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| UPDATE: May 2009 | MW: N/R | MF: N/R |
SYNONYMS:
|
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| |
SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
|
| EFFECT
REFERENCE
|
eye | rabbit
1,500 ng
|
N/R
|
NTIS** PB158-508
|
| |||
MUTATION DATA AND REFERENCES:
SYSTEM TEST
|
ROUTE/ | ORGANISM/ TISSUE
DOSE
|
REFERENCE
|
DNA damage
|
human
other cell types
|
10 µg/L/5 hour
|
TOLED5 132,141,2002
|
DNA inhibition
|
mouse
Ascites tumor
|
25 µg/kg
|
TOXIA6 11,379,1973
|
DNA inhibition
|
rat
liver
|
300 µg/L
|
ARTODN 44,175,1980
|
| |||
REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
|
| EFFECT
REFERENCE
|
intraperitoneal | mouse
lowest published toxic dose: 1,350 ng/kg (3 day pregnant)
|
Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) | Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)
JTEHD6 12,193,1983
|
| |||
TUMORIGENIC DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
|
| EFFECT
REFERENCE
|
N/R |
N/R
|
N/R
|
N/R
|
| |||
ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
|
| EFFECT
REFERENCE
|
inhalation | human
lethal concentration (50 percent kill): 0.15 µg/kg
|
N/R
|
JAPTO* 23,139,2003
|
inhalation | monkey
lethal concentration (50 percent kill): 7 µg/kg
|
Lung, Thorax, or Respiration: Acute pulmonary edema | Blood: Hemorrhage Nutritional and Gross Metabolic: Body temperature increase
TOXID9 78,163,2004
|
inhalation | rat
lethal concentration (30 percent kill): 11.21 mg/m3
|
Gastrointestinal: Hypermotility, diarrhea | Behavioral: Tremor Behavioral: Convulsions or effect on seizure threshold
HBPTO* 1,163,2001
|
inhalation | rat
lethal concentration (50 percent kill): 3.7 µg/kg
|
N/R
|
JAPTO* 23,139,2003
|
intramuscular | dog
lethal dose (50 percent kill): 600 ng/kg
|
N/R
|
85JCAE -,1454,1986
|
intraperitoneal | cat
lethal dose (50 percent kill): 29 µg/kg
|
N/R
|
HBPTO* 1,163,2001
|
intraperitoneal | cat
lowest published lethal dose: 40 µg/kg
|
N/R
|
HBPTO* 1,163,2001
|
intraperitoneal | guinea pig
lowest published lethal dose: 20 ng/kg
|
N/R
|
SCIEAS 144,1100,1964
|
intraperitoneal | monkey
lethal dose (50 percent kill): 30.3 µg/kg
|
N/R
|
HBPTO* 1,163,2001
|
intraperitoneal | mouse
lethal dose (50 percent kill): 2 µg/kg
|
N/R
|
TOXIA6 18,649,1980
|
intraperitoneal | mouse
lowest published toxic dose: 25 µg/kg
|
Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases
TOXIA6 41,333,2003
|
intraperitoneal | mouse
lowest published lethal dose: 3 µg/kg
|
N/R
|
TXCYAC 214,268,2005
|
intraperitoneal | rat
lethal dose (50 percent kill): 1,500 ng/kg
|
N/R
|
TOXIA6 18,649,1980
|
intraperitoneal | rat
lowest published lethal dose: 50 µg/kg
|
N/R
|
HBPTO* 1,163,2001
|
intraperitoneal | rabbit
lethal dose (50 percent kill): 7.82 µg/kg
|
N/R
|
HBPTO* 1,163,2001
|
intraperitoneal | rabbit
lowest published lethal dose: 10 µg/kg
|
N/R
|
HBPTO* 1,163,2001
|
intratracheal | cat
lethal dose (50 percent kill): 5 µg/kg
|
Behavioral: Convulsions or effect on seizure threshold | Lung, Thorax, or Respiration: Dyspnea Gastrointestinal: Hypermotility, diarrhea
NTIS** PB158-508
|
intratracheal | dog
lethal dose (50 percent kill): 5 µg/kg
|
Behavioral: Convulsions or effect on seizure threshold | Lung, Thorax, or Respiration: Dyspnea Gastrointestinal: Hypermotility, diarrhea
NTIS** PB158-508
|
intratracheal | rat
lethal dose (50 percent kill): 5 µg/kg
|
Behavioral: Convulsions or effect on seizure threshold | Lung, Thorax, or Respiration: Dyspnea Gastrointestinal: Hypermotility, diarrhea
NTIS** PB158-508
|
intratracheal | rabbit
lethal dose (50 percent kill): 500 ng/kg
|
Behavioral: Convulsions or effect on seizure threshold | Lung, Thorax, or Respiration: Dyspnea Gastrointestinal: Hypermotility, diarrhea
NTIS** PB158-508
|
intravenous | dog
lowest published lethal dose: 1,600 ng/kg
|
Behavioral: Food intake (animal) | Behavioral: Muscle weakness Nutritional and Gross Metabolic: Weight loss or decreased weight gain
JTEHD6 5,1073,1979
|
intravenous | mouse
lethal dose (50 percent kill): 2,200 ng/kg
|
Behavioral: Convulsions or effect on seizure threshold | Lung, Thorax, or Respiration: Dyspnea Gastrointestinal: Hypermotility, diarrhea
NTIS** PB158-508
|
intravenous | mouse
lowest published lethal dose: 2.7 µg/kg
|
N/R
|
HBPTO* 1,163,2001
|
intravenous | mouse
lethal dose (50 percent kill): 2.8 µg/kg
|
N/R
|
JAPTO* 23,139,2003
|
intravenous | mouse
lethal dose : 3 µg/kg
|
Liver: Other changes
|
TXAPA9 207,138,2005
|
intravenous | rabbit
lethal dose (50 percent kill): 540 ng/kg
|
Vascular: BP lowering not characterized in autonomic section
|
PHTOEH 74,148,1994
|
oral | human
lowest published lethal dose: 2 mg/kg
|
N/R
|
PCOC** -,963,1966
|
oral | man
lowest published toxic dose: 900 µg/kg
|
Lung, Thorax, or Respiration: Cyanosis | Gastrointestinal: Nausea or vomiting Nutritional and Gross Metabolic: Dehydration
HUTODJ 2,239,1983
|
oral | man
lowest published lethal dose: 300 µg/kg
|
Behavioral: Convulsions or effect on seizure threshold | Gastrointestinal: Nausea or vomiting
NTIS** PB158-508
|
oral | mouse
lowest published lethal dose: 30 mg/kg
|
Gastrointestinal: Hypermotility, diarrhea
|
CPBTAL 31,3222,1983
|
oral | rat
lowest published lethal dose: 30 mg/kg
|
Gastrointestinal: Hypermotility, diarrhea
|
CPBTAL 31,3222,1983
|
oral | rat
lethal dose (50 percent kill): 4,000 mg/kg
|
N/R
|
GISAAA -,47,1993
|
oral | rat
lowest published toxic dose: 800 mg/kg
|
Blood: Normocytic anemia | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases Blood: Other changes
GISAAA -,47,1993
|
oral | rat
lethal dose (60 percent kill): 20 mg/kg
|
N/R
|
TXCYAC 223,61,2006
|
oral | rabbit
lowest published lethal dose: 500 µg/kg
|
N/R
|
PCOC** -,963,1966
|
parenteral | dog
lowest published lethal dose: 30 µg/kg
|
Lung, Thorax, or Respiration: Cyanosis | Liver: Hepatitis (hepatocellular necrosis), diffuse Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)
APTSAI 41,351,1977
|
parenteral | rat
lethal dose (50 percent kill): 336 ng/kg
|
Behavioral: Somnolence (general depressed activity) | Behavioral: Food intake (animal)
NEREDZ 4,259,1979
|
subcutaneous | man
lowest published lethal dose: 43 µg/kg
|
Lung, Thorax, or Respiration: Cyanosis | Liver: Hepatitis (hepatocellular necrosis), diffuse Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)
APTSAI 41,351,1977
|
subcutaneous | mouse
lethal dose (50 percent kill): 22,100 ng/kg
|
Behavioral: Convulsions or effect on seizure threshold | Lung, Thorax, or Respiration: Dyspnea Gastrointestinal: Hypermotility, diarrhea
NTIS** PB158-508
|
unreported route | cat
lethal dose (50 percent kill): 200 ng/kg
|
Behavioral: Convulsions or effect on seizure threshold | Lung, Thorax, or Respiration: Dyspnea Gastrointestinal: Hypermotility, diarrhea
NTIS** PB158-508
|
unreported route | child
lowest published lethal dose: 500 µg/kg
|
Behavioral: Somnolence (general depressed activity) | Behavioral: Headache Gastrointestinal: Other changes
34ZIAG -,158,1969
|
unreported route | dog
lethal dose (50 percent kill): 600 ng/kg
|
Behavioral: Convulsions or effect on seizure threshold | Lung, Thorax, or Respiration: Dyspnea Gastrointestinal: Hypermotility, diarrhea
NTIS** PB158-508
|
unreported route | domestic animal
lethal dose (50 percent kill): 3 µg/kg
|
Behavioral: Convulsions or effect on seizure threshold | Lung, Thorax, or Respiration: Dyspnea Gastrointestinal: Hypermotility, diarrhea
NTIS** PB158-508
|
unreported route | domestic animal
lowest published lethal dose: 100 mg/kg
|
Lung, Thorax, or Respiration: Acute pulmonary edema
|
HBPTO* 1,163,2001
|
unreported route | guinea pig
lethal dose (50 percent kill): 800 ng/kg
|
Behavioral: Convulsions or effect on seizure threshold | Lung, Thorax, or Respiration: Dyspnea Gastrointestinal: Hypermotility, diarrhea
NTIS** PB158-508
|
unreported route | mouse
lethal dose (50 percent kill): 6 µg/kg
|
N/R
|
BBACAQ 295,582,1973
|
unreported route | rat
lethal dose (50 percent kill): 4 µg/kg
|
Behavioral: Convulsions or effect on seizure threshold | Lung, Thorax, or Respiration: Dyspnea Gastrointestinal: Hypermotility, diarrhea
NTIS** PB158-508
|
unreported route | rabbit
lethal dose (50 percent kill): 100 ng/kg
|
Behavioral: Convulsions or effect on seizure threshold | Lung, Thorax, or Respiration: Dyspnea Gastrointestinal: Hypermotility, diarrhea
NTIS** PB158-508
|
| |||
OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
|
| EFFECT
REFERENCE
|
oral | rat
lowest published toxic dose: 2,400 mg/kg/3 day- intermittent
|
Blood: Changes in erythrocyte (RBC) count | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Cabonic anhydrase Blood: Other changes
GISAAA -,47,1993
|
| |||
REVIEWS:
ORGANIZATION
|
STANDARD
|
|
REFERENCE
TOXICOLOGY REVIEW
|
|
BIPAA8 74,85,1976
|
TOXICOLOGY REVIEW
|
|
JTCTDW 38,67,2000
|
TOXICOLOGY REVIEW
|
|
MUREAV 544,217,2003
|
TOXICOLOGY REVIEW
|
|
TOLED5 140-141,287,2003
|
TOXICOLOGY REVIEW
|
|
TXCYAC 214,210,2005
|
TOXICOLOGY REVIEW
|
|
JTCTDW 42,201,2004
|
TOXICOLOGY REVIEW
|
|
ENTOX* -,702,2005
|
TOXICOLOGY REVIEW
|
|
AAPSJ* 8,E532,2006
|
TOXICOLOGY REVIEW
|
|
EMCNA* 25,375,2007
|
TOXICOLOGY REVIEW
|
|
HUTOX* -,731,1996
|
| ||
STANDARDS AND REGULATIONS:
ORGANIZATION
|
STANDARD
|
|
REFERENCE
N/R
|
N/R
|
N/R
|
| ||
NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION
|
STANDARD or SURVEY
|
|
REFERENCE
N/R
|
N/R
|
N/R
|
| ||
STATUS IN FEDERAL AGENCIES:
ORGANIZATION
|
|
REFERENCE
N/R
|
| ||
REFERENCES:
CODEN
|
|
REFERENCE
34ZIAG
|
"Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969
|
85JCAE
|
"Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia,
Avicenum, 1986
|
AAPSJ*
|
AAPS pharmSci [electronic resource] (Alexandria, Va. : American Association of Pharmaceutical
Scientists) V.1-6 1999-2004, continued by AAPS journal
|
APTSAI
|
Acta Pharmacologica et Toxicologica, Supplementun. (Munksgaard International Pub., POB 2148,
DK-1016 Copenhagen K, Denmark) No.1- 1947-
|
ARTODN
|
Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep.
Ger.) V.32- 1974-
|
BBACAQ
|
Biochimica et Biophysica Acta. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam,
Netherlands) V.1- 1947-
|
BIPAA8
|
Bulletin de l'Institut Pasteur (Paris). (SPPIF, B.P.22, F-41353 Vineuil, France) V.1-
1903-
|
CPBTAL
|
Chemical and Pharmaceutical Bulletin. (Japan Pub. Trading Co., USA, 1255 Howard St., San
Francisco, CA 94103) V.6- 1958-
|
EMCNA*
|
|
ENTOX*
|
Encyclopedia of Toxicology: Reference Book, Elsevier, 2005
|
GISAAA
|
Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga,
113095 Moscow, USSR) V.1- 1936-
|
HBPTO*
|
Handbook of pesticide toxicology. Robert Krieger ed, Academic press, 2001
|
HUTODJ
|
Human Toxicology. (Macmillan Press Ltd., Houndmills, Basingstoke, Hants., RG 21 2XS, UK) V.1-
1981-
|
HUTOX*
|
|
JAPTO*
|
Journal of Applied Toxicology (John Wiley & Sons, Ltd., Oldlands Way Bognor Regis West Sussex,
PO22 9SA England) V.1- 1981-
|
JTCTDW
|
Journal of Toxicology, Clinical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY
10016) V.19- 1982-
|
JTEHD6
|
Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW,
Washington, DC 20005) V.1- 1975/76-
|
MUREAV
|
Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1-
1964-
|
NEREDZ
|
Neurochemical Research. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) V.1- 1976-
|
NTIS**
|
National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse
for Scientific & Technical Information.
|
PCOC**
|
Pesticide Chemicals Official Compendium, Association of the American Pesticide Control
Officials, Inc., 1966. (Topeka, KS)
|
PHTOEH
|
Pharmacology and Toxicology (Copenhagen). (Munksgaard International Pub., POB 2148, DK-1016
Copenhagen K, Denmark) V.60- 1987-
|
SCIEAS
|
Science. (American Assoc. for the Advancement of Science, 1333 H St., NW, Washington, DC
20005) V.1- 1895-
|
TOLED5
|
Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands)
V.1- 1977-
|
TOXIA6
|
Toxicon. (Pergamon Press Ltd., Headington Hill Hall, Oxford OX3 OBW, UK) V.1- 1962-
|
TOXID9
|
Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1-
1981-
|
TXAPA9
|
Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802)
V.1- 1959-
|
TXCYAC
|
Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973-
|
| |
