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4 (3H) - Quinazolinone, 2 - methyl - 3 - o - tolyl - , hydrochloride

RTECS #: VA4025000

CAS #: 340-56-7

UPDATE: November 2007 MW: 286.78 MF: C16H14N2O•ClH


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. REPRODUCTIVE EFFECTS DATA:
  3. ACUTE TOXICITY DATA:
  4. REVIEWS:
  5. NIOSH DOCUMENTATION AND SURVEILLANCE:
  6. REFERENCES:

SYNONYMS:

  1. 2 - Methyl - 3 - tolylchinazolon - 4 hydrochloride (German)
  2. 2 - Methyl - 3 - o - tolyl - 4 (3H) - quinazolinone hydrochloride
  3. 2 - Methyl - 3 - (o - tolyl) - 4 - quinazolone hydrochloride
  4. 2 - Metil - 3 - (o - tolil) - 4 - chinazolone chloridrato (Italian)
  1. MTQ hydrochloride
  2. Melsedin
  3. Methaqualone hydrochloride
  4. Methylquinazolone hydrochloride


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 1,500 mg/kg (1-20 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetal death 		NATUAS 200,656,1963


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lethal dose (50 percent kill): 345 mg/kg Peripheral Nerve and Sensation: Spastic paralysis with/without sensory change

Behavioral: Sleep

Lung, Thorax, or Respiration: Respiratory depression 		NYKZAU 61,1,1965
intraperitoneal
rat 		lethal dose (50 percent kill): 124 mg/kg N/R 27ZQAG -,262,1972
intravenous
mouse 		lethal dose (50 percent kill): 120 mg/kg N/R 27ZQAG -,262,1972
intravenous
rat 		lethal dose (50 percent kill): 120 mg/kg N/R 27ZQAG -,262,1972
intravenous
rabbit 		lethal dose (50 percent kill): 120 mg/kg N/R 27ZQAG -,262,1972
oral
guinea pig 		lethal dose (50 percent kill): 360 mg/kg N/R 27ZQAG -,262,1972
oral
man 		lowest published toxic dose: 5,714 µg/kg Behavioral: Convulsions or effect on seizure threshold

Cardiac: Pulse rate increased without fall in BP

Lung, Thorax, or Respiration: Dyspnea 		CTOXAO 6,317,1973
oral
mouse 		lethal dose (50 percent kill): 400 mg/kg N/R ABMGAJ 13,591,1964
oral
rat 		lethal dose (50 percent kill): 240 mg/kg N/R FRXXBL #2081437
unreported route
mouse 		lethal dose (50 percent kill): 1,250 mg/kg N/R 27ZQAG -,262,1972
unreported route
rat 		lethal dose (50 percent kill): 326 mg/kg N/R 27ZQAG -,262,1972


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
TOXICOLOGY REVIEW
ENTOX* -,56,2005


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X6182;
Number of Industries 1;
Total Number of Facilities 16;
Number of Occupations 1;
Total Number of Employees Exposed 3,537;
Total Number of Female Employees Exposed 3,487


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
N/R


REFERENCES:

CODEN
REFERENCE
27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972
ABMGAJ Acta Biologica et Medica Germanica. (Berlin, Ger. Dem. Rep.) V.1-41, 1958-82. For publisher information, see BBIADT.
CTOXAO Clinical Toxicology. (New York, NY) V.1-18, 1968-81. For publisher information, see JTCTDW.
ENTOX* Encyclopedia of Toxicology: Reference Book, Elsevier, 2005
FRXXBL French Demande Patent Document. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231)
NATUAS Nature. (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736) V.1- 1869-
NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944-

FDA-proprietary drug

RTECS Compound Description:
   Drug
   Reproductive Effector
   Human Data

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