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Succinimide, 2 - ethyl - 2 - methyl -

RTECS #: WN2800000

CAS #: 77-67-8

UPDATE: May 2009 MW: 141.19 MF: C7H11NO2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. ACUTE TOXICITY DATA:
  5. REVIEWS:
  6. NIOSH DOCUMENTATION AND SURVEILLANCE:
  7. REFERENCES:

SYNONYMS:

  1. 2 - Ethyl - 2 - methylsuccinimide
  2. 3 - Ethyl - 3 - methylpyrrolidine - 2,5 - dione
  3. 3 - Ethyl - 3 - methyl - 2,5 - pyrrolidine - dione
  4. 3 - Methyl - 3 - ethylpyrrolidine - 2,5 - dione
  5. Aethosuximide (German)
  6. Asamid
  7. Atysmal
  8. C.I. 366
  9. CI 366
  10. Capitus
  11. Emeside
  12. Epileo Petit MAL
  13. Ethosuccimide
  14. Ethosuccinimide
  15. Ethosuxide
  16. Ethosuximide
  17. Ethymal
  18. Etomal
  19. Etosuximida
  20. H 940
  21. Mesentol
  22. PM 671
  1. Pemal
  2. Pemalin
  3. Pentinimid
  4. Petinimid
  5. Petnidan
  6. Pyknolepsinum
  7. Ronton
  8. Simatin (E)
  9. Simatin
  10. Succimal
  11. Succimitin
  12. Suxilep
  13. Suximal
  14. Suxin
  15. Suxinutin
  16. Thetamid
  17. Thilopemal
  18. Zarodan
  19. Zarondan - saft
  20. Zarontin
  21. alpha - Ethyl - alpha - methylsuccinimide
  22. gamma - Methyl - gamma - ethyl - succinimide


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis human lymphocyte 30 mg/L MUREAV 204,623,1988


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lowest published toxic dose: 962 mg/kg (8-10 day pregnant) Reproductive: Other developmental abnormalities TCMUD8 2,61,1982
oral
hamster 		lowest published toxic dose: 18,500 µg/kg (6-10 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) 40YJAX -,59,1979
oral
hamster 		lowest published toxic dose: 185 mg/kg (6-10 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system 40YJAX -,59,1979
oral
mouse 		lowest published toxic dose: 3,960 mg/kg (6-16 day pregnant) Reproductive: Specific developmental abnormalities: Central nervous system TXAPA9 40,365,1977
oral
rat 		lowest published toxic dose: 33,300 µg/kg (6-14 day pregnant) Reproductive: Effects on embryo or fetus: Extra embryonic structures (e.g., placenta, umbilical cord)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system 		40YJAX -,59,1979
oral
rat 		lowest published toxic dose: 66,600 µg/kg (6-14 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) 40YJAX -,59,1979
oral
rat 		lowest published toxic dose: 166 mg/kg (6-14 day pregnant) Reproductive: Other developmental abnormalities 40YJAX -,59,1979
oral
rat 		lowest published toxic dose: 2,250 mg/kg (9-17 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Effects on embryo or fetus: Fetal death 		EAMJAV 60,407,1983
oral
rabbit 		lowest published toxic dose: 48,100 µg/kg (6-18 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Extra embryonic structures (e.g., placenta, umbilical cord)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) 		40YJAX -,59,1979
subcutaneous
mouse 		lowest published toxic dose: 600 mg/kg (8 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) FAATDF 6,669,1986
subcutaneous
rat 		lowest published toxic dose: 160 mg/kg (5-20 day pregnant) Reproductive: Effects on newborn: Behavioral PBBHAU 36,163,1990
unreported route
mouse 		lowest published toxic dose: 2,626 mg/kg (8-10 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system

Reproductive: Specific developmental abnormalities: Cardiovascular (circulatory) system 		FEPRA7 38,438,1979


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intracerebral
rat 		lowest published toxic dose: 21,311 mg/kg Brain and Coverings: Changes in surface EEG BJPCBM 148,1076,2006
intraperitoneal
mouse 		lethal dose (50 percent kill): 1,325 mg/kg N/R USXXAM #4188398
intraperitoneal
mouse 		lowest published toxic dose: 75 mg/kg Behavioral: Anticonvulsant AEPPAE 370,99,2004
intraperitoneal
mouse 		lowest published toxic dose: 300 mg/kg Behavioral: Anticonvulsant

Behavioral: Muscle weakness 		AEPPAE 370,99,2004
intraperitoneal
rat 		lowest published toxic dose: 300 mg/kg Behavioral: Alteration of classical conditioning

Behavioral: Change in psychophysiological tests 		EPBEH* 5,857,2004
intraperitoneal
rat 		lowest published toxic dose: 100 mg/kg Behavioral: Anticonvulsant

Behavioral: Alteration of operant conditioning 		EJPHAZ 541,64,2006
intraperitoneal
rat 		lowest published toxic dose: 32 mg/kg Behavioral: Anticonvulsant JPETAB 317,1337,2006
intraperitoneal
rat 		lowest published toxic dose: 100 mg/kg Brain and Coverings: Changes in surface EEG BJPCBM 148,1076,2006
intraperitoneal
rat 		lowest published toxic dose: 100 mg/kg Brain and Coverings: Recordings from specific areas of CNS

Biochemical: Metabolism (intermediary): Other 		JPHSC* 100,227,2006
intravenous
mouse 		lethal dose (50 percent kill): 780 mg/kg Behavioral: Altered sleep time (including change in righting reflex)

Behavioral: Somnolence (general depressed activity)

Behavioral: Ataxia 		NEPHBW 24,427,1985
intravenous
rat 		lowest published toxic dose: 250 mg/kg Brain and Coverings: Changes in surface EEG JPETAB 318,947,2006
intravenous
rat 		lowest published toxic dose: 312.5 mg/kg Brain and Coverings: Changes in surface EEG

Behavioral: Antianxiety 		JPETAB 318,947,2006
oral
mouse 		lethal dose (50 percent kill): 1,530 mg/kg Behavioral: Altered sleep time (including change in righting reflex)

Behavioral: Ataxia

Lung, Thorax, or Respiration: Dyspnea 		EPILAK 4(4),66,1963
oral
mouse 		lowest published toxic dose: 152 mg/kg Behavioral: Convulsions or effect on seizure threshold JPETAB 308,127,2004
oral
mouse 		lowest published toxic dose: 200 mg/kg Brain and Coverings: Recordings from specific areas of CNS

Behavioral: Anticonvulsant 		JPHSC* 106,78,2008
oral
mouse 		lowest published toxic dose: 380 mg/kg Behavioral: Anticonvulsant PHREP* 58,936,2006
oral
rat 		lethal dose (50 percent kill): 1,820 mg/kg N/R YAKUD5 9,759,1967
oral
rat 		lowest published toxic dose: 194 mg/kg Reproductive: Other effects on male JPETAB 308,127,2004
parenteral
mouse 		lowest published toxic dose: 117.6 mg/kg Behavioral: Anticonvulsant PCJOAU 36,465,2002
parenteral
mouse 		lethal dose (50 percent kill): 1,325 mg/kg N/R PCJOAU 36,465,2002
subcutaneous
mouse 		lethal dose (50 percent kill): 1,810 mg/kg N/R NIIRDN 6,117,1982


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
TOXICOLOGY REVIEW
MUREAV 488,151,2001
TOXICOLOGY REVIEW
TPHSDY 24,542,2003
TOXICOLOGY REVIEW
TPHSDY 24,542,2003
TOXICOLOGY REVIEW
EJIME* 17,529,2006
TOXICOLOGY REVIEW
JTEHD6 7,399,2004
TOXICOLOGY REVIEW
HUTOX* -,319,1996


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X3882;
Number of Industries 4;
Total Number of Facilities 371;
Number of Occupations 6;
Total Number of Employees Exposed 7,032;
Total Number of Female Employees Exposed 4,379


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
N/R


REFERENCES:

CODEN
REFERENCE
40YJAX "Evaluation of Embryotoxicity, Mutagenicity and Carcinogenicity Risks In New Drugs, Proceedings of the Symposium on Toxicological Testing for Safety of New Drugs, 3rd, Prague, 1976," Benesova, O., et al., eds., Prague, Czechoslovakia, Univerzita Karlova, 1979
AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher information, see NSAPCC.
BJPCBM British Journal of Pharmacology. (Macmillan Press Ltd., Houndmills, Basingstoke, Hants. RG21 2XS, UK) V.34- 1968-
EAMJAV East African Medical Journal. (P.O. Box 41632, Nairobi, Kenya) V.9- 1932-
EJIME* European Journal of Internal Medicine: The Official Journal of the European Federation of Internal Medicine (EFIM) (Elsevier) V.10- 1999-
EJPHAZ European Journal of Pharmacology. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1967-
EPBEH* Epilepsy & Behavior (San Diego, CA : Academic Press) V.1- 2000-
EPILAK Epilepsia (New York). (Raven Press, 1185 Ave. of the Americas, New York, NY 10036) Ser.1-3: 1909-55; Ser.4: V.1- 1959-
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information, see TOSCF2
FEPRA7 Federation Proceedings, Federation of American Societies for Experimental Biology. (Bethesda, MD) V.1-46, 1942-87.
HUTOX*
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
JPHSC*
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NEPHBW Neuropharmacology. (Pergamon Press Ltd., Headington Hill Hall, Oxford OX3 OBW, UK) V.9- 1970-
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan)
PBBHAU Pharmacology, Biochemistry and Behavior. (ANKHO International Inc., P.O. Box 426, Fayetteville, NY 13066) V.1- 1973-
PCJOAU Pharmaceutical Chemistry Journal (English Translation). Translation of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No.1- 1967-
PHREP*
TCMUD8 Teratogenesis, Carcinogenesis, and Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1980-
TPHSDY Trends in Pharmacological Sciences. (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.1- 1979-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231)
YAKUD5 Gekkan Yakuji. Pharmaceuticals Monthly. (Yakugyo Jihosha, Inaoka Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan) V.1- 1959-

Used as an anticonvulsant

FDA-proprietary drug

RTECS Compound Description:
   Drug
   Mutagen
   Reproductive Effector
   Human Data

ALT CAS #: 8060-73-9
ALT CAS #: 39122-18-4
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