RTECS:UQ0333500 The Registry of Toxic Effects of Chemical Substances

4H - Pyrano (2,3 - b) (1,4) benzodioxin - 4 - one, decahydro - 4a,7,9 - trihydroxy - 2 - methyl - 6,8 - bis (methylamino) - , dihydrochloride, (2R - (2 - alpha,4a - beta,5a - beta,6 - beta,7 - beta,8 - beta,9 - alpha, 9a - alpha,10a - beta) ) -

RTECS #: UQ0333500

CAS #: 21736-83-4

UPDATE: March 2000 MW: 405.32 MF: C₁₄H₂₄N₂O₇•2ClH

NOTE:

TOXICITY DATA HAVE NOT BEEN EVALUATED. OMISSION OF A SUBSTANCE OR NOTATION DOES NOT IMPLY ANY RELIEF FROM REGULATORY RESPONSIBILITY.

TABLE OF CONTENTS:

SYNONYMS:

ACUTE TOXICITY DATA:

NIOSH DOCUMENTATION AND SURVEILLANCE:

REFERENCES:

SYNONYMS:

(+) - Spectinomycin dihydrochloride

Actinospectacin dihydrochloride

Spectinomycin dihydrochloride

Spectinomycin hydrochloride

Stanilo

SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

MUTATION DATA AND REFERENCES:
SYSTEM TEST ROUTE/
ORGANISM/
TISSUE DOSE REFERENCE
N/R N/R N/R N/R

REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

TUMORIGENIC DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
intramuscular
mouse lethal dose (50 percent kill): >5 gm/kg N/R NIIRDN 6,382,1982
intramuscular
rat lethal dose (50 percent kill): >2,500 mg/kg N/R NIIRDN 6,382,1982
intraperitoneal
mouse lethal dose (50 percent kill): 2,350 mg/kg N/R NIIRDN 6,382,1982
intraperitoneal
rat lethal dose (50 percent kill): 2,020 mg/kg N/R NIIRDN 6,382,1982
intravenous
mouse lethal dose (50 percent kill): 2,850 µg/kg N/R YAKUD5 7,100,1965
oral
monkey lethal dose (50 percent kill): 500 mg/kg N/R YAKUD5 7,100,1965
oral
mouse lethal dose (50 percent kill): >10 gm/kg N/R NIIRDN 6,382,1982
oral
rat lethal dose (50 percent kill): >5 gm/kg N/R NIIRDN 6,382,1982
subcutaneous
mouse lethal dose (50 percent kill): 8,400 mg/kg N/R NIIRDN 6,382,1982
subcutaneous
rat lethal dose (50 percent kill): >5 gm/kg N/R NIIRDN 6,382,1982

OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

REVIEWS:
ORGANIZATION STANDARD
REFERENCE

N/R N/R N/R

STANDARDS AND REGULATIONS:
ORGANIZATION STANDARD
REFERENCE

N/R N/R N/R

NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X5600;
Number of Industries 2;
Total Number of Facilities 28;
Number of Occupations 3;
Total Number of Employees Exposed 525;
Total Number of Female Employees Exposed 397

STATUS IN FEDERAL AGENCIES:
ORGANIZATION
REFERENCE

N/R

REFERENCES:
CODEN
REFERENCE

NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan)
YAKUD5 Gekkan Yakuji. Pharmaceuticals Monthly. (Yakugyo Jihosha, Inaoka Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan) V.1- 1959-

RTECS Compound Description:
Drug

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SYNONYMS:
(+) - Spectinomycin dihydrochloride Actinospectacin dihydrochloride Spectinomycin dihydrochloride	Spectinomycin hydrochloride Stanilo

SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
N/R	N/R	N/R	N/R

MUTATION DATA AND REFERENCES:
SYSTEM TEST	ROUTE/ ORGANISM/ TISSUE	DOSE	REFERENCE
N/R	N/R	N/R	N/R

REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
N/R	N/R	N/R	N/R

TUMORIGENIC DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
N/R	N/R	N/R	N/R

ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
intramuscular mouse	lethal dose (50 percent kill): >5 gm/kg	N/R	NIIRDN 6,382,1982
intramuscular rat	lethal dose (50 percent kill): >2,500 mg/kg	N/R	NIIRDN 6,382,1982
intraperitoneal mouse	lethal dose (50 percent kill): 2,350 mg/kg	N/R	NIIRDN 6,382,1982
intraperitoneal rat	lethal dose (50 percent kill): 2,020 mg/kg	N/R	NIIRDN 6,382,1982
intravenous mouse	lethal dose (50 percent kill): 2,850 µg/kg	N/R	YAKUD5 7,100,1965
oral monkey	lethal dose (50 percent kill): 500 mg/kg	N/R	YAKUD5 7,100,1965
oral mouse	lethal dose (50 percent kill): >10 gm/kg	N/R	NIIRDN 6,382,1982
oral rat	lethal dose (50 percent kill): >5 gm/kg	N/R	NIIRDN 6,382,1982
subcutaneous mouse	lethal dose (50 percent kill): 8,400 mg/kg	N/R	NIIRDN 6,382,1982
subcutaneous rat	lethal dose (50 percent kill): >5 gm/kg	N/R	NIIRDN 6,382,1982

OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
N/R	N/R	N/R	N/R

STANDARDS AND REGULATIONS:
ORGANIZATION	STANDARD	REFERENCE
N/R	N/R	N/R

NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION	STANDARD or SURVEY	REFERENCE
National Occupational Exposure Survey 1983	National Occupational Exposure Survey 1983: Hazard Code: X5600; Number of Industries 2; Total Number of Facilities 28; Number of Occupations 3; Total Number of Employees Exposed 525; Total Number of Female Employees Exposed 397

REFERENCES:
CODEN	REFERENCE
NIIRDN	Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan)
YAKUD5	Gekkan Yakuji. Pharmaceuticals Monthly. (Yakugyo Jihosha, Inaoka Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan) V.1- 1959-