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Pyrocatechol, 4 - (2 - aminoethyl) -

RTECS #: UX1088000

CAS #: 51-61-6

UPDATE: May 2009 MW: 153.20 MF: C8H11NO2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. REFERENCES:

SYNONYMS:

  1. 1,2 - Benzenediol, 4 - (2 - aminoethyl) - (9CI)
  2. 3,4 - Dihydroxyphenethylamine
  3. 3,4 - Dihydroxyphenylethylamine
  4. 3 - Hydroxytyramine
  5. 4 - (2 - Aminoethyl) pyrocatechol
  6. 4 - (Aminoethyl) catechol
  1. ASL 279
  2. DA
  3. Dopamin
  4. Dopamine
  5. Oxytyramine


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
DNA damage Escherichia coli 10 mg/L MUREAV 124,9,1983
DNA damage human fibroblast 50 mg/L MUREAV 124,9,1983
DNA damage mammal (species unspecified) lymphocyte 1 mg/L MUREAV 124,9,1983
DNA damage mouse lymphocyte 2,230 µmol/L MUREAV 203,155,1988
DNA inhibition human other cell types 3,800 nmol/L CNREA8 40,1414,1980
DNA inhibition mouse other cell types 3,800 nmol/L CNREA8 40,1414,1980
micronucleus test intravenous
mouse 		224 mg/kg MUREAV 124,9,1983


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intramuscular
rat 		lowest published toxic dose: 70 mg/kg (1-7 day pregnant) Reproductive: Effects on newborn: Other postnatal measures or effects TXAPA9 40,427,1977
intraperitoneal
rat 		lowest published toxic dose: 70 mg/kg (1-7 day pregnant) Reproductive: Effects on newborn: Other postnatal measures or effects TXAPA9 40,427,1977
intravenous
woman 		lowest published toxic dose: 120 µg/kg (2 hour after birth) Reproductive: Other effects on female GOBIDS 23,103,1987
subcutaneous
rat 		lowest published toxic dose: 300 mg/kg (30 day prior to copulation) Reproductive: Maternal effects: Ovaries, fallopian tubes AJOGAH 104,578,1969
subcutaneous
rat 		lowest published toxic dose: 100 mg/kg (10-14 day pregnant) Reproductive: Effects on newborn: Weaning or lactation index (e.g., # alive at weaning per # alive at day 4)

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)

Reproductive: Effects on newborn: Other postnatal measures or effects 		AJOGAH 104,578,1969
subcutaneous
rat 		lowest published toxic dose: 100 mg/kg (10-14 day pregnant) Reproductive: Specific developmental abnormalities: Eye, ear AJOGAH 104,578,1969


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intracerebral
rat 		lowest published toxic dose: 80 µg/kg/5 minute Behavioral: Change in psychophysiological tests NRTXDN 24,227,2003
intracerebral
rat 		lowest published toxic dose: 100 µg/kg Brain and Coverings: Other degenerative changes

Behavioral: Change in psychophysiological tests 		TOXID9 60,188,2001
intracerebral
rat 		lowest published toxic dose: 320 gm/kg Behavioral: Change in motor activity (specific assay) JPETAB 307,1038,2003
intracervical
mouse 		lethal dose (50 percent kill): 74 mg/kg Behavioral: Change in motor activity (specific assay) TYKNAQ 27,131,1980
intraperitoneal
mouse 		lethal dose (50 percent kill): 950 mg/kg Olfaction: Other olfaction effects

Lung, Thorax, or Respiration: Respiratory stimulation

Blood: Hemorrhage 		OYYAA2 8,835,1974
intraperitoneal
mouse 		lowest published toxic dose: 0.75 mg/kg Behavioral: Analgesia JOETD7 55,13,1996
intraperitoneal
rat 		lethal dose (50 percent kill): 163 mg/kg Lung, Thorax, or Respiration: Other changes

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Nutritional and Gross Metabolic: Dehydration 		TXAPA9 88,433,1987
intravenous
domestic animal 		lowest published toxic dose: 30 µg/kg/1 hour Vascular: BP elevation not characterized in autonomic section

Cardiac: Cardiac output 		CYLPDN 23,133,2002
intravenous
human 		lowest published toxic dose: 0.2 µg/kg Vascular: BP elevation not characterized in autonomic section

Kidney, Ureter, and Bladder: Urine volume decreased or anuria 		FATOAO 53,58,1990
intravenous
mouse 		lethal dose (50 percent kill): 59 mg/kg Olfaction: Other olfaction effects

Lung, Thorax, or Respiration: Respiratory stimulation

Blood: Hemorrhage 		OYYAA2 8,835,1974
intravenous
mouse 		lowest published toxic dose: 100 µg/kg Vascular: BP elevation not characterized in autonomic section BJPCBM 150,29,2007
intravenous
rat 		lowest published toxic dose: 2 µg/kg Brain and Coverings: Changes in circulation

Vascular: BP elevation not characterized in autonomic section 		EKFAE9 62,29,1999
intravenous
rat 		lowest published toxic dose: 8.25 mg/kg/30 minute Vascular: Measurement of regional blood flow BJCAAI 90,549,2004
unreported route
mammal (species unspecified) 		lethal dose (50 percent kill): 1,120 mg/kg N/R KHFZAN 24(4),42,1990


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lowest published toxic dose: 200 mg/kg/4 day- intermittent Blood: Changes in bone marrow not included in above

Tumorigenic: Active as anti-cancer agent

Biochemical: Metabolism (intermediary): Other proteins 		JCINAO 118,1380,2008
intraperitoneal
rat 		lowest published toxic dose: 9 gm/kg/30 day- continuous Blood: Normocytic anemia

Blood: Changes in spleen

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		KSRNAM 8,2311,1974
intraperitoneal
rat 		lowest published toxic dose: 10,920 mg/kg/26 week- intermittent Blood: Changes in spleen

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		KSRNAM 8,2311,1974


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
TOXICOLOGY REVIEW
TPHSDY 24,184,2003
TOXICOLOGY REVIEW
TOXIA6 47,1,2006
TOXICOLOGY REVIEW
JOPSEQ 20,708,2006
TOXICOLOGY REVIEW
JOPSEQ 20,602,2006
TOXICOLOGY REVIEW
JOPSEQ 20,176,2006
TOXICOLOGY REVIEW
JOPSEQ 20,194,2006
TOXICOLOGY REVIEW
JOPSEQ 20,143,2006
TOXICOLOGY REVIEW
AINCM* 7,63,2006
TOXICOLOGY REVIEW
EJPHAZ 545,22,2006
TOXICOLOGY REVIEW
HPCQA4 38,527,2007
TOXICOLOGY REVIEW
HUTOX* -,335,1996


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X3655;
Number of Industries 1;
Total Number of Facilities 50;
Number of Occupations 3;
Total Number of Employees Exposed 8,422;
Total Number of Female Employees Exposed 7,695


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
N/R


REFERENCES:

CODEN
REFERENCE
AINCM* Anaesthesia and Intensive Care Medicine (Abingdon: Medicine Pub. Co.) V.1- 2000-
AJOGAH American Journal of Obstetrics and Gynecology. (C.V. Mosby Co., 11830 Westline Industrial Dr., St. Louis, MO 63146) V.1- 1920-
BJCAAI British Journal of Cancer. (Macmillan Press Ltd., Houndmills, Basingstoke, Hants. RG21 2XS, UK) V.1- 1947-
BJPCBM British Journal of Pharmacology. (Macmillan Press Ltd., Houndmills, Basingstoke, Hants. RG21 2XS, UK) V.34- 1968-
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941-
CYLPDN Zhongguo Yaoli Xuebao. Acta Pharmacologica Sinica. Chinese Journal of Pharmacology. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.1- 1980-
EJPHAZ European Journal of Pharmacology. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1967-
EKFAE9 Eksperimental'naya i Klinicheskaya Farmakologiya. Experimental and Clinical Pharmacology. (Mezhdunarodnaya Kniga, ul. B. Yakimanka, 39, 117049 Moscow, Russia) V.55- 1992-
FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939-
GOBIDS Gynecologic and Obstetric Investigation. (S. Karger Pub., Inc., 79 Fifth Ave., New York, NY 10003) V.9- 1978-
HPCQA4 Human Pathology. (W.B. Saunders Co., W. Washington Sq., Philadelphia, PA 19105) V.1- 1970-
HUTOX*
JCINAO Journal of Clinical Investigation. (Rockefeller Univ. Press, 1230 York Ave., New York, NY 10021) V.1- 1924-
JOETD7 Journal of Ethnopharmacology. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1979-
JOPSEQ Journal of Psychopharmacology (Oxford). (Oxford University Press, Great Clarendon St., Oxford OX2 6DP, UK) V.1- 1987-
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
KHFZAN Khimiko-Farmatsevticheskii Zhurnal. Chemical Pharmaceutical Journal. For English translation, see PCJOAU. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1967-
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NRTXDN Neurotoxicology. (Intox Press, Inc., POB 34075, Little Rock, AR 72203) V.1- 1979-
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967-
TOXIA6 Toxicon. (Pergamon Press Ltd., Headington Hill Hall, Oxford OX3 OBW, UK) V.1- 1962-
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
TPHSDY Trends in Pharmacological Sciences. (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.1- 1979-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
TYKNAQ Tohoku Yakka Daigaku Kenkyu Nempo. Annual Report of the Tohoku College of Pharmacy. (Tohoku Yakka Daigaku, 4-4-1 Kamatsujima, Sendai, Japan) No.10- 1963-

Used as an adrenergic agent

RTECS Compound Description:
   Drug
   Mutagen
   Reproductive Effector
   Human Data
   Natural Product

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