RTECS:WG7400000 The Registry of Toxic Effects of Chemical Substances

Spectinomycin, dihydrochloride, pentahydrate

RTECS #: WG7400000

CAS #: 22189-32-8

UPDATE: April 1999 MW: 494.41 MF: C₁₄H₂₄N₂O₇•2ClH•5H₂O

NOTE:

TOXICITY DATA HAVE NOT BEEN EVALUATED. OMISSION OF A SUBSTANCE OR NOTATION DOES NOT IMPLY ANY RELIEF FROM REGULATORY RESPONSIBILITY.

TABLE OF CONTENTS:

SYNONYMS:

REPRODUCTIVE EFFECTS DATA:

ACUTE TOXICITY DATA:

OTHER MULTIPLE DOSE DATA:

NIOSH DOCUMENTATION AND SURVEILLANCE:

REFERENCES:

SYNONYMS:

Actinospectacin dihydrochloride pentahydrate

Espectinomicina dihydrochloride pentahydrate

M 141 dihydrochloride pentahydrate

Spectogard

Togamycin dihydrochloride pentahydrate

SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

MUTATION DATA AND REFERENCES:
SYSTEM TEST ROUTE/
ORGANISM/
TISSUE DOSE REFERENCE
N/R N/R N/R N/R

REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
intraperitoneal
mouse lowest published toxic dose: 2,400 mg/kg (7-12 day pregnant) Reproductive: Specific developmental abnormalities: Eye, ear KSRNAM 8,3008,1974
intraperitoneal
rat lowest published toxic dose: 2,400 mg/kg (9-14 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system KSRNAM 8,3018,1974

TUMORIGENIC DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
intramuscular
mouse lethal dose (50 percent kill): >5 gm/kg Behavioral: Somnolence (general depressed activity) JJANAX 29,43,1976
intramuscular
rat lethal dose (50 percent kill): >2,500 mg/kg Behavioral: Somnolence (general depressed activity) JJANAX 29,43,1976
intraperitoneal
mouse lethal dose (50 percent kill): 2,350 mg/kg Behavioral: Altered sleep time (including change in righting reflex)

Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Dyspnea JJANAX 29,43,1976
intraperitoneal
rat lethal dose (50 percent kill): 2,020 mg/kg Behavioral: Altered sleep time (including change in righting reflex)

Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Dyspnea JJANAX 29,43,1976
oral
mouse lethal dose (50 percent kill): >10 mg/kg Behavioral: Somnolence (general depressed activity) JJANAX 29,43,1976
oral
rat lethal dose (50 percent kill): >5 gm/kg Behavioral: Somnolence (general depressed activity) JJANAX 29,43,1976
subcutaneous
mouse lethal dose (50 percent kill): 8,400 mg/kg Behavioral: Convulsions or effect on seizure threshold JJANAX 29,43,1976
subcutaneous
rat lethal dose (50 percent kill): >5 gm/kg Behavioral: Convulsions or effect on seizure threshold JJANAX 29,43,1976

OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
intramuscular
rat lowest published toxic dose: 2,800 mg/kg/32 day- intermittent Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Endocrine: Changes in adrenal weight JJANAX 29,43,1976
intraperitoneal
rat lowest published toxic dose: 6,800 mg/kg/39 day- intermittent Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Kidney, Ureter, and Bladder: Other changes JJANAX 29,43,1976

REVIEWS:
ORGANIZATION STANDARD
REFERENCE

N/R N/R N/R

STANDARDS AND REGULATIONS:
ORGANIZATION STANDARD
REFERENCE

N/R N/R N/R

NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X6089;
Number of Industries 1;
Total Number of Facilities 17;
Number of Occupations 2;
Total Number of Employees Exposed 958;
Total Number of Female Employees Exposed 434

STATUS IN FEDERAL AGENCIES:
ORGANIZATION
REFERENCE

N/R

REFERENCES:
CODEN
REFERENCE

JJANAX Japanese Journal of Antibiotics. (Japan Antibiotics Research Assoc., 2-20-8 Kamiosaki, Shinagawa-ku, Tokyo 141, Japan) V.21- 1968-
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960-

Used as an antibacterial agent

FDA-proprietary drug

RTECS Compound Description:
Drug
Reproductive Effector

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SYNONYMS:
Actinospectacin dihydrochloride pentahydrate Espectinomicina dihydrochloride pentahydrate M 141 dihydrochloride pentahydrate	Spectogard Togamycin dihydrochloride pentahydrate

SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
N/R	N/R	N/R	N/R

MUTATION DATA AND REFERENCES:
SYSTEM TEST	ROUTE/ ORGANISM/ TISSUE	DOSE	REFERENCE
N/R	N/R	N/R	N/R

REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
intraperitoneal mouse	lowest published toxic dose: 2,400 mg/kg (7-12 day pregnant)	Reproductive: Specific developmental abnormalities: Eye, ear	KSRNAM 8,3008,1974
intraperitoneal rat	lowest published toxic dose: 2,400 mg/kg (9-14 day pregnant)	Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) Reproductive: Specific developmental abnormalities: Musculoskeletal system	KSRNAM 8,3018,1974

TUMORIGENIC DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
N/R	N/R	N/R	N/R

ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
intramuscular mouse	lethal dose (50 percent kill): >5 gm/kg	Behavioral: Somnolence (general depressed activity)	JJANAX 29,43,1976
intramuscular rat	lethal dose (50 percent kill): >2,500 mg/kg	Behavioral: Somnolence (general depressed activity)	JJANAX 29,43,1976
intraperitoneal mouse	lethal dose (50 percent kill): 2,350 mg/kg	Behavioral: Altered sleep time (including change in righting reflex) Behavioral: Convulsions or effect on seizure threshold Lung, Thorax, or Respiration: Dyspnea	JJANAX 29,43,1976
intraperitoneal rat	lethal dose (50 percent kill): 2,020 mg/kg	Behavioral: Altered sleep time (including change in righting reflex) Behavioral: Convulsions or effect on seizure threshold Lung, Thorax, or Respiration: Dyspnea	JJANAX 29,43,1976
oral mouse	lethal dose (50 percent kill): >10 mg/kg	Behavioral: Somnolence (general depressed activity)	JJANAX 29,43,1976
oral rat	lethal dose (50 percent kill): >5 gm/kg	Behavioral: Somnolence (general depressed activity)	JJANAX 29,43,1976
subcutaneous mouse	lethal dose (50 percent kill): 8,400 mg/kg	Behavioral: Convulsions or effect on seizure threshold	JJANAX 29,43,1976
subcutaneous rat	lethal dose (50 percent kill): >5 gm/kg	Behavioral: Convulsions or effect on seizure threshold	JJANAX 29,43,1976

OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
intramuscular rat	lowest published toxic dose: 2,800 mg/kg/32 day- intermittent	Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) Endocrine: Changes in adrenal weight	JJANAX 29,43,1976
intraperitoneal rat	lowest published toxic dose: 6,800 mg/kg/39 day- intermittent	Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) Kidney, Ureter, and Bladder: Other changes	JJANAX 29,43,1976

STANDARDS AND REGULATIONS:
ORGANIZATION	STANDARD	REFERENCE
N/R	N/R	N/R

NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION	STANDARD or SURVEY	REFERENCE
National Occupational Exposure Survey 1983	National Occupational Exposure Survey 1983: Hazard Code: X6089; Number of Industries 1; Total Number of Facilities 17; Number of Occupations 2; Total Number of Employees Exposed 958; Total Number of Female Employees Exposed 434

REFERENCES:
CODEN	REFERENCE
JJANAX	Japanese Journal of Antibiotics. (Japan Antibiotics Research Assoc., 2-20-8 Kamiosaki, Shinagawa-ku, Tokyo 141, Japan) V.21- 1968-
KSRNAM	Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960-