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Saponin

RTECS #: VQ1400000

CAS #: 8047-15-2

UPDATE: August 2003 MW: N/R MF: N/R


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. REPRODUCTIVE EFFECTS DATA:
  3. ACUTE TOXICITY DATA:
  4. NIOSH DOCUMENTATION AND SURVEILLANCE:
  5. STATUS IN FEDERAL AGENCIES:
  6. REFERENCES:

SYNONYMS:

  1. Crude saponine


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
rat 		lowest published toxic dose: 350 mg/kg (9-22 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) TRBMAV 30,319,1972


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published lethal concentration: 250 mg/m3/4 hour Olfaction: Other olfaction effects

Behavioral: Ataxia

Lung, Thorax, or Respiration: Dyspnea 		NTIS** OTS0590040
intravenous
cat 		lowest published lethal dose: 46 mg/kg N/R HBAMAK 4,1394,1935
intravenous
mouse 		lowest published lethal dose: 1 gm/kg N/R HBAMAK 4,1395,1935
intravenous
rat 		lowest published toxic dose: 100 mg/kg Cardiac: Pulse rate decreased with fall in BP

Vascular: BP lowering not characterized in autonomic section

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) 		CYLPDN 21,1095,2000
intravenous
rabbit 		lowest published lethal dose: 40 mg/kg N/R HBAMAK 4,1394,1935
oral
mouse 		lowest published lethal dose: 3 gm/kg N/R HBAMAK 4,1395,1935
subcutaneous
mouse 		lowest published lethal dose: 900 mg/kg N/R HBAMAK 4,1395,1935


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: A1126;
Number of Industries 2;
Total Number of Facilities 38;
Number of Occupations 3;
Total Number of Employees Exposed 730
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: A1126;
Number of Industries 7;
Total Number of Facilities 447;
Number of Occupations 11;
Total Number of Employees Exposed 3,396;
Total Number of Female Employees Exposed 1,448


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
CYLPDN Zhongguo Yaoli Xuebao. Acta Pharmacologica Sinica. Chinese Journal of Pharmacology. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.1- 1980-
HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." (Leipzig, Ger. Dem. Rep.)
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
TRBMAV Texas Reports on Biology and Medicine. (Galveston, TX) V.1-41(2), 1943-81/82. Discontinued.

RTECS Compound Description:
   Reproductive Effector
   Natural Product

ALT CAS #: 11006-75-0
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