RTECS:WK8400000 The Registry of Toxic Effects of Chemical Substances

Strontium chloride

RTECS #: WK8400000

CAS #: 10476-85-4

UPDATE: February 2006 MW: 158.52 MF: Cl₂Sr

NOTE:

TOXICITY DATA HAVE NOT BEEN EVALUATED. OMISSION OF A SUBSTANCE OR NOTATION DOES NOT IMPLY ANY RELIEF FROM REGULATORY RESPONSIBILITY.

TABLE OF CONTENTS:

MUTATION DATA:

ACUTE TOXICITY DATA:

OTHER MULTIPLE DOSE DATA:

REVIEWS:

NIOSH DOCUMENTATION AND SURVEILLANCE:

STATUS IN FEDERAL AGENCIES:

REFERENCES:

SYNONYMS:
N/R N/R

SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

MUTATION DATA AND REFERENCES:
SYSTEM TEST ROUTE/
ORGANISM/
TISSUE DOSE REFERENCE
cytogenetic analysis oral
mouse 260 mg/kg BTERDG 25,51,1990
sex chromosome loss and nondisjunction Saccharomyes cerevisiae 80 mmol/L MUTAEX 1,21,1986

REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

TUMORIGENIC DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
intraperitoneal
mouse lethal dose (50 percent kill): 908 mg/kg N/R COREAF 256,1043,1963
intraperitoneal
rat lethal dose (50 percent kill): 405 mg/kg N/R EQSSDX 1,1,1975
intravenous
mouse lethal dose (50 percent kill): 147.6 mg/kg N/R VCVN1* -,128,1988
intravenous
rat lethal dose (50 percent kill): 222 mg/kg N/R EQSSDX 1,1,1975
intravenous
rabbit lowest published lethal dose: 1,067 mg/kg N/R 38MKAJ 2A,1898,1981
oral
guinea pig lethal dose (50 percent kill): 5,143 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Change in motor activity (specific assay)

Gastrointestinal: Hypermotility, diarrhea GISAAA 30(11),18,1965
oral
guinea pig lethal dose (50 percent kill): 2,843 mg/kg N/R VCVN1* -,128,1988
oral
mouse lethal dose (50 percent kill): 1,874 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Change in motor activity (specific assay)

Gastrointestinal: Hypermotility, diarrhea GISAAA 30(11),18,1965
oral
mouse lethal dose (50 percent kill): 1,036 mg/kg N/R VCVN1* -,128,1988
oral
rat lethal dose (50 percent kill): 1,796 mg/kg N/R VCVN1* -,128,1988
oral
rabbit lethal dose (50 percent kill): 2,735 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Change in motor activity (specific assay)

Gastrointestinal: Hypermotility, diarrhea GISAAA 30(11),18,1965
oral
rabbit lethal dose (50 percent kill): 1,512 mg/kg N/R VCVN1* -,128,1988

OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
oral
monkey lowest published toxic dose: 2,800 mg/kg/7 day- intermittent Gastrointestinal: Ulceration or bleeding from stomach

Gastrointestinal: Other changes TXAPA9 197,252,2004
oral
mouse lowest published toxic dose: 14,000 mg/kg/7 day- intermittent Gastrointestinal: Changes in structure or function of esophagus

Gastrointestinal: Ulceration or bleeding from stomach

Gastrointestinal: Ulceration or bleeding from duodeum TOXID9 44,96,2005
oral
rat lowest published toxic dose: 21,798 mg/kg/17 week- intermittent Endocrine: Changes in spleen weight

Blood: Change in clotting factors

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases GISAAA 30(11),18,1965
oral
rat lowest published toxic dose: 1,579 mg/kg/35 week- intermittent Liver: Liver function tests impaired

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases GISAAA 30(11),18,1965
oral
rat lowest published toxic dose: 20,160 mg/kg/16 week- intermittent Blood: Change in clotting factors

Blood: Normocytic anemia

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase VCVN1* -,129,1988
oral
rabbit lowest published toxic dose: 19,432 mg/kg/35 week- intermittent Blood: Change in clotting factors

Endocrine: Changes in adrenal weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases GISAAA 30(11),18,1965

REVIEWS:
ORGANIZATION STANDARD
REFERENCE

TOXICOLOGY REVIEW
FOREAE 7,313,1942

STANDARDS AND REGULATIONS:
ORGANIZATION STANDARD
REFERENCE

N/R N/R N/R

NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 84462;
Number of Industries 6;
Total Number of Facilities 92;
Number of Occupations 6;
Total Number of Employees Exposed 2,018
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 84462;
Number of Industries 13;
Total Number of Facilities 879;
Number of Occupations 13;
Total Number of Employees Exposed 8,289;
Total Number of Female Employees Exposed 1,266

STATUS IN FEDERAL AGENCIES:
ORGANIZATION
REFERENCE

EPA GENETOX PROGRAM 1988, Negative: Cell transform.-SA7/SHE
EPA TSCA Section 8(b) CHEMICAL INVENTORY

REFERENCES:
CODEN
REFERENCE

38MKAJ "Patty's Industrial Hygiene and Toxicology," 3rd rev. ed., Clayton, G.D., and F.E. Clayton, eds., New York, John Wiley & Sons, Inc., 1978-82. Vol. 3 originally pub. in 1979; pub. as 2nd rev. ed. in 1985.
BTERDG Biological Trace Element Research. (Humana Press Inc., POB 2148, Clifton, NJ 07015) V.1- 1979-
COREAF Comptes Rendus Hebdomadaires des Seances, Academie des Sciences. (Paris, France) V.1-261, 1835-1965. For publisher information, see CRASEV.
EQSSDX Environmental Quality and Safety, Supplement. (Stuttgart, Fed. Rep. Ger.) V.1-5, 1975-76. Discontinued.
FOREAE Food Research. (Champaign, IL) V.1-25, 1936-60. For publisher information, see JFDSAZ.
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1986-
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
VCVN1* "Vrednie chemichescie veshestva. Neorganicheskie soedinenia elementov I-IV groopp" (Hazardous substances. Inornanic substances containing I-IV group elements), Filov V.A., Chimia, 1988.

Used in pyrotechnics and as dental desensitizer under the name ELECOL

FDA-over the counter drug

RTECS Compound Description:
Mutagen

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SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
N/R	N/R	N/R	N/R

MUTATION DATA AND REFERENCES:
SYSTEM TEST	ROUTE/ ORGANISM/ TISSUE	DOSE	REFERENCE
cytogenetic analysis	oral mouse	260 mg/kg	BTERDG 25,51,1990
sex chromosome loss and nondisjunction	Saccharomyes cerevisiae	80 mmol/L	MUTAEX 1,21,1986

REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
N/R	N/R	N/R	N/R

TUMORIGENIC DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
N/R	N/R	N/R	N/R

ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
intraperitoneal mouse	lethal dose (50 percent kill): 908 mg/kg	N/R	COREAF 256,1043,1963
intraperitoneal rat	lethal dose (50 percent kill): 405 mg/kg	N/R	EQSSDX 1,1,1975
intravenous mouse	lethal dose (50 percent kill): 147.6 mg/kg	N/R	VCVN1* -,128,1988
intravenous rat	lethal dose (50 percent kill): 222 mg/kg	N/R	EQSSDX 1,1,1975
intravenous rabbit	lowest published lethal dose: 1,067 mg/kg	N/R	38MKAJ 2A,1898,1981
oral guinea pig	lethal dose (50 percent kill): 5,143 mg/kg	Behavioral: Somnolence (general depressed activity) Behavioral: Change in motor activity (specific assay) Gastrointestinal: Hypermotility, diarrhea	GISAAA 30(11),18,1965
oral guinea pig	lethal dose (50 percent kill): 2,843 mg/kg	N/R	VCVN1* -,128,1988
oral mouse	lethal dose (50 percent kill): 1,874 mg/kg	Behavioral: Somnolence (general depressed activity) Behavioral: Change in motor activity (specific assay) Gastrointestinal: Hypermotility, diarrhea	GISAAA 30(11),18,1965
oral mouse	lethal dose (50 percent kill): 1,036 mg/kg	N/R	VCVN1* -,128,1988
oral rat	lethal dose (50 percent kill): 1,796 mg/kg	N/R	VCVN1* -,128,1988
oral rabbit	lethal dose (50 percent kill): 2,735 mg/kg	Behavioral: Somnolence (general depressed activity) Behavioral: Change in motor activity (specific assay) Gastrointestinal: Hypermotility, diarrhea	GISAAA 30(11),18,1965
oral rabbit	lethal dose (50 percent kill): 1,512 mg/kg	N/R	VCVN1* -,128,1988

OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
oral monkey	lowest published toxic dose: 2,800 mg/kg/7 day- intermittent	Gastrointestinal: Ulceration or bleeding from stomach Gastrointestinal: Other changes	TXAPA9 197,252,2004
oral mouse	lowest published toxic dose: 14,000 mg/kg/7 day- intermittent	Gastrointestinal: Changes in structure or function of esophagus Gastrointestinal: Ulceration or bleeding from stomach Gastrointestinal: Ulceration or bleeding from duodeum	TOXID9 44,96,2005
oral rat	lowest published toxic dose: 21,798 mg/kg/17 week- intermittent	Endocrine: Changes in spleen weight Blood: Change in clotting factors Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases	GISAAA 30(11),18,1965
oral rat	lowest published toxic dose: 1,579 mg/kg/35 week- intermittent	Liver: Liver function tests impaired Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases	GISAAA 30(11),18,1965
oral rat	lowest published toxic dose: 20,160 mg/kg/16 week- intermittent	Blood: Change in clotting factors Blood: Normocytic anemia Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase	VCVN1* -,129,1988
oral rabbit	lowest published toxic dose: 19,432 mg/kg/35 week- intermittent	Blood: Change in clotting factors Endocrine: Changes in adrenal weight Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases	GISAAA 30(11),18,1965

REVIEWS:
ORGANIZATION	STANDARD	REFERENCE
TOXICOLOGY REVIEW		FOREAE 7,313,1942

STANDARDS AND REGULATIONS:
ORGANIZATION	STANDARD	REFERENCE
N/R	N/R	N/R

NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION	STANDARD or SURVEY	REFERENCE
National Occupational Hazard Survey 1974	National Occupational Hazard Survey 1974: Hazard Code: 84462; Number of Industries 6; Total Number of Facilities 92; Number of Occupations 6; Total Number of Employees Exposed 2,018
National Occupational Exposure Survey 1983	National Occupational Exposure Survey 1983: Hazard Code: 84462; Number of Industries 13; Total Number of Facilities 879; Number of Occupations 13; Total Number of Employees Exposed 8,289; Total Number of Female Employees Exposed 1,266

STATUS IN FEDERAL AGENCIES:
ORGANIZATION	REFERENCE
EPA GENETOX PROGRAM 1988, Negative: Cell transform.-SA7/SHE
EPA TSCA Section 8(b) CHEMICAL INVENTORY

REFERENCES:
CODEN	REFERENCE
38MKAJ	"Patty's Industrial Hygiene and Toxicology," 3rd rev. ed., Clayton, G.D., and F.E. Clayton, eds., New York, John Wiley & Sons, Inc., 1978-82. Vol. 3 originally pub. in 1979; pub. as 2nd rev. ed. in 1985.
BTERDG	Biological Trace Element Research. (Humana Press Inc., POB 2148, Clifton, NJ 07015) V.1- 1979-
COREAF	Comptes Rendus Hebdomadaires des Seances, Academie des Sciences. (Paris, France) V.1-261, 1835-1965. For publisher information, see CRASEV.
EQSSDX	Environmental Quality and Safety, Supplement. (Stuttgart, Fed. Rep. Ger.) V.1-5, 1975-76. Discontinued.
FOREAE	Food Research. (Champaign, IL) V.1-25, 1936-60. For publisher information, see JFDSAZ.
GISAAA	Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
MUTAEX	Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1986-
TOXID9	Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
TXAPA9	Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
VCVN1*	"Vrednie chemichescie veshestva. Neorganicheskie soedinenia elementov I-IV groopp" (Hazardous substances. Inornanic substances containing I-IV group elements), Filov V.A., Chimia, 1988.