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Silane, dichloromethylphenyl -

RTECS #: VV3530000

CAS #: 149-74-6

UPDATE: February 2008 MW: 191.14 MF: C7H8Cl2Si


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. ACUTE TOXICITY DATA:
  3. OTHER MULTIPLE DOSE DATA:
  4. STANDARDS AND REGULATIONS:
  5. NIOSH DOCUMENTATION AND SURVEILLANCE:
  6. STATUS IN FEDERAL AGENCIES:
  7. REFERENCES:

SYNONYMS:

  1. Dichlor - fenyl - methylsilane (Czech)
  2. Dichloromethylphenylsilane
  1. Phenylmethyldichlorosilane


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mammal (species unspecified) 		lethal concentration (50 percent kill): 150 mg/m3 Lung, Thorax, or Respiration: Acute pulmonary edema

Liver: Fatty liver degeneration

Blood: Other changes 		TPKVAL 3,81,1961
inhalation
mammal (species unspecified) 		lethal concentration (50 percent kill): 0.15 gm/m3 Eye: Conjunctiva irritation

Eye: Other eye effects 		TPKVAL 3,81,1961
inhalation
mammal (species unspecified) 		lowest published lethal concentration: 0.1 gm/m3 Eye: Conjunctiva irritation

Eye: Corneal damage 		TPKVAL 3,81,1961
inhalation
mammal (species unspecified) 		lowest published toxic concentration: 0.8 gm/m3 Eye: Conjunctiva irritation

Eye: Corneal damage 		TPKVAL 3,81,1961
inhalation
mammal (species unspecified) 		lowest published lethal concentration: 0.8 gm/m3 N/R TPKVAL 5,173,1963
inhalation
mammal (species unspecified) 		lethal concentration (50 percent kill): 0.15 gm/m3 N/R TPKVAL 5,173,1963
inhalation
mammal (species unspecified) 		lethal concentration : 0.22 gm/m3 N/R TPKVAL 5,173,1963
inhalation
mouse 		lowest published lethal concentration: 30 mg/m3/2 hour Lung, Thorax, or Respiration: Other changes

Liver: Fatty liver degeneration

Blood: Changes in spleen 		TPKVAL 3,61,1961
inhalation
mouse 		lowest published lethal concentration: 0.4 gm/m3/2 hour Brain and Coverings: Other degenerative changes

Vascular: Other changes

Lung, Thorax, or Respiration: Other changes 		TPKVAL 3,61,1961
intraperitoneal
mouse 		lethal dose : 100 mg/kg N/R TPKVAL 3,81,1961
intraperitoneal
rat 		lethal dose : 100 mg/kg N/R TPKVAL 3,81,1961
ocular
rabbit 		lowest published toxic dose: 100 pph/1 minute Eye: Conjunctiva irritation

Eye: Corneal damage 		TPKVAL 3,61,1961
ocular
rabbit 		lowest published toxic dose: 100 pph Eye: Conjunctiva irritation

Eye: Other eye effects 		TPKVAL 3,81,1961
subcutaneous
mouse 		lethal dose : 100 mg/kg N/R TPKVAL 3,81,1961
skin
mouse 		lowest published lethal dose: 100 pph/5 minute Skin: After topical application: Corrosive TPKVAL 3,61,1961
skin
mouse 		lowest published toxic dose: 100 pph/1 minute Skin: After topical application: Primary irritation TPKVAL 3,81,1961
skin
mouse 		lowest published lethal dose: 100 pph/5 minute Behavioral: Muscle weakness

Behavioral: Ataxia

Lung, Thorax, or Respiration: Changes in pulmonary vascular resistance 		TPKVAL 3,81,1961
skin
rabbit 		lowest published toxic dose: 100 pph/1 hour Skin: After topical application: Corrosive TPKVAL 3,61,1961
skin
rabbit 		lowest published toxic dose: 100 pph Skin: After topical application: Primary irritation TPKVAL 3,81,1961


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published toxic concentration: 0.15 gm/m3/3 hour/76 day- intermittent Peripheral Nerve and Sensation: Recording from peripheral motor nerve

Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		TPKVAL 3,61,1961
inhalation
rat 		lowest published toxic concentration: 0.15 gm/m3/3 hour/30 day- intermittent Lung, Thorax, or Respiration: Other changes

Biochemical: Metabolism (intermediary): Other 		TPKVAL 3,61,1961
inhalation
rat 		lowest published toxic concentration: 0.8 gm/m3/3 hour/152 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain TPKVAL 3,61,1961
inhalation
rat 		lowest published toxic concentration: 0.8 gm/m3/3 hour/60 week- intermittent Brain and Coverings: Other degenerative changes

Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Lung, Thorax, or Respiration: Changes in pulmonary vascular resistance 		TPKVAL 3,61,1961
inhalation
rat 		lowest published toxic concentration: 0.8 gm/m3/91 day- intermittent Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Lung, Thorax, or Respiration: Fibrosis (interstitial)

Liver: Other changes 		TPKVAL 3,81,1961


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Exposure Limit - RUSSIA short term exposure limit 1 mg/m3, Skin, JUN2003


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X5731;
Number of Industries 1;
Total Number of Facilities 23;
Number of Occupations 2;
Total Number of Employees Exposed 68;
Total Number of Female Employees Exposed 45


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY


REFERENCES:

CODEN
REFERENCE
TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. (Izdatel'stvo Meditsina, Moscow, USSR) No.1- 1961-

RTECS Compound Description:
   Organometallic

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