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Sulfanilamide, N (sup 1) - (3,4 - dimethyl - 5 - isoxazolyl) -

RTECS #: WO9100000

CAS #: 127-69-5

UPDATE: May 2009 MW: 267.33 MF: C11H13N3O3S


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. 3,4 - Dimethylisoxazole - 5 - sulfanilamide
  2. 3,4 - Dimethylisoxazole - 5 - sulphanilamide
  3. 3,4 - Dimethyl - 5 - sulfanilamidoisoxazole
  4. 3,4 - Dimethyl - 5 - sulphanilamidoisoxazole
  5. 3,4 - Dimethyl - 5 - sulphonamidoisoxazole
  6. 4 - Amino - N - (3,4 - dimethyl - 5 - isoxazolyl) benzenesulphonamide
  7. 5 - (4 - Aminophenylsulfonamido) - 3,4 - dimethylisoxazole
  8. 5 - (4 - Aminophenylsulphonamido) - 3,4 - dimethylisoxazole
  9. 5 - (p - Aminobenzenesulfonamido) - 3,4 - dimethylisoxazole
  10. 5 - (p - Aminobenzenesulphonamide) - 3,4 - dimethylisoxazole
  11. 5 - (p - Aminobenzenesulphonamido) - 3,4 - dimethylisoxazole
  12. 5 - Sulfanilamido - 3,4 - dimethylisoxazole
  13. 5 - Sulphanilamido - 3,4 - dimethyl - isoxazole
  14. Alphazole
  15. Amidoxal
  16. Benzenesulfonamide, 4 - amino - N - (3,4 - dimethyl - 5 - isoxazolyl) -
  17. Chemouag
  18. Dorsulfan
  19. Entusil
  20. Entusul
  21. Gantrisin
  22. Gantrisine
  23. Gantrisona
  24. Gantrosan
  25. Isoxamin
  26. J - Sul
  27. Koro - sulf
  28. N' - (3,4) Dimethylisoxazol - 5 - yl - sulphanilamide
  29. N (sup 1) - (3,4 - Dimethyl - 5 - isoxazolyl) sulfanilamide
  30. N (sup 1) - (3,4 - Dimethyl - 5 - isoxazolyl) sulphanilamide
  31. NCI - C50022
  32. NU 445
  33. Neazolin
  34. Neoxazol
  35. Norilgan - S
  36. Novazolo
  37. Novosaxazole
  38. Pancid
  39. Renosulfan
  40. Roxosul
  41. Roxosul tablets
  42. Saxosozine
  43. Sodizole
  1. Soxamide
  2. Soxisol
  3. Soxitabs
  4. Soxomide
  5. Stansin
  6. Sulbio
  7. Sulfadimethylisoxazole
  8. Sulfafurazol
  9. Sulfafurazole
  10. Sulfagan
  11. Sulfaisoxazole
  12. Sulfapolar
  13. Sulfasoxazole
  14. Sulfasol
  15. Sulfazin
  16. Sulfisin
  17. Sulfisonazole
  18. Sulfisoxazol
  19. Sulfisoxazole
  20. Sulfizin
  21. Sulfizol
  22. Sulfizole
  23. Sulfoxol
  24. Suloxsol
  25. Sulphadimethylisoxazole
  26. Sulphafurazol
  27. Sulphafurazole
  28. Sulphafurazolum
  29. Sulphaisoxazole
  30. Sulphisoxazol
  31. Sulphisoxazole
  32. Sulphofurazole
  33. TL - Azole
  34. Thiasin
  35. U.S. - 67
  36. Unisulf
  37. Urisoxin
  38. Uritrisin
  39. Urogan
  40. V - Sul
  41. Vagilia
  42. sk - Soxazole


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
DNA damage rat liver 10 mmol/L MUREAV 368,59,1996
mutation in microorganisms Salmonella typhimurium 1,000 mg/L/2 hour (-enzymatic activation step) EMMUEG 44,329,2004
mutation in mammalian somatic cells mouse lymphocyte 750 mg/L SCIEAS 236,933,1987
sister chromatid exchange hamster ovary 100 mg/L SCIEAS 236,933,1987
specific locus test mouse ovary 3,741 µmol/L MUREAV 608,29,2006


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lowest published toxic dose: 6 gm/kg (7-12 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue) 		SEIJBO 13,7,1973
oral
rat 		lowest published toxic dose: 6 gm/kg (9-14 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue) 		SEIJBO 13,7,1973


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lethal dose (50 percent kill): >5 gm/kg N/R NIIRDN 6,391,1982
intravenous
mouse 		lethal dose (50 percent kill): 2,500 mg/kg N/R JJTOEX 4,105,1991
oral
mouse 		lethal dose (50 percent kill): 6,800 mg/kg N/R ARZNAD 15,1441,1965
oral
rat 		lethal dose (50 percent kill): 10 gm/kg N/R NIIRDN 6,391,1982
oral
rabbit 		lethal dose (50 percent kill): 20 gm/kg N/R NIIRDN 6,391,1982


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lowest published toxic dose: 91,000 mg/kg/26 week- intermittent Liver: Other changes

Endocrine: Other changes 		TOXID9 60,278,2001
skin
mouse 		lowest published toxic dose: 182,000 mg/kg/26 week- intermittent Liver: Other changes

Endocrine: Other changes 		TOXID9 60,278,2001


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
International Agency for Research on Cancer (IARC) Cancer Review Human Inadequate Evidence IMEMDT 24,275,1980
International Agency for Research on Cancer (IARC) Cancer Review Animal Inadequate Evidence IMEMDT 24,275,1980
International Agency for Research on Cancer (IARC) Cancer Review Group 3 IMSUDL 7,347,1987
TOXICOLOGY REVIEW
APHRER 40,1040,2006
TOXICOLOGY REVIEW
MUREAV 584,1,2005
TOXICOLOGY REVIEW
MUREAV 672,10,2009
TOXICOLOGY REVIEW
MUREAV 672,17,2009


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 80541;
Number of Industries 2;
Total Number of Facilities 353;
Number of Occupations 9;
Total Number of Employees Exposed 4,053
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 80541;
Number of Industries 2;
Total Number of Facilities 258;
Number of Occupations 5;
Total Number of Employees Exposed 5,506;
Total Number of Female Employees Exposed 3,068


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as a drug and in manufacture of DIETHANOLAMINE salt
NCI Carcinogenesis Bioassay (gavage);no evidence:mouse,rat NCITR* NCI-TR-138,1979


REFERENCES:

CODEN
REFERENCE
APHRER Annals of Pharmacotherpy. (Harvey Whitney Books Co., POB 42696, Cincinnati, OH 45242) V. 26- 1992-
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979-
JJTOEX Japanese Journal of Toxicology. (Yakugyo Jihosha, Hokushin Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo, 101, Japan) V.1- 1988-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NCITR* National Cancer Institute Carcinogenesis Technical Report Series. (Bethesda, MD) No.0-205. For publisher information, see NTPTR*.
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan)
SCIEAS Science. (American Assoc. for the Advancement of Science, 1333 H St., NW, Washington, DC 20005) V.1- 1895-
SEIJBO Senten Ijo. Congenital Anomalies. (Nippon Senten Ijo Gakkai, c/o Kinki Daigaku Igakubu Kaibagaku Kyoshitsu, 380 Nishiyama, Sayama-cho, Mirami-Kawachi-gun, Osaka-fu, Japan) V.1-26, 1960-86. For publisher information, see CGANE7.
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-

Used as a drug and in manufacture of DIETHANOLAMINE salt

FDA-proprietary drug

RTECS Compound Description:
   Tumorigen
   Drug
   Mutagen
   Reproductive Effector

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