CDC logo, Safer Healthier People CDC HomeCDC SearchCDC Health Topics A-Z
NIOSH - National Institute for Occupational Safety and Health

Search NIOSH  |  NIOSH Home  |  NIOSH Topics  |  Site Index  |  Databases and Information Resources  |  NIOSH Products  |  Contact Us




Pyridine, 2 - (benzyl (2 - (dimethylamino) ethyl) amino) - , monohydrochloride

RTECS #: US3150000

CAS #: 154-69-8

UPDATE: June 1996 MW: 291.86 MF: C16H21N3•ClH


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. NIOSH DOCUMENTATION AND SURVEILLANCE:
  6. REFERENCES:

SYNONYMS:

  1. 1,2 - Ethanediamine, N,N - dimethyl - N' - (phenylmethyl) - N' - 2 - pyridinyl - , monohydrochloride
  2. 2 - (Benzyl (2 - (dimethylamino) ethyl) amino) pyridine hydrochloride
  3. 2 - (Benzyl (2 - (dimethylamino) ethyl) amino) pyridine monohydrochloride
  4. Dehistin
  5. Dehistin monohydrochloride
  6. Ethylenediamine, N - benzyl - N',N' - dimethyl - N - (2 - pyridyl) - , hydrochloride
  7. N (sup 1) - alpha - Pyridyl - N (sup 1) - benzyl - N,N - dimethyl ethylenediamine monohydrochloride
  8. N,N - Dimethyl - N' - (2 - pyridyl) - N' - benzylethylenediamine hydrochloride
  9. N - Benzyl - N - dimethylaminoethyl alpha - aminopyridine hydrochloride
  10. N - Benzyl - N',N' - dimethyl - N - 2 - pyridyl - ethylenediamine hydrochloride
  11. N - Benzyl - N - alpha - pyridyl - N',N' - dimethyl - aethylendiamin - hydrochlorid (German)
  1. Piristin
  2. Pyrabenzamine
  3. Pyribenzamine hydrochloride
  4. Pyribenzamine monohydrochloride
  5. Pyridine, 2 - (benzyl (2 - (dimethylamino) ethyl) amino) - , hydrochloride
  6. Pyrinamine
  7. Stanzamine
  8. Tri - Tumine
  9. Tripelenamine hydrochloride
  10. Tripelennamine hydrochloride
  11. Tripelennamine monohydrochloride


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
unscheduled DNA synthesis rat liver 100 µmol/L ENMUDM 3,11,1981


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lethal dose (50 percent kill): 47 mg/kg Behavioral: Convulsions or effect on seizure threshold CTOXAO 16,17,1980
intravenous
dog 		lowest published lethal dose: 20 mg/kg N/R ARZNAD 19,1916,1969
intravenous
hamster 		lethal dose (50 percent kill): 13 mg/kg Behavioral: Tremor

Behavioral: Convulsions or effect on seizure threshold

Behavioral: Excitement 		JPETAB 97,371,1949
intravenous
mouse 		lethal dose (50 percent kill): 9 mg/kg Peripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage)

Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Respiratory depression 		JPETAB 92,249,1948
intravenous
rat 		lethal dose (50 percent kill): 12 mg/kg Behavioral: Convulsions or effect on seizure threshold

Behavioral: Excitement 		JLCMAK 31,749,1946
intravenous
rabbit 		lethal dose (50 percent kill): 9 mg/kg Behavioral: Convulsions or effect on seizure threshold

Behavioral: Excitement 		JLCMAK 31,749,1946
oral
dog 		lowest published lethal dose: 23 mg/kg Behavioral: Excitement

Behavioral: Muscle contraction or spasticity

Lung, Thorax, or Respiration: Dyspnea 		JHHBAI 81,55,1947
oral
guinea pig 		lethal dose (50 percent kill): 150 mg/kg N/R JOALAS 27,57,1956
oral
mouse 		lethal dose (50 percent kill): 97 mg/kg N/R JPETAB 99,488,1950
oral
rat 		lethal dose (50 percent kill): 469 mg/kg N/R JPMSAE 69,1198,1980
subcutaneous
guinea pig 		lethal dose (50 percent kill): 30 mg/kg Behavioral: Tremor

Behavioral: Convulsions or effect on seizure threshold

Behavioral: Muscle contraction or spasticity 		JPETAB 113,72,1955
subcutaneous
mouse 		lethal dose (50 percent kill): 41 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Tremor

Behavioral: Convulsions or effect on seizure threshold 		JPETAB 113,72,1955
subcutaneous
rat 		lethal dose (50 percent kill): 75 mg/kg N/R PSEBAA 78,708,1951
subcutaneous
rabbit 		lethal dose (50 percent kill): 33 mg/kg Behavioral: Convulsions or effect on seizure threshold

Behavioral: Excitement 		JLCMAK 31,749,1946
unreported route
man 		lowest published lethal dose: 15 mg/kg N/R 85DCAI 2,73,1970


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lowest published toxic dose: 7,380 mg/kg/90 day- continuous Cardiac: Changes in heart weight

Liver: Changes in liver weight 		JACTDZ 10(5),503,1991
oral
rat 		lowest published toxic dose: 1,918 mg/kg/14 day- continuous Behavioral: Somnolence (general depressed activity)

Musculoskeletal: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		JACTDZ 10(5),493,1991
oral
rat 		lowest published toxic dose: 12,330 mg/kg/90 day- continuous Liver: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		JACTDZ 10(5),493,1991


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 80567;
Number of Industries 2;
Total Number of Facilities 143;
Number of Occupations 7;
Total Number of Employees Exposed 3,071
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 80567;
Number of Industries 1;
Total Number of Facilities 56;
Number of Occupations 2;
Total Number of Employees Exposed 3,344;
Total Number of Female Employees Exposed 2,565


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
N/R


REFERENCES:

CODEN
REFERENCE
85DCAI "Poisoning; Toxicology, Symptoms, Treatments," 2nd ed., Arena, J.M., Springfield, IL, C.C. Thomas, 1970
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
CTOXAO Clinical Toxicology. (New York, NY) V.1-18, 1968-81. For publisher information, see JTCTDW.
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG.
JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued.
JHHBAI Bulletin of the Johns Hopkins Hospital. (Baltimore, MD) V.1-119, 1889-1966. For publisher information, see JHMJAX.
JLCMAK Journal of Laboratory and Clinical Medicine. (C.V. Mosby Co., 11830 Westline Industrial Dr., St. Louis, MO 63141) V.1- 1915-
JOALAS Journal of Allergy. (St. Louis, MO) V.1-47, 1929-71. For publisher information, see JACIBY.
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961-
PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04-

FDA-over the counter and proprietary drug

RTECS Compound Description:
   Drug
   Mutagen
   Human Data

 Click Here for Additional Information about RTECS

NIOSH Home |  NIOSH Search  |  Site Index  |  Topic List |  Contact Us