RTECS:WK4375000 The Registry of Toxic Effects of Chemical Substances

Streptomycin

RTECS #: WK4375000

CAS #: 57-92-1

UPDATE: February 2009 MW: 581.67 MF: C₂₁H₃₉N₇O₁₂

NOTE:

TOXICITY DATA HAVE NOT BEEN EVALUATED. OMISSION OF A SUBSTANCE OR NOTATION DOES NOT IMPLY ANY RELIEF FROM REGULATORY RESPONSIBILITY.

TABLE OF CONTENTS:

SYNONYMS:

MUTATION DATA:

REPRODUCTIVE EFFECTS DATA:

ACUTE TOXICITY DATA:

OTHER MULTIPLE DOSE DATA:

REVIEWS:

STANDARDS AND REGULATIONS:

NIOSH DOCUMENTATION AND SURVEILLANCE:

STATUS IN FEDERAL AGENCIES:

REFERENCES:

SYNONYMS:

Agrept

Agrimycin 17

Gerox

Hokko - mycin

NSC 14083

Neodiestreptopab

Strepcen

Streptomicina (Italian)

Streptomycine

Streptomycinum

Streptomyzin (German)

Streptomycin A

SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

MUTATION DATA AND REFERENCES:
SYSTEM TEST ROUTE/
ORGANISM/
TISSUE DOSE REFERENCE
cytogenetic analysis human leukocyte 9,200 mg/L MGGEAE 107,361,1970
cytogenetic analysis mouse mammary gland 10 mmol/L/24 hour- continuous JTSCDR 5,141,1980
DNA repair Escherichia coli 600 ng/well MUREAV 133,161,1984
mutation in microorganisms Escherichia coli 100 mg/L (-enzymatic activation step) NATUAS 271,385,1978
mutation in microorganisms Euglena gracilis 100 mg/L (-enzymatic activation step) AMACCQ 9,682,1976
mutation in microorganisms other microorganisms 250 mg/L (-enzymatic activation step) MUREAV 27,191,1975
mutation in microorganisms other microorganisms 40 mg/L (-enzymatic activation step) ANTBAL 25,822,1980
mutation in microorganisms Salmonella typhimurium 10 gm/L (+enzymatic activation step) SCIEAS 172,1058,1971
gene conversion and mitotic recombination Escherichia coli 200 痢/L IDZAAW 52,417,1977

REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
intraperitoneal
mouse lowest published toxic dose: 1,750 mg/kg (12-18 day pregnant) Reproductive: Specific developmental abnormalities: Eye, ear TJADAB 32,34B,1985
intravenous
rat lowest published toxic dose: 65 mg/kg (1 day pregnant) Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Effects on embryo or fetus: Extra embryonic structures (e.g., placenta, umbilical cord)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) AMASA4 32,35,1975
subcutaneous
mouse lowest published toxic dose: 25 mg/kg (14 day pregnant) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)

Reproductive: Effects on newborn: Physical CRSBAW 158,2065,1964
subcutaneous
rat lowest published toxic dose: 22,500 痢/kg (6-14 day pregnant) Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth) DPHFAK 23,383,1971
subcutaneous
rat lowest published toxic dose: 225 mg/kg (6-14 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Specific developmental abnormalities: Central nervous system DPHFAK 23,383,1971
subcutaneous
rat lowest published toxic dose: 1,125 mg/kg (6-14 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system DPHFAK 23,383,1971
unreported route
mouse lowest published toxic dose: 400 mg/kg (9-11 day pregnant) Reproductive: Effects on embryo or fetus: Fetal death TJADAB 14,250,1976
unreported route
woman lowest published toxic dose: 620 mg/kg (23-39 week pregnant) Reproductive: Specific developmental abnormalities: Eye, ear SJRDAH 50,61,1969
unreported route
woman lowest published toxic dose: 320 mg/kg (6-14 week pregnant) Reproductive: Specific developmental abnormalities: Eye, ear

Reproductive: Effects on newborn: Other postnatal measures or effects NEJMAG 271,949,1964

TUMORIGENIC DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
intraperitoneal
human lowest published toxic dose: 143 mg/kg Vascular: BP lowering not characterized in autonomic section

Lung, Thorax, or Respiration: Respiratory depression

Lung, Thorax, or Respiration: Other changes BMJOAE 1,556,1961
intraperitoneal
mouse lethal dose (50 percent kill): 305 mg/kg N/R HBPTO* 1,150,2001
intravenous
cat lowest published lethal dose: 150 mg/kg N/R 85ERAY 1,570,1978
intravenous
mouse lethal dose (50 percent kill): 90,200 痢/kg N/R ANTBAL 18,249,1973
intravenous
rat lowest published lethal dose: 175 mg/kg N/R 85ERAY 1,570,1978
intravenous
rabbit lowest published lethal dose: 175 mg/kg N/R NATWAY 43,183,1956
oral
cat lowest published lethal dose: 2 gm/kg N/R 85ERAY 1,570,1978
oral
human lowest published toxic dose: 400 mg/kg/28 day- intermittent Ear: Changes in vestibular functions RMSRA6 73,854,1953
oral
mouse lethal dose (50 percent kill): 500 mg/kg N/R YKYUA6 38,1493,1987
oral
rat lethal dose (50 percent kill): 9 gm/kg N/R 85ARAE 4,35,1976/1977
parenteral
human lowest published toxic dose: 28 mg/kg/ day Blood: Eosinophilia RMSRA6 73,820,1953
subcutaneous
cat lowest published lethal dose: 600 mg/kg N/R 85ERAY 1,570,1978
subcutaneous
dog lowest published lethal dose: 300 mg/kg N/R 85ERAY 1,570,1978
subcutaneous
guinea pig lowest published lethal dose: 600 mg/kg N/R 85ERAY 1,570,1978
subcutaneous
monkey lowest published lethal dose: 400 mg/kg N/R 85ERAY 1,570,1978
subcutaneous
mouse lethal dose (50 percent kill): 520 mg/kg N/R BJPCAL 15,496,1960
subcutaneous
rat lowest published lethal dose: 600 mg/kg N/R 85ERAY 1,570,1978
subcutaneous
rabbit lowest published lethal dose: 600 mg/kg N/R 85ERAY 1,570,1978
skin
mouse lethal dose (50 percent kill): 325 mg/kg N/R HBPTO* 1,150,2001
unreported route
mouse lethal dose (50 percent kill): 90 mg/kg N/R ARZNAD 5,213,1955

OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
inhalation
human lowest published toxic concentration: 0.26 mg/m³/8 week- intermittent Skin: After topical application: Dermatitis, allergic VCVPS* -,440,1998
intramuscular
dog lowest published toxic dose: 1 gm/kg/20 day- intermittent Kidney, Ureter, and Bladder: Proteinuria

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Metabolism (intermediary): Other proteins JPETAB 86,151,1946
intramuscular
guinea pig lowest published toxic dose: 5,600 mg/kg/14 day- intermittent Eye: Other eye effects CHHTAT 71,504,1991
intramuscular
woman lowest published toxic dose: 80 mg/kg/4 day- intermittent Gastrointestinal: Nausea or vomiting

Skin: After systemic exposure: Dermatitis, other

Nutritional and Gross Metabolic: Body temperature increase APHRER 39,165,2005
subcutaneous
dog lowest published toxic dose: 1 gm/kg/20 day- intermittent Kidney, Ureter, and Bladder: Proteinuria

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Metabolism (intermediary): Other proteins JPETAB 86,151,1946
unreported route
cat lowest published toxic dose: 2,300 mg/kg/23 day- intermittent Ear: Change in acuity

Behavioral: Ataxia AORHA2 68,698,1959
unreported route
human lowest published toxic dose: 1.7 gm/kg/120 day- intermittent Ear: Changes in vestibular functions

Ear: Change in acuity VCVPS* -,437,1998

REVIEWS:
ORGANIZATION STANDARD
REFERENCE

TOXICOLOGY REVIEW
CLANA4 10(Pt1),283,1973
TOXICOLOGY REVIEW
PLMJAP 6,160,1975
TOXICOLOGY REVIEW
MMWOAU 115,1661,1973
TOXICOLOGY REVIEW
MMWOAU 115,1685,1973
TOXICOLOGY REVIEW
INTEAG 15,7,1974
TOXICOLOGY REVIEW
CLPTAT 5,480,1964
TOXICOLOGY REVIEW
ARVPAX 5,447,1965
TOXICOLOGY REVIEW
ADVPA3 4,263,1966
TOXICOLOGY REVIEW
JOPDAB 59,1,1961
TOXICOLOGY REVIEW
BMJOAE 2,260,1965
TOXICOLOGY REVIEW
MUREAV 526,85,2003
TOXICOLOGY REVIEW
TPHSDY 23,397,2002
TOXICOLOGY REVIEW
ENTOX* -,93,2005
TOXICOLOGY REVIEW
EJIME* 17,529,2006
TOXICOLOGY REVIEW
FEREAC 73,31788,2008
TOXICOLOGY REVIEW
FEREAC 73,31788,2008

STANDARDS AND REGULATIONS:
ORGANIZATION STANDARD
REFERENCE

Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: RED Completed RBREV* -,149,1998
Occupational Exposure Limit - RUSSIA short term exposure limit 0.1 mg/m³, Skin, JUN2003

NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X3555;
Number of Industries 3;
Total Number of Facilities 272;
Number of Occupations 7;
Total Number of Employees Exposed 8,273;
Total Number of Female Employees Exposed 7,449

STATUS IN FEDERAL AGENCIES:
ORGANIZATION
REFERENCE

EPA GENETOX PROGRAM 1988, Negative: E coli polA without S9
EPA GENETOX PROGRAM 1988, Inconclusive: B subtilis rec assay

REFERENCES:
CODEN
REFERENCE

85ARAE "Agricultural Chemicals," Thomson, W.T., 4 vols., Fresno, CA, Thomson Publications, 1976/77 revision
85ERAY "Antibiotics: Origin, Nature, and Properties," Korzyoski, T., et al., eds., Washington, DC, American Soc. for Microbiology, 1978
ADVPA3 Advances in Pharmacology. (New York, NY) V.1-6, 1962-68. For publisher information, see AVPCAQ.
AMACCQ Antimicrobial Agents and Chemotherapy. (American Soc. for Microbiology, 1913 I St., NW, Washington, DC 20006) V.1- 1972-
AMASA4 Acta Medica Academiae Scientiarum Hungaricae. (Budapest, Hungary) V.1-39, 1950-82.
ANTBAL Antibiotiki. (Moscow, USSR) V.1-29, 1956-84. For publisher information, see AMBIEH.
AORHA2 Annals of Otology, Rhinology, & Laryngology. (Annals Publishing Co., 4507 Laclede Ave., St. Louis, MO 63108) V.6- 1897-
APHRER Annals of Pharmacotherpy. (Harvey Whitney Books Co., POB 42696, Cincinnati, OH 45242) V. 26- 1992-
ARVPAX Annual Review of Pharmacology. (Palo Alto, CA) V.1-15, 1961-75. For publisher information, see ARPTDI.
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
BJPCAL British Journal of Pharmacology and Chemotherapy. (London, UK) V.1-33, 1946-68. For publisher information, see BJPCBM.
BMJOAE British Medical Journal. (British Medical Assoc., BMA House, Tavistock Sq., London WC1H 9JR, UK) V.1- 1857-
CHHTAT Zhonghua Yixue Zazhi. Chinese Medical Journal. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.1- 1915- Suspended 1967-72.
CLANA4 Clinical Anesthesia. (Philadelphia, PA 19103) V.1-11, 1963-76.
CLPTAT Clinical Pharmacology and Therapeutics. (American Society for Clinical Pharmacology and Therapeutics, St. Louis Mo Mosby-Year Book) V.1- 1960-
CRSBAW Comptes Rendus des Seances de la Societe de Biologie et de Ses Filiales. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1849-
DPHFAK Dissertationes Pharmaceuticae et Pharmacologicae. (Warsaw, Poland) V.18-24, 1966-72. For publisher information, see PJPPAA.
EJIME* European Journal of Internal Medicine: The Official Journal of the European Federation of Internal Medicine (EFIM) (Elsevier) V.10- 1999-
ENTOX* Encyclopedia of Toxicology: Reference Book, Elsevier, 2005
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
HBPTO* Handbook of pesticide toxicology. Robert Krieger ed, Academic press, 2001
IDZAAW Japanese Journal of Genetics. Idengaku Zasshi. (Genetics Soc. of Japan, 111 Tanida, Mishima, Shizuoka-ken, Japan) V.1- 1921-
INTEAG Internist. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1960-
JOPDAB Journal of Pediatrics. (C.V. Mosby Co., 11830 Westline Industrial Dr., St. Louis, MO 63141) V.1- 1932-
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
JTSCDR Journal of Toxicological Sciences. (Japanese Soc. of Toxicological Sciences, 4th Floor, Gakkai Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku, Tokyo 113, Japan) V.1- 1976-
MGGEAE Molecular and General Genetics. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.99- 1967-
MMWOAU Muenchener Medicinische Wochenschrift. (Munich, Fed. Rep. Ger.) V.33-115, 1886-1973.
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NATUAS Nature. (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736) V.1- 1869-
NATWAY Naturwissenschaften. (Springer-Verlag, Heidelberger Platz 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.1- 1913-
NEJMAG New England Journal of Medicine. (Massachusetts Medical Soc., 10 Shattuck St., Boston, MA 02115) V.198- 1928-
PLMJAP Pahlavi Medical Journal. (Shiraz, Iran) V.1-9, 1970-78.
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
RMSRA6 Revue Medicale de la Suisse Romande. (Societe Medicale de La Suisse Romande, 2 rue Bellefontaine, 1003 Lausanne, Switzerland) V.1- 1881-
SCIEAS Science. (American Assoc. for the Advancement of Science, 1333 H St., NW, Washington, DC 20005) V.1- 1895-
SJRDAH Scandinavian Journal of Respiratory Diseases. (Copenhagen, Denmark) V.47-60, 1966-79. Discontinued.
TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968-
TPHSDY Trends in Pharmacological Sciences. (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.1- 1979-
VCVPS* "Vrednie chemichescie veshestva. Prirodnie organicheskie soedinenia" (Hazardous substances. Nature products.) Volkova N.V. et al., Sankt-Peterburg, 1998.
YKYUA6 Yakkyoku. Pharmacy. (Nanzando, 4-1-11, Yushima, Bunkyo-ku, Tokyo, Japan) V.1- 1950-

RTECS Compound Description:
   Agricultural Chemical
   Drug
   Mutagen
   Reproductive Effector
   Human Data
   Natural Product

Click Here for Additional Information about RTECS

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SYNONYMS:
Agrept Agrimycin 17 Gerox Hokko - mycin NSC 14083 Neodiestreptopab	Strepcen Streptomicina (Italian) Streptomycine Streptomycinum Streptomyzin (German) Streptomycin A

SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
N/R	N/R	N/R	N/R

MUTATION DATA AND REFERENCES:
SYSTEM TEST	ROUTE/ ORGANISM/ TISSUE	DOSE	REFERENCE
cytogenetic analysis	human leukocyte	9,200 mg/L	MGGEAE 107,361,1970
cytogenetic analysis	mouse mammary gland	10 mmol/L/24 hour- continuous	JTSCDR 5,141,1980
DNA repair	Escherichia coli	600 ng/well	MUREAV 133,161,1984
mutation in microorganisms	Escherichia coli	100 mg/L (-enzymatic activation step)	NATUAS 271,385,1978
mutation in microorganisms	Euglena gracilis	100 mg/L (-enzymatic activation step)	AMACCQ 9,682,1976
mutation in microorganisms	other microorganisms	250 mg/L (-enzymatic activation step)	MUREAV 27,191,1975
mutation in microorganisms	other microorganisms	40 mg/L (-enzymatic activation step)	ANTBAL 25,822,1980
mutation in microorganisms	Salmonella typhimurium	10 gm/L (+enzymatic activation step)	SCIEAS 172,1058,1971
gene conversion and mitotic recombination	Escherichia coli	200 痢/L	IDZAAW 52,417,1977

REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
intraperitoneal mouse	lowest published toxic dose: 1,750 mg/kg (12-18 day pregnant)	Reproductive: Specific developmental abnormalities: Eye, ear	TJADAB 32,34B,1985
intravenous rat	lowest published toxic dose: 65 mg/kg (1 day pregnant)	Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth) Reproductive: Effects on embryo or fetus: Extra embryonic structures (e.g., placenta, umbilical cord) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)	AMASA4 32,35,1975
subcutaneous mouse	lowest published toxic dose: 25 mg/kg (14 day pregnant)	Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) Reproductive: Effects on newborn: Physical	CRSBAW 158,2065,1964
subcutaneous rat	lowest published toxic dose: 22,500 痢/kg (6-14 day pregnant)	Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)	DPHFAK 23,383,1971
subcutaneous rat	lowest published toxic dose: 225 mg/kg (6-14 day pregnant)	Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) Reproductive: Specific developmental abnormalities: Central nervous system	DPHFAK 23,383,1971
subcutaneous rat	lowest published toxic dose: 1,125 mg/kg (6-14 day pregnant)	Reproductive: Specific developmental abnormalities: Musculoskeletal system	DPHFAK 23,383,1971
unreported route mouse	lowest published toxic dose: 400 mg/kg (9-11 day pregnant)	Reproductive: Effects on embryo or fetus: Fetal death	TJADAB 14,250,1976
unreported route woman	lowest published toxic dose: 620 mg/kg (23-39 week pregnant)	Reproductive: Specific developmental abnormalities: Eye, ear	SJRDAH 50,61,1969
unreported route woman	lowest published toxic dose: 320 mg/kg (6-14 week pregnant)	Reproductive: Specific developmental abnormalities: Eye, ear Reproductive: Effects on newborn: Other postnatal measures or effects	NEJMAG 271,949,1964

TUMORIGENIC DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
N/R	N/R	N/R	N/R

ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
intraperitoneal human	lowest published toxic dose: 143 mg/kg	Vascular: BP lowering not characterized in autonomic section Lung, Thorax, or Respiration: Respiratory depression Lung, Thorax, or Respiration: Other changes	BMJOAE 1,556,1961
intraperitoneal mouse	lethal dose (50 percent kill): 305 mg/kg	N/R	HBPTO* 1,150,2001
intravenous cat	lowest published lethal dose: 150 mg/kg	N/R	85ERAY 1,570,1978
intravenous mouse	lethal dose (50 percent kill): 90,200 痢/kg	N/R	ANTBAL 18,249,1973
intravenous rat	lowest published lethal dose: 175 mg/kg	N/R	85ERAY 1,570,1978
intravenous rabbit	lowest published lethal dose: 175 mg/kg	N/R	NATWAY 43,183,1956
oral cat	lowest published lethal dose: 2 gm/kg	N/R	85ERAY 1,570,1978
oral human	lowest published toxic dose: 400 mg/kg/28 day- intermittent	Ear: Changes in vestibular functions	RMSRA6 73,854,1953
oral mouse	lethal dose (50 percent kill): 500 mg/kg	N/R	YKYUA6 38,1493,1987
oral rat	lethal dose (50 percent kill): 9 gm/kg	N/R	85ARAE 4,35,1976/1977
parenteral human	lowest published toxic dose: 28 mg/kg/ day	Blood: Eosinophilia	RMSRA6 73,820,1953
subcutaneous cat	lowest published lethal dose: 600 mg/kg	N/R	85ERAY 1,570,1978
subcutaneous dog	lowest published lethal dose: 300 mg/kg	N/R	85ERAY 1,570,1978
subcutaneous guinea pig	lowest published lethal dose: 600 mg/kg	N/R	85ERAY 1,570,1978
subcutaneous monkey	lowest published lethal dose: 400 mg/kg	N/R	85ERAY 1,570,1978
subcutaneous mouse	lethal dose (50 percent kill): 520 mg/kg	N/R	BJPCAL 15,496,1960
subcutaneous rat	lowest published lethal dose: 600 mg/kg	N/R	85ERAY 1,570,1978
subcutaneous rabbit	lowest published lethal dose: 600 mg/kg	N/R	85ERAY 1,570,1978
skin mouse	lethal dose (50 percent kill): 325 mg/kg	N/R	HBPTO* 1,150,2001
unreported route mouse	lethal dose (50 percent kill): 90 mg/kg	N/R	ARZNAD 5,213,1955

OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
inhalation human	lowest published toxic concentration: 0.26 mg/m³/8 week- intermittent	Skin: After topical application: Dermatitis, allergic	VCVPS* -,440,1998
intramuscular dog	lowest published toxic dose: 1 gm/kg/20 day- intermittent	Kidney, Ureter, and Bladder: Proteinuria Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical: Metabolism (intermediary): Other proteins	JPETAB 86,151,1946
intramuscular guinea pig	lowest published toxic dose: 5,600 mg/kg/14 day- intermittent	Eye: Other eye effects	CHHTAT 71,504,1991
intramuscular woman	lowest published toxic dose: 80 mg/kg/4 day- intermittent	Gastrointestinal: Nausea or vomiting Skin: After systemic exposure: Dermatitis, other Nutritional and Gross Metabolic: Body temperature increase	APHRER 39,165,2005
subcutaneous dog	lowest published toxic dose: 1 gm/kg/20 day- intermittent	Kidney, Ureter, and Bladder: Proteinuria Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical: Metabolism (intermediary): Other proteins	JPETAB 86,151,1946
unreported route cat	lowest published toxic dose: 2,300 mg/kg/23 day- intermittent	Ear: Change in acuity Behavioral: Ataxia	AORHA2 68,698,1959
unreported route human	lowest published toxic dose: 1.7 gm/kg/120 day- intermittent	Ear: Changes in vestibular functions Ear: Change in acuity	VCVPS* -,437,1998

REVIEWS:
ORGANIZATION	STANDARD	REFERENCE
TOXICOLOGY REVIEW		CLANA4 10(Pt1),283,1973
TOXICOLOGY REVIEW		PLMJAP 6,160,1975
TOXICOLOGY REVIEW		MMWOAU 115,1661,1973
TOXICOLOGY REVIEW		MMWOAU 115,1685,1973
TOXICOLOGY REVIEW		INTEAG 15,7,1974
TOXICOLOGY REVIEW		CLPTAT 5,480,1964
TOXICOLOGY REVIEW		ARVPAX 5,447,1965
TOXICOLOGY REVIEW		ADVPA3 4,263,1966
TOXICOLOGY REVIEW		JOPDAB 59,1,1961
TOXICOLOGY REVIEW		BMJOAE 2,260,1965
TOXICOLOGY REVIEW		MUREAV 526,85,2003
TOXICOLOGY REVIEW		TPHSDY 23,397,2002
TOXICOLOGY REVIEW		ENTOX* -,93,2005
TOXICOLOGY REVIEW		EJIME* 17,529,2006
TOXICOLOGY REVIEW		FEREAC 73,31788,2008
TOXICOLOGY REVIEW		FEREAC 73,31788,2008

STANDARDS AND REGULATIONS:
ORGANIZATION	STANDARD	REFERENCE
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988	PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION	FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF	PESTICIDES: RED Completed	RBREV* -,149,1998
Occupational Exposure Limit - RUSSIA	short term exposure limit 0.1 mg/m³, Skin, JUN2003

NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION	STANDARD or SURVEY	REFERENCE
National Occupational Exposure Survey 1983	National Occupational Exposure Survey 1983: Hazard Code: X3555; Number of Industries 3; Total Number of Facilities 272; Number of Occupations 7; Total Number of Employees Exposed 8,273; Total Number of Female Employees Exposed 7,449

STATUS IN FEDERAL AGENCIES:
ORGANIZATION	REFERENCE
EPA GENETOX PROGRAM 1988, Negative: E coli polA without S9
EPA GENETOX PROGRAM 1988, Inconclusive: B subtilis rec assay

REFERENCES:
CODEN	REFERENCE
85ARAE	"Agricultural Chemicals," Thomson, W.T., 4 vols., Fresno, CA, Thomson Publications, 1976/77 revision
85ERAY	"Antibiotics: Origin, Nature, and Properties," Korzyoski, T., et al., eds., Washington, DC, American Soc. for Microbiology, 1978
ADVPA3	Advances in Pharmacology. (New York, NY) V.1-6, 1962-68. For publisher information, see AVPCAQ.
AMACCQ	Antimicrobial Agents and Chemotherapy. (American Soc. for Microbiology, 1913 I St., NW, Washington, DC 20006) V.1- 1972-
AMASA4	Acta Medica Academiae Scientiarum Hungaricae. (Budapest, Hungary) V.1-39, 1950-82.
ANTBAL	Antibiotiki. (Moscow, USSR) V.1-29, 1956-84. For publisher information, see AMBIEH.
AORHA2	Annals of Otology, Rhinology, & Laryngology. (Annals Publishing Co., 4507 Laclede Ave., St. Louis, MO 63108) V.6- 1897-
APHRER	Annals of Pharmacotherpy. (Harvey Whitney Books Co., POB 42696, Cincinnati, OH 45242) V. 26- 1992-
ARVPAX	Annual Review of Pharmacology. (Palo Alto, CA) V.1-15, 1961-75. For publisher information, see ARPTDI.
ARZNAD	Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
BJPCAL	British Journal of Pharmacology and Chemotherapy. (London, UK) V.1-33, 1946-68. For publisher information, see BJPCBM.
BMJOAE	British Medical Journal. (British Medical Assoc., BMA House, Tavistock Sq., London WC1H 9JR, UK) V.1- 1857-
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