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Sulfanilamide

RTECS #: WO8400000

CAS #: 63-74-1

UPDATE: August 2007 MW: 172.22 MF: C6H8N2O2S


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. TUMORIGENIC DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. REVIEWS:
  8. STANDARDS AND REGULATIONS:
  9. NIOSH DOCUMENTATION AND SURVEILLANCE:
  10. STATUS IN FEDERAL AGENCIES:
  11. REFERENCES:

SYNONYMS:

  1. 1162 F
  2. 4 - Aminobenzenesulfonamide
  3. 4 - Aminophenylsulfonamide
  4. Albexan
  5. Albosal
  6. Ambeside
  7. Aniline - p - sulfonic amide
  8. Antistrept
  9. Astreptine
  10. Astrocid
  11. Bacteramid
  12. Bactesid
  13. Benzenesulfonamide, p - amino -
  14. Collomide
  15. Colsulanyde
  16. Copticide
  17. Deseptyl
  18. Dipron
  19. Ergaseptine
  20. Erysipan
  21. Estreptocida
  22. F 1162
  23. Fourneau 1162
  24. Gerison
  25. Gombardol
  26. Lusil
  27. Lysococcine
  28. Neococcyl
  29. Orgaseptine
  30. PABS
  31. Prontalbin
  32. Prontosil album
  33. Prontosil I
  34. Prontosil White
  35. Prontylin
  36. Pronzin album
  37. Proseptal
  38. Proseptine
  39. Proseptol
  40. Pysococcine
  41. Rubiazol A
  1. Sanamid
  2. Septamide album
  3. Septanilam
  4. Septinal
  5. Septolix
  6. Septoplex
  7. Septoplix
  8. Stopton album
  9. Stramid
  10. Strepamide
  11. Strepsan
  12. Streptagol
  13. Streptamid
  14. Streptasol
  15. Streptosil
  16. Streptocid album
  17. Streptocide White
  18. Streptoclase
  19. Streptocom
  20. Streptol
  21. Strepton
  22. Streptozol
  23. Streptozone
  24. Streptrocide
  25. Sulfamidyl
  26. Sulfamine
  27. Sulfana
  28. Sulfanalone
  29. Sulfanil
  30. Sulfocidin
  31. Sulfocidine
  32. Sulfonamide
  33. Sulfonamide P
  34. Sulphanilamide
  35. Therapol
  36. White streptocide
  37. p - Aminobenzenesulfamide
  38. p - Aminobenzenesulfonamide
  39. p - Aminophenylsulfonamide
  40. p - Anilinesulfonamide
  41. p - Sulfamidoaniline


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis parenteral
other insects 		375 mg/kg ENECEV 4,397,1986
DNA adduct Escherichia coli 50 µmol/L MUREAV 89,95,1981
DNA damage rat liver 30 µmol/L SinJF# 26OCT1982
mutation in microorganisms Escherichia coli 50 µg/disc (-enzymatic activation step) APMBAY 6,23,1958


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 22 mg/kg (1-22 day pregnant) Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)

Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive)

Reproductive: Effects on newborn: Weaning or lactation index (e.g., # alive at weaning per # alive at day 4) 		JHHBAI 66,139,1940
oral
rat 		lowest published toxic dose: 22 mg/kg (1-22 day pregnant) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) JHHBAI 66,139,1940
unreported route
woman 		lowest published toxic dose: 974 mg/kg (34-37 week pregnant) Reproductive: Specific developmental abnormalities: Blood and lymphatic systems (including spleen and marrow) JAMAAP 117,1314,1941


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
subcutaneous
rat 		lowest published toxic dose: 135 mg/kg/9 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Tumorigenic: Tumors at site of application 		PSEBAA 68,330,1948


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lethal dose (50 percent kill): 5 mg/kg N/R ABANAE 5,886,1957/1958
intravenous
mouse 		lethal dose (50 percent kill): 500 mg/kg N/R ABANAE 5,972,1957/1958
intravenous
rat 		lethal dose (50 percent kill): 1,400 mg/kg N/R AEPPAE 211,367,1950
oral
dog 		lethal dose (50 percent kill): 2 gm/kg N/R PCOC** -,1079,1966
oral
guinea pig 		lethal dose (50 percent kill): 3,130 mg/kg N/R JPETAB 82,86,1944
oral
mouse 		lethal dose (50 percent kill): 3 gm/kg N/R NYKZAU 48,336,1952
oral
rat 		lethal dose (50 percent kill): 3,900 mg/kg N/R 85JCAE -,1072,1986
oral
rabbit 		lethal dose (50 percent kill): 1,300 mg/kg N/R GISAAA 31(3),11,1966
subcutaneous
mouse 		lethal dose (50 percent kill): 2,900 mg/kg N/R ARZNAD 5,213,1955


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
dog 		lowest published toxic dose: 60 gm/kg/30 day- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field JPETAB 65,405,1939
oral
rat 		lowest published toxic dose: 180 gm/kg/90 day- intermittent Blood: Changes in spleen

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		JPETAB 65,405,1939
oral
rat 		lowest published toxic dose: 82,200 mg/kg/39 week- intermittent Nutritional and Gross Metabolic: Other changes GISAAA 31(3),11,1966


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
TOXICOLOGY REVIEW
JMSHAO 10,343,1943
TOXICOLOGY REVIEW
PCNAA8 8,413,1961
TOXICOLOGY REVIEW
DPIRDU 2(6),13,1982
TOXICOLOGY REVIEW
MUREAV 488,151,2001
TOXICOLOGY REVIEW
TPHSDY 23,397,2002
TOXICOLOGY REVIEW
DIMON* 39,678,1993


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Exposure Limit - RUSSIA short term exposure limit 1 mg/m3, JUN2003


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 84382;
Number of Industries 3;
Total Number of Facilities 149;
Number of Occupations 9;
Total Number of Employees Exposed 3,565
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 84382;
Number of Industries 6;
Total Number of Facilities 654;
Number of Occupations 11;
Total Number of Employees Exposed 6,529;
Total Number of Female Employees Exposed 3,131


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Positive: Aspergillus-recombination
EPA GENETOX PROGRAM 1988, Negative: Aspergillus-aneuploidy; N crassa-aneuploidy
EPA GENETOX PROGRAM 1988, Inconclusive: Carcinogenicity-mouse/rat
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as an antibacterial agent
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
ABANAE Antibiotics Annual. (New York, NY) 1953-60. For publisher information, see AMACCQ.
AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher information, see NSAPCC.
APMBAY Applied Microbiology. (Washington, DC) V.1-30, 1953-75. For publisher information, see AEMIDF.
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
DIMON* Disease-a Month (Chicago : Year Book Publishers) V. 24- 1978-
DPIRDU Dangerous Properties of Industrial Materials Report. (Van Nostrand Reinhold, 115 Fifth Ave., New York, NY 10003) V.1- 1981-
ENECEV Environment and Ecology. (Environment and Ecology, C/o Dr. S.K. Konar, Dept. of Zoology, Kalyani University, Kalyani 741253, West Bengal, India) V.1- 1983-
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
JAMAAP JAMA, Journal of the American Medical Association. (AMA, 535 N. Dearborn St., Chicago, IL 60610) V.1- 1883-
JHHBAI Bulletin of the Johns Hopkins Hospital. (Baltimore, MD) V.1-119, 1889-1966. For publisher information, see JHMJAX.
JMSHAO Journal of the Mount Sinai Hospital (New York). (New York, NY) V.1-36, 1934-69. For publisher information, see MSJMAZ.
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944-
PCNAA8 Pediatric Clinics of North America. (W.B. Saunders Co., W. Washington Sq., Philadelphia, PA 19105) V.1- 1954-
PCOC** Pesticide Chemicals Official Compendium, Association of the American Pesticide Control Officials, Inc., 1966. (Topeka, KS)
PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04-
SinJF# Personal Communication from J.F. Sina, Merck Institute for Therapeutic Research, West Point, PA 19486, Oct. 26, 1982
TPHSDY Trends in Pharmacological Sciences. (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.1- 1979-

Used as an antibacterial agent

RTECS Compound Description:
   Agricultural Chemical
   Tumorigen
   Drug
   Mutagen
   Reproductive Effector
   Human Data
   Natural Product

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