RTECS:UU4200000 The Registry of Toxic Effects of Chemical Substances

Pyridinium, 2 - formyl - 1 - methyl - , chloride, oxime

RTECS #: UU4200000

CAS #: 51-15-0

UPDATE: August 2006 MW: 172.63 MF: C₇H₉N₂O•Cl

NOTE:

TOXICITY DATA HAVE NOT BEEN EVALUATED. OMISSION OF A SUBSTANCE OR NOTATION DOES NOT IMPLY ANY RELIEF FROM REGULATORY RESPONSIBILITY.

TABLE OF CONTENTS:

SYNONYMS:

ACUTE TOXICITY DATA:

OTHER MULTIPLE DOSE DATA:

REVIEWS:

NIOSH DOCUMENTATION AND SURVEILLANCE:

REFERENCES:

SYNONYMS:

1 - Methyl - 2 - aldoximinopyridinium chloride

1 - Methyl - 2 - pyridinium aldoxime chloride

1 - Methyl - 2 - formylpyridinium chloride oxime

2 - (Hydroxyiminomethyl) - 1 - methylpyridinium chloride

2 - Formyl - 1 - methylpyridinium chloride oxime

2 - Formyl - N - methylpyridinium oxime chloride

2 - PAM chloride

2 - Pam

2 - Pyridine aldoxime methyl chloride

2 - Pyridine - aldoxime chloride

N - Methylpyridinium chloride 2 - aldoxime

N - Metylpyridinium - 2 - aldoxime chloride

Pralidoxime chloride

Protopam

Protopam chloride

Pyridine - 2 - aldoxime methochloride

Pyridinium aldoxime methochloride

Pyridinium, 2 - ( (hydroxyimino) methyl) - 1 - methyl - , chloride

SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

MUTATION DATA AND REFERENCES:
SYSTEM TEST ROUTE/
ORGANISM/
TISSUE DOSE REFERENCE
N/R N/R N/R N/R

REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

TUMORIGENIC DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
intramuscular
dog lethal dose (50 percent kill): 75 mg/kg N/R FAATDF 4,S106,1984
intramuscular
guinea pig lethal dose (50 percent kill): 168 mg/kg N/R TXAPA9 16,40,1970
intramuscular
mouse lethal dose (50 percent kill): 100 mg/kg N/R DCTODJ 8,431,1985
intramuscular
rat lethal dose (50 percent kill): 150 mg/kg N/R TXAPA9 16,40,1970
intraperitoneal
mouse lethal dose (50 percent kill): 155 mg/kg N/R ARZNAD 14,5,1964
intraperitoneal
rat lowest published toxic dose: 38,358 µg/kg Blood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase JAPTO* 25,68,2005
intravenous
human lowest published toxic dose: 15 mg/kg Vascular: BP elevation not characterized in autonomic section AEHLAU 15,599,1967
intravenous
man lowest published toxic dose: 14 mg/kg Behavioral: Coma

Lung, Thorax, or Respiration: Bronchiolar constriction, including asthma

Lung, Thorax, or Respiration: Cyanosis 34ZIAG -,449,1969
intravenous
mouse lethal dose (50 percent kill): 90 mg/kg N/R ARZNAD 14,5,1964
intravenous
pig lowest published toxic dose: 33.3 mg/kg Blood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase JAPTO* 24,429,2004
intravenous
rat lethal dose (50 percent kill): 96 mg/kg N/R TXAPA9 16,40,1970
intravenous
rabbit lethal dose (50 percent kill): 95 mg/kg N/R JPETAB 132,50,1961
intravenous
woman lowest published toxic dose: 144 mg/kg/18 hour Behavioral: Change in motor activity (specific assay)

Vascular: Other changes

Gastrointestinal: Changes in structure or function of salivary glands JTCTDW 38,47,2000
oral
mouse lethal dose (50 percent kill): 4,100 mg/kg N/R JPMSAE 53,1143,1964
subcutaneous
rat lowest published lethal dose: 30 mg/kg Behavioral: Anticonvulsant TXCYAC 196,31,2004

OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
intraperitoneal
rat lowest published toxic dose: 172.6 mg/kg/5 day- intermittent Blood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase JAPTO* 24,257,2004

REVIEWS:
ORGANIZATION STANDARD
REFERENCE

TOXICOLOGY REVIEW
JPMSAE 53,1143,1964
TOXICOLOGY REVIEW
AJMEAZ 50,475,1971
TOXICOLOGY REVIEW
MUREAV 488,151,2001

STANDARDS AND REGULATIONS:
ORGANIZATION STANDARD
REFERENCE

N/R N/R N/R

NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X6078;
Number of Industries 1;
Total Number of Facilities 17;
Number of Occupations 2;
Total Number of Employees Exposed 968;
Total Number of Female Employees Exposed 494

STATUS IN FEDERAL AGENCIES:
ORGANIZATION
REFERENCE

N/R

REFERENCES:
CODEN
REFERENCE

34ZIAG "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969
AEHLAU Archives of Environmental Health. (Heldref Pub., 4000 Albemarle St., NW, Washington, DC 20016) V.1- 1960-
AJMEAZ American Journal of Medicine. (Technical Pub., 875 Third Ave., New York, NY 10022) V.1- 1946-
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.1- 1977/78-
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information, see TOSCF2
JAPTO* Journal of Applied Toxicology (John Wiley & Sons, Ltd., Oldlands Way Bognor Regis West Sussex, PO22 9SA England) V.1- 1981-
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961-
JTCTDW Journal of Toxicology, Clinical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.19- 1982-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973-

Used as a cholinesterase reactivator

FDA-proprietary drug

RTECS Compound Description:
   Agricultural Chemical
   Drug
   Human Data

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SYNONYMS:
1 - Methyl - 2 - aldoximinopyridinium chloride 1 - Methyl - 2 - pyridinium aldoxime chloride 1 - Methyl - 2 - formylpyridinium chloride oxime 2 - (Hydroxyiminomethyl) - 1 - methylpyridinium chloride 2 - Formyl - 1 - methylpyridinium chloride oxime 2 - Formyl - N - methylpyridinium oxime chloride 2 - PAM chloride 2 - Pam 2 - Pyridine aldoxime methyl chloride	2 - Pyridine - aldoxime chloride N - Methylpyridinium chloride 2 - aldoxime N - Metylpyridinium - 2 - aldoxime chloride Pralidoxime chloride Protopam Protopam chloride Pyridine - 2 - aldoxime methochloride Pyridinium aldoxime methochloride Pyridinium, 2 - ( (hydroxyimino) methyl) - 1 - methyl - , chloride

SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
N/R	N/R	N/R	N/R

MUTATION DATA AND REFERENCES:
SYSTEM TEST	ROUTE/ ORGANISM/ TISSUE	DOSE	REFERENCE
N/R	N/R	N/R	N/R

REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
N/R	N/R	N/R	N/R

TUMORIGENIC DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
N/R	N/R	N/R	N/R

ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
intramuscular dog	lethal dose (50 percent kill): 75 mg/kg	N/R	FAATDF 4,S106,1984
intramuscular guinea pig	lethal dose (50 percent kill): 168 mg/kg	N/R	TXAPA9 16,40,1970
intramuscular mouse	lethal dose (50 percent kill): 100 mg/kg	N/R	DCTODJ 8,431,1985
intramuscular rat	lethal dose (50 percent kill): 150 mg/kg	N/R	TXAPA9 16,40,1970
intraperitoneal mouse	lethal dose (50 percent kill): 155 mg/kg	N/R	ARZNAD 14,5,1964
intraperitoneal rat	lowest published toxic dose: 38,358 µg/kg	Blood: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase	JAPTO* 25,68,2005
intravenous human	lowest published toxic dose: 15 mg/kg	Vascular: BP elevation not characterized in autonomic section	AEHLAU 15,599,1967
intravenous man	lowest published toxic dose: 14 mg/kg	Behavioral: Coma Lung, Thorax, or Respiration: Bronchiolar constriction, including asthma Lung, Thorax, or Respiration: Cyanosis	34ZIAG -,449,1969
intravenous mouse	lethal dose (50 percent kill): 90 mg/kg	N/R	ARZNAD 14,5,1964
intravenous pig	lowest published toxic dose: 33.3 mg/kg	Blood: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase	JAPTO* 24,429,2004
intravenous rat	lethal dose (50 percent kill): 96 mg/kg	N/R	TXAPA9 16,40,1970
intravenous rabbit	lethal dose (50 percent kill): 95 mg/kg	N/R	JPETAB 132,50,1961
intravenous woman	lowest published toxic dose: 144 mg/kg/18 hour	Behavioral: Change in motor activity (specific assay) Vascular: Other changes Gastrointestinal: Changes in structure or function of salivary glands	JTCTDW 38,47,2000
oral mouse	lethal dose (50 percent kill): 4,100 mg/kg	N/R	JPMSAE 53,1143,1964
subcutaneous rat	lowest published lethal dose: 30 mg/kg	Behavioral: Anticonvulsant	TXCYAC 196,31,2004

OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
intraperitoneal rat	lowest published toxic dose: 172.6 mg/kg/5 day- intermittent	Blood: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase	JAPTO* 24,257,2004

REVIEWS:
ORGANIZATION	STANDARD	REFERENCE
TOXICOLOGY REVIEW		JPMSAE 53,1143,1964
TOXICOLOGY REVIEW		AJMEAZ 50,475,1971
TOXICOLOGY REVIEW		MUREAV 488,151,2001

STANDARDS AND REGULATIONS:
ORGANIZATION	STANDARD	REFERENCE
N/R	N/R	N/R

NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION	STANDARD or SURVEY	REFERENCE
National Occupational Exposure Survey 1983	National Occupational Exposure Survey 1983: Hazard Code: X6078; Number of Industries 1; Total Number of Facilities 17; Number of Occupations 2; Total Number of Employees Exposed 968; Total Number of Female Employees Exposed 494

REFERENCES:
CODEN	REFERENCE
34ZIAG	"Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969
AEHLAU	Archives of Environmental Health. (Heldref Pub., 4000 Albemarle St., NW, Washington, DC 20016) V.1- 1960-
AJMEAZ	American Journal of Medicine. (Technical Pub., 875 Third Ave., New York, NY 10022) V.1- 1946-
ARZNAD	Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
DCTODJ	Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.1- 1977/78-
FAATDF	Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information, see TOSCF2
JAPTO*	Journal of Applied Toxicology (John Wiley & Sons, Ltd., Oldlands Way Bognor Regis West Sussex, PO22 9SA England) V.1- 1981-
JPETAB	Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
JPMSAE	Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961-
JTCTDW	Journal of Toxicology, Clinical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.19- 1982-
MUREAV	Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
TXAPA9	Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
TXCYAC	Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973-