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Pyridine, 2 - ( (2 - (dimethylamino) ethyl) (p - methoxybenzyl) amino) - , maleate (1:1)

RTECS #: UT1225000

CAS #: 59-33-6

UPDATE: May 2008 MW: 401.51 MF: C17H23N3O•C4H4O4


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. TUMORIGENIC DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. REVIEWS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. 1,2 - Ethanediamine, N - ( (4 - methoxyphenyl) methyl) - N,N' - dimethyl - N - 2 - pyridinyl - , (Z) - 2 - butenedioat
  2. 2 - ( (2 - (Dimethylamino) ethyl) (p - methoxybenzyl) amino) pyridine bimaleate
  3. 2 - ( (2 - (Dimethylamino) ethyl) (p - methoxybenzyl) amino) pyridine maleate
  4. 2786 R.P. maleate
  5. AH
  6. Anisopyradamine
  7. Anthisan maleate
  8. Antihist
  9. Diaminide maleate
  10. Mepyramine maleate
  11. Minihist
  12. N,N - Dimethyl - N' - (4 - methoxybenzyl) - N' - (2 - pyridyl) ethylenediamine maleate
  13. N - Dimethylaminoethyl - N - p - methoxy - alpha - aminopyridine maleate
  14. N - p - Methoxybenzyl - N' - N' - dimethyl - N - alpha - pyridylethylenediamine maleate
  1. Neo - Antergan meleate
  2. Paramal
  3. Paraminyl maleate
  4. Pymafed
  5. Pyra maleate
  6. Pyranilamine maleate
  7. Pyraninyl
  8. Pyranisamine maleate
  9. Pyrilamine maleate
  10. Renstamin
  11. Stangen maleate
  12. Statomin maleate
  13. Thylogen maleate


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
unscheduled DNA synthesis rat liver 5 µmol/L ENMUDM 3,11,1981
mutation in microorganisms mouse lymphocyte 400 mg/L (+enzymatic activation step) MUREAV 189,285,1987
specific locus test intraperitoneal
mouse 		1,619 µmol/L MUREAV 608,29,2006


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intramuscular
rat 		lowest published toxic dose: 50 mg/kg (1 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) LIFSAK 2,303,1963
oral
mouse 		lowest published toxic dose: 4,200 mg/kg (1-21 day pregnant) Reproductive: Effects on newborn: Stillbirth

Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive) 		ARZNAD 18,188,1968
oral
mouse 		lowest published toxic dose: 420 mg/kg (1-21 day pregnant) Reproductive: Effects on newborn: Weaning or lactation index (e.g., # alive at weaning per # alive at day 4) ARZNAD 18,188,1968
oral
rat 		lowest published toxic dose: 100 mg/kg (1 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) LIFSAK 2,303,1963


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 77 gm/kg/2 year- continuous Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Liver: Tumors 		FCTOD7 22,27,1984


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intracerebral
rat 		lowest published toxic dose: 222.2 µg/kg Behavioral: Change in psychophysiological tests EJPHAZ 465,91,2003
intraperitoneal
mouse 		lethal dose (50 percent kill): 100 mg/kg N/R PLMEAA 42,75,1981
intraperitoneal
mouse 		lowest published toxic dose: 5.6 mg/kg Behavioral: Antianxiety NEROEW 29,441,2004
intraperitoneal
rat 		lowest published toxic dose: 30 mg/kg Behavioral: Change in psychophysiological tests LIFSAK 70,2199,2002
intraperitoneal
rat 		lowest published toxic dose: 40 mg/kg Behavioral: Alteration of operant conditioning PSCHDL 171,212,2004
intravenous
guinea pig 		lethal dose (50 percent kill): 24,400 µg/kg N/R AIPTAK 113,313,1958
intravenous
mouse 		lethal dose (50 percent kill): 23 mg/kg N/R AIPTAK 155,47,1965
oral
child 		lowest published lethal dose: 42 mg/kg Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Acute pulmonary edema

Gastrointestinal: Nausea or vomiting 		LANCAO 2,809,1952
oral
mouse 		lethal dose (50 percent kill): 220 mg/kg N/R AIPTAK 155,47,1965
oral
rat 		lethal dose (50 percent kill): 513 mg/kg N/R TXAPA9 1,42,1959
oral
woman 		lowest published toxic dose: 200 mg/kg Behavioral: Convulsions or effect on seizure threshold

Cardiac: Other changes

Vascular: BP elevation not characterized in autonomic section 		JAMAAP 257,660,1987
subcutaneous
guinea pig 		lethal dose (50 percent kill): 44 mg/kg N/R APFRAD 20,463,1962
subcutaneous
mouse 		lethal dose (50 percent kill): 141 mg/kg N/R ARZNAD 14,940,1964
subcutaneous
mouse 		lowest published toxic dose: 10 mg/kg Behavioral: Analgesia EJPHAZ 503,63,2004
subcutaneous
mouse 		lowest published toxic dose: 3 mg/kg Behavioral: Change in motor activity (specific assay) JPETAB 308,474,2004
subcutaneous
mouse 		lowest published toxic dose: 10 mg/kg Behavioral: Ataxia JPETAB 308,474,2004
subcutaneous
rat 		lowest published lethal dose: 150 mg/kg Behavioral: Tremor CRSBAW 144,887,1950


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
rat 		lowest published toxic dose: 60 mg/kg/3 day- intermittent Behavioral: Change in psychophysiological tests CYLPDN 22,609,2001
intraperitoneal
rat 		lowest published toxic dose: 240 mg/kg/12 day- intermittent Behavioral: Tolerance CYLPDN 22,609,2001
oral
mouse 		lowest published toxic dose: 7,378 mg/kg/14 day- continuous Gastrointestinal: Changes in structure or function of salivary glands JACTDZ 12,337,1993
oral
mouse 		lowest published toxic dose: 91 gm/kg/90 day- continuous Cardiac: Changes in heart weight

Kidney, Ureter, and Bladder: Changes in bladder weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		JACTDZ 12,337,1993
oral
rat 		lowest published toxic dose: 8,766 gm/kg/90 day- continuous Liver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases 		JACTDZ 12,175,1993


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
TOXICOLOGY REVIEW
JRPMAP 12,27,1974
TOXICOLOGY REVIEW
MUREAV 588,88,2005
TOXICOLOGY REVIEW
MUREAV 584,1,2005


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 80498;
Number of Industries 3;
Total Number of Facilities 1,580;
Number of Occupations 9;
Total Number of Employees Exposed 6,126
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 80498;
Number of Industries 3;
Total Number of Facilities 342;
Number of Occupations 13;
Total Number of Employees Exposed 3,505;
Total Number of Female Employees Exposed 1,579


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY


REFERENCES:

CODEN
REFERENCE
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898-
APFRAD Annales Pharmaceutiques Francaises. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1943-
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
CRSBAW Comptes Rendus des Seances de la Societe de Biologie et de Ses Filiales. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1849-
CYLPDN Zhongguo Yaoli Xuebao. Acta Pharmacologica Sinica. Chinese Journal of Pharmacology. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.1- 1980-
EJPHAZ European Journal of Pharmacology. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1967-
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG.
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982-
JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued.
JAMAAP JAMA, Journal of the American Medical Association. (AMA, 535 N. Dearborn St., Chicago, IL 60610) V.1- 1883-
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
JRPMAP Journal of Reproductive Medicine. (2 Jacklynn Ct., St. Louis, MO 63132) V.3- 1969-
LANCAO Lancet. (7 Adam St., London WC2N 6AD, UK) V.1- 1823-
LIFSAK Life Sciences. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1-8, 1962-69; V.14- 1974-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NEROEW Neuropsychopharmacology. (Elsevier Science, 655 Avenue of the Americas, New York, NY 10010) V.1- 1987-
PLMEAA Planta Medica. (Georg Thieme Verlag, Postfach 732, D-7000 Stuttgart 1, Fed. Rep. Ger.) V.1- 1953-
PSCHDL Psychopharmacology (Berlin). (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.47- 1976-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-

Used as a pharmaceutical and veterinary drug

FDA-over the counter and proprietary drug

RTECS Compound Description:
   Tumorigen
   Drug
   Mutagen
   Reproductive Effector
   Human Data

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