RTECS:UV1230000 The Registry of Toxic Effects of Chemical Substances

Pyridoxamine dihydrochloride

RTECS #: UV1230000

CAS #: 524-36-7

UPDATE: April 1995 MW: 241.14 MF: C₈H₁₂N₂O₂•2ClH

NOTE:

TOXICITY DATA HAVE NOT BEEN EVALUATED. OMISSION OF A SUBSTANCE OR NOTATION DOES NOT IMPLY ANY RELIEF FROM REGULATORY RESPONSIBILITY.

TABLE OF CONTENTS:

SYNONYMS:

ACUTE TOXICITY DATA:

NIOSH DOCUMENTATION AND SURVEILLANCE:

REFERENCES:

SYNONYMS:

2 - Methyl - 3 - hydroxy - 4 - aminomethyl - 5 - hydroxymethylpyridene dihydrochloride

3 - Pyridinemethanol, 4 - (aminomethyl) - 5 - hydroxy - 6 - methyl - , dihydrochloride

4 - (Aminomethyl) - 5 - hydroxy - 6 - methyl - 3 - pyridinemethanol dihydrochloride

Pyridoxylamine dihydrochloride

SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

MUTATION DATA AND REFERENCES:
SYSTEM TEST ROUTE/
ORGANISM/
TISSUE DOSE REFERENCE
N/R N/R N/R N/R

REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

TUMORIGENIC DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
intravenous
cat lethal dose (50 percent kill): 540 mg/kg Behavioral: Convulsions or effect on seizure threshold

Gastrointestinal: Changes in structure or function of salivary glands

Gastrointestinal: Hypermotility, diarrhea ARZNAD 11,922,1961
intravenous
mouse lethal dose (50 percent kill): 590 mg/kg Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Dyspnea ARZNAD 11,922,1961
intravenous
pigeon lethal dose (50 percent kill): 795 mg/kg Behavioral: Altered sleep time (including change in righting reflex)

Behavioral: Convulsions or effect on seizure threshold ARZNAD 11,922,1961
intravenous
rat lethal dose (50 percent kill): 800 mg/kg Behavioral: Convulsions or effect on seizure threshold

Behavioral: Excitement ARZNAD 11,922,1961
intravenous
rabbit lethal dose (50 percent kill): 700 mg/kg Peripheral Nerve and Sensation: Spastic paralysis with/without sensory change

Behavioral: Convulsions or effect on seizure threshold ARZNAD 11,922,1961
oral
cat lethal dose (50 percent kill): >1 gm/kg Behavioral: Convulsions or effect on seizure threshold

Gastrointestinal: Changes in structure or function of salivary glands

Gastrointestinal: Hypermotility, diarrhea ARZNAD 11,922,1961
oral
mouse lethal dose (50 percent kill): 5,100 mg/kg Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Dyspnea ARZNAD 11,922,1961
oral
rat lethal dose (50 percent kill): 7,500 mg/kg Behavioral: Convulsions or effect on seizure threshold

Behavioral: Excitement ARZNAD 11,922,1961
subcutaneous
mouse lethal dose (50 percent kill): 2,950 mg/kg Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Dyspnea ARZNAD 11,922,1961
subcutaneous
rat lethal dose (50 percent kill): 4,720 mg/kg Behavioral: Convulsions or effect on seizure threshold

Behavioral: Excitement ARZNAD 11,922,1961

OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

REVIEWS:
ORGANIZATION STANDARD
REFERENCE

N/R N/R N/R

STANDARDS AND REGULATIONS:
ORGANIZATION STANDARD
REFERENCE

N/R N/R N/R

NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X4950;
Number of Industries 1;
Total Number of Facilities 6;
Number of Occupations 1;
Total Number of Employees Exposed 44;
Total Number of Female Employees Exposed 32

STATUS IN FEDERAL AGENCIES:
ORGANIZATION
REFERENCE

N/R

REFERENCES:
CODEN
REFERENCE

ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-

RTECS Compound Description:
Drug

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SYNONYMS:
2 - Methyl - 3 - hydroxy - 4 - aminomethyl - 5 - hydroxymethylpyridene dihydrochloride 3 - Pyridinemethanol, 4 - (aminomethyl) - 5 - hydroxy - 6 - methyl - , dihydrochloride	4 - (Aminomethyl) - 5 - hydroxy - 6 - methyl - 3 - pyridinemethanol dihydrochloride Pyridoxylamine dihydrochloride

SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
N/R	N/R	N/R	N/R

MUTATION DATA AND REFERENCES:
SYSTEM TEST	ROUTE/ ORGANISM/ TISSUE	DOSE	REFERENCE
N/R	N/R	N/R	N/R

REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
N/R	N/R	N/R	N/R

TUMORIGENIC DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
N/R	N/R	N/R	N/R

ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
intravenous cat	lethal dose (50 percent kill): 540 mg/kg	Behavioral: Convulsions or effect on seizure threshold Gastrointestinal: Changes in structure or function of salivary glands Gastrointestinal: Hypermotility, diarrhea	ARZNAD 11,922,1961
intravenous mouse	lethal dose (50 percent kill): 590 mg/kg	Behavioral: Convulsions or effect on seizure threshold Lung, Thorax, or Respiration: Dyspnea	ARZNAD 11,922,1961
intravenous pigeon	lethal dose (50 percent kill): 795 mg/kg	Behavioral: Altered sleep time (including change in righting reflex) Behavioral: Convulsions or effect on seizure threshold	ARZNAD 11,922,1961
intravenous rat	lethal dose (50 percent kill): 800 mg/kg	Behavioral: Convulsions or effect on seizure threshold Behavioral: Excitement	ARZNAD 11,922,1961
intravenous rabbit	lethal dose (50 percent kill): 700 mg/kg	Peripheral Nerve and Sensation: Spastic paralysis with/without sensory change Behavioral: Convulsions or effect on seizure threshold	ARZNAD 11,922,1961
oral cat	lethal dose (50 percent kill): >1 gm/kg	Behavioral: Convulsions or effect on seizure threshold Gastrointestinal: Changes in structure or function of salivary glands Gastrointestinal: Hypermotility, diarrhea	ARZNAD 11,922,1961
oral mouse	lethal dose (50 percent kill): 5,100 mg/kg	Behavioral: Convulsions or effect on seizure threshold Lung, Thorax, or Respiration: Dyspnea	ARZNAD 11,922,1961
oral rat	lethal dose (50 percent kill): 7,500 mg/kg	Behavioral: Convulsions or effect on seizure threshold Behavioral: Excitement	ARZNAD 11,922,1961
subcutaneous mouse	lethal dose (50 percent kill): 2,950 mg/kg	Behavioral: Convulsions or effect on seizure threshold Lung, Thorax, or Respiration: Dyspnea	ARZNAD 11,922,1961
subcutaneous rat	lethal dose (50 percent kill): 4,720 mg/kg	Behavioral: Convulsions or effect on seizure threshold Behavioral: Excitement	ARZNAD 11,922,1961

OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
N/R	N/R	N/R	N/R

STANDARDS AND REGULATIONS:
ORGANIZATION	STANDARD	REFERENCE
N/R	N/R	N/R

NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION	STANDARD or SURVEY	REFERENCE
National Occupational Exposure Survey 1983	National Occupational Exposure Survey 1983: Hazard Code: X4950; Number of Industries 1; Total Number of Facilities 6; Number of Occupations 1; Total Number of Employees Exposed 44; Total Number of Female Employees Exposed 32

REFERENCES:
CODEN	REFERENCE
ARZNAD	Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-