RTECS:VA1700000 The Registry of Toxic Effects of Chemical Substances

6 - Quinazolinesulfonamide, 1,2,3,4 - tetrahydro - 7 - chloro - 2 - methyl - 4 - oxo - 3 - o - tolyl -

RTECS #: VA1700000

CAS #: 17560-51-9

UPDATE: February 2008 MW: 365.86 MF: C₁₆H₁₆ClN₃O₃S

NOTE:

TOXICITY DATA HAVE NOT BEEN EVALUATED. OMISSION OF A SUBSTANCE OR NOTATION DOES NOT IMPLY ANY RELIEF FROM REGULATORY RESPONSIBILITY.

TABLE OF CONTENTS:

SYNONYMS:

REPRODUCTIVE EFFECTS DATA:

ACUTE TOXICITY DATA:

REVIEWS:

NIOSH DOCUMENTATION AND SURVEILLANCE:

REFERENCES:

SYNONYMS:

2 - Methyl - 3 - o - tolyl - 6 - sulfamyl - 7 - chloro - 1,2,3,4 - tetrahydro - 4 - quinazolinone

6 - Quinazolinesulfonamide, 7 - chloro - 1,2,3,4 - tetrahydro - 2 - methyl - 4 - oxo - 3 - o - tolyl -

7 - Chloro - 1,2,3,4 - tetrahydro - 2 - methyl - 3 - (2 - methylphenyl) - 4 - oxo - 6 - quinazolinesulfonamide

7 - Chloro - 1,2,3,4 - tetrahydro - 2 - methyl - 4 - oxo - 3 - o - tolyl - 6 - quinazolinesulfonamide

Diulo

Metenix

Metolazone

Microx

Mykrox

Oldren

S720 - 22

SR 720 - 22

Zaroxolyn

SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

MUTATION DATA AND REFERENCES:
SYSTEM TEST ROUTE/
ORGANISM/
TISSUE DOSE REFERENCE
N/R N/R N/R N/R

REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
oral
rat lowest published toxic dose: 22 mg/kg (7-17 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system

Reproductive: Specific developmental abnormalities: Urogenital system

Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth) KSRNAM 12,3394,1978
oral
rat lowest published toxic dose: 2,750 mg/kg (7-17 day pregnant) Reproductive: Effects on embryo or fetus: Extra embryonic structures (e.g., placenta, umbilical cord) KSRNAM 12,3394,1978
oral
rabbit lowest published toxic dose: 130 mg/kg (6-18 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) KSRNAM 12,3417,1978

TUMORIGENIC DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
intraperitoneal
mouse lethal dose (50 percent kill): >1,500 mg/kg Behavioral: Somnolence (general depressed activity)

Nutritional and Gross Metabolic: Body temperature decrease USXXAM #3360518
intraperitoneal
rat lethal dose (50 percent kill): >5 gm/kg N/R YAKUD5 24,261,1982
oral
man lowest published toxic dose: 2 mg/kg/2 week- intermittent Vascular: Structural changes in vessels PGMJAO 67,860,1991
oral
mouse lethal dose (50 percent kill): >5 gm/kg N/R USXXAM #3360518
oral
rat lethal dose (50 percent kill): >5 gm/kg N/R NIIRDN 6,APP-20,1982
oral
woman lowest published toxic dose: 150 痢/kg Behavioral: General anesthetic

Behavioral: Convulsions or effect on seizure threshold

Behavioral: Muscle contraction or spasticity BMJOAE 1,1381,1976
subcutaneous
mouse lethal dose (50 percent kill): >5 gm/kg N/R YAKUD5 24,261,1982
subcutaneous
rat lethal dose (50 percent kill): >5 gm/kg N/R YAKUD5 24,261,1982

OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

REVIEWS:
ORGANIZATION STANDARD
REFERENCE

TOXICOLOGY REVIEW
MUREAV 488,151,2001
TOXICOLOGY REVIEW
EMMUEG 43,143,2004
TOXICOLOGY REVIEW
DIMON* 39,678,1993
TOXICOLOGY REVIEW
ENTOX* -,170,2005

STANDARDS AND REGULATIONS:
ORGANIZATION STANDARD
REFERENCE

N/R N/R N/R

NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X6159;
Number of Industries 1;
Total Number of Facilities 27;
Number of Occupations 1;
Total Number of Employees Exposed 642;
Total Number of Female Employees Exposed 346

STATUS IN FEDERAL AGENCIES:
ORGANIZATION
REFERENCE

N/R

REFERENCES:
CODEN
REFERENCE

BMJOAE British Medical Journal. (British Medical Assoc., BMA House, Tavistock Sq., London WC1H 9JR, UK) V.1- 1857-
DIMON* Disease-a Month (Chicago : Year Book Publishers) V. 24- 1978-
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
ENTOX* Encyclopedia of Toxicology: Reference Book, Elsevier, 2005
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan)
PGMJAO Postgraduate Medical Journal. (Blackwell Scientific Pub. Ltd., POB 88, Oxford, UK) V.1- 1925-
USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231)
YAKUD5 Gekkan Yakuji. Pharmaceuticals Monthly. (Yakugyo Jihosha, Inaoka Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan) V.1- 1959-

Used as a diuretic and antihypertensive agent

FDA-proprietary drug

RTECS Compound Description:
   Drug
   Reproductive Effector
   Human Data

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SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
N/R	N/R	N/R	N/R

MUTATION DATA AND REFERENCES:
SYSTEM TEST	ROUTE/ ORGANISM/ TISSUE	DOSE	REFERENCE
N/R	N/R	N/R	N/R

REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
oral rat	lowest published toxic dose: 22 mg/kg (7-17 day pregnant)	Reproductive: Specific developmental abnormalities: Musculoskeletal system Reproductive: Specific developmental abnormalities: Urogenital system Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)	KSRNAM 12,3394,1978
oral rat	lowest published toxic dose: 2,750 mg/kg (7-17 day pregnant)	Reproductive: Effects on embryo or fetus: Extra embryonic structures (e.g., placenta, umbilical cord)	KSRNAM 12,3394,1978
oral rabbit	lowest published toxic dose: 130 mg/kg (6-18 day pregnant)	Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)	KSRNAM 12,3417,1978

TUMORIGENIC DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
N/R	N/R	N/R	N/R

ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
intraperitoneal mouse	lethal dose (50 percent kill): >1,500 mg/kg	Behavioral: Somnolence (general depressed activity) Nutritional and Gross Metabolic: Body temperature decrease	USXXAM #3360518
intraperitoneal rat	lethal dose (50 percent kill): >5 gm/kg	N/R	YAKUD5 24,261,1982
oral man	lowest published toxic dose: 2 mg/kg/2 week- intermittent	Vascular: Structural changes in vessels	PGMJAO 67,860,1991
oral mouse	lethal dose (50 percent kill): >5 gm/kg	N/R	USXXAM #3360518
oral rat	lethal dose (50 percent kill): >5 gm/kg	N/R	NIIRDN 6,APP-20,1982
oral woman	lowest published toxic dose: 150 痢/kg	Behavioral: General anesthetic Behavioral: Convulsions or effect on seizure threshold Behavioral: Muscle contraction or spasticity	BMJOAE 1,1381,1976
subcutaneous mouse	lethal dose (50 percent kill): >5 gm/kg	N/R	YAKUD5 24,261,1982
subcutaneous rat	lethal dose (50 percent kill): >5 gm/kg	N/R	YAKUD5 24,261,1982

OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
N/R	N/R	N/R	N/R

REVIEWS:
ORGANIZATION	STANDARD	REFERENCE
TOXICOLOGY REVIEW		MUREAV 488,151,2001
TOXICOLOGY REVIEW		EMMUEG 43,143,2004
TOXICOLOGY REVIEW		DIMON* 39,678,1993
TOXICOLOGY REVIEW		ENTOX* -,170,2005

STANDARDS AND REGULATIONS:
ORGANIZATION	STANDARD	REFERENCE
N/R	N/R	N/R

NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION	STANDARD or SURVEY	REFERENCE
National Occupational Exposure Survey 1983	National Occupational Exposure Survey 1983: Hazard Code: X6159; Number of Industries 1; Total Number of Facilities 27; Number of Occupations 1; Total Number of Employees Exposed 642; Total Number of Female Employees Exposed 346

REFERENCES:
CODEN	REFERENCE
BMJOAE	British Medical Journal. (British Medical Assoc., BMA House, Tavistock Sq., London WC1H 9JR, UK) V.1- 1857-
DIMON*	Disease-a Month (Chicago : Year Book Publishers) V. 24- 1978-
EMMUEG	Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
ENTOX*	Encyclopedia of Toxicology: Reference Book, Elsevier, 2005
KSRNAM	Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960-
MUREAV	Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NIIRDN	Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan)
PGMJAO	Postgraduate Medical Journal. (Blackwell Scientific Pub. Ltd., POB 88, Oxford, UK) V.1- 1925-
USXXAM	United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231)
YAKUD5	Gekkan Yakuji. Pharmaceuticals Monthly. (Yakugyo Jihosha, Inaoka Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan) V.1- 1959-