RTECS:WK2100000 The Registry of Toxic Effects of Chemical Substances

Streptamine, O - 3 - amino - 3 - deoxy - alpha - D - glucopyranosyl - (1 - 4) - O - (2,6 - diamino - 2,3,6 - trideoxy - alpha - D - ribohexopyranosyl - (1 - 6) ) - 2 - deoxy - , D -

RTECS #: WK2100000

CAS #: 32986-56-4

UPDATE: November 2008 MW: 467.60 MF: C₁₈H₃₇N₅O₉

NOTE:

TOXICITY DATA HAVE NOT BEEN EVALUATED. OMISSION OF A SUBSTANCE OR NOTATION DOES NOT IMPLY ANY RELIEF FROM REGULATORY RESPONSIBILITY.

TABLE OF CONTENTS:

SYNONYMS:

REPRODUCTIVE EFFECTS DATA:

ACUTE TOXICITY DATA:

OTHER MULTIPLE DOSE DATA:

REVIEWS:

STANDARDS AND REGULATIONS:

NIOSH DOCUMENTATION AND SURVEILLANCE:

STATUS IN FEDERAL AGENCIES:

REFERENCES:

SYNONYMS:

1 - Epitobramycin

3' - Deoxykanamycin B

Deoxykanamycin B

Distobram

Gernebcin

Nebramycin factor 6

Nebramycin VI

Obracin

Obramycin

Tobradistin

Tobralex

Tobramycin

Tobrex

SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

MUTATION DATA AND REFERENCES:
SYSTEM TEST ROUTE/
ORGANISM/
TISSUE DOSE REFERENCE
N/R N/R N/R N/R

REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
intramuscular
mouse lowest published toxic dose: 600 mg/kg (7-12 day pregnant) Reproductive: Effects on embryo or fetus: Fetal death NKRZAZ 23,1544,1975
intramuscular
mouse lowest published toxic dose: 150 mg/kg (7-12 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system NKRZAZ 23,1544,1975
intramuscular
rat lowest published toxic dose: 150 mg/kg (9-14 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system NKRZAZ 23,1544,1975
intraperitoneal
rat lowest published toxic dose: 600 mg/kg (10-19 day pregnant) Reproductive: Effects on newborn: Physical TCMUD8 12,19,1992

TUMORIGENIC DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
intramuscular
mouse lethal dose (50 percent kill): 440 mg/kg N/R YKYUA6 27,1467,1976
intramuscular
rat lethal dose (50 percent kill): 913 mg/kg N/R IYKEDH 8,107,1977
intraperitoneal
mouse lethal dose (50 percent kill): 445 mg/kg N/R JIMRBV 2,100,1974
intraperitoneal
rat lethal dose (50 percent kill): 1,030 mg/kg N/R JIMRBV 2,100,1974
intravenous
man lowest published toxic dose: 37,714 痢/kg Kidney, Ureter, and Bladder: Urine volume increased AJKDDP 23,118,1994
intravenous
mouse lethal dose (50 percent kill): 72,500 痢/kg Behavioral: Convulsions or effect on seizure threshold

Behavioral: Ataxia

Lung, Thorax, or Respiration: Dyspnea ANTBAL 29,361,1984
intravenous
mouse lethal dose (50 percent kill): 70 mg/kg N/R VCVPS* -,438,1998
intravenous
rat lethal dose (50 percent kill): 104 mg/kg N/R JIMRBV 2,100,1974
oral
mouse lethal dose (50 percent kill): >11,500 mg/kg N/R YKYUA6 27,1467,1976
oral
rat lethal dose (50 percent kill): >7,500 mg/kg N/R YKYUA6 27,1467,1976
subcutaneous
mouse lethal dose (50 percent kill): 367 mg/kg Eye: Ptosis

Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Respiratory depression TXAPA9 25,398,1973
subcutaneous
pig lethal dose (50 percent kill): 676 mg/kg Eye: Ptosis

Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Respiratory depression TXAPA9 25,398,1973
subcutaneous
rat lethal dose (50 percent kill): 969 mg/kg Olfaction: Other olfaction effects TXAPA9 22,332,1972

OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
intramuscular
dog lowest published toxic dose: 1,050 mg/kg/35 day- continuous Kidney, Ureter, and Bladder: Other changes

Endocrine: Other changes

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) KSRNAM 15,3587,1987
intramuscular
dog lowest published toxic dose: 840 mg/kg/4 week- intermittent Behavioral: Somnolence (general depressed activity)

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field NKRZAZ 23,1494,1975
intramuscular
guinea pig lowest published toxic dose: 2,800 mg/kg/4 week- intermittent Ear: Change in acuity

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field NKRZAZ 23,1522,1975
intramuscular
guinea pig lowest published toxic dose: 540 mg/kg/90 day- intermittent Ear: Change in cochlear structure or function NKRZAZ 23,3707,1975
intramuscular
guinea pig lowest published toxic dose: 180 mg/kg/18 day- intermittent Ear: Changes in vestibular functions VCVPS* -,439,1998
intramuscular
monkey lowest published toxic dose: 630 mg/kg/21 day- intermittent Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Kidney, Ureter, and Bladder: Changes in bladder weight

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) NKRZAZ 26(Suppl 3),85,1978
intramuscular
rat lowest published toxic dose: 1,680 mg/kg/4 week- intermittent Kidney, Ureter, and Bladder: Other changes in urine composition

Kidney, Ureter, and Bladder: Changes in bladder weight

Blood: Normocytic anemia NKRZAZ 23,1470,1975
intramuscular
rat lowest published toxic dose: 4,550 mg/kg/26 week- intermittent Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Kidney, Ureter, and Bladder: Changes in bladder weight

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) NKRZAZ 23,1470,1975
intraperitoneal
rat lowest published toxic dose: 800 mg/kg/10 day- intermittent Kidney, Ureter, and Bladder: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes

Biochemical: Metabolism (intermediary): Other AMACCQ 34,139,1990
intraperitoneal
rat lowest published toxic dose: 800 mg/kg/4 day- intermittent Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain REFAE8 16,583,1994
intravenous
child lowest published toxic dose: 67.5 mg/kg/9 day- intermittent Kidney, Ureter, and Bladder: Renal function tests depressed JNCIEQ 95,1869,2003
intravenous
child lowest published toxic dose: 80 mg/kg/10 day- intermittent Kidney, Ureter, and Bladder: Renal function tests depressed JNCIEQ 95,1869,2003
intravenous
dog lowest published toxic dose: 1,050 mg/kg/35 day- continuous Kidney, Ureter, and Bladder: Other changes

Endocrine: Other changes

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) KSRNAM 15,3587,1987
oral
rat lowest published toxic dose: 3,600 mg/kg/30 day- intermittent Kidney, Ureter, and Bladder: Changes in bladder weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases TXAPA9 25,398,1973
oral
rat lowest published toxic dose: 10,800 mg/kg/90 day- intermittent Kidney, Ureter, and Bladder: Changes in bladder weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases TXAPA9 25,398,1973
subcutaneous
guinea pig lowest published toxic dose: 1,072 mg/kg/16 day- intermittent Ear: Change in cochlear structure or function TXAPA9 65,222,1982
subcutaneous
rat lowest published toxic dose: 1,200 mg/kg/10 day- intermittent Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) TOPADD 19,66,1991
subcutaneous
rat lowest published toxic dose: 560 mg/kg/14 day- intermittent Kidney, Ureter, and Bladder: Other changes in urine composition AMACCQ 13,34,1978
subcutaneous
rat lowest published toxic dose: 3,250 mg/kg/65 day- intermittent Eye: Other eye effects

Ear: Changes in vestibular functions

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) TXAPA9 25,398,1973
unreported route
human lowest published toxic dose: 34 mg/kg/10 day- intermittent Ear: Change in acuity

Ear: Changes in vestibular functions VCVPS* -,437,1998
unreported route
rat lowest published toxic dose: 560 mg/kg/14 day- intermittent Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) CLREAS 26,141A,1978

REVIEWS:
ORGANIZATION STANDARD
REFERENCE

TOXICOLOGY REVIEW
MUREAV 488,151,2001

STANDARDS AND REGULATIONS:
ORGANIZATION STANDARD
REFERENCE

Occupational Exposure Limit - RUSSIA short term exposure limit 0.1 mg/m³, JUN2003

NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X3662;
Number of Industries 4;
Total Number of Facilities 721;
Number of Occupations 10;
Total Number of Employees Exposed 22,265;
Total Number of Female Employees Exposed 17,753

STATUS IN FEDERAL AGENCIES:
ORGANIZATION
REFERENCE

EPA GENETOX PROGRAM 1988, Negative: S cerevisiae-homozygosis

REFERENCES:
CODEN
REFERENCE

AJKDDP American Journal of Kidney Diseases. (Grune & Stratton, Inc., Journal Subscription Dept., POB 6280, Duluth, MN 55806) V.1- 1981-
AMACCQ Antimicrobial Agents and Chemotherapy. (American Soc. for Microbiology, 1913 I St., NW, Washington, DC 20006) V.1- 1972-
ANTBAL Antibiotiki. (Moscow, USSR) V.1-29, 1956-84. For publisher information, see AMBIEH.
CLREAS Clinical Research. (Slack Inc., 6900 Grove Rd., Thorofare, NJ 08086) V.6- 1958-
IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970-
JIMRBV Journal of International Medical Research. (Cambridge Medical Pub. Ltd., 435/437 Wellingborough Rd., Northampton, NN1 4EZ, UK) V.1- 1972-
JNCIEQ Journal of the National Cancer Institute (1988). (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.80- 1988-
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NKRZAZ Chemotherapy (Tokyo). (Nippon Kagaku Ryoho Gakkai, 2-20-8 Kamiosaki, Shinagawa-Ku, Tokyo 141, Japan) V.1- 1953-
REFAE8 Renal Failure. (Marcel Dekker Journals, POB 5005, Monticello, NY 12701) V.10- 1987-
TCMUD8 Teratogenesis, Carcinogenesis, and Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1980-
TOPADD Toxicologic Pathology. (c/o Dr. F.A. de la Iglesia, Warner-Lambert Co., Pharmaceutical Research Div., POB 1047, Ann Arbor, MI 48106) V.6(3/4)- 1978-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
VCVPS* "Vrednie chemichescie veshestva. Prirodnie organicheskie soedinenia" (Hazardous substances. Nature products.) Volkova N.V. et al., Sankt-Peterburg, 1998.
YKYUA6 Yakkyoku. Pharmacy. (Nanzando, 4-1-11, Yushima, Bunkyo-ku, Tokyo, Japan) V.1- 1950-

Used as an antibacterial and antibiotic

FDA-proprietary drug

RTECS Compound Description:
   Drug
   Mutagen
   Reproductive Effector
   Human Data
   Natural Product

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SYNONYMS:
1 - Epitobramycin 3' - Deoxykanamycin B Deoxykanamycin B Distobram Gernebcin Nebramycin factor 6 Nebramycin VI	Obracin Obramycin Tobradistin Tobralex Tobramycin Tobrex

SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
N/R	N/R	N/R	N/R

MUTATION DATA AND REFERENCES:
SYSTEM TEST	ROUTE/ ORGANISM/ TISSUE	DOSE	REFERENCE
N/R	N/R	N/R	N/R

REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
intramuscular mouse	lowest published toxic dose: 600 mg/kg (7-12 day pregnant)	Reproductive: Effects on embryo or fetus: Fetal death	NKRZAZ 23,1544,1975
intramuscular mouse	lowest published toxic dose: 150 mg/kg (7-12 day pregnant)	Reproductive: Specific developmental abnormalities: Musculoskeletal system	NKRZAZ 23,1544,1975
intramuscular rat	lowest published toxic dose: 150 mg/kg (9-14 day pregnant)	Reproductive: Specific developmental abnormalities: Musculoskeletal system	NKRZAZ 23,1544,1975
intraperitoneal rat	lowest published toxic dose: 600 mg/kg (10-19 day pregnant)	Reproductive: Effects on newborn: Physical	TCMUD8 12,19,1992

TUMORIGENIC DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
N/R	N/R	N/R	N/R

ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
intramuscular mouse	lethal dose (50 percent kill): 440 mg/kg	N/R	YKYUA6 27,1467,1976
intramuscular rat	lethal dose (50 percent kill): 913 mg/kg	N/R	IYKEDH 8,107,1977
intraperitoneal mouse	lethal dose (50 percent kill): 445 mg/kg	N/R	JIMRBV 2,100,1974
intraperitoneal rat	lethal dose (50 percent kill): 1,030 mg/kg	N/R	JIMRBV 2,100,1974
intravenous man	lowest published toxic dose: 37,714 痢/kg	Kidney, Ureter, and Bladder: Urine volume increased	AJKDDP 23,118,1994
intravenous mouse	lethal dose (50 percent kill): 72,500 痢/kg	Behavioral: Convulsions or effect on seizure threshold Behavioral: Ataxia Lung, Thorax, or Respiration: Dyspnea	ANTBAL 29,361,1984
intravenous mouse	lethal dose (50 percent kill): 70 mg/kg	N/R	VCVPS* -,438,1998
intravenous rat	lethal dose (50 percent kill): 104 mg/kg	N/R	JIMRBV 2,100,1974
oral mouse	lethal dose (50 percent kill): >11,500 mg/kg	N/R	YKYUA6 27,1467,1976
oral rat	lethal dose (50 percent kill): >7,500 mg/kg	N/R	YKYUA6 27,1467,1976
subcutaneous mouse	lethal dose (50 percent kill): 367 mg/kg	Eye: Ptosis Behavioral: Somnolence (general depressed activity) Lung, Thorax, or Respiration: Respiratory depression	TXAPA9 25,398,1973
subcutaneous pig	lethal dose (50 percent kill): 676 mg/kg	Eye: Ptosis Behavioral: Somnolence (general depressed activity) Lung, Thorax, or Respiration: Respiratory depression	TXAPA9 25,398,1973
subcutaneous rat	lethal dose (50 percent kill): 969 mg/kg	Olfaction: Other olfaction effects	TXAPA9 22,332,1972

OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
intramuscular dog	lowest published toxic dose: 1,050 mg/kg/35 day- continuous	Kidney, Ureter, and Bladder: Other changes Endocrine: Other changes Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)	KSRNAM 15,3587,1987
intramuscular dog	lowest published toxic dose: 840 mg/kg/4 week- intermittent	Behavioral: Somnolence (general depressed activity) Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	NKRZAZ 23,1494,1975
intramuscular guinea pig	lowest published toxic dose: 2,800 mg/kg/4 week- intermittent	Ear: Change in acuity Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	NKRZAZ 23,1522,1975
intramuscular guinea pig	lowest published toxic dose: 540 mg/kg/90 day- intermittent	Ear: Change in cochlear structure or function	NKRZAZ 23,3707,1975
intramuscular guinea pig	lowest published toxic dose: 180 mg/kg/18 day- intermittent	Ear: Changes in vestibular functions	VCVPS* -,439,1998
intramuscular monkey	lowest published toxic dose: 630 mg/kg/21 day- intermittent	Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) Kidney, Ureter, and Bladder: Changes in bladder weight Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)	NKRZAZ 26(Suppl 3),85,1978
intramuscular rat	lowest published toxic dose: 1,680 mg/kg/4 week- intermittent	Kidney, Ureter, and Bladder: Other changes in urine composition Kidney, Ureter, and Bladder: Changes in bladder weight Blood: Normocytic anemia	NKRZAZ 23,1470,1975
intramuscular rat	lowest published toxic dose: 4,550 mg/kg/26 week- intermittent	Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) Kidney, Ureter, and Bladder: Changes in bladder weight Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)	NKRZAZ 23,1470,1975
intraperitoneal rat	lowest published toxic dose: 800 mg/kg/10 day- intermittent	Kidney, Ureter, and Bladder: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes Biochemical: Metabolism (intermediary): Other	AMACCQ 34,139,1990
intraperitoneal rat	lowest published toxic dose: 800 mg/kg/4 day- intermittent	Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Nutritional and Gross Metabolic: Weight loss or decreased weight gain	REFAE8 16,583,1994
intravenous child	lowest published toxic dose: 67.5 mg/kg/9 day- intermittent	Kidney, Ureter, and Bladder: Renal function tests depressed	JNCIEQ 95,1869,2003
intravenous child	lowest published toxic dose: 80 mg/kg/10 day- intermittent	Kidney, Ureter, and Bladder: Renal function tests depressed	JNCIEQ 95,1869,2003
intravenous dog	lowest published toxic dose: 1,050 mg/kg/35 day- continuous	Kidney, Ureter, and Bladder: Other changes Endocrine: Other changes Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)	KSRNAM 15,3587,1987
oral rat	lowest published toxic dose: 3,600 mg/kg/30 day- intermittent	Kidney, Ureter, and Bladder: Changes in bladder weight Nutritional and Gross Metabolic: Weight loss or decreased weight gain Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases	TXAPA9 25,398,1973
oral rat	lowest published toxic dose: 10,800 mg/kg/90 day- intermittent	Kidney, Ureter, and Bladder: Changes in bladder weight Nutritional and Gross Metabolic: Weight loss or decreased weight gain Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases	TXAPA9 25,398,1973
subcutaneous guinea pig	lowest published toxic dose: 1,072 mg/kg/16 day- intermittent	Ear: Change in cochlear structure or function	TXAPA9 65,222,1982
subcutaneous rat	lowest published toxic dose: 1,200 mg/kg/10 day- intermittent	Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)	TOPADD 19,66,1991
subcutaneous rat	lowest published toxic dose: 560 mg/kg/14 day- intermittent	Kidney, Ureter, and Bladder: Other changes in urine composition	AMACCQ 13,34,1978
subcutaneous rat	lowest published toxic dose: 3,250 mg/kg/65 day- intermittent	Eye: Other eye effects Ear: Changes in vestibular functions Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)	TXAPA9 25,398,1973
unreported route human	lowest published toxic dose: 34 mg/kg/10 day- intermittent	Ear: Change in acuity Ear: Changes in vestibular functions	VCVPS* -,437,1998
unreported route rat	lowest published toxic dose: 560 mg/kg/14 day- intermittent	Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)	CLREAS 26,141A,1978

REVIEWS:
ORGANIZATION	STANDARD	REFERENCE
TOXICOLOGY REVIEW		MUREAV 488,151,2001

STANDARDS AND REGULATIONS:
ORGANIZATION	STANDARD	REFERENCE
Occupational Exposure Limit - RUSSIA	short term exposure limit 0.1 mg/m³, JUN2003

NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION	STANDARD or SURVEY	REFERENCE
National Occupational Exposure Survey 1983	National Occupational Exposure Survey 1983: Hazard Code: X3662; Number of Industries 4; Total Number of Facilities 721; Number of Occupations 10; Total Number of Employees Exposed 22,265; Total Number of Female Employees Exposed 17,753

STATUS IN FEDERAL AGENCIES:
ORGANIZATION	REFERENCE
EPA GENETOX PROGRAM 1988, Negative: S cerevisiae-homozygosis

REFERENCES:
CODEN	REFERENCE
AJKDDP	American Journal of Kidney Diseases. (Grune & Stratton, Inc., Journal Subscription Dept., POB 6280, Duluth, MN 55806) V.1- 1981-
AMACCQ	Antimicrobial Agents and Chemotherapy. (American Soc. for Microbiology, 1913 I St., NW, Washington, DC 20006) V.1- 1972-
ANTBAL	Antibiotiki. (Moscow, USSR) V.1-29, 1956-84. For publisher information, see AMBIEH.
CLREAS	Clinical Research. (Slack Inc., 6900 Grove Rd., Thorofare, NJ 08086) V.6- 1958-
IYKEDH	Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970-
JIMRBV	Journal of International Medical Research. (Cambridge Medical Pub. Ltd., 435/437 Wellingborough Rd., Northampton, NN1 4EZ, UK) V.1- 1972-
JNCIEQ	Journal of the National Cancer Institute (1988). (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.80- 1988-
KSRNAM	Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960-
MUREAV	Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NKRZAZ	Chemotherapy (Tokyo). (Nippon Kagaku Ryoho Gakkai, 2-20-8 Kamiosaki, Shinagawa-Ku, Tokyo 141, Japan) V.1- 1953-
REFAE8	Renal Failure. (Marcel Dekker Journals, POB 5005, Monticello, NY 12701) V.10- 1987-
TCMUD8	Teratogenesis, Carcinogenesis, and Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1980-
TOPADD	Toxicologic Pathology. (c/o Dr. F.A. de la Iglesia, Warner-Lambert Co., Pharmaceutical Research Div., POB 1047, Ann Arbor, MI 48106) V.6(3/4)- 1978-
TXAPA9	Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
VCVPS*	"Vrednie chemichescie veshestva. Prirodnie organicheskie soedinenia" (Hazardous substances. Nature products.) Volkova N.V. et al., Sankt-Peterburg, 1998.
YKYUA6	Yakkyoku. Pharmacy. (Nanzando, 4-1-11, Yushima, Bunkyo-ku, Tokyo, Japan) V.1- 1950-