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Pyrocatechol, 4 - (2 - aminoethyl) - , hydrochloride

RTECS #: UX1092000

CAS #: 62-31-7

UPDATE: November 2008 MW: 189.66 MF: C8H11NO2•ClH


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. 1,2 - Benzenediol, 4 - (2 - aminoethyl) - , hydrochloride
  2. 3 - Hydroxytyramine hydrochloride
  3. 4 - (2 - Aminoethyl) pyrocatechol hydrochloride
  4. Dopamine chloride
  1. Dopamine hydrochloride
  2. Intropin
  3. P 498
  4. m - Hydroxytyramine hydrochloride


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
DNA adduct mouse liver 6 µmol/L JJIND8 62,947,1979
DNA repair Bacillus subtilis 900 µg/disc MUREAV 137,17,1984
mutation in microorganisms Escherichia coli 2,500 µg/plate (-enzymatic activation step) MUREAV 467,41,2000
mutation in mammalian somatic cells mouse lymphocyte 93,800 µg/L MUREAV 124,9,1983


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
rat 		lowest published toxic dose: 7 mg/kg (1-7 day pregnant) Reproductive: Other developmental abnormalities TXAPA9 38,251,1976
intraperitoneal
rat 		lowest published toxic dose: 2,100 µg/kg (7-12 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system KSRNAM 8,2311,1974
intravenous
domestic animal 		lowest published toxic dose: 361 mg/kg (15 week pregnant) Reproductive: Specific developmental abnormalities: Blood and lymphatic systems (including spleen and marrow) AJOGAH 130,211,1978
intravenous
rat 		lowest published toxic dose: 300 mg/kg (6-15 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) ARZNAD 28,2208,1978
intravenous
rat 		lowest published toxic dose: 900 mg/kg (6-15 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system ARZNAD 28,2208,1978


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intracerebral
rat 		lowest published toxic dose: 80 µg/kg Behavioral: Alteration of operant conditioning NEROEW 25,440,2001
intraperitoneal
mouse 		lethal dose (50 percent kill): 914 mg/kg Olfaction: Other olfaction effects

Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Dyspnea 		KSRNAM 8,2311,1974
intraperitoneal
mouse 		lowest published toxic dose: 0.56 mg/kg Gastrointestinal: Decreased motility or constipation AJCHM* 30,207,2002
intraperitoneal
rat 		lethal dose (50 percent kill): 597 mg/kg Olfaction: Other olfaction effects

Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Dyspnea 		KSRNAM 8,2311,1974
intravenous
dog 		lethal dose (50 percent kill): 79 mg/kg Eye: Mydriasis (pupilliary dilation)

Behavioral: Ataxia

Gastrointestinal: Hypermotility, diarrhea 		ARZNAD 28,2208,1978
intravenous
man 		lowest published toxic dose: 1,429 µg/kg Eye: Mydriasis (pupilliary dilation) CCMDC7 9,658,1981
intravenous
mouse 		lethal dose (50 percent kill): 156 mg/kg Olfaction: Other olfaction effects

Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Dyspnea 		KSRNAM 8,2311,1974
intravenous
rat 		lethal dose (50 percent kill): 4,800 µg/kg Olfaction: Other olfaction effects

Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Dyspnea 		KSRNAM 8,2311,1974
intravenous
rat 		lowest published toxic dose: 200 µg/kg/10 minute Vascular: Regional or general arteriolar constriction JPETAB 314,162,2005
intravenous
rat 		lowest published toxic dose: 150 µg/kg/10 minute Vascular: BP elevation not characterized in autonomic section JPETAB 314,162,2005
intravenous
rabbit 		lethal dose (50 percent kill): 90 mg/kg Olfaction: Other olfaction effects

Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Dyspnea 		KSRNAM 8,2311,1974
intravenous
rabbit 		lowest published toxic dose: 150 µg/kg/15 minute Cardiac: Cardiac output PHREP* 58,48,2006
intravenous
rabbit 		lowest published toxic dose: 270 µg/kg/27 minute Cardiac: Cardiac output

Vascular: Other changes 		PHREP* 58,48,2006
oral
mouse 		lethal dose (50 percent kill): 4,361 mg/kg Olfaction: Other olfaction effects

Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Dyspnea 		KSRNAM 8,2311,1974
oral
rat 		lethal dose (50 percent kill): 2,859 mg/kg Olfaction: Other olfaction effects

Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Dyspnea 		KSRNAM 8,2311,1974
subcutaneous
mouse 		lethal dose (50 percent kill): 1,366 mg/kg Olfaction: Other olfaction effects

Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Dyspnea 		KSRNAM 8,2311,1974
subcutaneous
rat 		lethal dose (50 percent kill): 647 mg/kg Olfaction: Other olfaction effects

Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Dyspnea 		KSRNAM 8,2311,1974


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intravenous
dog 		lowest published toxic dose: 42 mg/kg/6 week- intermittent Cardiac: Pulse rate increased without fall in BP

Cardiac: Pulse rate decreased with fall in BP 		ARZNAD 28,2208,1978
intravenous
rat 		lowest published toxic dose: 420 mg/kg/6 week- intermittent Cardiac: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		ARZNAD 28,2208,1978


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
TOXICOLOGY REVIEW
EMMUEG 43,36,2004


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X3889;
Number of Industries 1;
Total Number of Facilities 135;
Number of Occupations 3;
Total Number of Employees Exposed 5,239;
Total Number of Female Employees Exposed 3,875


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY


REFERENCES:

CODEN
REFERENCE
AJCHM* The American Journal of Chinese Medicine (Singapore ; River Edge, NJ : World Scientific Pub.) V.7- 1979-
AJOGAH American Journal of Obstetrics and Gynecology. (C.V. Mosby Co., 11830 Westline Industrial Dr., St. Louis, MO 63146) V.1- 1920-
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
CCMDC7 Critical Care Medicine. (Williams & Wilkins, 428 E. Preston Street, Baltimore, MD 21202) V.1- 1973-
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
JJIND8 JNCI, Journal of the National Cancer Institute. (Washington, DC) V.61-79, 1978-87. For publisher information, see JNCIEQ.
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NEROEW Neuropsychopharmacology. (Elsevier Science, 655 Avenue of the Americas, New York, NY 10010) V.1- 1987-
PHREP*
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-

Used as antihypotensive

FDA-proprietary drug

RTECS Compound Description:
   Drug
   Mutagen
   Reproductive Effector
   Human Data
   Natural Product

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