RTECS:VA1350000 The Registry of Toxic Effects of Chemical Substances

Quinazoline, 4 - amino - 6,7 - dimethoxy - 2 - (4 - (2 - furoyl) piperazin - 1 - yl) - , hydrochloride

RTECS #: VA1350000

CAS #: 19237-84-4

UPDATE: February 2009 MW: 419.91 MF: C₁₉H₂₁N₅O₄𥺂lH

NOTE:

TOXICITY DATA HAVE NOT BEEN EVALUATED. OMISSION OF A SUBSTANCE OR NOTATION DOES NOT IMPLY ANY RELIEF FROM REGULATORY RESPONSIBILITY.

TABLE OF CONTENTS:

SYNONYMS:

REPRODUCTIVE EFFECTS DATA:

ACUTE TOXICITY DATA:

OTHER MULTIPLE DOSE DATA:

NIOSH DOCUMENTATION AND SURVEILLANCE:

REFERENCES:

SYNONYMS:

1 - (4 - Amino - 6,7 - dimethoxy - 2 - quinazolinyl) - 4 - (2 - furanylcarbonyl) piperazine hydrochloride

1 - (4 - Amino - 6,7 - dimethoxy - 2 - quinazolinyl) - 4 - (2 - furoyl) piperazine monohydrochloride

2 - (4 - (2 - Furoyl) piperazin - 1 - yl) - 4 - amino - 6,7 - dimethoxyquinazoline hydrochloride

CP - 12299 - 1

Deprazolin

Furazosin hydrochloride

Hypovase

Hypovasole

Minipress

Peripress

Piperazine, 1 - (4 - amino - 6,7 - dimethoxy - 2 - quinazolinyl) - 4 - (2 - furoyl) - , monohydrochloride

Pratsiol

Prazosin clorhidrato (Spanish)

Prazosin hydrochloride

Sinetens

SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

MUTATION DATA AND REFERENCES:
SYSTEM TEST ROUTE/
ORGANISM/
TISSUE DOSE REFERENCE
N/R N/R N/R N/R

REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
implant
rat lowest published toxic dose: 30 mg/kg (3 day male) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Effects on fertility: Male fertility index (e.g., # males impregnating females per # males exposed to fertile nonpregnant females) JRPFA4 70,643,1984
oral
rat lowest published toxic dose: 4,150 mg/kg (8 week male/2 week prior to copulation-9 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) OYYAA2 17,57,1979
oral
rat lowest published toxic dose: 300 mg/kg (9-14 day pregnant) Reproductive: Effects on embryo or fetus: Fetal death OYYAA2 17,57,1979
oral
rat lowest published toxic dose: 8,700 mg/kg (14-22 day pregnant/20 day after birth) Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive) OYYAA2 17,57,1979
oral
rat lowest published toxic dose: 1,450 mg/kg (14-22 day pregnant/20 day after birth) Reproductive: Effects on newborn: Weaning or lactation index (e.g., # alive at weaning per # alive at day 4) OYYAA2 17,57,1979
oral
rabbit lowest published toxic dose: 90 mg/kg (9-14 day pregnant) Reproductive: Effects on embryo or fetus: Fetal death OYYAA2 17,57,1979
oral
rabbit lowest published toxic dose: 450 mg/kg (9-14 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) OYYAA2 17,57,1979
subcutaneous
rat lowest published toxic dose: 4 mg/kg (22 day pregnant) Reproductive: Maternal effects: Parturition JRPFA4 76,415,1986
subcutaneous
rat lowest published toxic dose: 12 mg/kg (4-5 day pregnant) Reproductive: Maternal effects: Uterus, cervix, vagina

Reproductive: Other effects on female JRPFA4 81,51,1987
subcutaneous
rat lowest published toxic dose: 1,400 mg/kg (1 day male) Reproductive: Paternal effects: Testes, epididymis, sperm duct

Reproductive: Effects on fertility: Male fertility index (e.g., # males impregnating females per # males exposed to fertile nonpregnant females)

Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea) CCPTAY 41,441,1990
unreported route
dog lowest published toxic dose: 9,125 mg/kg (52 week male) Reproductive: Paternal effects: Testes, epididymis, sperm duct YHTPAD 18,343,1983
unreported route
rat lowest published toxic dose: 9,125 mg/kg (52 week male) Reproductive: Paternal effects: Testes, epididymis, sperm duct YHTPAD 18,343,1983

TUMORIGENIC DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
intraperitoneal
mouse lethal dose (50 percent kill): 60 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Ataxia

Gastrointestinal: Hypermotility, diarrhea OYYAA2 17,39,1979
intraperitoneal
mouse lowest published toxic dose: 1 mg/kg Nutritional and Gross Metabolic: Body temperature decrease PHTOEH 93,48,2003
intraperitoneal
mouse lowest published toxic dose: 0.125 mg/kg Behavioral: Analgesia PHMCAA 68,154,2003
intraperitoneal
mouse lowest published toxic dose: 0.25 mg/kg Eye: Ptosis

Behavioral: Tremor

Behavioral: Change in motor activity (specific assay) AEPPAE 369,338,2004
intraperitoneal
rat lethal dose (50 percent kill): 102 mg/kg Eye: Lacrimation

Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Respiratory depression OYYAA2 17,39,1979
intraperitoneal
rat lowest published toxic dose: 0.3 mg/kg Behavioral: Change in motor activity (specific assay) PSCHDL 169,176,2003
intraperitoneal
rat lowest published toxic dose: 8 mg/kg Behavioral: Alteration of operant conditioning PSCHDL 171,212,2004
intravenous
dog lowest published toxic dose: 2,981 ng/kg Vascular: BP lowering not characterized in autonomic section EJPHAZ 497,327,2004
intravenous
dog lowest published toxic dose: 4,031 ng/kg Autonomic Nervous System: Central sympatholytic

Kidney, Ureter, and Bladder: Other changes EJPHAZ 497,327,2004
intravenous
dog lowest published toxic dose: 5.3 痢/kg Reproductive: Paternal effects: Testes, epididymis, sperm duct EJPHAZ 580,256,2008
intravenous
dog lowest published toxic dose: 13 痢/kg Kidney, Ureter, and Bladder: Structural or functional change in ureter

Reproductive: Paternal effects: Testes, epididymis, sperm duct EJPHAZ 580,256,2008
intravenous
guinea pig lowest published toxic dose: 0.1 mg/kg Vascular: BP lowering not characterized in autonomic section EJPHAZ 452,97,2002
intravenous
mouse lethal dose (50 percent kill): 92 mg/kg Behavioral: Convulsions or effect on seizure threshold

Behavioral: Ataxia

Lung, Thorax, or Respiration: Dyspnea NCDREP 4,1,1986
intravenous
rat lethal dose (50 percent kill): 73 mg/kg Behavioral: Convulsions or effect on seizure threshold

Behavioral: Ataxia

Lung, Thorax, or Respiration: Dyspnea NCDREP 4,1,1986
intravenous
rat lowest published toxic dose: 0.3 mg/kg Peripheral Nerve and Sensation: Recording from afferent nerve EJPHAZ 489,207,2004
intravenous
rat lowest published toxic dose: 1 痢/kg Vascular: BP lowering not characterized in autonomic section BJPCBM 145,567,2005
intravenous
rabbit lowest published toxic dose: 3,000 痢/kg Eye: Miosis (pupilliary constriction) AEPPAE 372,346,2006
oral
dog lethal dose (50 percent kill): >700 mg/kg Gastrointestinal: Changes in structure or function of salivary glands

Gastrointestinal: Nausea or vomiting

Kidney, Ureter, and Bladder: Other changes OYYAA2 17,39,1979
oral
human lowest published toxic dose: 285 痢/kg Vascular: BP lowering not characterized in autonomic section JAMAAP 238,157,1977
oral
man lowest published toxic dose: 1,714 痢/kg Behavioral: Coma

Lung, Thorax, or Respiration: Dyspnea HUTODJ 4,53,1985
oral
mouse lethal dose (50 percent kill): 5 gm/kg N/R MDACAP 11,64,1975
oral
rat lethal dose (50 percent kill): 1,950 mg/kg Gastrointestinal: Changes in structure or function of salivary glands

Gastrointestinal: Nausea or vomiting

Kidney, Ureter, and Bladder: Other changes OYYAA2 17,39,1979
oral
woman lowest published toxic dose: 13 mg/kg/6 week- intermittent Brain and Coverings: Encephalitis

Behavioral: Somnolence (general depressed activity)

Behavioral: Toxic psychosis BMJOAE 293,1347,1986
oral
woman lowest published toxic dose: 10 痢/kg Behavioral: Coma

Vascular: BP lowering not characterized in autonomic section

Skin and Appendages: Other: Sweating DICPBB 21,723,1987
subcutaneous
mouse lethal dose (50 percent kill): 3,100 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Ataxia

Lung, Thorax, or Respiration: Respiratory depression OYYAA2 17,39,1979
subcutaneous
rat lethal dose (50 percent kill): 3,750 mg/kg Eye: Lacrimation

Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Respiratory depression OYYAA2 17,39,1979
subcutaneous
rat lowest published toxic dose: 0.5 mg/kg Behavioral: Alteration of classical conditioning

Behavioral: Change in psychophysiological tests PSCHDL 177,438,2005

OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
intraperitoneal
rat lowest published toxic dose: 2.6 mg/kg/7 day- intermittent Brain and Coverings: Other degenerative changes PHREP* 57,850,2005
oral
rat lowest published toxic dose: 19,840 mg/kg/31 day- intermittent Cardiac: Changes in heart weight

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Related to Chronic Data: Changes in ovarian weight OYYAA2 17,39,1979
oral
rat lowest published toxic dose: 582 gm/kg/5 week- intermittent Kidney, Ureter, and Bladder: Other changes

Endocrine: Changes in spleen weight

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) OYYAA2 17,39,1979

REVIEWS:
ORGANIZATION STANDARD
REFERENCE

N/R N/R N/R

STANDARDS AND REGULATIONS:
ORGANIZATION STANDARD
REFERENCE

N/R N/R N/R

NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X4879;
Number of Industries 1;
Total Number of Facilities 70;
Number of Occupations 1;
Total Number of Employees Exposed 1,092;
Total Number of Female Employees Exposed 700

STATUS IN FEDERAL AGENCIES:
ORGANIZATION
REFERENCE

N/R

REFERENCES:
CODEN
REFERENCE

AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher information, see NSAPCC.
BJPCBM British Journal of Pharmacology. (Macmillan Press Ltd., Houndmills, Basingstoke, Hants. RG21 2XS, UK) V.34- 1968-
BMJOAE British Medical Journal. (British Medical Assoc., BMA House, Tavistock Sq., London WC1H 9JR, UK) V.1- 1857-
CCPTAY Contraception. (Geron-X, Inc., POB 1108, Los Altos, CA 94022) V.1- 1970-
DICPBB Drug Intelligence and Clinical Pharmacy. (POB 42435, Cincinnati, OH 45242) V.3- 1969-
EJPHAZ European Journal of Pharmacology. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1967-
HUTODJ Human Toxicology. (Macmillan Press Ltd., Houndmills, Basingstoke, Hants., RG 21 2XS, UK) V.1- 1981-
JAMAAP JAMA, Journal of the American Medical Association. (AMA, 535 N. Dearborn St., Chicago, IL 60610) V.1- 1883-
JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1960-
MDACAP Medicamentos de Actualidad. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1965-
NCDREP New Cardiovascular Drugs. (Raven Press, 1185 Ave. of the Americas, New York, NY 10036) 1985-
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967-
PHMCAA Pharmacologist. (American Soc. for Pharmacology and Experimental Therapeutics, 9650 Rockville Pike, Bethesda, MD 20014) V.1- 1959-
PHREP*

PHTOEH Pharmacology and Toxicology (Copenhagen). (Munksgaard International Pub., POB 2148, DK-1016 Copenhagen K, Denmark) V.60- 1987-
PSCHDL Psychopharmacology (Berlin). (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.47- 1976-
YHTPAD Yaoxue Tongbao. Bulletin of Pharmacology. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.13-23, 1978-88. For publisher information, see ZYZAEU.

Used as an antihypertensive drug

FDA-proprietary drug

RTECS Compound Description:
   Drug
   Reproductive Effector
   Human Data

ALT CAS #: 86126-06-9
Click Here for Additional Information about RTECS

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SYNONYMS:
1 - (4 - Amino - 6,7 - dimethoxy - 2 - quinazolinyl) - 4 - (2 - furanylcarbonyl) piperazine hydrochloride 1 - (4 - Amino - 6,7 - dimethoxy - 2 - quinazolinyl) - 4 - (2 - furoyl) piperazine monohydrochloride 2 - (4 - (2 - Furoyl) piperazin - 1 - yl) - 4 - amino - 6,7 - dimethoxyquinazoline hydrochloride CP - 12299 - 1 Deprazolin Furazosin hydrochloride Hypovase Hypovasole	Minipress Peripress Piperazine, 1 - (4 - amino - 6,7 - dimethoxy - 2 - quinazolinyl) - 4 - (2 - furoyl) - , monohydrochloride Pratsiol Prazosin clorhidrato (Spanish) Prazosin hydrochloride Sinetens

SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
N/R	N/R	N/R	N/R

MUTATION DATA AND REFERENCES:
SYSTEM TEST	ROUTE/ ORGANISM/ TISSUE	DOSE	REFERENCE
N/R	N/R	N/R	N/R

REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
implant rat	lowest published toxic dose: 30 mg/kg (3 day male)	Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) Reproductive: Effects on fertility: Male fertility index (e.g., # males impregnating females per # males exposed to fertile nonpregnant females)	JRPFA4 70,643,1984
oral rat	lowest published toxic dose: 4,150 mg/kg (8 week male/2 week prior to copulation-9 day pregnant)	Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)	OYYAA2 17,57,1979
oral rat	lowest published toxic dose: 300 mg/kg (9-14 day pregnant)	Reproductive: Effects on embryo or fetus: Fetal death	OYYAA2 17,57,1979
oral rat	lowest published toxic dose: 8,700 mg/kg (14-22 day pregnant/20 day after birth)	Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive)	OYYAA2 17,57,1979
oral rat	lowest published toxic dose: 1,450 mg/kg (14-22 day pregnant/20 day after birth)	Reproductive: Effects on newborn: Weaning or lactation index (e.g., # alive at weaning per # alive at day 4)	OYYAA2 17,57,1979
oral rabbit	lowest published toxic dose: 90 mg/kg (9-14 day pregnant)	Reproductive: Effects on embryo or fetus: Fetal death	OYYAA2 17,57,1979
oral rabbit	lowest published toxic dose: 450 mg/kg (9-14 day pregnant)	Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)	OYYAA2 17,57,1979
subcutaneous rat	lowest published toxic dose: 4 mg/kg (22 day pregnant)	Reproductive: Maternal effects: Parturition	JRPFA4 76,415,1986
subcutaneous rat	lowest published toxic dose: 12 mg/kg (4-5 day pregnant)	Reproductive: Maternal effects: Uterus, cervix, vagina Reproductive: Other effects on female	JRPFA4 81,51,1987
subcutaneous rat	lowest published toxic dose: 1,400 mg/kg (1 day male)	Reproductive: Paternal effects: Testes, epididymis, sperm duct Reproductive: Effects on fertility: Male fertility index (e.g., # males impregnating females per # males exposed to fertile nonpregnant females) Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)	CCPTAY 41,441,1990
unreported route dog	lowest published toxic dose: 9,125 mg/kg (52 week male)	Reproductive: Paternal effects: Testes, epididymis, sperm duct	YHTPAD 18,343,1983
unreported route rat	lowest published toxic dose: 9,125 mg/kg (52 week male)	Reproductive: Paternal effects: Testes, epididymis, sperm duct	YHTPAD 18,343,1983

TUMORIGENIC DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
N/R	N/R	N/R	N/R

ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
intraperitoneal mouse	lethal dose (50 percent kill): 60 mg/kg	Behavioral: Somnolence (general depressed activity) Behavioral: Ataxia Gastrointestinal: Hypermotility, diarrhea	OYYAA2 17,39,1979
intraperitoneal mouse	lowest published toxic dose: 1 mg/kg	Nutritional and Gross Metabolic: Body temperature decrease	PHTOEH 93,48,2003
intraperitoneal mouse	lowest published toxic dose: 0.125 mg/kg	Behavioral: Analgesia	PHMCAA 68,154,2003
intraperitoneal mouse	lowest published toxic dose: 0.25 mg/kg	Eye: Ptosis Behavioral: Tremor Behavioral: Change in motor activity (specific assay)	AEPPAE 369,338,2004
intraperitoneal rat	lethal dose (50 percent kill): 102 mg/kg	Eye: Lacrimation Behavioral: Somnolence (general depressed activity) Lung, Thorax, or Respiration: Respiratory depression	OYYAA2 17,39,1979
intraperitoneal rat	lowest published toxic dose: 0.3 mg/kg	Behavioral: Change in motor activity (specific assay)	PSCHDL 169,176,2003
intraperitoneal rat	lowest published toxic dose: 8 mg/kg	Behavioral: Alteration of operant conditioning	PSCHDL 171,212,2004
intravenous dog	lowest published toxic dose: 2,981 ng/kg	Vascular: BP lowering not characterized in autonomic section	EJPHAZ 497,327,2004
intravenous dog	lowest published toxic dose: 4,031 ng/kg	Autonomic Nervous System: Central sympatholytic Kidney, Ureter, and Bladder: Other changes	EJPHAZ 497,327,2004
intravenous dog	lowest published toxic dose: 5.3 痢/kg	Reproductive: Paternal effects: Testes, epididymis, sperm duct	EJPHAZ 580,256,2008
intravenous dog	lowest published toxic dose: 13 痢/kg	Kidney, Ureter, and Bladder: Structural or functional change in ureter Reproductive: Paternal effects: Testes, epididymis, sperm duct	EJPHAZ 580,256,2008
intravenous guinea pig	lowest published toxic dose: 0.1 mg/kg	Vascular: BP lowering not characterized in autonomic section	EJPHAZ 452,97,2002
intravenous mouse	lethal dose (50 percent kill): 92 mg/kg	Behavioral: Convulsions or effect on seizure threshold Behavioral: Ataxia Lung, Thorax, or Respiration: Dyspnea	NCDREP 4,1,1986
intravenous rat	lethal dose (50 percent kill): 73 mg/kg	Behavioral: Convulsions or effect on seizure threshold Behavioral: Ataxia Lung, Thorax, or Respiration: Dyspnea	NCDREP 4,1,1986
intravenous rat	lowest published toxic dose: 0.3 mg/kg	Peripheral Nerve and Sensation: Recording from afferent nerve	EJPHAZ 489,207,2004
intravenous rat	lowest published toxic dose: 1 痢/kg	Vascular: BP lowering not characterized in autonomic section	BJPCBM 145,567,2005
intravenous rabbit	lowest published toxic dose: 3,000 痢/kg	Eye: Miosis (pupilliary constriction)	AEPPAE 372,346,2006
oral dog	lethal dose (50 percent kill): >700 mg/kg	Gastrointestinal: Changes in structure or function of salivary glands Gastrointestinal: Nausea or vomiting Kidney, Ureter, and Bladder: Other changes	OYYAA2 17,39,1979
oral human	lowest published toxic dose: 285 痢/kg	Vascular: BP lowering not characterized in autonomic section	JAMAAP 238,157,1977
oral man	lowest published toxic dose: 1,714 痢/kg	Behavioral: Coma Lung, Thorax, or Respiration: Dyspnea	HUTODJ 4,53,1985
oral mouse	lethal dose (50 percent kill): 5 gm/kg	N/R	MDACAP 11,64,1975
oral rat	lethal dose (50 percent kill): 1,950 mg/kg	Gastrointestinal: Changes in structure or function of salivary glands Gastrointestinal: Nausea or vomiting Kidney, Ureter, and Bladder: Other changes	OYYAA2 17,39,1979
oral woman	lowest published toxic dose: 13 mg/kg/6 week- intermittent	Brain and Coverings: Encephalitis Behavioral: Somnolence (general depressed activity) Behavioral: Toxic psychosis	BMJOAE 293,1347,1986
oral woman	lowest published toxic dose: 10 痢/kg	Behavioral: Coma Vascular: BP lowering not characterized in autonomic section Skin and Appendages: Other: Sweating	DICPBB 21,723,1987
subcutaneous mouse	lethal dose (50 percent kill): 3,100 mg/kg	Behavioral: Somnolence (general depressed activity) Behavioral: Ataxia Lung, Thorax, or Respiration: Respiratory depression	OYYAA2 17,39,1979
subcutaneous rat	lethal dose (50 percent kill): 3,750 mg/kg	Eye: Lacrimation Behavioral: Somnolence (general depressed activity) Lung, Thorax, or Respiration: Respiratory depression	OYYAA2 17,39,1979
subcutaneous rat	lowest published toxic dose: 0.5 mg/kg	Behavioral: Alteration of classical conditioning Behavioral: Change in psychophysiological tests	PSCHDL 177,438,2005

OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
intraperitoneal rat	lowest published toxic dose: 2.6 mg/kg/7 day- intermittent	Brain and Coverings: Other degenerative changes	PHREP* 57,850,2005
oral rat	lowest published toxic dose: 19,840 mg/kg/31 day- intermittent	Cardiac: Changes in heart weight Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Related to Chronic Data: Changes in ovarian weight	OYYAA2 17,39,1979
oral rat	lowest published toxic dose: 582 gm/kg/5 week- intermittent	Kidney, Ureter, and Bladder: Other changes Endocrine: Changes in spleen weight Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)	OYYAA2 17,39,1979

STANDARDS AND REGULATIONS:
ORGANIZATION	STANDARD	REFERENCE
N/R	N/R	N/R

NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION	STANDARD or SURVEY	REFERENCE
National Occupational Exposure Survey 1983	National Occupational Exposure Survey 1983: Hazard Code: X4879; Number of Industries 1; Total Number of Facilities 70; Number of Occupations 1; Total Number of Employees Exposed 1,092; Total Number of Female Employees Exposed 700

REFERENCES:
CODEN	REFERENCE
AEPPAE	Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher information, see NSAPCC.
BJPCBM	British Journal of Pharmacology. (Macmillan Press Ltd., Houndmills, Basingstoke, Hants. RG21 2XS, UK) V.34- 1968-
BMJOAE	British Medical Journal. (British Medical Assoc., BMA House, Tavistock Sq., London WC1H 9JR, UK) V.1- 1857-
CCPTAY	Contraception. (Geron-X, Inc., POB 1108, Los Altos, CA 94022) V.1- 1970-
DICPBB	Drug Intelligence and Clinical Pharmacy. (POB 42435, Cincinnati, OH 45242) V.3- 1969-
EJPHAZ	European Journal of Pharmacology. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1967-
HUTODJ	Human Toxicology. (Macmillan Press Ltd., Houndmills, Basingstoke, Hants., RG 21 2XS, UK) V.1- 1981-
JAMAAP	JAMA, Journal of the American Medical Association. (AMA, 535 N. Dearborn St., Chicago, IL 60610) V.1- 1883-
JRPFA4	Journal of Reproduction and Fertility. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1960-
MDACAP	Medicamentos de Actualidad. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1965-
NCDREP	New Cardiovascular Drugs. (Raven Press, 1185 Ave. of the Americas, New York, NY 10036) 1985-
OYYAA2	Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967-
PHMCAA	Pharmacologist. (American Soc. for Pharmacology and Experimental Therapeutics, 9650 Rockville Pike, Bethesda, MD 20014) V.1- 1959-
PHREP*
PHTOEH	Pharmacology and Toxicology (Copenhagen). (Munksgaard International Pub., POB 2148, DK-1016 Copenhagen K, Denmark) V.60- 1987-
PSCHDL	Psychopharmacology (Berlin). (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.47- 1976-
YHTPAD	Yaoxue Tongbao. Bulletin of Pharmacology. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.13-23, 1978-88. For publisher information, see ZYZAEU.