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4H - Pyran - 4 - one, 3 - hydroxy - 2 - methyl -

RTECS #: UQ1050000

CAS #: 118-71-8

UPDATE: December 1997 MW: 126.12 MF: C6H6O3


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. NIOSH DOCUMENTATION AND SURVEILLANCE:
  7. STATUS IN FEDERAL AGENCIES:
  8. REFERENCES:

SYNONYMS:

  1. 2 - Methyl - 3 - hydroxy - 4 - pyrone
  2. 2 - Methyl - 3 - oxy - gamma - pyrone
  3. 2 - Methyl pyromeconic acid
  4. 3 - Hydroxy - 2 - methyl - 4H - pyran - 4 - one
  5. 3 - Hydroxy - 2 - methyl - gamma - pyrone
  6. 3 - Hydroxy - 2 - methyl - 4 - pyrone
  7. Corps praline
  1. Larixic acid
  2. Larixinic acid
  3. Maltol
  4. Palatone
  5. Talmon
  6. Vetol


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
skin
rabbit 		500 mg/24 hour moderate FCTXAV 13,841,1975


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
mutation in microorganisms Salmonella typhimurium 1 mg/plate (+enzymatic activation step) MUREAV 67,367,1979
mutation in microorganisms Salmonella typhimurium 3,333 µg/plate (-enzymatic activation step) ENMUDM 8(Suppl 7),1,1986
micronucleus test intraperitoneal
mouse 		250 mg/kg FCTOD7 26,487,1988
sister chromatid exchange human lymphocyte 500 µmol/L MUREAV 169,129,1986


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lethal dose (16 percent kill): 1,400 mg/kg N/R RPTOAN 38,213,1975
oral
chicken 		lethal dose (50 percent kill): 3,720 mg/kg N/R TXAPA9 15,604,1969
oral
guinea pig 		lethal dose (50 percent kill): 1,410 mg/kg N/R DOWCC* -,-,1967
oral
mouse 		lethal dose (50 percent kill): 550 mg/kg N/R FAONAU 44A,56,1967
oral
rat 		lethal dose (50 percent kill): 1,410 mg/kg N/R FAONAU 44A,56,1967
oral
rabbit 		lethal dose (50 percent kill): 1,620 mg/kg N/R DOWCC* -,-,1967
subcutaneous
mouse 		lethal dose (50 percent kill): 820 mg/kg N/R CPBTAL 22,1008,1974
skin
rabbit 		lethal dose : >5 gm/kg N/R FCTXAV 13,841,1975


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
dog 		lowest published toxic dose: 20,500 mg/kg/41 day- intermittent Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		TXAPA9 15,604,1969
oral
rat 		lowest published toxic dose: 90 gm/kg/90 day- intermittent Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		TXAPA9 15,604,1969


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X2610;
Number of Industries 3;
Total Number of Facilities 508;
Number of Occupations 5;
Total Number of Employees Exposed 1,733;
Total Number of Female Employees Exposed 642


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY


REFERENCES:

CODEN
REFERENCE
CPBTAL Chemical and Pharmaceutical Bulletin. (Japan Pub. Trading Co., USA, 1255 Howard St., San Francisco, CA 94103) V.6- 1958-
DOWCC* Dow Chemical Company Reports. (Dow Chemical USA, Health and Environment Research, Toxicology Research Lab., Midland, MI 48640)
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG.
FAONAU FAO Nutrition Meetings Report Series. (Rome, Italy) No.?-57, 1948-77. Discontinued.
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982-
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7.
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
RPTOAN Russian Pharmacology and Toxicology (English Translation). Translation of FATOAO. (Euromed Pub., 33, Woodlands Rd., Surbiton, Surrey, UK) V.30- 1967-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-

Used as a flavor-enhancing agent

RTECS Compound Description:
   Drug
   Mutagen
   Human Data
   Primary Irritant

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