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| UPDATE: May 2008 | MW: N/R | MF: N/R |
SYNONYMS:
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SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
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| EFFECT
REFERENCE
|
N/R |
N/R
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N/R
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N/R
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MUTATION DATA AND REFERENCES:
SYSTEM TEST
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ROUTE/ | ORGANISM/ TISSUE
DOSE
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REFERENCE
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specific locus test
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oral | Drosophila melanogaster
12 pph/48 hour- continuous
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EMMUEG 45,90,2005
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heritable translocation test
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multiple | Drosophila melanogaster
12 pph/48 hour
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EMMUEG 45,90,2005
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REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
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| EFFECT
REFERENCE
|
intramuscular | rat
lowest published toxic dose: 1 mL/kg (1 day prior to copulation)
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Reproductive: Effects on fertility: Female fertility index (e.g., # females pregnant per # sperm positive females; # females pregnant per # females mated)
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EKFAE9 57,49,1994
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TUMORIGENIC DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
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| EFFECT
REFERENCE
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N/R |
N/R
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N/R
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N/R
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ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
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| EFFECT
REFERENCE
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intramuscular | rat
lowest published toxic dose: 1 mL/kg
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Endocrine: Effect on menstrual cycle | Reproductive: Maternal effects: Oogenesis Reproductive: Maternal effects: Uterus, cervix, vagina
EKFAE9 57,49,1994
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intravenous | mouse
lethal dose (50 percent kill): 22,100 mg/kg
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N/R
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NIIRDN 6,434,1982
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intravenous | rat
lethal dose (50 percent kill): 16,500 mg/kg
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N/R
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NIIRDN 6,434,1982
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OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
|
| EFFECT
REFERENCE
|
oral | mouse
lowest published toxic dose: 168 gm/kg/20 week- continuous
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Skin and Appendages: Other: Hair
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EXPDE* 12,30,2003
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REVIEWS:
ORGANIZATION
|
STANDARD
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REFERENCE
N/R
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N/R
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N/R
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STANDARDS AND REGULATIONS:
ORGANIZATION
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STANDARD
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REFERENCE
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988
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PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION
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FEREAC 54,7740,1989
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Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF
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PESTICIDES: RED Completed
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RBREV* -,344,1998
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NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION
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STANDARD or SURVEY
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REFERENCE
National Occupational Hazard Survey 1974
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National Occupational Hazard Survey 1974: Hazard Code: M0682; | Number of Industries 169; Total Number of Facilities 23,566; Number of Occupations 112; Total Number of Employees Exposed 264,305
National Occupational Exposure Survey 1983
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National Occupational Exposure Survey 1983: Hazard Code: M0682 |
Number of Industries 119; Total Number of Facilities 16,607; Number of Occupations 119; Total Number of Employees Exposed 314,419; Total Number of Female Employees Exposed 142,134 | ||||
STATUS IN FEDERAL AGENCIES:
ORGANIZATION
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REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
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Used as a food and feed additive, flavor, cosmetic and perfume ingredient
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EPA TSCA Section 8(d) unpublished health/safety studies
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EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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REFERENCES:
CODEN
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REFERENCE
EKFAE9
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Eksperimental'naya i Klinicheskaya Farmakologiya. Experimental and Clinical Pharmacology.
(Mezhdunarodnaya Kniga, ul. B. Yakimanka, 39, 117049 Moscow, Russia) V.55- 1992-
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EMMUEG
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Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY
10003) V.10- 1987-
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EXPDE*
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Experimental dermatology (Copenhagen : Munksgaard) V.1- 1992-
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FEREAC
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Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
V.1- 1936-
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NIIRDN
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Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan)
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RBREV*
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Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report),
Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental
Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
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