RTECS:WZ6700000 The Registry of Toxic Effects of Chemical Substances

alpha - Terpineol

RTECS #: WZ6700000

CAS #: 98-55-5

UPDATE: May 2009 MW: 154.28 MF: C₁₀H₁₈O

NOTE:

TOXICITY DATA HAVE NOT BEEN EVALUATED. OMISSION OF A SUBSTANCE OR NOTATION DOES NOT IMPLY ANY RELIEF FROM REGULATORY RESPONSIBILITY.

TABLE OF CONTENTS:

SYNONYMS:

SKIN AND EYE IRRITATION DATA:

ACUTE TOXICITY DATA:

OTHER MULTIPLE DOSE DATA:

REVIEWS:

NIOSH DOCUMENTATION AND SURVEILLANCE:

STATUS IN FEDERAL AGENCIES:

REFERENCES:

SYNONYMS:

2 - (4 - Methyl - 3 - cyclohexenyl) - 2 - propanol

3 - Cyclohexene - 1 - methanol, alpha,alpha,4 - trimethyl - (9CI)

PC 593

Terpenol

Terpineol schlechthin

Terpineol 350

alpha,alpha,4 - Trimethyl - 3 - cyclohexene - 1 - methanol

dl - alpha - Terpineol

p - Menth - 1 - en - 8 - ol (8CI)

SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
skin
mouse 50% severe TOXID9 -,270,2008

MUTATION DATA AND REFERENCES:
SYSTEM TEST ROUTE/
ORGANISM/
TISSUE DOSE REFERENCE
N/R N/R N/R N/R

REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

TUMORIGENIC DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
intramuscular
mouse lethal dose (50 percent kill): 2 gm/kg N/R JSICAZ 21,342,1962
oral
mouse lethal dose (50 percent kill): 2,830 mg/kg N/R CPBTAL 33,1669,1985
oral
rat lethal dose (50 percent kill): 5,170 mg/kg N/R GTPZAB 31(2),29,1987
oral
rat lowest published toxic dose: 2,900 mg/kg Peripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage)

Behavioral: Somnolence (general depressed activity)

Behavioral: Ataxia VCVPS* -,301,1998
unreported route
mouse lethal dose (50 percent kill): 2,830 mg/kg N/R HBPTO* 1,827,2001

OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
oral
rat lowest published toxic dose: 7,755 mg/kg/30 day- intermittent Brain and Coverings: Other degenerative changes

Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases GTPZAB 31(2),29,1987

REVIEWS:
ORGANIZATION STANDARD
REFERENCE

TOXICOLOGY REVIEW
FCTOD7 46,S1,2008

STANDARDS AND REGULATIONS:
ORGANIZATION STANDARD
REFERENCE

N/R N/R N/R

NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 80268;
Number of Industries 37;
Total Number of Facilities 2,241;
Number of Occupations 47;
Total Number of Employees Exposed 16,136
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 80268;
Number of Industries 125;
Total Number of Facilities 20,420;
Number of Occupations 102;
Total Number of Employees Exposed 328,085;
Total Number of Female Employees Exposed 125,759

STATUS IN FEDERAL AGENCIES:
ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as a growth stimulant for agricultural plants and as fragrance raw material
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001

REFERENCES:
CODEN
REFERENCE

CPBTAL Chemical and Pharmaceutical Bulletin. (Japan Pub. Trading Co., USA, 1255 Howard St., San Francisco, CA 94103) V.6- 1958-
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982-
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
HBPTO* Handbook of pesticide toxicology. Robert Krieger ed, Academic press, 2001
JSICAZ Journal of Scientific and Industrial Research, Section C: Biological Sciences. (New Delhi, India) V.14-21, 1955-62. For publisher information, see IJEBA6.
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
VCVPS* "Vrednie chemichescie veshestva. Prirodnie organicheskie soedinenia" (Hazardous substances. Nature products.) Volkova N.V. et al., Sankt-Peterburg, 1998.

Used as a growth stimulant for agricultural plants and as fragrance raw material

RTECS Compound Description:
Natural Product
Primary Irritant

ALT CAS #: 2438-12-2
ALT CAS #: 22347-88-2
Click Here for Additional Information about RTECS

NIOSH Home | NIOSH Search | Site Index | Topic List | Contact Us

SYNONYMS:
2 - (4 - Methyl - 3 - cyclohexenyl) - 2 - propanol 3 - Cyclohexene - 1 - methanol, alpha,alpha,4 - trimethyl - (9CI) PC 593 Terpenol Terpineol schlechthin	Terpineol 350 alpha,alpha,4 - Trimethyl - 3 - cyclohexene - 1 - methanol dl - alpha - Terpineol p - Menth - 1 - en - 8 - ol (8CI)

SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
skin mouse	50%	severe	TOXID9 -,270,2008

MUTATION DATA AND REFERENCES:
SYSTEM TEST	ROUTE/ ORGANISM/ TISSUE	DOSE	REFERENCE
N/R	N/R	N/R	N/R

REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
N/R	N/R	N/R	N/R

TUMORIGENIC DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
N/R	N/R	N/R	N/R

ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
intramuscular mouse	lethal dose (50 percent kill): 2 gm/kg	N/R	JSICAZ 21,342,1962
oral mouse	lethal dose (50 percent kill): 2,830 mg/kg	N/R	CPBTAL 33,1669,1985
oral rat	lethal dose (50 percent kill): 5,170 mg/kg	N/R	GTPZAB 31(2),29,1987
oral rat	lowest published toxic dose: 2,900 mg/kg	Peripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage) Behavioral: Somnolence (general depressed activity) Behavioral: Ataxia	VCVPS* -,301,1998
unreported route mouse	lethal dose (50 percent kill): 2,830 mg/kg	N/R	HBPTO* 1,827,2001

OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
oral rat	lowest published toxic dose: 7,755 mg/kg/30 day- intermittent	Brain and Coverings: Other degenerative changes Liver: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases	GTPZAB 31(2),29,1987

REVIEWS:
ORGANIZATION	STANDARD	REFERENCE
TOXICOLOGY REVIEW		FCTOD7 46,S1,2008

STANDARDS AND REGULATIONS:
ORGANIZATION	STANDARD	REFERENCE
N/R	N/R	N/R

NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION	STANDARD or SURVEY	REFERENCE
National Occupational Hazard Survey 1974	National Occupational Hazard Survey 1974: Hazard Code: 80268; Number of Industries 37; Total Number of Facilities 2,241; Number of Occupations 47; Total Number of Employees Exposed 16,136
National Occupational Exposure Survey 1983	National Occupational Exposure Survey 1983: Hazard Code: 80268; Number of Industries 125; Total Number of Facilities 20,420; Number of Occupations 102; Total Number of Employees Exposed 328,085; Total Number of Female Employees Exposed 125,759

STATUS IN FEDERAL AGENCIES:
ORGANIZATION	REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as a growth stimulant for agricultural plants and as fragrance raw material
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001

REFERENCES:
CODEN	REFERENCE
CPBTAL	Chemical and Pharmaceutical Bulletin. (Japan Pub. Trading Co., USA, 1255 Howard St., San Francisco, CA 94103) V.6- 1958-
FCTOD7	Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982-
GTPZAB	Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
HBPTO*	Handbook of pesticide toxicology. Robert Krieger ed, Academic press, 2001
JSICAZ	Journal of Scientific and Industrial Research, Section C: Biological Sciences. (New Delhi, India) V.14-21, 1955-62. For publisher information, see IJEBA6.
TOXID9	Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
VCVPS*	"Vrednie chemichescie veshestva. Prirodnie organicheskie soedinenia" (Hazardous substances. Nature products.) Volkova N.V. et al., Sankt-Peterburg, 1998.