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2 - Pyrazolin - 5 - one, 3 - methyl - 1 - phenyl -

RTECS #: UQ9625000

CAS #: 89-25-8

UPDATE: November 2008 MW: 174.22 MF: C10H10N2O


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. REPRODUCTIVE EFFECTS DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. 1 - Fenyl - 3 - methyl - 2 - pyrazolin - 5 - on (Czech)
  2. 1 - Phenyl - 3 - methyl - 5 - oxo - 2 - pyrazoline
  3. 1 - Phenyl - 3 - methyl - 5 - pyrazolone
  4. 1 - Phenyl - 3 - methylpyrazolone - 5
  5. 3 - Methyl - 1 - phenyl - 2 - pyrazolin - 5 - one
  6. 3 - Methyl - 1 - phenyl - 5 - pyrazolone
  7. 3H - Pyrazol - 3 - one, 2,4 - dihydro - 5 - methyl - 2 - phenyl -
  8. 5 - Pyrazolone, 3 - methyl - 1 - phenyl -
  1. C.I. Developer 1
  2. Developer Z
  3. Edaravone
  4. MCI - 186
  5. NCI - C03952
  6. Norantipyrine
  7. Norphenazone


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		500 mg/24 hour mild 85JCAE -,828,1986


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
morphological transform rat embryo 31 µg/plate JJATDK 1,190,1981
specific locus test mouse lymphocyte 300 mg/L EMMUEG 17,196,1991


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intravenous
rat 		lowest published toxic dose: 540 mg/kg (17-22 day pregnant/21 day after birth) Reproductive: Effects on newborn: Delayed effects YACHDS 25(Suppl 7),S1649,1997
intravenous
rat 		lowest published toxic dose: 17 gm/kg (63 day male/15 day prior to copulation/7 day pregnant) Reproductive: Other effects on male

Reproductive: Other effects on female 		YACHDS 25(Suppl 7),S1615,1997
intravenous
rat 		lowest published toxic dose: 330 mg/kg (7-17 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) YACHDS 25(Suppl 7),S1625,1997
intravenous
rabbit 		lowest published toxic dose: 1,300 mg/kg (6-18 day pregnant) Reproductive: Effects on embryo or fetus: Extra embryonic structures (e.g., placenta, umbilical cord) YACHDS 25(Suppl 7),S1641,1997


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lethal dose (50 percent kill): 2,012 mg/kg N/R RPTOAN 36,27,1973
intraperitoneal
mouse 		lowest published toxic dose: 1 mg/kg Biochemical: Neurotransmitters or modulators (putative): Catecholamine levels in CNS

Biochemical: Neurotransmitters or modulators (putative): Dopamine in striatum 		EJPHAZ 542,92,2006
intraperitoneal
mouse 		lowest published toxic dose: 3 mg/kg Brain and Coverings: Other degenerative changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes 		EJPHAZ 542,92,2006
intravenous
dog 		lowest published lethal dose: 600 mg/kg Behavioral: Ataxia

Liver: Other changes

Blood: Changes in spleen 		YACHDS 25(Suppl 7),S1517,1997
intravenous
dog 		lowest published toxic dose: 3 mg/kg Vascular: Regional or general arteriolar or venous dilation

Vascular: Measurement of regional blood flow 		JPHSC* 104,341,2007
intravenous
mouse 		lethal dose (50 percent kill): 588 mg/kg Eye: Lacrimation

Lung, Thorax, or Respiration: Acute pulmonary edema

Liver: Other changes 		YACHDS 25(Suppl 7),S1517,1997
intravenous
rat 		lethal dose (50 percent kill): 631 mg/kg Eye: Lacrimation

Lung, Thorax, or Respiration: Acute pulmonary edema

Liver: Other changes 		YACHDS 25(Suppl 7),S1517,1997
intravenous
rat 		lowest published toxic dose: 1.5 mg/kg Brain and Coverings: Other degenerative changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases 		BPBLEO 29,713,2006
oral
mouse 		lethal dose (50 percent kill): 1,683 mg/kg Eye: Lacrimation

Lung, Thorax, or Respiration: Acute pulmonary edema

Liver: Other changes 		YACHDS 25(Suppl 7),S1517,1997
oral
rat 		lethal dose (50 percent kill): 1,915 mg/kg Eye: Lacrimation

Lung, Thorax, or Respiration: Acute pulmonary edema

Liver: Other changes 		YACHDS 25(Suppl 7),S1517,1997
subcutaneous
mouse 		lethal dose (50 percent kill): 691 mg/kg Eye: Lacrimation

Lung, Thorax, or Respiration: Acute pulmonary edema

Liver: Other changes 		YACHDS 25(Suppl 7),S1517,1997
subcutaneous
rat 		lethal dose (50 percent kill): 1,101 mg/kg Eye: Lacrimation

Lung, Thorax, or Respiration: Acute pulmonary edema

Liver: Other changes 		YACHDS 25(Suppl 7),S1517,1997


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
rat 		lowest published toxic dose: 20 mg/kg/2 day- intermittent Brain and Coverings: Other degenerative changes

Behavioral: Alteration of operant conditioning 		ACPSI* 24,1241,2003
intravenous
dog 		lowest published toxic dose: 9 gm/kg/30 day- intermittent Endocrine: Changes in spleen weight

Blood: Changes in erythrocyte (RBC) count

Blood: Changes in platelet count 		YACHDS 25(Suppl 7),S1549,1997
intravenous
dog 		lowest published toxic dose: 18,200 mg/kg/26 week- continuous Gastrointestinal: Changes in structure or function of salivary glands

Kidney, Ureter, and Bladder: Changes in bladder weight

Blood: Changes in spleen 		YACHDS 25(Suppl 7),S1589,1997
intravenous
rat 		lowest published toxic dose: 3 gm/kg/30 day- intermittent Behavioral: Food intake (animal)

Lung, Thorax, or Respiration: Changes in lung weight

Liver: Changes in liver weight 		YACHDS 25(Suppl 7),S1531,1997
intravenous
rat 		lowest published toxic dose: 5,460 mg/kg/26 week- intermittent Behavioral: Food intake (animal)

Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Other changes in urine composition 		YACHDS 25(Suppl 7),S1567,1997


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 83422;
Number of Industries 2;
Total Number of Facilities 11;
Number of Occupations 2;
Total Number of Employees Exposed 114
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 83422;
Number of Industries 5;
Total Number of Facilities 62;
Number of Occupations 5;
Total Number of Employees Exposed 580;
Total Number of Female Employees Exposed 137


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Negative/limited: Carcinogenicity-mouse/rat
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as a color additive in hair colorants and as an intermediate in dyes and pigments
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Bioassay (feed);no evidence:mouse,rat NCITR* NCI-TR-141,1978


REFERENCES:

CODEN
REFERENCE
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
ACPSI* Acta pharmacologica Sinica (Shanghai : Shanghai Institute of Materia Medica : Chinese Academy of Science ; Carlton, VIC, Australia : Blackwell Publishing Asia, 2005) V.21- 2000-
BPBLEO Biological and Pharmaceutical Bulletin. (Pharmaceutical Society of Japan, 2-12-15-201 Shibuya Shibuya-ku, Tokyo 150, Japan) V.16- 1993-
EJPHAZ European Journal of Pharmacology. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1967-
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
JJATDK JAT, Journal of Applied Toxicology. (John Wiley & Sons Ltd., Baffins Lane, Chichester, W. Sussex PO19 1UD, UK) V.1- 1981-
JPHSC*
NCITR* National Cancer Institute Carcinogenesis Technical Report Series. (Bethesda, MD) No.0-205. For publisher information, see NTPTR*.
RPTOAN Russian Pharmacology and Toxicology (English Translation). Translation of FATOAO. (Euromed Pub., 33, Woodlands Rd., Surbiton, Surrey, UK) V.30- 1967-
YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972-

Used as a color additive in hair colorants and as an intermediate in dyes and pigments

RTECS Compound Description:
   Tumorigen
   Drug
   Mutagen
   Reproductive Effector
   Primary Irritant

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