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2 - Pyridineacetamide, alpha - (2 - (diisopropylamino) ethyl) - alpha - phenyl - , phosphate

RTECS #: UR8440000

CAS #: 22059-60-5

UPDATE: February 2007 MW: 437.53 MF: C21H29N3O•H3O4P


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. REPRODUCTIVE EFFECTS DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. NIOSH DOCUMENTATION AND SURVEILLANCE:
  6. REFERENCES:

SYNONYMS:

  1. 2 - Pyridineacetamide, alpha - (2 - (bis (1 - methylethyl) amino) ethyl) - alpha - phenyl - , phosphate (9CI)
  2. Disopyramide phosphate
  3. Norpace
  4. Rythmodan
  1. SC 13957
  2. SC 7031 phosphate
  3. alpha - (2 - Diisopropylaminoethyl) - alpha - phenyl - 2 - pyridineacetamide phosphate


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
rat 		lowest published toxic dose: 4,095 mg/kg (10 week male/2 week prior to copulation-7 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) JZKEDZ 7,145,1981
intraperitoneal
rat 		lowest published toxic dose: 1,820 mg/kg (10 week male/2 week prior to copulation-7 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system JZKEDZ 7,145,1981
intraperitoneal
rat 		lowest published toxic dose: 600 mg/kg (17-22 day pregnant) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) JZKEDZ 7,175,1981
intravenous
rat 		lowest published toxic dose: 330 mg/kg (7-17 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system

Reproductive: Effects on newborn: Behavioral 		JZKEDZ 7,157,1981
oral
rat 		lowest published toxic dose: 2,240 mg/kg (17-22 day pregnant/26 day after birth) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) JZKEDZ 10,111,1984
oral
rat 		lowest published toxic dose: 770 mg/kg (7-17 day pregnant) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) JZKEDZ 10,87,1984


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mammal (species unspecified) 		lethal dose (50 percent kill): 114 mg/kg N/R TOVEFN (1),14,2001
intraperitoneal
mouse 		lethal dose (50 percent kill): 190 mg/kg Behavioral: Convulsions or effect on seizure threshold

Behavioral: Change in motor activity (specific assay)

Lung, Thorax, or Respiration: Dyspnea 		YACHDS 9(Suppl 1),5,1981
intraperitoneal
rat 		lethal dose (50 percent kill): 255 mg/kg Behavioral: Convulsions or effect on seizure threshold

Behavioral: Change in motor activity (specific assay)

Lung, Thorax, or Respiration: Dyspnea 		YACHDS 9(Suppl 1),5,1981
intravenous
dog 		lowest published lethal dose: 30 mg/kg Behavioral: Convulsions or effect on seizure threshold

Cardiac: Pulse rate increased without fall in BP

Lung, Thorax, or Respiration: Respiratory stimulation 		JZKEDZ 6,147,1980
intravenous
human 		lowest published toxic dose: 0.83 mg/kg Cardiac: Change in rate

Cardiac: Cardiac output

Vascular: Measurement of regional blood flow 		FATOAO 48,73,1985
intravenous
mouse 		lethal dose (50 percent kill): 81 mg/kg Behavioral: Convulsions or effect on seizure threshold

Behavioral: Change in motor activity (specific assay)

Lung, Thorax, or Respiration: Dyspnea 		YACHDS 9(Suppl 1),5,1981
intravenous
rat 		lethal dose (50 percent kill): 41 mg/kg Eye: Ptosis

Behavioral: Convulsions or effect on seizure threshold

Skin and Appendages: Other: Hair 		JZKEDZ 7,133,1981
oral
child 		lowest published lethal dose: 30 mg/kg Behavioral: Convulsions or effect on seizure threshold

Kidney, Ureter, and Bladder: Urine volume decreased or anuria

Nutritional and Gross Metabolic: Body temperature decrease 		MJAUAJ 2,335,1978
oral
mammal (species unspecified) 		lethal dose (50 percent kill): 333 mg/kg N/R TOVEFN (1),14,2001
oral
man 		lowest published toxic dose: 286 mg/kg Cardiac: EKG changes not diagnostic of above

Vascular: BP lowering not characterized in autonomic section

Lung, Thorax, or Respiration: Cyanosis 		PGMJAO 56,256,1980
oral
man 		lowest published toxic dose: 43 mg/kg/5 day- intermittent Endocrine: Hypoglycemia NYSJAM 83,1057,1983
oral
man 		lowest published lethal dose: 214 mg/kg N/R JATOD3 6,255,1982
oral
man 		lowest published toxic dose: 1,429 µg/kg Endocrine: Hypoglycemia NNGAAS 72,1177,1983
oral
man 		lowest published toxic dose: 45 mg/kg/1 week- intermittent Behavioral: Coma SMJOAV 76,1453,1983
oral
mouse 		lethal dose (50 percent kill): 820 mg/kg Behavioral: Convulsions or effect on seizure threshold

Behavioral: Change in motor activity (specific assay)

Lung, Thorax, or Respiration: Dyspnea 		YACHDS 9(Suppl 1),5,1981
oral
rat 		lethal dose (50 percent kill): 880 mg/kg Behavioral: Convulsions or effect on seizure threshold

Behavioral: Change in motor activity (specific assay)

Lung, Thorax, or Respiration: Dyspnea 		YACHDS 9(Suppl 1),5,1981
oral
woman 		lowest published lethal dose: 60 mg/kg/10 day- intermittent Endocrine: Hypoglycemia NYSJAM 83,1057,1983
oral
woman 		lowest published toxic dose: 8 mg/kg/1 day- intermittent Liver: Liver function tests impaired

Blood: Change in clotting factors

Blood: Thrombocytopenia 		SMJOAV 75,496,1982
oral
woman 		lowest published toxic dose: 20 mg/kg/3 day- intermittent Cardiac: Arrythmias (indlucing changes in conduction)

Cardiac: Pulse rate increased without fall in BP 		AHJOA2 105,870,1983
oral
woman 		lowest published lethal dose: 75 mg/kg Cardiac: EKG changes not diagnostic of above

Vascular: BP lowering not characterized in autonomic section

Lung, Thorax, or Respiration: Other changes 		JIMSAX 71,552,1978
subcutaneous
mouse 		lethal dose (50 percent kill): 680 mg/kg Behavioral: Convulsions or effect on seizure threshold

Behavioral: Change in motor activity (specific assay)

Lung, Thorax, or Respiration: Dyspnea 		YACHDS 9(Suppl 1),5,1981
subcutaneous
rat 		lethal dose (50 percent kill): 1 gm/kg Behavioral: Convulsions or effect on seizure threshold

Behavioral: Change in motor activity (specific assay)

Lung, Thorax, or Respiration: Dyspnea 		YACHDS 9(Suppl 1),5,1981


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
rat 		lowest published toxic dose: 5,600 mg/kg/35 day- continuous Endocrine: Changes in adrenal weight

Endocrine: Changes in thymus weight

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		YACHDS 15,991,1987
intraperitoneal
rat 		lowest published toxic dose: 2,800 mg/kg/4 week- intermittent Endocrine: Hyperglycemia

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases 		JZKEDZ 7,133,1981
intravenous
dog 		lowest published toxic dose: 1,575 mg/kg/5 week- intermittent Behavioral: Convulsions or effect on seizure threshold

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		JZKEDZ 6,147,1980
intravenous
rat 		lowest published toxic dose: 1,800 mg/kg/30 day- intermittent Lung, Thorax, or Respiration: Respiratory stimulation

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		YACHDS 9(Suppl 1),5,1981
oral
rat 		lowest published toxic dose: 8,400 mg/kg/28 day- intermittent Eye: Ptosis

Behavioral: Somnolence (general depressed activity)

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) 		JZKEDZ 10,51,1984


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X4711;
Number of Industries 3;
Total Number of Facilities 146;
Number of Occupations 5;
Total Number of Employees Exposed 5,578;
Total Number of Female Employees Exposed 3,263


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
N/R


REFERENCES:

CODEN
REFERENCE
AHJOA2 American Heart Journal. (C.V. Mosby Co., 11830 Westline Industrial Dr., St. Louis, MO 63146) V.1- 1925-
FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939-
JATOD3 Journal of Analytical Toxicology. (Preston Pub. Inc., POB 48312, Niles, IL 60648) V.1- 1977-
JIMSAX Journal of the Irish Medical Association. (Dublin, Ireland) V.28-67, 1951-74.
JZKEDZ Jitchuken Zenrinsho Kenkyuho. Central Institute for Experimental Animals, Research Reports. (Jikken Dobutsu Chuo Kenkyusho, 1433 Nogawa, Takatsu-ku, Kawasaki 211, Japan) V.1- 1975-
MJAUAJ Medical Journal of Australia. (Australasian Medical Pub. Co. Ltd., 71-79 Arundel St., Glebe, N.S.W., Australia) V.1- 1914-
NNGAAS Nippon Naika Gakkai Zasshi. Journal of the Japanese Society of Internal Medicine. (Nippon Naika Gakkai, 33-5, 3-chome, Hongo, Bunkyo-ku, Tokyo 113, Japan) V.1- 1913-
NYSJAM New York State Journal of Medicine. (Medical Soc. of the State of New York, POB 5405, Lake Success, NY 11042) V.1- 1901-
PGMJAO Postgraduate Medical Journal. (Blackwell Scientific Pub. Ltd., POB 88, Oxford, UK) V.1- 1925-
SMJOAV Southern Medical Journal. (Southern Medical Assoc., POB 2446, Birmingham, AL 35205) V.1- 1908-
TOVEFN Toksikologicheskii Vestnik. (18-20 Vadkovskii per. Moscow, 101479, Russia) History Unknown
YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972-

Used as an antiarrhythmic agent

FDA-proprietary drug

RTECS Compound Description:
   Drug
   Reproductive Effector
   Human Data

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