RTECS:VV7336000 The Registry of Toxic Effects of Chemical Substances

Silica, crystalline - tripoli

RTECS #: VV7336000

CAS #: 1317-95-9

UPDATE: May 2009 MW: N/R MF: N/R

NOTE:

TOXICITY DATA HAVE NOT BEEN EVALUATED. OMISSION OF A SUBSTANCE OR NOTATION DOES NOT IMPLY ANY RELIEF FROM REGULATORY RESPONSIBILITY.

TABLE OF CONTENTS:

SYNONYMS:

OTHER MULTIPLE DOSE DATA:

REVIEWS:

STANDARDS AND REGULATIONS:

NIOSH DOCUMENTATION AND SURVEILLANCE:

STATUS IN FEDERAL AGENCIES:

REFERENCES:

SYNONYMS:

Randanite

Silica, crystalline - tripoli (ACGIH:OSHA)

Tripoli

SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

MUTATION DATA AND REFERENCES:
SYSTEM TEST ROUTE/
ORGANISM/
TISSUE DOSE REFERENCE
N/R N/R N/R N/R

REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

TUMORIGENIC DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
inhalation
rat lowest published toxic concentration: 100 mg/m³/3 day- intermittent Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Lung, Thorax, or Respiration: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases ARDSBL 141(Suppl),A3-A937,1990

REVIEWS:
ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.025 mg/m³ (respirable) DTLVS* TLV/BEI,2007
International Agency for Research on Cancer (IARC) Cancer Review Animal Sufficient Evidence IMEMDT 42,39,1987
International Agency for Research on Cancer (IARC) Cancer Review Human Limited Evidence IMEMDT 42,39,1987
International Agency for Research on Cancer (IARC) Cancer Review Group 2A IMSUDL 7,341,1987

STANDARDS AND REGULATIONS:
ORGANIZATION STANDARD
REFERENCE

Mine Safety and Health Administration (MSHA) STANDARD - respirable dust in air time-weighted average 10 mg/m³/% resp. SiO2+2 DTLWS* 3,33,1973
Mine Safety and Health Administration (MSHA) STANDARD - total dust in air time-weighted average 30 mg/m³/% SiO2+3 DTLWS* 3,33,1973
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 10 mg/m³/(% resp SiO2+2) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 10 mg/m³/(% resp SiO2+2) CFRGBR 29,1926.55,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 0.1 mg/m³, JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 0.1 mg/m³ (dust), MAR2002
Occupational Exposure Limit - JAPAN Occupational Exposure Limit- continuous 0.03 mg/m³ (respirable), APR2007
Occupational Exposure Limit - KOREA time-weighted average 0.1 mg/m³, 2006
Occupational Exposure Limit - MEXICO time-weighted average 0.1 mg/m³ (respirable), 2004
Occupational Exposure Limit - NEW ZEALAND time-weighted average 0.2 mg/m³ (respirable dust), JAN2002
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 0.025 mg/m³ (respirable)
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 0.025 mg/m³ (respirable)

NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO SILICA, crystalline tripoli-air Carcinogen;
10 hour time-weighted average 0.05 mg/m³ NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 74655;
Number of Industries 33;
Total Number of Facilities 3,594;
Number of Occupations 26;
Total Number of Employees Exposed 20,803
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X9247;
Number of Industries 1;
Total Number of Facilities 52;
Number of Occupations 1;
Total Number of Employees Exposed 156
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X9681;
Number of Industries 3;
Total Number of Facilities 90;
Number of Occupations 1;
Total Number of Employees Exposed 1,635
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 74655;
Number of Industries 29;
Total Number of Facilities 2,287;
Number of Occupations 19;
Total Number of Employees Exposed 22,615;
Total Number of Female Employees Exposed 3,267

STATUS IN FEDERAL AGENCIES:
ORGANIZATION
REFERENCE

NTP 9th Report on Carcinogens, 2000:Known to be human carcinogen
OSHA ANALYTICAL METHOD #ID213

REFERENCES:
CODEN
REFERENCE

ARDSBL American Review of Respiratory Disease. (American Lung Assoc., 1740 Broadway, New York, NY 10019) V.80- 1959-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
DTLWS* "Documentation of the Threshold Limit Values for Substances in Workroom Air," Supplements. For publisher information, see 85INA8.
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.

Used as buffing compound for silver, copper, brass, aluminum and zinc

RTECS Compound Description:
Tumorigen

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SYNONYMS:
Randanite Silica, crystalline - tripoli (ACGIH:OSHA)	Tripoli

SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
N/R	N/R	N/R	N/R

MUTATION DATA AND REFERENCES:
SYSTEM TEST	ROUTE/ ORGANISM/ TISSUE	DOSE	REFERENCE
N/R	N/R	N/R	N/R

REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
N/R	N/R	N/R	N/R

TUMORIGENIC DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
N/R	N/R	N/R	N/R

ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
N/R	N/R	N/R	N/R

OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
inhalation rat	lowest published toxic concentration: 100 mg/m³/3 day- intermittent	Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi Lung, Thorax, or Respiration: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases	ARDSBL 141(Suppl),A3-A937,1990

REVIEWS:
ORGANIZATION	STANDARD	REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value	time-weighted average 0.025 mg/m³ (respirable)	DTLVS* TLV/BEI,2007
International Agency for Research on Cancer (IARC) Cancer Review	Animal Sufficient Evidence	IMEMDT 42,39,1987
International Agency for Research on Cancer (IARC) Cancer Review	Human Limited Evidence	IMEMDT 42,39,1987
International Agency for Research on Cancer (IARC) Cancer Review	Group 2A	IMSUDL 7,341,1987

STANDARDS AND REGULATIONS:
ORGANIZATION	STANDARD	REFERENCE
Mine Safety and Health Administration (MSHA) STANDARD - respirable dust in air	time-weighted average 10 mg/m³/% resp. SiO2+2	DTLWS* 3,33,1973
Mine Safety and Health Administration (MSHA) STANDARD - total dust in air	time-weighted average 30 mg/m³/% SiO2+3	DTLWS* 3,33,1973
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)	8 hour time-weighted average 10 mg/m³/(% resp SiO2+2)	CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)	8 hour time-weighted average 10 mg/m³/(% resp SiO2+2)	CFRGBR 29,1926.55,1994
Occupational Exposure Limit - AUSTRALIA	time-weighted average 0.1 mg/m³, JUL2008
Occupational Exposure Limit - BELGIUM	time-weighted average 0.1 mg/m³ (dust), MAR2002
Occupational Exposure Limit - JAPAN	Occupational Exposure Limit- continuous 0.03 mg/m³ (respirable), APR2007
Occupational Exposure Limit - KOREA	time-weighted average 0.1 mg/m³, 2006
Occupational Exposure Limit - MEXICO	time-weighted average 0.1 mg/m³ (respirable), 2004
Occupational Exposure Limit - NEW ZEALAND	time-weighted average 0.2 mg/m³ (respirable dust), JAN2002
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN	American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value; time-weighted average 0.025 mg/m³ (respirable)
Occupational Exposure Limit IN SINGAPORE, VIETNAM	American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.025 mg/m³ (respirable)

NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION	STANDARD or SURVEY	REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO SILICA, crystalline tripoli-air	Carcinogen; 10 hour time-weighted average 0.05 mg/m³	NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974	National Occupational Hazard Survey 1974: Hazard Code: 74655; Number of Industries 33; Total Number of Facilities 3,594; Number of Occupations 26; Total Number of Employees Exposed 20,803
National Occupational Exposure Survey 1983	National Occupational Exposure Survey 1983: Hazard Code: X9247; Number of Industries 1; Total Number of Facilities 52; Number of Occupations 1; Total Number of Employees Exposed 156
National Occupational Exposure Survey 1983	National Occupational Exposure Survey 1983: Hazard Code: X9681; Number of Industries 3; Total Number of Facilities 90; Number of Occupations 1; Total Number of Employees Exposed 1,635
National Occupational Exposure Survey 1983	National Occupational Exposure Survey 1983: Hazard Code: 74655; Number of Industries 29; Total Number of Facilities 2,287; Number of Occupations 19; Total Number of Employees Exposed 22,615; Total Number of Female Employees Exposed 3,267

STATUS IN FEDERAL AGENCIES:
ORGANIZATION	REFERENCE
NTP 9th Report on Carcinogens, 2000:Known to be human carcinogen
OSHA ANALYTICAL METHOD #ID213

REFERENCES:
CODEN	REFERENCE
ARDSBL	American Review of Respiratory Disease. (American Lung Assoc., 1740 Broadway, New York, NY 10019) V.80- 1959-
CFRGBR	Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DTLVS*	The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
DTLWS*	"Documentation of the Threshold Limit Values for Substances in Workroom Air," Supplements. For publisher information, see 85INA8.
IMEMDT	IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
IMSUDL	IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979-
NIOSH*	National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.