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Pteridine, 2,4,7 - triamino - 6 - phenyl -

RTECS #: UO3470000

CAS #: 396-01-0

UPDATE: May 2008 MW: 253.30 MF: C12H11N7


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. TUMORIGENIC DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. 2,4,7 - Pteridinetriamine, 6 - phenyl - (9CI)
  2. 2,4,7 - Triamino - 6 - fenilpteridina (Italian)
  3. 2,4,7 - Triamino - 6 - phenylpteridine
  4. 6 - Phenyl - 2,4,7 - pteridinetriamine
  5. 6 - Phenyl - 2,4,7 - triaminopteridine
  6. Ademine
  7. Diren
  8. Ditak
  9. Dyrenium
  10. Dytac
  11. Jatropur
  12. NCI C56042
  13. Noridil
  1. Pterofen
  2. Pterophene
  3. SKF 8542
  4. Taturil
  5. Teriam
  6. Teridin
  7. Tri - Span
  8. Triampur
  9. Triamteren
  10. Triamterene
  11. Triamteril
  12. Triamteril complex
  13. Triteren


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis hamster lung 2,800 µg/L GMCRDC 27,95,1981
micronucleus test hamster lung 12,600 µg/L SNSHBT (20),574,1980
morphological transform hamster embryo 25 mg/L ENMUDM 8(Suppl 6),4,1986
sister chromatid exchange hamster lung 12,600 µg/L SNSHBT (20),574,1980


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lowest published toxic dose: 34,944 mg/kg/2 year- continuous Tumorigenic: Neoplastic by RTECS criteria

Liver: Tumors 		NTPTR* NTP-TR-420,1993
oral
mouse 		lowest published toxic dose: 34,608 mg/kg/103 week- continuous Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Liver: Tumors

Endocrine: Thyroid weight (goiter) 		NTIS** PB94-213782
oral
rat 		lowest published toxic dose: 21,840 mg/kg/2 year- continuous Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Liver: Tumors 		NTPTR* NTP-TR-420,1993
oral
rat 		lowest published toxic dose: 6,489 mg/kg/103 week- continuous Tumorigenic: Neoplastic by RTECS criteria

Liver: Tumors 		NTIS** PB94-213782


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lethal dose (50 percent kill): 249 mg/kg N/R NIIRDN 6,519,1982
intraperitoneal
rat 		lethal dose (50 percent kill): 200 mg/kg N/R YAKUD5 21,775,1979
intravenous
mouse 		lethal dose (50 percent kill): 25,077 µg/kg N/R PHARAT 50,419,1995
oral
mouse 		lethal dose (50 percent kill): 285 mg/kg N/R FRXXBL #2314719
oral
rat 		lethal dose (50 percent kill): 400 mg/kg N/R YAKUD5 21,775,1979
oral
woman 		lowest published toxic dose: 42 mg/kg/3 week- intermittent Liver: Hepatitis (hepatocellular necrosis), zonal

Nutritional and Gross Metabolic: Body temperature increase 		MJAUAJ 147,262,1987
subcutaneous
mouse 		lethal dose (50 percent kill): 620 mg/kg N/R NIIRDN 6,519,1982
unreported route
mouse 		lowest published lethal dose: 25 mg/kg N/R ARZNAD 35,1688,1985


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lowest published toxic dose: 8,190 mg/kg/13 week- continuous Endocrine: Other changes

Blood: Changes in leukocyte (WBC) count

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		NTPTR* NTP-TR-420,1993
oral
rat 		lowest published toxic dose: 157 mg/kg/3 week- intermittent Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases 		ARZNAD 31,1257,1981
oral
rat 		lowest published toxic dose: 2,700 mg/m3/15 day- continuous Endocrine: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		NTPTR* NTP-TR-420,1993
oral
rat 		lowest published toxic dose: 6,370 mg/m3/13 week- continuous Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		NTPTR* NTP-TR-420,1993


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
TOXICOLOGY REVIEW
NEJMAG 343,1608,2000
TOXICOLOGY REVIEW
MUREAV 488,151,2001
TOXICOLOGY REVIEW
MUTAEX 14,5,1999
TOXICOLOGY REVIEW
EMMUEG 43,143,2004
TOXICOLOGY REVIEW
MUREAV 612,115,2006
TOXICOLOGY REVIEW
MUREAV 584,1,2005
TOXICOLOGY REVIEW
TOPADD 32(Suppl. 2),71,2004


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X5679;
Number of Industries 1;
Total Number of Facilities 60;
Number of Occupations 1;
Total Number of Employees Exposed 587;
Total Number of Female Employees Exposed 310


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
NTP Carcinogenesis Studies (feed);some evidence:mouse NTPTR* NTP-TR-420,1993
NCI Carcinogenesis Studies (feed);equivocal evidence:mouse,rat


REFERENCES:

CODEN
REFERENCE
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG.
FRXXBL French Demande Patent Document. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231)
GMCRDC Gann Monograph on Cancer Research. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No. 11- 1971-
MJAUAJ Medical Journal of Australia. (Australasian Medical Pub. Co. Ltd., 71-79 Arundel St., Glebe, N.S.W., Australia) V.1- 1914-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1986-
NEJMAG New England Journal of Medicine. (Massachusetts Medical Soc., 10 Shattuck St., Boston, MA 02115) V.198- 1928-
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan)
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206-
PHARAT Pharmazie. (VEB Verlag Volk und Gesundheit, Neue Gruenstr. 18, Berlin DDR-1020, Ger. Dem. Rep.) V.1- 1946-
SNSHBT Senshokutai. Chromosome. (Sensyokutai Gakkai, Kaokusai Kirisutokyo Daigaku, Mitaka, Tokyo-to, Japan) No.1- 1946- Adopted new numbering in 1976.
TOPADD Toxicologic Pathology. (c/o Dr. F.A. de la Iglesia, Warner-Lambert Co., Pharmaceutical Research Div., POB 1047, Ann Arbor, MI 48106) V.6(3/4)- 1978-
YAKUD5 Gekkan Yakuji. Pharmaceuticals Monthly. (Yakugyo Jihosha, Inaoka Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan) V.1- 1959-

Used as an oral natriuretic agent

FDA-proprietary drug

RTECS Compound Description:
   Tumorigen
   Drug
   Mutagen
   Human Data

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