CDC logo, Safer Healthier People CDC HomeCDC SearchCDC Health Topics A-Z
NIOSH - National Institute for Occupational Safety and Health

Search NIOSH  |  NIOSH Home  |  NIOSH Topics  |  Site Index  |  Databases and Information Resources  |  NIOSH Products  |  Contact Us




Salicylic acid, acetate

RTECS #: VO0700000

CAS #: 50-78-2

UPDATE: May 2009 MW: 180.17 MF: C9H8O4


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. 2 - (Acetyloxy) benzoic acid
  2. 2 - Acetoxybenzoic acid
  3. A.S.A.
  4. A.S.A. empirin
  5. AC 5230
  6. ASA
  7. Acenterine
  8. Acesal
  9. Aceticyl
  10. Acetilsalicilico
  11. Acetilum acidulatum
  12. Acetisal
  13. Acetol
  14. Acetonyl
  15. Acetophen
  16. Acetosal
  17. Acetosalic acid
  18. Acetosalin
  19. Acetylin
  20. Acetylsal
  21. Acetylsalicylic acid
  22. Acetylsalicylic acid (ACGIH)
  23. Acetylsalicylsaure (German)
  24. Acide acetylsalicylique (French)
  25. Acido O - acetil - benzoico (Italian)
  26. Acido acetilsalicilico (Italian)
  27. Acidum acetylsalicylicum
  28. Acimetten
  29. Acisal
  30. Acylpyrin
  31. Asagran
  32. Aspergum
  33. Aspirdrops
  34. Aspirin
  35. Aspirina 03
  36. Aspro Clear
  37. Asteric
  38. Benaspir
  39. Benzoic acid, 2 - (acetyloxy) - (9CI)
  1. Bialpirinia
  2. Caprin
  3. Colfarit
  4. Contrheuma retard
  5. Delgesic
  6. Dolean pH 8
  7. Duramax
  8. ECM
  9. Ecotrin
  10. Empirin
  11. Endydol
  12. Entericin
  13. Enterosarine
  14. Entrophen
  15. Globoid
  16. Helicon
  17. Idragin
  18. Istopirin
  19. Kapsazal
  20. Kyselina 2 - acetoxybenzoova (Czech)
  21. Kyselina acetylsalicylova (Czech)
  22. Measurin
  23. Medisyl
  24. Micristin
  25. Neuronika
  26. Novid
  27. Polopiryna
  28. Rheumin tabletten
  29. Rhonal
  30. Salacetin
  31. Salcetogen
  32. Saletin
  33. Solpyron
  34. Triple - sal
  35. Xaxa
  36. Yasta
  37. Zorprin
  38. o - Acetoxybenzoic acid
  39. o - Carboxyphenyl acetate


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis hamster lung 1,660 mg/L GMCRDC 27,95,1981
cytogenetic analysis human fibroblast 100 mg/L ACYTAN 16,41,1972
cytogenetic analysis human leukocyte 100 µg/L SCIEAS 171,829,1971
cytogenetic analysis human lymphocyte 10 mg/L BEXBAN 78,1194,1974
DNA inhibition human lymphocyte 100 µmol/L FEPRA7 36,1748,1977
DNA repair Bacillus subtilis 5 mg/disc JNUDAT 34,183,1992
morphological transform rat embryo 108 µg/plate JJATDK 1,190,1981
other mutation test systems human lymphocyte 75 mg/L NEZAAQ 37,673,1982
sister chromatid exchange intraperitoneal
mouse 		100 mg/kg MUREAV 370,1,1996


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intrauterine
rat 		lowest published toxic dose: 2 mg/kg (4 day pregnant) Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea) CCPTAY 24,283,1981
oral
cat 		lowest published toxic dose: 300 mg/kg (10-15 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system 		TJADAB 14,21,1976
oral
dog 		lowest published toxic dose: 3,200 mg/kg (23-30 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system

Reproductive: Specific developmental abnormalities: Cardiovascular (circulatory) system

Reproductive: Specific developmental abnormalities: Respiratory system 		TJADAB 20,313,1979
oral
mouse 		lowest published toxic dose: 1,200 mg/kg (8-9 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue) 		LANCAO 1,606,1965
oral
mouse 		lowest published toxic dose: 800 mg/kg (17 day pregnant) Reproductive: Effects on embryo or fetus: Fetal death

Reproductive: Other effects to embryo or fetus

Reproductive: Other developmental abnormalities 		APTOA6 29,250,1971
oral
mouse 		lowest published toxic dose: 19,200 mg/kg (6-21 day pregnant) Reproductive: Effects on newborn: Stillbirth

Reproductive: Effects on newborn: Other neonatal measures or effects 		LANCAO 1,565,1964
oral
mouse 		lowest published toxic dose: 2,500 mg/kg (6-15 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system 		TXCYAC 37,315,1985
oral
mouse 		lowest published toxic dose: 3,825 mg/kg (1 day pregnant-30 day after birth) Reproductive: Effects on newborn: Other postnatal measures or effects BJCAAI 88,1480,2003
oral
rat 		lowest published toxic dose: 1 gm/kg (12 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetal death 		TJADAB 27,261,1983
oral
rat 		lowest published toxic dose: 2,100 mg/kg (14 day male) Reproductive: Paternal effects: Testes, epididymis, sperm duct IJEBA6 18,1408,1980
oral
rat 		lowest published toxic dose: 200 mg/kg (9 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) TJADAB 16,127,1977
oral
rat 		lowest published toxic dose: 10 mg/kg (22 day pregnant) Reproductive: Maternal effects: Parturition

Reproductive: Effects on newborn: Stillbirth

Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth) 		NATUAS 240,21,1972
oral
rat 		lowest published toxic dose: 500 mg/kg (9 day pregnant) Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Specific developmental abnormalities: Eye, ear

Reproductive: Specific developmental abnormalities: Musculoskeletal system 		ANREAK 163,175,1969
oral
rat 		lowest published toxic dose: 125 mg/kg (12 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system TJADAB 27,261,1983
oral
rat 		lowest published toxic dose: 1 gm/kg (3 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) YHHPAL 31,416,1996
oral
rat 		lowest published toxic dose: 250 mg/kg (9 day pregnant) Reproductive: Specific developmental abnormalities: Cardiovascular (circulatory) system

Reproductive: Specific developmental abnormalities: Respiratory system

Reproductive: Other developmental abnormalities 		TOXID9 60,220,2001
oral
rat 		lowest published toxic dose: 500 mg/kg (10 day pregnant) Reproductive: Specific developmental abnormalities: Cardiovascular (circulatory) system

Reproductive: Specific developmental abnormalities: Respiratory system

Reproductive: Other developmental abnormalities 		TOXID9 60,220,2001
oral
rat 		lowest published toxic dose: 500 mg/kg (11 day pregnant) Reproductive: Specific developmental abnormalities: Cardiovascular (circulatory) system TOXID9 60,220,2001
oral
rat 		lowest published toxic dose: 3,000 mg/kg (6-17 day pregnant) Reproductive: Specific developmental abnormalities: Respiratory system

Reproductive: Other developmental abnormalities 		TOXID9 60,220,2001
oral
rat 		lowest published toxic dose: 720 mg/kg (18-21 day pregnant) Reproductive: Effects on newborn: Other postnatal measures or effects TXCYAC 232,257,2007
oral
rat 		lowest published toxic dose: 250 mg/kg (9 day pregnant) Reproductive: Effects on embryo or fetus: Fetal death BDERB* 68,27,2003
oral
rat 		lowest published toxic dose: 500 mg/kg (9 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system 		BDERB* 68,27,2003
oral
rat 		lowest published toxic dose: 500 mg/kg (9 day pregnant) Reproductive: Specific developmental abnormalities: Cardiovascular (circulatory) system

Reproductive: Other developmental abnormalities 		BDERB* 68,27,2003
oral
rat 		lowest published toxic dose: 625 mg/kg (9 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system BDERB* 68,27,2003
oral
rat 		lowest published toxic dose: 625 mg/kg (10 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetal death

Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue) 		BDERB* 68,27,2003
oral
rat 		lowest published toxic dose: 625 mg/kg (10 day pregnant) Reproductive: Specific developmental abnormalities: Cardiovascular (circulatory) system BDERB* 68,27,2003
oral
rat 		lowest published toxic dose: 500 mg/kg (10 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) BDERB* 68,27,2003
oral
rat 		lowest published toxic dose: 750 mg/kg (10 day pregnant) Reproductive: Other developmental abnormalities BDERB* 68,27,2003
oral
rat 		lowest published toxic dose: 500 mg/kg (11 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) BDERB* 68,27,2003
oral
rat 		lowest published toxic dose: 750 mg/kg (11 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetal death

Reproductive: Specific developmental abnormalities: Musculoskeletal system 		BDERB* 68,27,2003
oral
rat 		lowest published toxic dose: 750 mg/kg (11 day pregnant) Reproductive: Specific developmental abnormalities: Urogenital system BDERB* 68,27,2003
oral
rat 		lowest published toxic dose: 600 mg/kg (6-17 day pregnant) Reproductive: Effects on embryo or fetus: Fetal death BDERB* 68,27,2003
oral
rat 		lowest published toxic dose: 3,000 mg/kg (6-17 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Extra embryonic structures (e.g., placenta, umbilical cord)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) 		BDERB* 68,27,2003
oral
rat 		lowest published toxic dose: 3,000 mg/kg (6-17 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system

Reproductive: Specific developmental abnormalities: Cardiovascular (circulatory) system 		BDERB* 68,27,2003
oral
rat 		lowest published toxic dose: 3,000 mg/kg (6-17 day pregnant) Reproductive: Specific developmental abnormalities: Gastrointestinal system

Reproductive: Specific developmental abnormalities: Urogenital system

Reproductive: Other developmental abnormalities 		BDERB* 68,27,2003
oral
rabbit 		lowest published toxic dose: 800 mg/kg (8-15 day pregnant) Reproductive: Specific developmental abnormalities: Body wall

Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)

Reproductive: Specific developmental abnormalities: Musculoskeletal system 		BANMAC 159,433,1975
oral
rabbit 		lowest published toxic dose: 1,800 mg/kg (8-16 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system

Reproductive: Specific developmental abnormalities: Cardiovascular (circulatory) system

Reproductive: Effects on embryo or fetus: Fetal death 		TXAPA9 10,244,1967
oral
rabbit 		lowest published toxic dose: 1,750 mg/kg (6-12 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) LANCAO 1,763,1964
oral
rabbit 		lowest published toxic dose: 600 mg/kg (2 day prior to copulation) Reproductive: Effects on fertility: Other measures of fertility JJPAAZ 28,909,1978
oral
rabbit 		lowest published toxic dose: 4,550 mg/kg (7-19 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) BDERB* 68,38,2003
oral
woman 		lowest published toxic dose: 7,500 mg/kg (34-37 week pregnant) Reproductive: Other effects on female

Reproductive: Effects on newborn: Stillbirth 		AJPEEK 15,39,1998
oral
woman 		lowest published toxic dose: 700 mg/kg (35-36 week pregnant) Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Specific developmental abnormalities: Cardiovascular (circulatory) system

Reproductive: Effects on newborn: Biochemical and metabolic 		CPEDAM 34,174,1995
oral
woman 		lowest published toxic dose: 546 mg/kg (37-39 week pregnant) Reproductive: Effects on newborn: Other postnatal measures or effects CPEDAM 32,740,1993
oral
woman 		lowest published toxic dose: 546 mg/kg (37-39 week pregnant) Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)

Reproductive: Other developmental abnormalities 		CPEDAM 32,740,1993
oral
woman 		lowest published toxic dose: 17,550 mg/kg (12-39 week pregnant) Reproductive: Maternal effects: Parturition LANCAO 2,1159,1973
oral
woman 		lowest published toxic dose: 100 mg/kg (37 week pregnant) Reproductive: Effects on newborn: Other neonatal measures or effects NEJMAG 307,909,1982
oral
woman 		lowest published toxic dose: 17,280 mg/kg (1-39 week pregnant) Reproductive: Specific developmental abnormalities: Cardiovascular (circulatory) system

Reproductive: Specific developmental abnormalities: Respiratory system

Reproductive: Effects on newborn: Apgar score (human only) 		JOPDAB 92,478,1978
oral
woman 		lowest published toxic dose: 189 mg/kg (12-39 week pregnant) Reproductive: Maternal effects: Parturition

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Blood and lymphatic systems (including spleen and marrow) 		NEJMAG 321,357,1989
subcutaneous
mouse 		lowest published toxic dose: 500 mg/kg (11 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) JTSCDR 7,177,1982
subcutaneous
rat 		lowest published toxic dose: 1,800 mg/kg (12 day male) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct 		INJFA3 23,282,1978
subcutaneous
rat 		lowest published toxic dose: 380 mg/kg (9 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Other developmental abnormalities 		BCPCA6 22,407,1973
subcutaneous
rat 		lowest published toxic dose: 500 mg/kg (11 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetal death

Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue) 		RCOCB8 38,209,1982
subcutaneous
rat 		lowest published toxic dose: 500 mg/kg (11 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system RCOCB8 38,209,1982
subcutaneous
rat 		lowest published toxic dose: 500 mg/kg (11 day pregnant) Reproductive: Effects on embryo or fetus: Extra embryonic structures (e.g., placenta, umbilical cord)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue) 		RCOCB8 39,179,1983
subcutaneous
rat 		lowest published toxic dose: 300 mg/kg (1 day prior to copulation) Reproductive: Effects on fertility: Other measures of fertility PRGLBA 1,3,1972
unreported route
dog 		lowest published toxic dose: 3 gm/kg (20-34 day pregnant) Reproductive: Effects on embryo or fetus: Fetal death JZKEDZ 6,37,1980
unreported route
rat 		lowest published toxic dose: 3,500 mg/kg (6-15 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system

Reproductive: Other developmental abnormalities 		JACTDZ 2(4),325,1983
unreported route
rabbit 		lowest published toxic dose: 11,250 mg/kg (16-30 day pregnant) Reproductive: Effects on embryo or fetus: Fetal death AKGIAO 43(12),10,1967
unreported route
woman 		lowest published toxic dose: 1,200 mg/kg (20 day prior to copulation) Reproductive: Maternal effects: Menstrual cycle changes or disorders CCPTAY 29,181,1984


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lowest published lethal dose: 1,216 mg/kg N/R PCJOAU 34,353,2000
intraperitoneal
mouse 		lowest published toxic dose: 100 mg/kg Gastrointestinal: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes

Biochemical: Metabolism (intermediary): Histamines (including liberation not immunochemical in origin) 		EJPHAZ 460,63,2003
intraperitoneal
mouse 		lethal dose (50 percent kill): 167 mg/kg N/R USXXAM #6656449
intraperitoneal
mouse 		lowest published toxic dose: 10 mg/kg Behavioral: Change in psychophysiological tests PSCHDL 171,382,2004
intraperitoneal
mouse 		lowest published toxic dose: 250 mg/kg Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation FRMCE8 60,955,2005
intraperitoneal
mouse 		lowest published toxic dose: 39.15 mg/kg Behavioral: Analgesia FRMCE8 60,961,2005
intraperitoneal
rat 		lethal dose (50 percent kill): 340 mg/kg N/R NYKZAU 62,11,1966
intraperitoneal
rat 		lowest published toxic dose: 100 mg/kg Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation BJPCBM 129,343,2000
intraperitoneal
rat 		lowest published toxic dose: 50 mg/kg Behavioral: Analgesia BJPCBM 129,343,2000
intraperitoneal
rat 		lowest published toxic dose: 500 mg/kg Liver: Other changes

Biochemical: Metabolism (intermediary): Lipids including transport 		EKFAE9 59,43,1996
intravenous
dog 		lethal dose (50 percent kill): 681 mg/kg Behavioral: Analgesia AIPTAK 149,571,1964
intravenous
guinea pig 		lowest published toxic dose: 2 mg/kg Blood: Change in clotting factors EJPHAZ 498,179,2004
intravenous
human 		lowest published toxic dose: 14.3 mg/kg Behavioral: Analgesia EJNSC* 26,1344,2007
intravenous
monkey 		lowest published toxic dose: 1 mg/kg Blood: Change in clotting factors PHMCAA 70,100,2004
intravenous
mouse 		lowest published toxic dose: 10 mg/kg Vascular: Measurement of regional blood flow EJPHAZ 455,53,2002
intravenous
mouse 		lowest published toxic dose: 250 mg/kg Vascular: Measurement of regional blood flow

Gastrointestinal: Other changes

Blood: Other changes 		BJPCBM 143,193,2004
intravenous
mouse 		lowest published toxic dose: 30 mg/kg Blood: Hemorrhage TOXIA6 51,1131,2008
intravenous
rat 		lethal dose (50 percent kill): 495 mg/kg N/R GWXXAW #4101325
intravenous
rat 		lowest published toxic dose: 30 mg/kg Blood: Change in clotting factors TOXIA6 51,1131,2008
oral
child 		lowest published toxic dose: 10 mg/kg/1 day- intermittent Lung, Thorax, or Respiration: Acute pulmonary edema

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Kidney, Ureter, and Bladder: Urine volume decreased or anuria 		CTOXAO 18,247,1981
oral
child 		lowest published lethal dose: 104 mg/kg Lung, Thorax, or Respiration: Acute pulmonary edema

Gastrointestinal: Nausea or vomiting

Blood: Hemorrhage 		LANCAO 2,809,1952
oral
child 		lowest published toxic dose: 39 mg/kg/13 day- intermittent Liver: Hepatitis (hepatocellular necrosis), diffuse AJDCAI 139,453,1985
oral
child 		lowest published toxic dose: 780 mg/kg Cardiac: Cardiomyopathy including infarction

Lung, Thorax, or Respiration: Acute pulmonary edema

Kidney, Ureter, and Bladder: Hematuria 		JEMME* 13,657,1995
oral
dog 		lethal dose (50 percent kill): 700 mg/kg Behavioral: Altered sleep time (including change in righting reflex)

Lung, Thorax, or Respiration: Respiratory depression 		ARZNAD 21,719,1971
oral
guinea pig 		lethal dose (50 percent kill): 1,075 mg/kg Behavioral: Altered sleep time (including change in righting reflex)

Behavioral: Somnolence (general depressed activity)

Behavioral: Tremor 		JAPMA8 47,479,1958
oral
hamster 		lethal dose (50 percent kill): 3,500 mg/kg N/R ATSUDG 7,365,1984
oral
human 		lowest published toxic dose: 669 mg/kg/11 day Liver: Liver function tests impaired AJHPA9 35,330,1978
oral
human 		lowest published toxic dose: 2,880 mg/kg/8 week Ear: Tinnitus

Gastrointestinal: Nausea or vomiting

Gastrointestinal: Decreased motility or constipation 		ARZNAD 33,631,1983
oral
human 		lowest published toxic dose: 480 mg/kg/7 day- intermittent Ear: Tinnitus

Behavioral: Somnolence (general depressed activity)

Gastrointestinal: Other changes 		ARZNAD 25,281,1975
oral
human 		lowest published toxic dose: 1,050 mg/kg/14 day- intermittent Vascular: Other changes CLPTAT 67,530,2000
oral
human 		lowest published toxic dose: 5.4 mg/kg Vascular: Other changes

Blood: Other changes 		CLPTAT 67,299,2000
oral
human 		lowest published toxic dose: 1.2 mg/kg Blood: Change in clotting factors

Blood: Other changes 		EJPHAZ 499,315,2004
oral
human 		lowest published toxic dose: 2.7 mg/kg Kidney, Ureter, and Bladder: Other changes in urine composition

Immunological Including Allergic: Other immediate (humoral): uticaria, allergic rhinitis, serum sickness (multiple organ involvement)

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation 		JACIBY 113,771,2004
oral
human 		lowest published toxic dose: 2.14 mg/kg Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Blood: Other changes

Biochemical: Metabolism (intermediary): Lipids including transport 		FCLPH* 17,363,2003
oral
infant 		lowest published toxic dose: 120 mg/kg Lung, Thorax, or Respiration: Respiratory stimulation

Kidney, Ureter, and Bladder: Hematuria

Nutritional and Gross Metabolic: Dehydration 		BMJOAE 1,1081,1979
oral
mammal (species unspecified) 		lethal dose (50 percent kill): 1,750 mg/kg N/R IJMRAQ 81,621,1985
oral
man 		lowest published toxic dose: 13,036 mg/kg/5 year- intermittent Gastrointestinal: Other changes

Musculoskeletal: Joints

Skin: After systemic exposure: Dermatitis, other 		AIMEAS 126,665,1997
oral
man 		lowest published toxic dose: 857 mg/kg Behavioral: Coma

Lung, Thorax, or Respiration: Respiratory stimulation 		HUTODJ 7,161,1988
oral
man 		lowest published toxic dose: 1,625 mg/kg Behavioral: Coma

Nutritional and Gross Metabolic: Body temperature increase 		CPEDAM 24,678,1985
oral
mouse 		lowest published toxic dose: 90 mg/kg Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation FATOAO 54,47,1991
oral
mouse 		lowest published toxic dose: 300 mg/kg Gastrointestinal: Ulceration or bleeding from stomach PCJOAU 36,11,2002
oral
mouse 		lowest published toxic dose: 23 mg/kg Behavioral: Analgesia JPETAB 303,340,2002
oral
mouse 		lowest published toxic dose: 200 mg/kg Gastrointestinal: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes

Biochemical: Metabolism (intermediary): Histamines (including liberation not immunochemical in origin) 		EJPHAZ 460,63,2003
oral
mouse 		lethal dose (50 percent kill): 250 mg/kg N/R USXXAM #6656449
oral
mouse 		lowest published lethal dose: 1,216 mg/kg N/R FRMCE8 60,203,2005
oral
mouse 		lowest published toxic dose: 100 mg/kg Behavioral: Change in psychophysiological tests JPETAB 307,699,2003
oral
mouse 		lowest published toxic dose: 200 mg/kg Behavioral: Analgesia

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation 		BPBLEO 30,465,2007
oral
rat 		lowest published toxic dose: 150 mg/kg Behavioral: Abuse INJPD2 33,350,2001
oral
rat 		lowest published toxic dose: 17 mg/kg Behavioral: Analgesia FATOAO 51,78,1988
oral
rat 		lowest published toxic dose: 250 mg/kg Gastrointestinal: Alteration in gastric secretion

Gastrointestinal: Ulceration or bleeding from stomach 		FCLPH* 16,311,2002
oral
rat 		lethal dose (50 percent kill): 200 mg/kg N/R USXXAM #6656449
oral
rat 		lowest published toxic dose: 120 mg/kg Gastrointestinal: Necrotic changes

Blood: Hemorrhage

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation 		JMCMAR 46,747,2003
oral
rat 		lowest published toxic dose: 50 mg/kg Spinal Cord: Other degenerative changes PHMCAA 69,123,2003
oral
rat 		lowest published toxic dose: 200 mg/kg Gastrointestinal: Ulceration or bleeding from stomach

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation 		INJPD2 38,397,2006
oral
rat 		lowest published toxic dose: 300 mg/kg Nutritional and Gross Metabolic: Body temperature decrease INJPD2 38,408,2006
oral
rat 		lowest published toxic dose: 50 mg/kg Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation PHREP* 57,802,2005
oral
rat 		lowest published toxic dose: 100 mg/kg Behavioral: Analgesia

Gastrointestinal: Ulceration or bleeding from stomach

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation 		PHREP* 57,802,2005
oral
rat 		lowest published toxic dose: 250 mg/kg Gastrointestinal: Ulceration or bleeding from stomach FTRPAE 70,542,1999
oral
rabbit 		lethal dose (50 percent kill): 1,010 mg/kg Behavioral: Change in motor activity (specific assay) GTPZAB 24(3),43,1980
oral
rabbit 		lowest published toxic dose: 500 mg/kg Gastrointestinal: Ulceration or bleeding from stomach

Gastrointestinal: Hypermotility, diarrhea

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		BDERB* 68,38,2003
oral
woman 		lowest published toxic dose: 525 mg/kg/5 day- intermittent Liver: Hepatitis (hepatocellular necrosis), diffuse AIMEAS 80,74,1974
oral
woman 		lowest published toxic dose: 480 mg/kg/5 day- intermittent Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Biochemical: Metabolism (intermediary): Other 		NEJMAG 296,418,1977
oral
woman 		lowest published toxic dose: 800 mg/kg Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Musculoskeletal: Other changes 		AJEMEN 7,409,1989
oral
woman 		lowest published toxic dose: 194.4 mg/kg Ear: Tinnitus

Gastrointestinal: Nausea or vomiting 		APHRER 38,1186,2004
oral
woman 		lowest published toxic dose: 194.4 mg/kg Ear: Tinnitus

Gastrointestinal: Other changes

Blood: Other changes 		APHRER 38,1186,2004
oral
woman 		lowest published toxic dose: 13 mg/kg Vascular: Other changes

Immunological Including Allergic: Other immediate (humoral): uticaria, allergic rhinitis, serum sickness (multiple organ involvement) 		APHRER 39,944,2005
rectal
rat 		lethal dose (50 percent kill): 790 mg/kg N/R 34ZIAG -,67,1969
rectal
woman 		lowest published toxic dose: 4,550 mg/kg Brain and Coverings: Encephalitis

Behavioral: Coma

Cardiac: Arrythmias (indlucing changes in conduction) 		APHRER 28,467,1994
subcutaneous
mouse 		lethal dose (50 percent kill): 1,020 mg/kg N/R CPBTAL 28,1237,1980
subcutaneous
mouse 		lowest published toxic dose: 100 mg/kg Behavioral: Analgesia FTRPAE 73,375,2002
skin
mouse 		lowest published toxic dose: 50 mg/kg Immunological Including Allergic: Decrease in cellular immune response FATOAO 47,84,1984
skin
rat 		lowest published toxic dose: 50 mg/kg Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation FATOAO 47,84,1984
unreported route
man 		lowest published lethal dose: 294 mg/kg N/R 85DCAI 2,73,1970
unreported route
mouse 		lethal dose (50 percent kill): 1,350 mg/kg N/R USXXAM #5240918


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published toxic concentration: 25 mg/m3/4 hour/17 week- intermittent Brain and Coverings: Recordings from specific areas of CNS

Blood: Change in clotting factors

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) 		GTPZAB 24(3),43,1980
intraperitoneal
rat 		lowest published toxic dose: 8,750 mg/kg/21 day- intermittent Kidney, Ureter, and Bladder: Changes in both tubules and glomeruli JDGRAX 19,327,1990
intraperitoneal
rat 		lowest published toxic dose: 60 mg/kg/3 day- intermittent Gastrointestinal: Ulceration or bleeding from stomach CPBTAL 55,76,2007
oral
dog 		lowest published toxic dose: 1,200 mg/kg/2 day- intermittent Blood: Change in clotting factors FATOBP 159,19,1986
oral
dog 		lowest published toxic dose: 12,000 mg/kg/10 day- intermittent Blood: Change in clotting factors FATOAO 49,49,1986
oral
human 		lowest published toxic dose: 85.8 mg/kg/30 day- intermittent Gastrointestinal: Ulceration or bleeding from duodeum NEJMAG 343,834,2000
oral
human 		lowest published toxic dose: 10 mg/kg/7 day- intermittent Gastrointestinal: Ulceration or bleeding from stomach EJCPAS -,S85,2002
oral
human 		lowest published toxic dose: 261.507 mg/kg/183 day- intermittent Blood: Change in clotting factors NSAPCC 372(Suppl 1),147,2006
oral
human 		lowest published toxic dose: 6.4 mg/kg/3 day- intermittent Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Blood: Other changes

Biochemical: Metabolism (intermediary): Lipids including transport 		FCLPH* 17,363,2003
oral
man 		lowest published toxic dose: 2,555 mg/kg/5 year- intermittent Blood: Eosinophilia APHRER 38,2172,2004
oral
man 		lowest published toxic dose: 8,395 mg/kg/5 year- intermittent Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands JNCIEQ 97,975,2005
oral
mouse 		lowest published toxic dose: 12,600 mg/kg/7 day- intermittent Blood: Normocytic anemia

Blood: Changes in bone marrow not included in above

Blood: Changes in leukocyte (WBC) count 		INJPD2 36,226,2004
oral
mouse 		lowest published toxic dose: 22,500 mg/kg/25 week- intermittent Blood: Normocytic anemia

Blood: Changes in bone marrow not included in above

Blood: Changes in leukocyte (WBC) count 		INJPD2 36,226,2004
oral
rat 		lowest published toxic dose: 200 mg/kg/4 day- intermittent Gastrointestinal: Ulceration or bleeding from stomach TXAPA9 52,454,1980
oral
rat 		lowest published toxic dose: 8,127 mg/kg/43 week- continuous Kidney, Ureter, and Bladder: Other changes in urine composition APTOA6 26,105,1968
oral
rat 		lowest published toxic dose: 9,500 mg/kg/3 week- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field JPETAB 89,205,1947
oral
rat 		lowest published toxic dose: 2,500 mg/kg/10 day- intermittent Endocrine: Hypoglycemia

Blood: Other changes 		FATOBP 159,75,1986
oral
rat 		lowest published toxic dose: 5,000 mg/kg/10 day- intermittent Endocrine: Other changes

Blood: Other changes 		FATOBP 159,75,1986
oral
rat 		lowest published toxic dose: 32.4 mg/kg/3 day- intermittent Blood: Change in clotting factors EKFAE9 62,38,1999
oral
rat 		lowest published toxic dose: 560 mg/kg/4 week- continuous Skin and Appendages: Tumors

Tumorigenic: Protects against induction of experimental tumors

Tumorigenic: Active as anti-cancer agent 		CALEDQ 143,195,1999
oral
rat 		lowest published toxic dose: 1,500 mg/kg/2 week- intermittent Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) 		TXCYAC 188,161,2003
oral
rat 		lowest published toxic dose: 180 mg/kg/10 day- intermittent Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) EJPHAZ 477,59,2003
oral
rat 		lowest published toxic dose: 450 mg/kg/15 day- intermittent Gastrointestinal: Ulceration or bleeding from stomach JPETAB 311,1264,2004
oral
rat 		: 150 mg/kg/5 day- intermittent Vascular: Other changes

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation 		ACPSI* 25,1633,2004
oral
rat 		lowest published toxic dose: 2,100 mg/kg/21 day- intermittent Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation EJPHAZ 551,131,2006
oral
rat 		lowest published toxic dose: 1,440 mg/kg/4 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		TXCYAC 232,257,2007
oral
rat 		lowest published toxic dose: 360 mg/kg/4 day- intermittent Reproductive: Other effects on female TXCYAC 232,257,2007
oral
rat 		lowest published toxic dose: 1,400 mg/kg/2 week- intermittent Cardiac: Other changes

Kidney, Ureter, and Bladder: Changes primarily in glomeruli

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		HETOEA 22,143,2003
oral
rat 		lowest published toxic dose: 7,056 mg/kg/42 week- continuous Tumorigenic: Active as anti-cancer agent CNREA8 66,4542,2006
oral
rat 		lowest published toxic dose: 875 mg/kg/7 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain BDERB* 68,27,2003
oral
rat 		lowest published toxic dose: 400 mg/kg/2 day- intermittent Blood: Hemorrhage EJPHAZ 587,209,2008
oral
rabbit 		lowest published toxic dose: 3,250 mg/kg/13 day- intermittent Behavioral: Somnolence (general depressed activity)

Gastrointestinal: Hypermotility, diarrhea 		BDERB* 68,38,2003
oral
rabbit 		lowest published toxic dose: 2,500 mg/kg/10 day- intermittent Gastrointestinal: Other changes

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		BDERB* 68,38,2003
oral
rabbit 		lowest published toxic dose: 1,750 mg/kg/7 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain BDERB* 68,38,2003
oral
rabbit 		lowest published toxic dose: 1,500 mg/kg/6 day- intermittent Behavioral: Food intake (animal) BDERB* 68,38,2003
oral
woman 		lowest published toxic dose: 0.36 mg/kg/24 week- intermittent Lung, Thorax, or Respiration: Tumors BJCAAI 87,49,2002
oral
woman 		lowest published toxic dose: 261 mg/kg/5 year- intermittent Skin and Appendages: Other: Breast

Tumorigenic: Active as anti-cancer agent 		CNREA8 63,6096,2003
oral
woman 		lowest published toxic dose: 300 mg/kg/3 day- intermittent Behavioral: Coma

Nutritional and Gross Metabolic: Changes in: Metabolic acidosis

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		NRTXDN 28,33,2007
oral
woman 		lowest published toxic dose: 13,559 mg/kg/20 year- intermittent Gastrointestinal: Changes in structure or function of exocrine pancreas

Gastrointestinal: Tumors 		JNCIEQ 96,22,2004
subcutaneous
mouse 		lowest published toxic dose: 2,520 mg/kg/3 week- continuous Endocrine: Hypoglycemia

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) 		SCIEAS 293,1673,2001
subcutaneous
rat 		lowest published toxic dose: 840 mg/kg/1 week- continuous Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Metabolism (intermediary): Lipids including transport 		SCIEAS 293,1673,2001
subcutaneous
rat 		lowest published toxic dose: 2,520 mg/kg/3 week- continuous Endocrine: Hypoglycemia

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Metabolism (intermediary): Lipids including transport 		SCIEAS 293,1673,2001
skin
mouse 		lowest published toxic dose: 500 mg/kg/10 day- intermittent Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation FATOAO 47,84,1984


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 5 mg/m3 DTLVS* TLV/BEI,2007
TOXICOLOGY REVIEW
JJIND8 94,252,2002
TOXICOLOGY REVIEW
REPTED 17,255,2003
TOXICOLOGY REVIEW
DICPBB 8,690,1974
TOXICOLOGY REVIEW
PLMJAP 6,160,1975
TOXICOLOGY REVIEW
JPHAA3 NS16,147,1976
TOXICOLOGY REVIEW
AUHPAI 3(3),100,1973
TOXICOLOGY REVIEW
JRPMAP 12,27,1974
TOXICOLOGY REVIEW
CLCHAU 19,361,1973
TOXICOLOGY REVIEW
AJMEAZ 38,409,1965
TOXICOLOGY REVIEW
ATXKA8 28,135,1971
TOXICOLOGY REVIEW
AIMDAP 141,358,1981
TOXICOLOGY REVIEW
MUREAV 488,151,2001
TOXICOLOGY REVIEW
TOLED5 144,383,2003
TOXICOLOGY REVIEW
EMMUEG 43,143,2004
TOXICOLOGY REVIEW
TPHSDY 24,245,2003
TOXICOLOGY REVIEW
TPHSDY 24,154,2003
TOXICOLOGY REVIEW
TPHSDY 24,323,2003
TOXICOLOGY REVIEW
TPHSDY 24,331,2003
TOXICOLOGY REVIEW
TPHSDY 24,335,2003
TOXICOLOGY REVIEW
APHRER 37,1675,2003
TOXICOLOGY REVIEW
APHRER 39,51,2005
TOXICOLOGY REVIEW
APHRER 39,944,2005
TOXICOLOGY REVIEW
JPETAB 314,1,2005
TOXICOLOGY REVIEW
AJMEAZ 119,624,2006
TOXICOLOGY REVIEW
AJMEAZ 119,552,2006
TOXICOLOGY REVIEW
AINCM* 7,63,2006
TOXICOLOGY REVIEW
BPCEM* 17,237,2003
TOXICOLOGY REVIEW
ENTOX* -,36,2005
TOXICOLOGY REVIEW
EJIME* 17,529,2006
TOXICOLOGY REVIEW
DIMON* 40,258,1994
TOXICOLOGY REVIEW
DIMON* 40,258,1994
TOXICOLOGY REVIEW
DIMON* 39,678,1993
TOXICOLOGY REVIEW
JEMME* 32,63,2007
TOXICOLOGY REVIEW
ENTOX* -,742,2005
TOXICOLOGY REVIEW
BJPCBM 146,477,2005
TOXICOLOGY REVIEW
BJPCBM 147,S241,2006
TOXICOLOGY REVIEW
TOPADD 32(Suppl. 2),71,2004
TOXICOLOGY REVIEW
FCLPH* 17,393,2003
TOXICOLOGY REVIEW
AJEMEN 22,404,2004
TOXICOLOGY REVIEW
PHREP* 59,247,2007
TOXICOLOGY REVIEW
MJAUAJ 185,501,2006
TOXICOLOGY REVIEW
HUTOX* -,411,1996


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Active registration RBREV* -,351,1998
Occupational Exposure Limit - AUSTRALIA time-weighted average 5 mg/m3, JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 5 mg/m3, MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 5 mg/m3, OCT 2002
Occupational Exposure Limit - KOREA time-weighted average 5 mg/m3, 2006
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 5 mg/m3, 2003
Occupational Exposure Limit - NEW ZEALAND time-weighted average 5 mg/m3, JAN2002
Occupational Exposure Limit - NORWAY time-weighted average 5 gm/m3, JAN1999
Occupational Exposure Limit - RUSSIA short term exposure limit 0.5 mg/m3, JUN2003
Occupational Exposure Limit - SWITZERLAND MAK- week 5 mg/m3, DEC2006
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 5 mg/m3, 2005
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 5 mg/m3
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 5 mg/m3


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO ACETYLSALICYLIC ACID-air 10 hour time-weighted average 5 mg/m3 NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 84517;
Number of Industries 12;
Total Number of Facilities 1,746;
Number of Occupations 16;
Total Number of Employees Exposed 10,452
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X1189;
Number of Industries 1;
Total Number of Facilities 27;
Number of Occupations 1;
Total Number of Employees Exposed 191;
Total Number of Female Employees Exposed 82
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 84517;
Number of Industries 9;
Total Number of Facilities 491;
Number of Occupations 22;
Total Number of Employees Exposed 10,776;
Total Number of Female Employees Exposed 6,083


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Negative: Sperm morphology-mouse
EPA GENETOX PROGRAM 1988, Inconclusive: Mammalian micronucleus
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as a pharmaceutical and veterinary drug
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
34ZIAG "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969
85DCAI "Poisoning; Toxicology, Symptoms, Treatments," 2nd ed., Arena, J.M., Springfield, IL, C.C. Thomas, 1970
ACPSI* Acta pharmacologica Sinica (Shanghai : Shanghai Institute of Materia Medica : Chinese Academy of Science ; Carlton, VIC, Australia : Blackwell Publishing Asia, 2005) V.21- 2000-
ACYTAN Acta Cytologica. (Science Printers and Pub., Inc., 2 Jacklynn Ct., St. Louis, MO 63132) V.1- 1957-
AIMDAP Archives of Internal Medicine. (AMA, 535 N. Dearborn St., Chicago, IL 60610) V.1- 1908-
AIMEAS Annals of Internal Medicine. (American College of Physicians, 4200 Pine St., Philadelphia, PA 19104) V.1- 1927-
AINCM* Anaesthesia and Intensive Care Medicine (Abingdon: Medicine Pub. Co.) V.1- 2000-
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898-
AJDCAI American Journal of Diseases of Children. (AMA, 535 N. Dearborn St., Chicago, IL 60610) V.1-80(3), 1911-50; V.100- 1960-
AJEMEN American Journal of Emergency Medicine. (WB Saunders, Philadelphia, PA) V.1- 1983-
AJHPA9 American Journal of Hospital Pharmacy. (American Soc. of Hospital Pharmacists, 4630 Montgomery Ave., Bethesda, MD 20814) V.15- 1958-
AJMEAZ American Journal of Medicine. (Technical Pub., 875 Third Ave., New York, NY 10022) V.1- 1946-
AJPEEK American Journal of Perinatology. (Thieme Medical Publishers, Inc. 381 Park Ave. S., New York, NY 10157-0208) V.1- 1983-
AKGIAO Akushcherstvo i Ginekologiya (Moscow). (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) No.1- 1936-
ANREAK Anatomical Record. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1906/08-
APHRER Annals of Pharmacotherpy. (Harvey Whitney Books Co., POB 42696, Cincinnati, OH 45242) V. 26- 1992-
APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59, 1945-86. For publisher information, see PHTOEH
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
ATSUDG Archives of Toxicology, Supplement. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) No.1- 1978-
ATXKA8 Archiv fuer Toxikologie. (Berlin, Fed. Rep. Ger.) V.15-31, 1954-74. For publisher information, see ARTODN.
AUHPAI Australian Journal of Hospital Pharmacy. (B.R. Miller, POB 125, Heidelberg, Vic., Australia) V.1- 1971-
BANMAC Bulletin de l'Academie Nationale de Medicine (Paris). (Imprimeries Reunies de Chambray, 226, route d'Apremont, F-73490 La Ravoire, France) V.1- 1836-
BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958-
BDERB*
BEXBAN Bulletin of Experimental Biology and Medicine (English Translation). Translation of BEBMAE. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) V.41- 1956-
BJCAAI British Journal of Cancer. (Macmillan Press Ltd., Houndmills, Basingstoke, Hants. RG21 2XS, UK) V.1- 1947-
BJPCBM British Journal of Pharmacology. (Macmillan Press Ltd., Houndmills, Basingstoke, Hants. RG21 2XS, UK) V.34- 1968-
BMJOAE British Medical Journal. (British Medical Assoc., BMA House, Tavistock Sq., London WC1H 9JR, UK) V.1- 1857-
BPBLEO Biological and Pharmaceutical Bulletin. (Pharmaceutical Society of Japan, 2-12-15-201 Shibuya Shibuya-ku, Tokyo 150, Japan) V.16- 1993-
BPCEM* Best Practice & Research Clinical Endocrinology and Metabolism (Elsevier Ltd.) V.13- 1999-
CALEDQ Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1975-
CCPTAY Contraception. (Geron-X, Inc., POB 1108, Los Altos, CA 94022) V.1- 1970-
CLCHAU Clinical Chemistry (Winston-Salem, NC). (American Assoc. for Clinical Chemistry, 1725 K St., NW, Washington, DC 20006) V.1- 1955-
CLPTAT Clinical Pharmacology and Therapeutics. (American Society for Clinical Pharmacology and Therapeutics, St. Louis Mo Mosby-Year Book) V.1- 1960-
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941-
CPBTAL Chemical and Pharmaceutical Bulletin. (Japan Pub. Trading Co., USA, 1255 Howard St., San Francisco, CA 94103) V.6- 1958-
CPEDAM Clinical Pediatrics (Philadelphia). (Lippincott/Harper, Journal Fulfillment Dept., 2350 Virginia Ave., Hagerstown, MD 21740) V.1- 1962-
CTOXAO Clinical Toxicology. (New York, NY) V.1-18, 1968-81. For publisher information, see JTCTDW.
DICPBB Drug Intelligence and Clinical Pharmacy. (POB 42435, Cincinnati, OH 45242) V.3- 1969-
DIMON* Disease-a Month (Chicago : Year Book Publishers) V. 24- 1978-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
EJCPAS European Journal of Clinical Pharmacology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.3- 1970-
EJIME* European Journal of Internal Medicine: The Official Journal of the European Federation of Internal Medicine (EFIM) (Elsevier) V.10- 1999-
EJNSC*
EJPHAZ European Journal of Pharmacology. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1967-
EKFAE9 Eksperimental'naya i Klinicheskaya Farmakologiya. Experimental and Clinical Pharmacology. (Mezhdunarodnaya Kniga, ul. B. Yakimanka, 39, 117049 Moscow, Russia) V.55- 1992-
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
ENTOX* Encyclopedia of Toxicology: Reference Book, Elsevier, 2005
FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939-
FATOBP Farmakologiya i Toksikologiya (Kiev). Pharmacology and Toxicology. (Kievskii Nauchno- Issledovatel'skii Institut Farmakologii i Toksikologii, Kiev, USSR) No.1- 1964-
FCLPH* Fundamental & Clinical Pharmacology (Oxford : Blackwell Science) 2001-
FEPRA7 Federation Proceedings, Federation of American Societies for Experimental Biology. (Bethesda, MD) V.1-46, 1942-87.
FRMCE8 Farmaco. (Societa Chimica Italiana, Corso Strada Nova, 86, Casella Postale 227, 27100 Pavia, Italy) V.44- 1989-
FTRPAE Fitoterapia. (Inverni della Beffa SpA, via Ripamonti, 99, 20141 Milan, Italy) V.18- 1947-
GMCRDC Gann Monograph on Cancer Research. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No. 11- 1971-
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
GWXXAW German Patent Document. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231)
HETOEA Human & Experimental Toxicology. (Macmillan Press Ltd., Brunel Road, Houndmills, Basingstoke, Hampshire, RG21 2XS, UK) V.9- 1990-
HUTODJ Human Toxicology. (Macmillan Press Ltd., Houndmills, Basingstoke, Hants., RG 21 2XS, UK) V.1- 1981-
HUTOX*
IJEBA6 Indian Journal of Experimental Biology. (Publications & Information Directorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-
IJMRAQ Indian Journal of Medical Research. (Indian Council of Medical Research, Ansari Nagar, New Delhi 110 029, India) V.1- 1913-
INJFA3 International Journal of Fertility. (Allen Press, 1041 New Hampshire, St., Lawrence, KS 66044) V.1- 1955-
INJPD2 Indian Journal of Pharmacology. (Dept. of Pharmacology, Baranas Hindu Univ., Varanasi 221 005, India) V.1- 1968(?)-
JACIBY Journal of Allergy and Clinical Immunology. (Mosby-Year Book Inc., 11830 Westline Industrial Drive, St. Louis, MO 63146-3318) V.48- 1971-
JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued.
JAPMA8 Journal of the American Pharmaceutical Association, Scientific Edition. (Washington, DC) V.29-49, 1940-60. For publisher information, see JPMSAE.
JDGRAX Journal of Drug Research. (National Organization for Drug Research and Control, POB 29, Cairo, Egypt) V.2- 1969-
JEMME* The Journal of emergency medicine (New York : Pergamon Press) V.1- 1983-
JJATDK JAT, Journal of Applied Toxicology. (John Wiley & Sons Ltd., Baffins Lane, Chichester, W. Sussex PO19 1UD, UK) V.1- 1981-
JJIND8 JNCI, Journal of the National Cancer Institute. (Washington, DC) V.61-79, 1978-87. For publisher information, see JNCIEQ.
JJPAAZ Japanese Journal of Pharmacology. (Japanese Pharmacological Soc., c/o Dept. of Pharmacology, Faculty of Medicine, Kyoto Univ., Sakyo-ku, Kyoto 606, Japan) V.1- 1951-
JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963-
JNCIEQ Journal of the National Cancer Institute (1988). (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.80- 1988-
JNUDAT Journal of Nihon University School of Dentistry. (Nihon University School of Dentistry, 1-8-13 Surugadai, Kanda, Chiyoda-ku, Tokyo, 101, Japan) V.1- 1958-
JOPDAB Journal of Pediatrics. (C.V. Mosby Co., 11830 Westline Industrial Dr., St. Louis, MO 63141) V.1- 1932-
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
JPHAA3 Journal of the American Pharmaceutical Association. (Washington, DC) V.1-28, 1912-39; New series: V.1-17, 1961-77.
JRPMAP Journal of Reproductive Medicine. (2 Jacklynn Ct., St. Louis, MO 63132) V.3- 1969-
JTSCDR Journal of Toxicological Sciences. (Japanese Soc. of Toxicological Sciences, 4th Floor, Gakkai Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku, Tokyo 113, Japan) V.1- 1976-
JZKEDZ Jitchuken Zenrinsho Kenkyuho. Central Institute for Experimental Animals, Research Reports. (Jikken Dobutsu Chuo Kenkyusho, 1433 Nogawa, Takatsu-ku, Kawasaki 211, Japan) V.1- 1975-
LANCAO Lancet. (7 Adam St., London WC2N 6AD, UK) V.1- 1823-
MJAUAJ Medical Journal of Australia. (Australasian Medical Pub. Co. Ltd., 71-79 Arundel St., Glebe, N.S.W., Australia) V.1- 1914-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NATUAS Nature. (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736) V.1- 1869-
NEJMAG New England Journal of Medicine. (Massachusetts Medical Soc., 10 Shattuck St., Boston, MA 02115) V.198- 1928-
NEZAAQ Nippon Eiseigaku Zasshi. Japanese Journal of Hygiene. (Nippon Eisei Gakkai, c/o Kyoto Daigaku Igakubu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.1- 1946-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NRTXDN Neurotoxicology. (Intox Press, Inc., POB 34075, Little Rock, AR 72203) V.1- 1979-
NSAPCC Naunyn-Schmiedeberg's Archives of Pharmacology. (Springer Verlag, Heidelberger, Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.272- 1972-
NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944-
PCJOAU Pharmaceutical Chemistry Journal (English Translation). Translation of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No.1- 1967-
PHMCAA Pharmacologist. (American Soc. for Pharmacology and Experimental Therapeutics, 9650 Rockville Pike, Bethesda, MD 20014) V.1- 1959-
PHREP*
PLMJAP Pahlavi Medical Journal. (Shiraz, Iran) V.1-9, 1970-78.
PRGLBA Prostaglandins. (Geron-X, Inc., P.O. Box 1108, Los Altos, CA 94022) V.1- 1972-
PSCHDL Psychopharmacology (Berlin). (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.47- 1976-
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
RCOCB8 Research Communications in Chemical Pathology and Pharmacology. (PJD Pub. Ltd., P.O. Box 966, Westbury, NY 11590) V.1- 1970-
REPTED Reproductive Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987-
SCIEAS Science. (American Assoc. for the Advancement of Science, 1333 H St., NW, Washington, DC 20005) V.1- 1895-
TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968-
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
TOPADD Toxicologic Pathology. (c/o Dr. F.A. de la Iglesia, Warner-Lambert Co., Pharmaceutical Research Div., POB 1047, Ann Arbor, MI 48106) V.6(3/4)- 1978-
TOXIA6 Toxicon. (Pergamon Press Ltd., Headington Hill Hall, Oxford OX3 OBW, UK) V.1- 1962-
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
TPHSDY Trends in Pharmacological Sciences. (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.1- 1979-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973-
USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231)
YHHPAL Yaoxue Xuebao. Acta Pharmaceutica Sinica. Pharmaceutical Journal. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.1- 1953- Suspended 1966-78.

Used as a pharmaceutical and veterinary drug

FDA-over the counter and proprietary drug

RTECS Compound Description:
   Tumorigen
   Drug
   Mutagen
   Reproductive Effector
   Human Data

ALT CAS #: 2349-94-2
ALT CAS #: 11126-35-5
ALT CAS #: 11126-37-7
ALT CAS #: 26914-13-6
ALT CAS #: 98201-60-6
 Click Here for Additional Information about RTECS

NIOSH Home |  NIOSH Search  |  Site Index  |  Topic List |  RTECS List |  Contact Us