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1 - Pyrrolidinecarboxylic acid, 1 - (D - 3 - mercapto - 2 - methyl - 1 - propionyl) - , L - (S,S) -

RTECS #: UY0550000

CAS #: 62571-86-2

UPDATE: May 2009 MW: 217.31 MF: C9H15NO3S


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. REPRODUCTIVE EFFECTS DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. REFERENCES:

SYNONYMS:

  1. ( - ) - Captopril
  2. (2S) - 1 - (3 - Mercapto - 2 - methylpropionyl) - L - proline
  3. 1 - ( (2S) - 3 - Mercapto - 2 - methylpropionyl) - L - proline
  4. 1 - (3 - Mercapto - 2 - methyl - 1 - oxopropyl) - L - proline
  5. 1 - (D - 3 - Mercapto - 2 - methyl - 1 - oxopropyl) - L - proline (S,S)
  6. Capoten
  7. Captopril
  8. Captopryl
  1. D - 2 - Methyl - 3 - mercaptopropanoyl - L - proline
  2. D - 3 - Mercapto - 2 - methylpropanoyl - L - proline
  3. D - 3 - Mercapto - 2 - methylpropionylproline
  4. L - Captopril
  5. L - Proline, 1 - (3 - mercapto - 2 - methyl - 1 - oxopropyl) - , (S) -
  6. SA 333
  7. SQ 14,225


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
man 		lowest published toxic dose: 228 mg/kg (43 week male) Reproductive: Paternal effects: Breast development BMJOAE 296,1262,1988
oral
rat 		lowest published toxic dose: 48 gm/kg (30 day male) Reproductive: Paternal effects: Testes, epididymis, sperm duct

Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands 		YACHDS 13,7041,1985
oral
rat 		lowest published toxic dose: 100 mg/kg (6-15 day pregnant) Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)

Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) 		RCOCB8 73,221,1991
oral
rat 		lowest published toxic dose: 100 mg/kg (6-15 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system RCOCB8 73,221,1991
oral
rabbit 		lowest published toxic dose: 40 mg/kg (15-30 day pregnant) Reproductive: Effects on embryo or fetus: Fetal death PSEBAA 170,378,1982
oral
rabbit 		lowest published toxic dose: 8,250 µg/kg (24-28 day pregnant) Reproductive: Effects on fertility: Other measures of fertility

Reproductive: Effects on embryo or fetus: Fetal death 		LANCAO 1,1256,1980


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intracerebral
rat 		lowest published toxic dose: 200 µg/kg Vascular: BP lowering not characterized in autonomic section BJMRDK 34,815,2001
inhalation
rat 		lowest published toxic concentration: 6.37 mg/m3/4 hour Behavioral: Change in motor activity (specific assay)

Lung, Thorax, or Respiration: Other changes

Nutritional and Gross Metabolic: Body temperature decrease 		TOVEFN (3),43,2002
inhalation
rat 		lowest published toxic concentration: 1.28 mg/m3/4 hour Cardiac: EKG changes not diagnostic of above

Liver: Liver function tests impaired

Liver: Other changes 		TOVEFN (3),43,2002
inhalation
rat 		lowest published toxic concentration: 1.28 mg/m3/4 hour Kidney, Ureter, and Bladder: Renal function tests depressed

Kidney, Ureter, and Bladder: Other changes in urine composition 		TOVEFN (3),43,2002
inhalation
rat 		lowest published toxic concentration: 12.58 mg/m3/4 hour Endocrine: Other changes

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) 		TOVEFN (3),43,2002
intraperitoneal
mouse 		lowest published toxic dose: 100 mg/kg Liver: Other changes

Blood: Changes in bone marrow not included in above

Biochemical: Metabolism (intermediary): Other proteins 		ARTODN 79,482,2005
intraperitoneal
mouse 		lethal dose (50 percent kill): 357.5 mg/kg Behavioral: Tremor TOVEFN (3),43,2002
intravenous
mouse 		lethal dose (50 percent kill): 663 mg/kg N/R IYKEDH 14,297,1983
intravenous
rat 		lethal dose (50 percent kill): 554 mg/kg N/R IYKEDH 14,297,1983
intravenous
rat 		lowest published toxic dose: 1 mg/kg Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) DCTODJ 26,213,2003
intravenous
rat 		lowest published toxic dose: 3,999 µg/kg Reproductive: Maternal effects: Uterus, cervix, vagina EJPHAZ 525,154,2005
intravenous
rat 		lowest published toxic dose: 1 mg/kg/1 minute Gastrointestinal: Other changes JPETAB 318,725,2006
intravenous
rat 		lowest published toxic dose: 5 mg/kg/1 minute Vascular: BP lowering not characterized in autonomic section JPETAB 318,725,2006
intravenous
rat 		lowest published toxic dose: 10 µg/kg Vascular: BP lowering not characterized in autonomic section BJPCBM 145,567,2005
oral
dog 		lethal dose : >600 mg/kg Gastrointestinal: Nausea or vomiting 44XQA7 -,137,1980
oral
human 		lowest published toxic dose: 714.3 µg/kg Kidney, Ureter, and Bladder: Changes in blood vessels or in circulation of kidney JCPCDT 35,758,2000
oral
human 		lowest published toxic dose: 2.14 mg/kg Cardiac: Cardiac output

Vascular: Regional or general arteriolar or venous dilation

Vascular: Measurement of regional blood flow 		BJMRDK 36,771,2003
oral
man 		lowest published lethal dose: 16 mg/kg N/R JTCTDW 28,379,1990
oral
man 		lowest published toxic dose: 4 mg/kg/8 day- intermittent Behavioral: Toxic psychosis AJPSAO 142,270,1985
oral
man 		lowest published toxic dose: 239 mg/kg/6 week- intermittent Taste: Change in function

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Blood: Normocytic anemia 		AJMEAZ 71,493,1981
oral
man 		lowest published lethal dose: 2,500 µg/kg/3 day- intermittent Kidney, Ureter, and Bladder: Urine volume decreased or anuria

Kidney, Ureter, and Bladder: Other changes 		PGMJAO 60,561,1984
oral
man 		lowest published toxic dose: 2,679 µg/kg/5 day- intermittent Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) IJMDAI 21,892,1985
oral
man 		lowest published toxic dose: 7,143 µg/kg/2 day- intermittent Skin: After systemic exposure: Dermatitis, other BMJOAE 294,91,1987
oral
man 		lowest published toxic dose: 12,500 µg/kg/25 day- intermittent Blood: Other hemolysis with or without anemia CMAJAX 129,525,1983
oral
man 		lowest published toxic dose: 87 mg/kg/18 week- intermittent Kidney, Ureter, and Bladder: Changes primarily in glomeruli

Kidney, Ureter, and Bladder: Proteinuria

Kidney, Ureter, and Bladder: Hematuria 		AIMEAS 112,550,1990
oral
man 		lowest published lethal dose: 2,680 µg/kg/5 day- intermittent Behavioral: Somnolence (general depressed activity)

Nutritional and Gross Metabolic: Changes in: K 		SMJOAV 86,1269,1993
oral
monkey 		lethal dose : >1,500 mg/kg Gastrointestinal: Nausea or vomiting 44XQA7 -,137,1980
oral
mouse 		lethal dose (50 percent kill): 2,078 mg/kg N/R FCTOD7 39,1135,2001
oral
mouse 		lethal dose (50 percent kill): 4,487.6 mg/kg Behavioral: Tremor TOVEFN (3),43,2002
oral
rat 		lethal dose (50 percent kill): 4,245 mg/kg N/R IYKEDH 14,297,1983
oral
rat 		lowest published toxic dose: 1 mg/kg Lung, Thorax, or Respiration: Other changes

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes 		JPETAB 309,1141,2004
oral
rat 		lethal dose (50 percent kill): 4,771.1 mg/kg Behavioral: Tremor TOVEFN (3),43,2002
oral
rat 		lowest published toxic dose: 50 mg/kg/36 hour Vascular: Contraction (isolated tissue) JPETAB 313,359,2005
oral
rat 		lowest published toxic dose: 40 mg/kg Cardiac: Pulse rate decreased with fall in BP JPETAB 312,1326,2005
oral
rat 		lowest published toxic dose: 50 mg/kg Blood: Change in clotting factors FCLPH* 18(Suppl 1),80,2004
oral
rat 		lowest published toxic dose: 50 mg/kg Vascular: BP lowering not characterized in autonomic section JPHSC* 100,271,2006
oral
woman 		lowest published toxic dose: 10 mg/kg Behavioral: Somnolence (general depressed activity)

Vascular: BP lowering not characterized in autonomic section 		AEMED3 20,1125,1991
oral
woman 		lowest published toxic dose: 14 mg/kg/2 week- intermittent Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Biochemical: Metabolism (intermediary): Other 		AIMEAS 104,126,1986
oral
woman 		lowest published lethal dose: 1,500 µg/kg/7 week Behavioral: Somnolence (general depressed activity)

Vascular: BP lowering not characterized in autonomic section

Lung, Thorax, or Respiration: Dyspnea 		AIMEAS 94,58,1981
oral
woman 		lowest published toxic dose: 10 mg/kg/10 day- intermittent Skin: After systemic exposure: Dermatitis, other BMJOAE 294,91,1987
subcutaneous
mouse 		lethal dose (50 percent kill): >2,400 mg/kg N/R YAKUD5 24,2439,1982
subcutaneous
rat 		lethal dose (50 percent kill): >600 mg/kg N/R YAKUD5 24,2439,1982


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lowest published toxic dose: 60 mg/kg/10 day- intermittent Vascular: Structural changes in vessels JJIND8 95,388,2003
oral
dog 		lowest published toxic dose: 9,100 mg/kg/91 day- intermittent Kidney, Ureter, and Bladder: Other changes

Skin: After systemic exposure: Dermatitis, other 		JTSCDR 6(Suppl 2),247,1981
oral
monkey 		lowest published toxic dose: 6,300 mg/kg/28 day- intermittent Blood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes 		44XQA7 -,137,1980
oral
mouse 		lowest published toxic dose: 60 gm/kg/150 day- intermittent Vascular: BP lowering not characterized in autonomic section

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) 		TOXID9 72,285,2003
oral
mouse 		lowest published toxic dose: 800 mg/kg/40 day- intermittent Tumorigenic: Active as anti-cancer agent CCREF4 7,1073,2001
oral
rat 		lowest published toxic dose: 45 gm/kg/13 week- intermittent Kidney, Ureter, and Bladder: Changes in bladder weight

Blood: Pigmented or nucleated red blood cells

Blood: Changes in erythrocyte (RBC) count 		ARZNAD 45,15,1995
oral
rat 		lowest published toxic dose: 3 gm/kg/30 day- intermittent Cardiac: Changes in heart weight

Liver: Changes in liver weight

Blood: Changes in other cell count (unspecified) 		JTSCDR 6(Suppl 2),189,1981
oral
rat 		lowest published toxic dose: 36,500 mg/kg/1 year- continuous Cardiac: Changes in heart weight

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Blood: Changes in erythrocyte (RBC) count 		JTSCDR 6(Suppl 2),215,1981
oral
rat 		lowest published toxic dose: 490 mg/kg/5 week- intermittent Vascular: BP lowering not characterized in autonomic section CYLPDN 21,727,2000
oral
rat 		lowest published toxic dose: 240 mg/kg/4 day- intermittent Behavioral: Fluid intake BJMRDK 34,407,2001
oral
rat 		lowest published toxic dose: 120 mg/kg/2 day- intermittent Behavioral: Fluid intake

Nutritional and Gross Metabolic: Changes in: Na 		BJMRDK 38,1669,2005
oral
rat 		lowest published toxic dose: 3,500 mg/kg/10 week- intermittent Vascular: BP lowering not characterized in autonomic section

Vascular: Contraction (isolated tissue) 		JPETAB 313,359,2005
oral
rat 		lowest published toxic dose: 700 mg/kg/2 week- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain BPBLEO 28,367,2005
oral
rat 		lowest published toxic dose: 2,800 mg/kg/8 week- intermittent Kidney, Ureter, and Bladder: Other changes in urine composition BPBLEO 28,367,2005
oral
rat 		lowest published toxic dose: 9,660 mg/kg/92 day- continuous Brain and Coverings: Other degenerative changes

Vascular: BP lowering not characterized in autonomic section

Vascular: Regional or general arteriolar or venous dilation 		BJPCBM 144,349,2005
oral
rat 		lowest published toxic dose: 8,648 mg/kg/92 day- continuous Brain and Coverings: Changes in circulation

Vascular: Regional or general arteriolar or venous dilation

Vascular: BP lowering not characterized in autonomic section 		BJPCBM 144,349,2005
oral
rat 		lowest published toxic dose: 60 gm/kg/40 week- intermittent Cardiac: Changes in heart weight

Endocrine: Other changes

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) 		FCLPH* 19,457,2005
oral
rat 		lowest published toxic dose: 210 mg/kg/7 day- intermittent Vascular: BP lowering not characterized in autonomic section BPBLEO 30,1278,2007
oral
rat 		lowest published toxic dose: 1,260 mg/kg/42 day- intermittent Vascular: BP lowering not characterized in autonomic section

Vascular: Relaxation (isolated tissue)

Biochemical: Metabolism (intermediary): Lipids including transport 		BPBLEO 30,1278,2007
oral
rat 		lowest published toxic dose: 500 mg/kg/10 day- intermittent Blood: Change in clotting factors PHREP* 57,135,2005
skin
rabbit 		lowest published toxic dose: 50 pph/10 day- intermittent Skin: After topical application: Primary irritation

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		TOVEFN (3),43,2002


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
TOXICOLOGY REVIEW
MUREAV 488,151,2001
TOXICOLOGY REVIEW
TPHSDY 23,177,2002
TOXICOLOGY REVIEW
TPHSDY 23,434,2002
TOXICOLOGY REVIEW
TPHSDY 23,539,2002
TOXICOLOGY REVIEW
TPHSDY 24,391,2003
TOXICOLOGY REVIEW
APHRER 38,831,2004
TOXICOLOGY REVIEW
APHRER 39,470,2005
TOXICOLOGY REVIEW
APHRER 40,699,2006
TOXICOLOGY REVIEW
EJIME* 17,529,2006
TOXICOLOGY REVIEW
DIMON* 39,678,1993
TOXICOLOGY REVIEW
TOPADD 32(Suppl. 2),71,2004
TOXICOLOGY REVIEW
HUTOX* -,395,1996


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Exposure Limit - RUSSIA short term exposure limit 0.02 mg/m3, JUN2003


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X4863;
Number of Industries 1;
Total Number of Facilities 27;
Number of Occupations 1;
Total Number of Employees Exposed 642;
Total Number of Female Employees Exposed 346


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
N/R


REFERENCES:

CODEN
REFERENCE
44XQA7 "Captopril and Hypertension, Collection of Papers presented at a Symposium, Princeton, N.J., 1979?," Case, David B., et al. eds., New York, Plenum Publishing, 1980
AEMED3 Annals of Emergency Medicine. (American College of Emergency Physicians, 1125 Executive Circle, Irving, TX 75038)
AIMEAS Annals of Internal Medicine. (American College of Physicians, 4200 Pine St., Philadelphia, PA 19104) V.1- 1927-
AJMEAZ American Journal of Medicine. (Technical Pub., 875 Third Ave., New York, NY 10022) V.1- 1946-
AJPSAO American Journal of Psychiatry. (American Psychiatric Assoc., Circulation Dept., 1400 K St., NW, Washington, DC 20005) V.78- 1921-
APHRER Annals of Pharmacotherpy. (Harvey Whitney Books Co., POB 42696, Cincinnati, OH 45242) V. 26- 1992-
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974-
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
BJMRDK Brazilian Journal of Medical and Biological Research. (Associacao Brasileira de Divulgacao Cientifica, Faculdade de Medicina de Ribeirao Preto, USP, 141000 Ribeirao Preto, SP, Brazil) V.14- 1981-
BJPCBM British Journal of Pharmacology. (Macmillan Press Ltd., Houndmills, Basingstoke, Hants. RG21 2XS, UK) V.34- 1968-
BMJOAE British Medical Journal. (British Medical Assoc., BMA House, Tavistock Sq., London WC1H 9JR, UK) V.1- 1857-
BPBLEO Biological and Pharmaceutical Bulletin. (Pharmaceutical Society of Japan, 2-12-15-201 Shibuya Shibuya-ku, Tokyo 150, Japan) V.16- 1993-
CCREF4 Clinical Cancer Research. (Clinical Cancer Research, POB 3000, Denville, NJ 07834) V.1- 1995-
CMAJAX Canadian Medical Association Journal. (Canadian Medical Assoc., POB 8650, Ottawa, ON K1G 0G8, Canada) V.1- 1911-
CYLPDN Zhongguo Yaoli Xuebao. Acta Pharmacologica Sinica. Chinese Journal of Pharmacology. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.1- 1980-
DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.1- 1977/78-
DIMON* Disease-a Month (Chicago : Year Book Publishers) V. 24- 1978-
EJIME* European Journal of Internal Medicine: The Official Journal of the European Federation of Internal Medicine (EFIM) (Elsevier) V.10- 1999-
EJPHAZ European Journal of Pharmacology. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1967-
FCLPH* Fundamental & Clinical Pharmacology (Oxford : Blackwell Science) 2001-
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982-
HUTOX*
IJMDAI Israel Journal of Medical Sciences. (POB 1435, Jerusalem 91013, Israel) V.1- 1965-
IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970-
JCPCDT Journal of Cardiovascular Pharmacology. (Raven Press, 1140 Ave. of the Americas, New York, NY 10036) V.1- 1979-
JJIND8 JNCI, Journal of the National Cancer Institute. (Washington, DC) V.61-79, 1978-87. For publisher information, see JNCIEQ.
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
JPHSC*
JTCTDW Journal of Toxicology, Clinical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.19- 1982-
JTSCDR Journal of Toxicological Sciences. (Japanese Soc. of Toxicological Sciences, 4th Floor, Gakkai Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku, Tokyo 113, Japan) V.1- 1976-
LANCAO Lancet. (7 Adam St., London WC2N 6AD, UK) V.1- 1823-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
PGMJAO Postgraduate Medical Journal. (Blackwell Scientific Pub. Ltd., POB 88, Oxford, UK) V.1- 1925-
PHREP*
PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04-
RCOCB8 Research Communications in Chemical Pathology and Pharmacology. (PJD Pub. Ltd., P.O. Box 966, Westbury, NY 11590) V.1- 1970-
SMJOAV Southern Medical Journal. (Southern Medical Assoc., POB 2446, Birmingham, AL 35205) V.1- 1908-
TOPADD Toxicologic Pathology. (c/o Dr. F.A. de la Iglesia, Warner-Lambert Co., Pharmaceutical Research Div., POB 1047, Ann Arbor, MI 48106) V.6(3/4)- 1978-
TOVEFN Toksikologicheskii Vestnik. (18-20 Vadkovskii per. Moscow, 101479, Russia) History Unknown
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
TPHSDY Trends in Pharmacological Sciences. (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.1- 1979-
YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972-
YAKUD5 Gekkan Yakuji. Pharmaceuticals Monthly. (Yakugyo Jihosha, Inaoka Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan) V.1- 1959-

Used to treat refractory systemic hypertension and as experimental drug in heart failure

FDA-proprietary drug

RTECS Compound Description:
   Drug
   Reproductive Effector
   Human Data

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