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2H - Pyran - 2,4 (3H) - dione, 3 - acetyl - 6 - methyl - , sodium salt

RTECS #: UP8225000

CAS #: 4418-26-2

UPDATE: May 2009 MW: 190.14 MF: C8H7O4•Na


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. REPRODUCTIVE EFFECTS DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. REVIEWS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. 3 - (1 - Hydroxyethylidene) - 6 - methyl - 2H - pyran - 2,4 (3H) - dione, sodium salt
  2. 4 - Hexenoic acid, 2 - acetyl - 5 - hydroxy - 3 - oxo, delta - lactone, sodium deriv.
  3. DHA - S
  4. DHA - sodium
  5. DHN
  6. Dehydroacetic acid, sodium salt
  1. Harven
  2. Kyselina dehydroacetova sodna sul (Czech)
  3. Prevan
  4. Sodium dehydroacetate
  5. Sodium dehydroacetic acid


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		100 mg mild JACTDZ 4(3),123,1985


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis hamster fibroblast 30 gm/L FCTOD7 22,623,1984
cytogenetic analysis hamster lung 2,500 mg/L GMCRDC 27,95,1981
micronucleus test intraperitoneal
mouse 		125 mg/kg FCTOD7 26,487,1988


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lowest published toxic dose: 500 mg/kg (6-15 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system 		NKEZA4 27,91,1980
oral
mouse 		lowest published toxic dose: 2 gm/kg (6-15 day pregnant) Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Effects on embryo or fetus: Fetal death 		NKEZA4 27,91,1980
oral
rat 		lowest published toxic dose: 600 mg/kg (6-17 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system 		ESKHA5 (106),54,1988


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intravenous
dog 		lethal dose (50 percent kill): 400 mg/kg Behavioral: Muscle weakness

Behavioral: Ataxia

Gastrointestinal: Nausea or vomiting 		JPETAB 99,69,1950
oral
dog 		lowest published lethal dose: 452 mg/kg Behavioral: Ataxia

Lung, Thorax, or Respiration: Dyspnea

Gastrointestinal: Changes in structure or function of salivary glands 		JPETAB 99,69,1950
oral
mouse 		lethal dose (50 percent kill): 1,050 mg/kg N/R JACTDZ 4(3),123,1985
oral
rat 		lethal dose (50 percent kill): 500 mg/kg N/R JACTDZ 4(3),123,1985
oral
rabbit 		lethal dose (50 percent kill): 500 mg/kg N/R LONZA# 02JUN1980


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
monkey 		lowest published toxic dose: 6,786 mg/kg/26 day- intermittent Behavioral: Convulsions or effect on seizure threshold

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		JPETAB 99,57,1950


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
TOXICOLOGY REVIEW
JACTDZ 4(3),123,1985
TOXICOLOGY REVIEW
MUREAV 657,84,2008


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X2427;
Number of Industries 1;
Total Number of Facilities 130;
Number of Occupations 1;
Total Number of Employees Exposed 130


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Negative: In vitro SCE-nonhuman
EPA TSCA Section 8(b) CHEMICAL INVENTORY


REFERENCES:

CODEN
REFERENCE
ESKHA5 Eisei Shikenjo Hokoku. Bulletin of the Institute of Hygienic Sciences. (Kokuritsu Eisei Shikenjo Kagaku, 18-1 Bushitsu Johobu, Setagaya-ku, Tokyo 158, Japan) V.1- 1886-
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982-
GMCRDC Gann Monograph on Cancer Research. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No. 11- 1971-
JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued.
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
LONZA# Personal Communication from LONZA Ltd., CH-4002, Basel, Switzerland
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NKEZA4 Nippon Koshu Eisei Zasshi. Japanese Journal of Public Health. (Nippon Koshu Eisei Gakkai, 1-29-8 Shinjuku, Shinjuku-ku, Tokyo 160, Japan) V.1- 1954-

Used as a dip fungicide

RTECS Compound Description:
   Agricultural Chemical
   Mutagen
   Reproductive Effector
   Primary Irritant

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