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Silane, trichloro -

RTECS #: VV5950000

CAS #: 10025-78-2

UPDATE: February 2008 MW: 135.45 MF: Cl3HSi


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. ACUTE TOXICITY DATA:
  3. OTHER MULTIPLE DOSE DATA:
  4. REVIEWS:
  5. STANDARDS AND REGULATIONS:
  6. NIOSH DOCUMENTATION AND SURVEILLANCE:
  7. STATUS IN FEDERAL AGENCIES:
  8. REFERENCES:

SYNONYMS:

  1. Silane A - 19
  2. Silici - chloroforme (French)
  3. Siliciumchloroform (German)
  4. Silicochloroform
  1. Trichloorsilaan (Dutch)
  2. Trichloromonosilane
  3. Trichlorsilan (German)
  4. Triclorosilano (Italian)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mammal (species unspecified) 		lethal concentration (50 percent kill): 1 gm/m3 Lung, Thorax, or Respiration: Acute pulmonary edema

Liver: Fatty liver degeneration

Blood: Other changes 		TPKVAL 3,81,1961
inhalation
mammal (species unspecified) 		lethal concentration (50 percent kill): 1 gm/m3 Blood: Hemorrhage TPKVAL 3,81,1961
inhalation
mammal (species unspecified) 		lowest published lethal concentration: 0.8 gm/m3 Eye: Conjunctiva irritation

Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi 		TPKVAL 3,81,1961
inhalation
mammal (species unspecified) 		lowest published toxic concentration: 0.5 gm/m3 Behavioral: Convulsions or effect on seizure threshold

Vascular: Other changes

Lung, Thorax, or Respiration: Changes in pulmonary vascular resistance 		TPKVAL 3,81,1961
inhalation
mouse 		lethal concentration (50 percent kill): 1,500 mg/m3/2 hour N/R 85GMAT -,114,1982
inhalation
mouse 		lowest published toxic concentration: 0.8 gm/m3/2 hour N/R TPKVAL 3,73,1961
inhalation
mouse 		lowest published lethal concentration: 1.02 gm/m3/2 hour Skin: After systemic exposure: Dermatitis, other TPKVAL 3,73,1961
inhalation
mouse 		lethal concentration : 1.22 gm/m3/2 hour Peripheral Nerve and Sensation: Recording from peripheral motor nerve TPKVAL 3,73,1961
inhalation
mouse 		lethal concentration (50 percent kill): 1.52 gm/m3/2 hour Eye: Conjunctiva irritation

Eye: Corneal damage 		TPKVAL 3,73,1961
inhalation
rat 		lowest published lethal concentration: 500 ppm/4 hour N/R UCDS** 2/21/1979
ocular
rabbit 		lowest published toxic dose: 100 pph Eye: Conjunctiva irritation

Eye: Corneal damage 		TPKVAL 3,73,1961
ocular
rabbit 		lowest published toxic dose: 100 pph Eye: Other eye effects TPKVAL 3,81,1961
oral
rat 		lethal dose (50 percent kill): 1,030 mg/kg N/R JIHTAB 31,60,1949
skin
mouse 		lowest published toxic dose: 100 pph/1 minute Peripheral Nerve and Sensation: Recording from peripheral motor nerve

Skin: After topical application: Primary irritation 		TPKVAL 3,73,1961
skin
mouse 		lowest published toxic dose: 100 pph/2 minute Skin: After topical application: Corrosive TPKVAL 3,73,1961
skin
mouse 		lowest published toxic dose: 100 pph/1 minute Skin: After topical application: Primary irritation TPKVAL 3,81,1961
skin
rabbit 		lowest published toxic dose: 100 pph/1 hour Skin: After topical application: Corrosive TPKVAL 3,73,1961
skin
rabbit 		lowest published toxic dose: 100 pph Skin: After topical application: Corrosive TPKVAL 3,81,1961


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published toxic concentration: 0.25 gm/m3/182 day- intermittent Behavioral: Somnolence (general depressed activity)

Cardiac: Other changes

Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi 		TPKVAL 3,73,1961


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
TOXICOLOGY REVIEW
CHHSA* 9,6,2002


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Exposure Limit - RUSSIA short term exposure limit 1 mg/m3, Skin, JUN2003


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X3556;
Number of Industries 3;
Total Number of Facilities 23;
Number of Occupations 4;
Total Number of Employees Exposed 2,201;
Total Number of Female Employees Exposed 267


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982
CHHSA* Chemical Health & Safety (Orlando, FL : Published by Elsevier Inc. for the ACS Division of Chemical Health and Safety) V.1- 1994-
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU.
TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. (Izdatel'stvo Meditsina, Moscow, USSR) No.1- 1961-
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817)

NIOSH PROFILE (SILICON AND ITS COMPOUNDS), SRI, 2/77

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