The Registry of Toxic Effects of Chemical Substances

Succinic acid

RTECS #: WM4900000

CAS #: 110-15-6

UPDATE: November 2004 MW: 118.10 MF: C4H6O4


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. NIOSH DOCUMENTATION AND SURVEILLANCE:
  7. STATUS IN FEDERAL AGENCIES:
  8. REFERENCES:

SYNONYMS:

  1. 1,2 - Ethanedicarboxylic acid
  2. Amber acid
  3. Asuccin
  4. Bernsteinsaure (German)
  5. Butanedioic acid
  1. Ethylenesuccinic acid
  2. Kyselina jantarova (Czech)
  3. Wormwood
  4. Wormwood acid


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		750 µg severe AJOPAA 29,1363,1946


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
DNA inhibition human fibroblast 20 mmol/L MUREAV 183,89,1987


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lethal dose (50 percent kill): 2,702 mg/kg N/R TXCYAC 62,203,1990
intraperitoneal
mouse 		lowest published toxic dose: 3 mg/kg Behavioral: Food intake (animal)

Behavioral: Antianxiety 		LIFSAK 73,3257,2003
intraperitoneal
rat 		lowest published toxic dose: 100 mg/kg Blood: Change in clotting factors FATOAO 51,45,1988
intravenous
mouse 		lethal dose (50 percent kill): 1,400 mg/kg N/R YHTPAD 18,100,1983
oral
mouse 		lowest published toxic dose: 3 mg/kg Behavioral: Antianxiety LIFSAK 73,3257,2003
oral
mouse 		lowest published toxic dose: 1.5 mg/kg Behavioral: Antianxiety

Nutritional and Gross Metabolic: Body temperature decrease 		LIFSAK 73,3257,2003
oral
rat 		lethal dose (50 percent kill): 2,260 mg/kg N/R KODAK* #82-0158


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
rat 		lowest published toxic dose: 350 mg/kg/7 day- intermittent Endocrine: Other changes

Blood: Change in clotting factors 		FATOAO 51,45,1988


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 84381;
Number of Industries 18;
Total Number of Facilities 316;
Number of Occupations 21;
Total Number of Employees Exposed 3,351
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 84381;
Number of Industries 16;
Total Number of Facilities 1,652;
Number of Occupations 38;
Total Number of Employees Exposed 31,198;
Total Number of Female Employees Exposed 16,182


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY


REFERENCES:

CODEN
REFERENCE
AJOPAA American Journal of Ophthalmology. (Ophthalmic Pub. Co., 435 N. Michigan Ave., Suite 1415, Chicago, IL 60611) Series 3: V.1- 1918-
FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939-
KODAK* Kodak Company Reports. (343 State St., Rochester, NY 14650)
LIFSAK Life Sciences. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1-8, 1962-69; V.14- 1974-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973-
YHTPAD Yaoxue Tongbao. Bulletin of Pharmacology. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.13-23, 1978-88. For publisher information, see ZYZAEU.

Used in photography and in manufacture of lacquers, dyes, esters for perfumes, succinates

RTECS Compound Description:
   Drug
   Mutagen
   Human Data
   Primary Irritant

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