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Sulfuryl fluoride

RTECS #: WT5075000

CAS #: 2699-79-8

UPDATE: May 2009 MW: 102.06 MF: F2O2S


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. REPRODUCTIVE EFFECTS DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. Fluorure de sulfuryle (French)
  2. Sulfuric oxyfluoride
  3. Sulfuryl difluoride
  1. Sulfuryl fluoride (ACGIH:OSHA)
  2. Vikane
  3. Vikane fumigant


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published toxic concentration: 225 ppm/6 hour (6-15 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system 		FAATDF 13,79,1989
inhalation
rabbit 		lowest published toxic concentration: 225 ppm/6 hour (6-18 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Cardiovascular (circulatory) system 		FAATDF 13,79,1989


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mouse 		lowest published lethal concentration: 1,200 ppm/1 hour Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Cyanosis 		AMPMAR 34,581,1973
inhalation
mouse 		lethal concentration (50 percent kill): 642 ppm/4 hour N/R FEREAC 67,7158,2002
inhalation
rat 		lethal concentration (50 percent kill): 991 ppm/4 hour Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Acute pulmonary edema

Lung, Thorax, or Respiration: Cyanosis 		FAATDF 7,664,1986
inhalation
rabbit 		lowest published lethal concentration: 5,000 ppm/1 hour Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Cyanosis 		AMPMAR 34,581,1973
oral
guinea pig 		lethal dose (50 percent kill): 100 mg/kg N/R DOWCC*
oral
rat 		lethal dose (50 percent kill): 100 mg/kg N/R 85ARAE 3,15,1976/1977


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
dog 		lowest published toxic concentration: 1,106 mg/kg/2 week- intermittent Behavioral: Tremor

Behavioral: Tetany

Lung, Thorax, or Respiration: Other changes 		FEREAC 69,3240,2004
inhalation
dog 		lowest published toxic concentration: 1,134 mg/kg/2 week- intermittent Behavioral: Tremor

Behavioral: Tetany

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		FEREAC 69,3240,2004
inhalation
dog 		lowest published toxic concentration: 4,500 mg/kg/90 day- intermittent Brain and Coverings: Other degenerative changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		FEREAC 69,3240,2004
inhalation
dog 		lowest published toxic concentration: 4,590 mg/kg/90 day- intermittent Brain and Coverings: Other degenerative changes

Behavioral: Tremor

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		FEREAC 69,3240,2004
inhalation
dog 		lowest published toxic concentration: 7,300 mg/kg/1 year- intermittent Lung, Thorax, or Respiration: Other changes

Musculoskeletal: Changes in teeth and supporting structures

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		FEREAC 69,3240,2004
inhalation
mouse 		lowest published toxic concentration: 80 ppm/6 hour/78 week- intermittent Brain and Coverings: Other degenerative changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		TOXID9 14,394,1994
inhalation
mouse 		lowest published toxic concentration: 10,890 mg/kg/90 day- intermittent Brain and Coverings: Other degenerative changes

Endocrine: Evidence of thyroid hyperfunction

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		FEREAC 69,3240,2004
inhalation
mouse 		lowest published toxic concentration: 55,348 mg/kg/1.5 year- intermittent Brain and Coverings: Other degenerative changes

Endocrine: Evidence of thyroid hyperfunction

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		FEREAC 69,3240,2004
inhalation
mouse 		lowest published toxic concentration: 55,348 mg/kg/1.5 year- intermittent Brain and Coverings: Other degenerative changes

Cardiac: Other changes

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		FEREAC 69,3240,2004
inhalation
rat 		lowest published toxic concentration: 600 ppm/6 hour/2 week- intermittent Kidney, Ureter, and Bladder: Proteinuria

Blood: Changes in leukocyte (WBC) count

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		FAATDF 12,540,1989
inhalation
rat 		lowest published toxic concentration: 300 ppm/6 hour/13 week- intermittent Olfaction: Other olfaction effects

Lung, Thorax, or Respiration: Other changes

Kidney, Ureter, and Bladder: Other changes in urine composition 		FAATDF 12,540,1989
inhalation
rat 		lowest published toxic concentration: 80 ppm/6 hour/2 year- intermittent Kidney, Ureter, and Bladder: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		TOXID9 14,394,1994
inhalation
rat 		lowest published toxic concentration: 3,486 mg/kg/2 week- intermittent Kidney, Ureter, and Bladder: Other changes

Kidney, Ureter, and Bladder: Changes in kidney weight 		FEREAC 69,3240,2004
inhalation
rat 		lowest published toxic concentration: 7,200 mg/kg/90 day- intermittent Musculoskeletal: Changes in teeth and supporting structures FEREAC 69,3240,2004
inhalation
rat 		lowest published toxic concentration: 10,220 mg/kg/2 year- intermittent Musculoskeletal: Changes in teeth and supporting structures FEREAC 69,3240,2004
inhalation
rat 		lowest published toxic concentration: 45,260 mg/kg/2 year- intermittent Kidney, Ureter, and Bladder: Other changes

Musculoskeletal: Changes in teeth and supporting structures

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		FEREAC 69,3240,2004
inhalation
rat 		lowest published toxic concentration: 5,110 mg/kg/1 year- intermittent Musculoskeletal: Changes in teeth and supporting structures FEREAC 69,3240,2004
inhalation
rabbit 		lowest published toxic concentration: 337 ppm/6 hour/13 week- intermittent Liver: Changes in liver weight

Blood: Changes in leukocyte (WBC) count

Nutritional and Gross Metabolic: Changes in: Other metals 		FAATDF 12,540,1989
inhalation
rabbit 		lowest published toxic concentration: 1,260 mg/kg/2 week- intermittent Brain and Coverings: Other degenerative changes

Lung, Thorax, or Respiration: Other changes 		FEREAC 69,3240,2004
inhalation
rabbit 		lowest published toxic concentration: 2,610 mg/kg/90 day- intermittent Liver: Changes in liver weight

Musculoskeletal: Changes in teeth and supporting structures

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		FEREAC 69,3240,2004
inhalation
rabbit 		lowest published toxic concentration: 2,520 mg/kg/90 day- intermittent Brain and Coverings: Other degenerative changes

Liver: Changes in liver weight

Musculoskeletal: Changes in teeth and supporting structures 		FEREAC 69,3240,2004


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 5 ppm;short term exposure limit 10 ppm DTLVS* TLV/BEI,2007


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: RED Completed RBREV* -,150,1998
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 5 ppm (20 mg/m3) DTLVS* 3,241,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 5 ppm (20 mg/m3) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 5 ppm (20 mg/m3) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 5 ppm (20 mg/m3) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 5 ppm (20 mg/m3) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 2.5 mg(F)/m3, JUL2008
Occupational Exposure Limit - AUSTRALIA time-weighted average 5 ppm (21 mg/m3), short term exposure limit 10 ppm (42 mg/m3), JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 2.5 mg(F)/m3, MAR2002
Occupational Exposure Limit - BELGIUM time-weighted average 5 ppm (21 mg/m3), short term exposure limit 10 ppm (43 mg/m3), MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 2.5 mg(F)/m3, OCT 2002
Occupational Exposure Limit - DENMARK time-weighted average 5 ppm (20 mg/m3), OCT 2002
Occupational Exposure Limit - EC time-weighted average 2.5 mg(F)/m3, FEB 2006
Occupational Exposure Limit - FINLAND time-weighted average 5 ppm (20 mg/m3), short term exposure limit 10 ppm (40 mg/m3), JAN1999
Occupational Exposure Limit - FRANCE VME 5 ppm (20 mg/m3), FEB2006
Occupational Exposure Limit - GERMANY MAK 1 mg(F)/m3 (inhalable), 2005
Occupational Exposure Limit - HUNGARY time-weighted average 2.5 mg(F)/m3, short term exposure limit 10 mg(F)/m3, Skin, SEP2000
Occupational Exposure Limit - KOREA time-weighted average 5 ppm (20 mg/m3), short term exposure limit 10 ppm (40 mg/m3), 2006
Occupational Exposure Limit - MEXICO time-weighted average 5 ppm (20 mg/m3);
short term exposure limit 10 ppm (40 mg/m3), 2004
Occupational Exposure Limit - MEXICO time-weighted average 2.5 mg(F)/m3, 2004
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 20 mg/m3, 2003
Occupational Exposure Limit - NEW ZEALAND time-weighted average 5 ppm (21 mg/m3), short term exposure limit 10 ppm (42 mg/m3), JAN2002
Occupational Exposure Limit - NEW ZEALAND time-weighted average 2.5 mg(F)/m3, JAN2002
Occupational Exposure Limit - NORWAY time-weighted average 5 ppm (20 mg/m3), JAN1999
Occupational Exposure Limit - POLAND MAC(time-weighted average) 1 mg(HF)/m3, MAC(short term exposure limit) 3 mg(HF)/m3, JAN1999
Occupational Exposure Limit - SWEDEN time-weighted average 2 mg(F)/m3, JUN2005
Occupational Exposure Limit - SWITZERLAND MAK- week 5 ppm (20 mg/m3), DEC2006
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 5 ppm (21 mg/m3);
short term exposure limit 10 ppm (42 mg/m3), 2005
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 2.5 mg(F)/m3, 2005
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 5 ppm;
short term exposure limit 10 ppm
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 5 ppm;
short term exposure limit 10 ppm


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO SULFURYL FLUORIDE-air 10 hour time-weighted average 5 ppm;
short term exposure limit 10 ppm 		NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 70960;
Number of Industries 1;
Total Number of Facilities 11;
Number of Occupations 3;
Total Number of Employees Exposed 357
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 70960;
Number of Industries 2;
Total Number of Facilities 350;
Number of Occupations 3;
Total Number of Employees Exposed 5,136


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as a fumigant
NIOSH Analytical Method, 1994: Sulfuryl fluoride, 6012


REFERENCES:

CODEN
REFERENCE
85ARAE "Agricultural Chemicals," Thomson, W.T., 4 vols., Fresno, CA, Thomson Publications, 1976/77 revision
AMPMAR Archives des Maladies Professionnelles de Medecine du Travail et de Securite Sociale. (SPPIF, B.P.22, F-41353 Vineuil, France) V.7- 1946-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information, see TOSCF2
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-

Used as a fumigant

NIOSH PROFILE (FUMIGANTS), SRC, 10/77

RTECS Compound Description:
   Agricultural Chemical
   Reproductive Effector

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