RTECS:WK2110000 The Registry of Toxic Effects of Chemical Substances

Streptamine, O - 3 - amino - 3 - deoxy - alpha - D - glucopyranosyl - (1 - 6) - O - (2,6 - diamino - 2,3,6 - trideoxy - alpha - D - ribohexopyranosyl - (1 - 4) ) - 2 - deoxy - , D - , sulfate (salt)

RTECS #: WK2110000

CAS #: 49842-07-1

UPDATE: December 1999 MW: 1,154.16 MF: C₁₈H₃₇N₅O₉•xH₂O₄S

NOTE:

TOXICITY DATA HAVE NOT BEEN EVALUATED. OMISSION OF A SUBSTANCE OR NOTATION DOES NOT IMPLY ANY RELIEF FROM REGULATORY RESPONSIBILITY.

TABLE OF CONTENTS:

SYNONYMS:

ACUTE TOXICITY DATA:

OTHER MULTIPLE DOSE DATA:

NIOSH DOCUMENTATION AND SURVEILLANCE:

REFERENCES:

SYNONYMS:

1 - Epitobramycin sulfate

Nebcin

Obracine

Tenemicin

Tobramycin sulphate

SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

MUTATION DATA AND REFERENCES:
SYSTEM TEST ROUTE/
ORGANISM/
TISSUE DOSE REFERENCE
N/R N/R N/R N/R

REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

TUMORIGENIC DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
intraperitoneal
mouse lethal dose (50 percent kill): 262 mg/kg Autonomic Nervous System: Other (direct) parasympathomimetic

Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Dyspnea ANTBAL 24,60,1979
intravenous
mouse lethal dose (50 percent kill): 77 mg/kg Autonomic Nervous System: Other (direct) parasympathomimetic

Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Dyspnea ANTBAL 24,60,1979
intravenous
rat lethal dose (50 percent kill): 126 mg/kg Autonomic Nervous System: Other (direct) parasympathomimetic

Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Dyspnea ANTBAL 24,60,1979
intravenous
woman lowest published lethal dose: 15 mg/kg/5 day- intermittent Behavioral: Wakefulness

Behavioral: Hallucinations, distorted perceptions JAMAAP 247,1319,1982
oral
mouse lethal dose (50 percent kill): >10,500 mg/kg N/R ANTBAL 24,60,1979
subcutaneous
mouse lethal dose (50 percent kill): 560 mg/kg Autonomic Nervous System: Other (direct) parasympathomimetic

Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Dyspnea ANTBAL 24,60,1979
subcutaneous
rat lethal dose (50 percent kill): 1,680 mg/kg Autonomic Nervous System: Other (direct) parasympathomimetic

Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Dyspnea ANTBAL 24,60,1979

OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
intramuscular
guinea pig lowest published toxic dose: 1,400 mg/kg/14 day- intermittent Ear: Change in cochlear structure or function LARYA8 86,259,1976
intramuscular
guinea pig lowest published toxic dose: 1,400 mg/kg/7 day- intermittent Ear: Change in cochlear structure or function LARYA8 86,259,1976
subcutaneous
cat lowest published toxic dose: 8,400 mg/kg/30 week- intermittent Ear: Change in cochlear structure or function

Behavioral: Altered sleep time (including change in righting reflex)

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) TXAPA9 77,479,1985
subcutaneous
rat lowest published toxic dose: 1,600 mg/kg/8 day- intermittent Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Endocrine: Changes in adrenal weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases ANTBAL 24,60,1979
subcutaneous
rat lowest published toxic dose: 2,240 mg/kg/2 week- intermittent Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field PHTOEH 84,147,1999

REVIEWS:
ORGANIZATION STANDARD
REFERENCE

N/R N/R N/R

STANDARDS AND REGULATIONS:
ORGANIZATION STANDARD
REFERENCE

N/R N/R N/R

NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X4326;
Number of Industries 1;
Total Number of Facilities 305;
Number of Occupations 7;
Total Number of Employees Exposed 21,896;
Total Number of Female Employees Exposed 17,672

STATUS IN FEDERAL AGENCIES:
ORGANIZATION
REFERENCE

N/R

REFERENCES:
CODEN
REFERENCE

ANTBAL Antibiotiki. (Moscow, USSR) V.1-29, 1956-84. For publisher information, see AMBIEH.
JAMAAP JAMA, Journal of the American Medical Association. (AMA, 535 N. Dearborn St., Chicago, IL 60610) V.1- 1883-
LARYA8 Laryngoscope. (Laryngoscope Co., 9216 Clayton Rd., Suite 18, St. Louis, MO 63124) V.1- 1896-
PHTOEH Pharmacology and Toxicology (Copenhagen). (Munksgaard International Pub., POB 2148, DK-1016 Copenhagen K, Denmark) V.60- 1987-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-

RTECS Compound Description:
Drug
Human Data

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SYNONYMS:
1 - Epitobramycin sulfate Nebcin Obracine	Tenemicin Tobramycin sulphate

SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
N/R	N/R	N/R	N/R

MUTATION DATA AND REFERENCES:
SYSTEM TEST	ROUTE/ ORGANISM/ TISSUE	DOSE	REFERENCE
N/R	N/R	N/R	N/R

REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
N/R	N/R	N/R	N/R

TUMORIGENIC DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
N/R	N/R	N/R	N/R

ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
intraperitoneal mouse	lethal dose (50 percent kill): 262 mg/kg	Autonomic Nervous System: Other (direct) parasympathomimetic Behavioral: Convulsions or effect on seizure threshold Lung, Thorax, or Respiration: Dyspnea	ANTBAL 24,60,1979
intravenous mouse	lethal dose (50 percent kill): 77 mg/kg	Autonomic Nervous System: Other (direct) parasympathomimetic Behavioral: Convulsions or effect on seizure threshold Lung, Thorax, or Respiration: Dyspnea	ANTBAL 24,60,1979
intravenous rat	lethal dose (50 percent kill): 126 mg/kg	Autonomic Nervous System: Other (direct) parasympathomimetic Behavioral: Convulsions or effect on seizure threshold Lung, Thorax, or Respiration: Dyspnea	ANTBAL 24,60,1979
intravenous woman	lowest published lethal dose: 15 mg/kg/5 day- intermittent	Behavioral: Wakefulness Behavioral: Hallucinations, distorted perceptions	JAMAAP 247,1319,1982
oral mouse	lethal dose (50 percent kill): >10,500 mg/kg	N/R	ANTBAL 24,60,1979
subcutaneous mouse	lethal dose (50 percent kill): 560 mg/kg	Autonomic Nervous System: Other (direct) parasympathomimetic Behavioral: Convulsions or effect on seizure threshold Lung, Thorax, or Respiration: Dyspnea	ANTBAL 24,60,1979
subcutaneous rat	lethal dose (50 percent kill): 1,680 mg/kg	Autonomic Nervous System: Other (direct) parasympathomimetic Behavioral: Convulsions or effect on seizure threshold Lung, Thorax, or Respiration: Dyspnea	ANTBAL 24,60,1979

OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
intramuscular guinea pig	lowest published toxic dose: 1,400 mg/kg/14 day- intermittent	Ear: Change in cochlear structure or function	LARYA8 86,259,1976
intramuscular guinea pig	lowest published toxic dose: 1,400 mg/kg/7 day- intermittent	Ear: Change in cochlear structure or function	LARYA8 86,259,1976
subcutaneous cat	lowest published toxic dose: 8,400 mg/kg/30 week- intermittent	Ear: Change in cochlear structure or function Behavioral: Altered sleep time (including change in righting reflex) Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)	TXAPA9 77,479,1985
subcutaneous rat	lowest published toxic dose: 1,600 mg/kg/8 day- intermittent	Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) Endocrine: Changes in adrenal weight Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases	ANTBAL 24,60,1979
subcutaneous rat	lowest published toxic dose: 2,240 mg/kg/2 week- intermittent	Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) Nutritional and Gross Metabolic: Weight loss or decreased weight gain Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	PHTOEH 84,147,1999

STANDARDS AND REGULATIONS:
ORGANIZATION	STANDARD	REFERENCE
N/R	N/R	N/R

NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION	STANDARD or SURVEY	REFERENCE
National Occupational Exposure Survey 1983	National Occupational Exposure Survey 1983: Hazard Code: X4326; Number of Industries 1; Total Number of Facilities 305; Number of Occupations 7; Total Number of Employees Exposed 21,896; Total Number of Female Employees Exposed 17,672

REFERENCES:
CODEN	REFERENCE
ANTBAL	Antibiotiki. (Moscow, USSR) V.1-29, 1956-84. For publisher information, see AMBIEH.
JAMAAP	JAMA, Journal of the American Medical Association. (AMA, 535 N. Dearborn St., Chicago, IL 60610) V.1- 1883-
LARYA8	Laryngoscope. (Laryngoscope Co., 9216 Clayton Rd., Suite 18, St. Louis, MO 63124) V.1- 1896-
PHTOEH	Pharmacology and Toxicology (Copenhagen). (Munksgaard International Pub., POB 2148, DK-1016 Copenhagen K, Denmark) V.60- 1987-
TXAPA9	Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-