 77,859,1965
parenteral
rat 		lowest published toxic dose: 92 mg/kg (23 day male) Reproductive: Effects on fertility: Mating performance (e.g., # sperm positive females per # females mated; # copulations per # estrus cycles) ENDOAO 29,409,1941
parenteral
woman 		lowest published toxic dose: 18,500 µg/kg (31 day prior to copulation) Reproductive: Maternal effects: Menstrual cycle changes or disorders

Reproductive: Effects on fertility: Other measures of fertility 		PSEBAA 44,319,1940
subcutaneous
cattle 		lowest published toxic dose: 5,500 µg/kg (40-60 day pregnant) Reproductive: Specific developmental abnormalities: Urogenital system JANSAG 64,1858,1987
subcutaneous
domestic animal 		lowest published toxic dose: 693 mg/kg (40-60 day pregnant) Reproductive: Specific developmental abnormalities: Endocrine system

Reproductive: Effects on newborn: Biochemical and metabolic 		JANSAG 68,4100,1990
subcutaneous
guinea pig 		lowest published toxic dose: 80 mg/kg (30-45 day pregnant) Reproductive: Effects on fertility: Mating performance (e.g., # sperm positive females per # females mated; # copulations per # estrus cycles)

Reproductive: Maternal effects: Menstrual cycle changes or disorders

Reproductive: Specific developmental abnormalities: Urogenital system 		JCPPAV 57,166,1964
subcutaneous
guinea pig 		lowest published toxic dose: 150 mg/kg (28-58 day pregnant) Reproductive: Effects on newborn: Delayed effects HOBEAO 6,139,1975
subcutaneous
horse, donkey 		lowest published toxic dose: 1,575 µg/kg (9 day male) Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands JANSAG 51,1358,1980
subcutaneous
monkey 		lowest published toxic dose: 30 mg/kg (40-64 day pregnant) Reproductive: Effects on newborn: Biochemical and metabolic JCEMAZ 85,1206,2000
subcutaneous
mouse 		lowest published toxic dose: 4 mg/kg (1 day male) Reproductive: Paternal effects: Testes, epididymis, sperm duct

Reproductive: Effects on fertility: Mating performance (e.g., # sperm positive females per # females mated; # copulations per # estrus cycles) 		DEPBA5 12,231,1979
subcutaneous
mouse 		lowest published toxic dose: 200 mg/kg (12 day pregnant) Reproductive: Specific developmental abnormalities: Skin and skin appendages ENDOAO 76,789,1965
subcutaneous
mouse 		lowest published toxic dose: 40 mg/kg (1 day prior to copulation) Reproductive: Effects on fertility: Female fertility index (e.g., # females pregnant per # sperm positive females; # females pregnant per # females mated) PSEBAA 85,673,1954
subcutaneous
mouse 		lowest published toxic dose: 20 mg/kg (10 day prior to copulation) Reproductive: Other effects on female ECJPAE 23,327,1976
subcutaneous
mouse 		lowest published toxic dose: 190 mg/kg (35 day male) Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands JOENAK 46,477,1970
subcutaneous
rat 		lowest published toxic dose: 50 µg/kg (1 day prior to copulation) Reproductive: Maternal effects: Ovaries, fallopian tubes

Reproductive: Maternal effects: Uterus, cervix, vagina 		JRPFA4 30,55,1972
subcutaneous
rat 		lowest published toxic dose: 200 µg/kg (20 day male) Reproductive: Paternal effects: Testes, epididymis, sperm duct JOURAA 45,780,1941
subcutaneous
rat 		lowest published toxic dose: 7,500 µg/kg (17 day pregnant) Reproductive: Specific developmental abnormalities: Urogenital system

Reproductive: Effects on newborn: Delayed effects 		JOENAK 48,477,1970
subcutaneous
rat 		lowest published toxic dose: 50 µg/kg (1 day prior to copulation) Reproductive: Effects on fertility: Other measures of fertility ACENA7 49,193,1965
subcutaneous
rat 		lowest published toxic dose: 6,250 µg/kg (15 day pregnant) Reproductive: Specific developmental abnormalities: Skin and skin appendages AAMMAU 66,207,1977
subcutaneous
rat 		lowest published toxic dose: 6,250 µg/kg (multigenerations) Reproductive: Specific developmental abnormalities: Urogenital system

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) 		AAMMAU 66,207,1977
subcutaneous
rat 		lowest published toxic dose: 50 µg/kg (1 day prior to copulation) Reproductive: Maternal effects: Menstrual cycle changes or disorders

Reproductive: Effects on fertility: Mating performance (e.g., # sperm positive females per # females mated; # copulations per # estrus cycles)

Reproductive: Effects on fertility: Female fertility index (e.g., # females pregnant per # sperm positive females; # females pregnant per # females mated) 		PSEBAA 122,88,1966
subcutaneous
rat 		lowest published toxic dose: 15 mg/kg (14-19 day pregnant) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)

Reproductive: Effects on newborn: Physical

Reproductive: Effects on newborn: Delayed effects 		TOSCF2 65,71,2002
subcutaneous
rat 		lowest published toxic dose: 150 mg/kg (14-19 day pregnant) Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)

Reproductive: Effects on newborn: Weaning or lactation index (e.g., # alive at weaning per # alive at day 4) 		TOSCF2 65,71,2002
subcutaneous
rat 		lowest published toxic dose: 30 mg/kg (14-19 day pregnant) Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth) TOXID9 60,224,2001
subcutaneous
rat 		lowest published toxic dose: 4.5 mg/kg (14-19 day pregnant) Reproductive: Specific developmental abnormalities: Urogenital system

Reproductive: Effects on newborn: Physical 		TOXID9 60,224,2001
subcutaneous
rat 		lowest published toxic dose: 30 mg/kg (14-19 day pregnant) Reproductive: Specific developmental abnormalities: Urogenital system TOXID9 66,371,2002
subcutaneous
rabbit 		lowest published toxic dose: 1,500 µg/kg (27-29 day pregnant) Reproductive: Maternal effects: Postpartum

Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on fertility: Abortion 		JRPFA4 23,285,1970
subcutaneous
rabbit 		lowest published toxic dose: 10 mg/kg (5 day prior to copulation) Reproductive: Maternal effects: Uterus, cervix, vagina ANREAK 142,469,1962
subcutaneous
rabbit 		lowest published toxic dose: 500 µg/kg (1 day male) Reproductive: Effects on fertility: Mating performance (e.g., # sperm positive females per # females mated; # copulations per # estrus cycles) JPHYA7 181,568,1965
unreported route
rat 		lowest published toxic dose: 20 mg/kg (5 day male) Reproductive: Effects on fertility: Mating performance (e.g., # sperm positive females per # females mated; # copulations per # estrus cycles) ANENAG 24(Suppl 3),1,1963
unreported route
rat 		lowest published toxic dose: 3,500 mg/kg (10-16 day pregnant) Reproductive: Effects on fertility: Female fertility index (e.g., # females pregnant per # sperm positive females; # females pregnant per # females mated)

Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetal death 		SAKNAH 64,737,1971


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
implant
hamster 		lowest published toxic dose: 360 mg/kg Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Musculoskeletal: Tumors

Reproductive: Other reproductive system tumors 		CNREA8 25,141,1965
implant
mouse 		lowest published toxic dose: 5,200 mg/kg/65 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Reproductive: Tumorigenic effects: Uterine tumors 		NATUAS 192,1303,1961
implant
rat 		lowest published toxic dose: 432 mg/kg/48 week- continuous Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Reproductive: Tumorigenic effects: Prostate tumors 		CNREA8 37,1929,1977
subcutaneous
rat 		lowest published toxic dose: 10 mg/kg Tumorigenic: Neoplastic by RTECS criteria

Skin and Appendages: Tumors 		JSONDX 5,396,1984


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
implant
mouse 		lowest published toxic dose: 800 mg/kg Tumorigenic: Active as anti-cancer agent CNREA8 66,6482,2006
implant
rat 		lowest published toxic dose: 250 mg/kg Skin and Appendages: Other: Breast BJMRDK 38,553,2005
intraperitoneal
mouse 		lethal dose (50 percent kill): 970 mg/kg N/R NIIRDN 6,487,1982
intraperitoneal
rat 		lethal dose (50 percent kill): 585 mg/kg N/R NIIRDN 6,487,1982
oral
mouse 		lethal dose (50 percent kill): 1,350 mg/kg N/R NIIRDN 6,487,1982
oral
rat 		lethal dose (50 percent kill): 1 gm/kg N/R NIIRDN 6,487,1982
subcutaneous
mouse 		lethal dose (50 percent kill): >5 gm/kg N/R NIIRDN 6,487,1982
subcutaneous
rat 		lethal dose (50 percent kill): >5 gm/kg N/R NIIRDN 6,487,1982
subcutaneous
rat 		lowest published toxic dose: 0.4 mg/kg Behavioral: Food intake (animal)

Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands 		JTEHF8 68,2277,2005


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
rat 		lowest published toxic dose: 3,900 mg/kg/26 week- intermittent Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in bladder weight

Endocrine: Changes in spleen weight 		KSRNAM 7,2786,1973
oral
rat 		lowest published toxic dose: 3 mg/kg/30 day- intermittent Endocrine: Androgenic TOSCF2 60,285,2001
parenteral
rat 		lowest published toxic dose: 500 µg/kg/2 day- intermittent Behavioral: Change in psychophysiological tests

Endocrine: Androgenic 		EVHPAZ 110(Suppl 3),435,2002
subcutaneous
mouse 		: 280 mg/kg/14 day- intermittent Related to Chronic Data: Changes in prostate weight BPBLEO 27,333,2004
subcutaneous
mouse 		lowest published toxic dose: 32 mg/kg/4 day- intermittent Immunological Including Allergic: Decreased immune response JTEHF8 70,138,2007
subcutaneous
mouse 		lowest published toxic dose: 112 mg/kg/2 week- intermittent Endocrine: Androgenic

Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands 		JTEHF8 70,138,2007
subcutaneous
quail 		lowest published toxic dose: 320 mg/kg/32 day- intermittent Behavioral: Change in psychophysiological tests

Behavioral: Aggression

Related to Chronic Data: Changes in testicular weight 		HOBEAO 49,4,2006
subcutaneous
rat 		lowest published toxic dose: 1,560 mg/kg/26 week- intermittent Cardiac: Changes in heart weight

Kidney, Ureter, and Bladder: Changes in bladder weight

Endocrine: Changes in thymus weight 		KSRNAM 7,2786,1973
subcutaneous
rat 		lowest published toxic dose: 960 mg/kg/40 week- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Changes in testicular weight

Related to Chronic Data: Changes in prostate weight 		PRSTDS 31,9,1997
subcutaneous
rat 		lowest published toxic dose: 1,333.3 mg/kg/28 week- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain PRSTDS 31,9,1997
subcutaneous
rat 		lowest published toxic dose: 2,856 mg/kg/60 week- intermittent Kidney, Ureter, and Bladder: Changes in kidney weight

Related to Chronic Data: Changes in prostate weight

Related to Chronic Data: Changes in testicular weight 		PRSTDS 31,9,1997
subcutaneous
rat 		lowest published toxic dose: 1.25 mg/kg/5 day- intermittent Endocrine: Androgenic

Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands

Related to Chronic Data: Changes in prostate weight 		JTSCDR 25,403,2000
subcutaneous
rat 		lowest published toxic dose: 1.25 mg/kg/5 day- intermittent Endocrine: Androgenic

Related to Chronic Data: Changes in prostate weight 		JTSCDR 25,403,2000
subcutaneous
rat 		lowest published toxic dose: 150 mg/kg/6 day- intermittent Reproductive: Maternal effects: Parturition TOSCF2 65,71,2002
subcutaneous
rat 		lowest published toxic dose: 500 µg/kg/10 day- intermittent Related to Chronic Data: Changes in prostate weight TOSCF2 70,202,2002
subcutaneous
rat 		lowest published toxic dose: 2 mg/kg/10 day- intermittent Endocrine: Androgenic

Related to Chronic Data: Changes in prostate weight 		TXCYAC 199,145,2004
subcutaneous
rat 		lowest published toxic dose: 4 mg/kg/10 day- intermittent Endocrine: Androgenic

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Related to Chronic Data: Changes in prostate weight 		TXCYAC 199,145,2004
subcutaneous
rat 		lowest published toxic dose: 3.5 mg/kg/7 day- intermittent Endocrine: Change in LH

Related to Chronic Data: Changes in prostate weight 		TXCYAC 207,21,2005
subcutaneous
rat 		lowest published toxic dose: 70 mg/kg/7 day- intermittent Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases 		ARTODN 76,8,2002
subcutaneous
rat 		lowest published toxic dose: 5,000 µg/kg/10 day- intermittent Endocrine: Androgenic

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) 		JAPTO* 25,176,2005
subcutaneous
rat 		lowest published toxic dose: 4 mg/kg/10 day- intermittent Reproductive: Other effects on male TOXID9 66,276,2002
subcutaneous
rat 		lowest published toxic dose: 0.5 mg/kg/10 day- intermittent Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands

Related to Chronic Data: Changes in prostate weight 		TOXID9 60,223,2001
subcutaneous
rat 		lowest published toxic dose: 1.25 mg/kg/5 day- intermittent Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands TOXID9 60,224,2001
subcutaneous
rat 		lowest published toxic dose: 12 mg/kg/6 day- intermittent Reproductive: Maternal effects: Parturition

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		TOXID9 60,224,2001
subcutaneous
rat 		lowest published toxic dose: 30 mg/kg/6 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain TOXID9 66,371,2002
subcutaneous
rat 		lowest published toxic dose: 4 mg/kg/10 day- intermittent Endocrine: Changes in adrenal weight

Related to Chronic Data: Changes in prostate weight 		TXCYAC 213,147,2005
subcutaneous
rat 		lowest published toxic dose: 10.77 mg/kg/14 day- intermittent Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands

Reproductive: Other effects on male 		JPETAB 304,1323,2003
subcutaneous
rat 		lowest published toxic dose: 4.2 mg/kg/14 day- continuous Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands JPETAB 304,1334,2003
subcutaneous
rat 		lowest published toxic dose: 7 mg/kg/14 day- continuous Reproductive: Other effects on male JPETAB 304,1334,2003
subcutaneous
rat 		lowest published toxic dose: 17.5 mg/kg/14 day- intermittent Reproductive: Other effects on male JPETAB 312,546,2005
subcutaneous
rat 		lowest published toxic dose: 2.94 mg/kg/2 week- intermittent Musculoskeletal: Other changes JMCMAR 49,7596,2006
subcutaneous
rat 		lowest published toxic dose: 5.88 mg/kg/2 week- intermittent Related to Chronic Data: Changes in prostate weight JMCMAR 49,7596,2006
subcutaneous
rat 		lowest published toxic dose: 3.64 mg/kg/2 week- intermittent Endocrine: Change in LH JMCMAR 49,7596,2006
subcutaneous
rat 		lowest published toxic dose: 12 mg/kg/12 day- intermittent Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands

Related to Chronic Data: Changes in prostate weight 		TOLED5 165,149,2006
subcutaneous
rat 		lowest published toxic dose: 4 mg/kg/10 day- intermittent Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands

Related to Chronic Data: Changes in prostate weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects 		TXCYAC 239,77,2007
subcutaneous
rat 		lowest published toxic dose: 12 mg/kg/12 day- intermittent Liver: Other changes

Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands

Related to Chronic Data: Changes in prostate weight 		TOLED5 169,64,2007
subcutaneous
rat 		lowest published toxic dose: 7 mg/kg/7 day- intermittent Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands NSAPCC 369(Suppl 1),R116,2004
subcutaneous
rat 		lowest published toxic dose: 4 mg/kg/30 day- intermittent Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands

Reproductive: Effects on fertility: Mating performance (e.g., # sperm positive females per # females mated; # copulations per # estrus cycles)

Related to Chronic Data: Changes in prostate weight 		FTRPAE 78,530,2007
skin
rat 		lowest published toxic dose: 1 gm/m3/30 day- intermittent Endocrine: Effect on menstrual cycle TOVEFN (2),6,1996
skin
rat 		lowest published toxic dose: 100 gm/m3/4 day- intermittent Endocrine: Effect on menstrual cycle TOVEFN (2),6,1996
unreported route
rat 		lowest published toxic dose: 4 mg/kg/10 day- intermittent Musculoskeletal: Other changes

Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands

Related to Chronic Data: Changes in prostate weight 		NSAPCC 375(Suppl 1),75,2007
unreported route
rat 		lowest published toxic dose: 10 mg/kg/10 day- intermittent Musculoskeletal: Other changes

Reproductive: Paternal effects: Testes, epididymis, sperm duct

Related to Chronic Data: Changes in testicular weight 		NSAPCC 375(Suppl 1),75,2007


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
International Agency for Research on Cancer (IARC) Cancer Review Animal Sufficient Evidence IMEMDT 21,519,1979
TOXICOLOGY REVIEW
CANCAR 40,1825,1977
TOXICOLOGY REVIEW
ACRSAJ 1,173,1953
TOXICOLOGY REVIEW
TOLED5 140-141,161,2003
TOXICOLOGY REVIEW
ENTOX* -,121,2005
TOXICOLOGY REVIEW
TOLED5 158,167,2005


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Exposure Limit - RUSSIA short term exposure limit 0.005 mg/m3, Skin, JUN2003


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X6098;
Number of Industries 1;
Total Number of Facilities 7;
Number of Occupations 2;
Total Number of Employees Exposed 628;
Total Number of Female Employees Exposed 314


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Positive: Carcinogenicity-mouse/rat; Sperm morphology-human
EPA TSCA Section 8(b) CHEMICAL INVENTORY


REFERENCES:

CODEN
REFERENCE
AAMMAU Archives d'Anatomie Microscopique et de Morphologie Experimentale. (SPPIF, B.P.22, F-41353 Vineuil, France) V.36-76, 1947-1987. For publisher information, see BSTME2.
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Used as a drug for the treatment of hypogonadism and metastatic breast cancer

FDA-proprietary drug

RTECS Compound Description:
   Tumorigen
   Drug
   Mutagen
   Reproductive Effector
   Human Data
   Hormone

 Click Here for Additional Information about RTECS

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